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Cytokine gene polymorphism and graft-versus-host disease: a survey in Iranian bone marrow transplanted patients.

Abstract：

:Graft versus host disease (GVHD) is a major complication of bone marrow transplantation (BMT). Numerous studies have shown the potential role of cytokine genotypes in the occurrence of GVHD. In this retrospective, case-control study we aimed to investigate the association between 13 cytokine genes and acute GVHD (aGVHD) after HLA-identical sibling BMT in 91 Iranian subjects. Negative association was found between aGVHD and donor IL-10/GCC haplotype or donor IL-4Ra-A allele in the population study. When compared within the leukemia subgroup, we observed positive association between recipient IL-1α -889/C allele and aGVHD. Also there were negative association between recipient IL-10/CAA haplotype and donor IL-4Ra/A allele and development of aGVHD. Among the different genotypes only donor IL-4Ra and donor IL-12 showed significant association. We conclude that several cytokine polymorphisms are positively and negatively associated with aGVHD in Iranian HLA matched siblings, of which IL-4Ra and IL-12 may play important roles.

journal_name

Mol Biol Rep

journal_title

Molecular biology reports

authors

Noori-Daloii MR,Jalilian N,Izadi P,Sobhani M,Rabii-Gilani Z,Yekaninejad MS

doi

10.1007/s11033-013-2585-4

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

4861-7

issue

8

eissn

0301-4851

issn

1573-4978

journal_volume

40

pub_type

杂志文章

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