Abstract：
:It is well known that transcriptionally inactive rRNA genes are correlated with DNA hyper-methylation and histone hypo-methylation and there is clear evidence in humans that DNA and histone modification which alter chromatin structure are related to chromosome fragility. Very little is known about the biological cause of 45S rDNA fragility. In this report we characterized the chromosome breakage or gap associated with 45S rDNA in a fish species Channa punctatus. The rDNA mapping in C. punctatus, showed many chromosome breakages or gap formations, and all occurred exclusively in the 45S rDNA sites in anterior kidney cells. We observed that the number of chromosomes plus chromosome fragments was often more than the expected 32 in most cells. Total 67 % metaphase spread showed the expected or normal 32 chromosomes, while 33 % metaphase spread showed 33 and/or 34 chromosomes and/or chromosome fragments. The chromosome lesions observed in this study are very similar cytologically to that of fragile sites observed in human chromosomes. Possible causes for the spontaneous expression of fragile sites and their potential biological significance are also discussed in present report.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Singh M,Barman ASdoi
10.1007/s11033-012-2112-zsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
723-9issue
1eissn
0301-4851issn
1573-4978journal_volume
40pub_type
杂志文章abstract：:Responses of plants to salinity stress and the development of salt tolerance are extremely complex. Proteomics is a powerful technique to identify proteins associated with a particular environmental or developmental signal. We employed a proteomic approach to further understand the mechanism of plant responses to sali...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1460-z
更新日期：2012-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05840-6
更新日期：2020-10-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11033-014-3405-1
更新日期：2014-08-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：1998-07-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-019-04824-5
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s11033-020-05336-3
更新日期：2020-04-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1745-2
更新日期：2012-09-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-9948-x
更新日期：2011-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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更新日期：2011-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-3002-8
更新日期：2014-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1976-04-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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pub_type： 杂志文章
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