Sequence variation in promoter regions of genes for CC chemokine ligands (CCL)19 and 21 in Czech patients with myocardial infarction.

Abstract:

:Recruitment of inflammatory cells to the arterial wall is an important pathogenic mechanism of atherosclerosis and coronary artery disease (CAD). Functional variability in the genes encoding for chemokines that promote infiltration of atherosclerotic plaques by macrophages and lymphocytes may therefore contribute to the genetic susceptibility to CAD. We, therefore, investigated the association between myocardial infarction (MI) and polymorphisms in the promoter regions of the chemokine genes CCL19 and CCL21. Based on re-sequencing screening we selected and, using PCR-SSP, determined three polymorphisms of CCL19 gene (GenBank ID rs2233872) and CCL21 gene (GenBank ID rs11574914 and rs11574915) in 211 Czech patients with MI and 150 healthy control subjects. There was no difference in allelic frequencies of the investigated SNPs between patients and controls (p>0.05). However, the proportion of homozygotes for the minor G allele of the CCL21 promoter variant (rs11574915 GG) was lower among the MI patients (1%) in comparison with the control subjects (5%, nominal p=0.03). Though rare in the Czech population, CCL21 (rs11574915) GG genotype may confer protection from myocardial infarction. Our preliminary data have to be independently replicated.

journal_name

Mol Biol Rep

authors

Stahelova A,Petrkova J,Petrek M,Mrazek F

doi

10.1007/s11033-014-3175-9

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

3163-8

issue

5

eissn

0301-4851

issn

1573-4978

journal_volume

41

pub_type

杂志文章
  • Development and characterization of novel polymorphic microsatellite loci in Siniperca scherzeri Steindachner and Siniperca chuatsi (Basilewsky).

    abstract::De novo assemblies of transcriptome sequence of F(1) interspecies hybrids between Mandarin fish Siniperca chuatsi (Basilewsky) (♀) and Golden mandarin fish Siniperca scherzeri Steindachner (♂) were generated using Illumina sequencing. In the present study, 64 microsatellite primer pairs were designed on basis of the t...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1958-4

    authors: Huang W,Liang X,Qu C,Cao J,Zhao C,Cao L

    更新日期:2013-02-01 00:00:00

  • Molecular characterization of antigen B2 subunit in two genotypes of Echinococcus granulosus from Indian bubaline isolates, its stage specific expression and serological evaluation.

    abstract::Echinococcus granulosus is a parasitic helminth which affects both man and animals. During infection with larval stage of the organism secretory and membrane-bound (S/M) proteins play a meaningful role for evasion of immune system. Antigen B (AgB) is one of them. Present investigation has defined sequence diversity of...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0332-7

    authors: Pan D,Bera AK,Bandyopadhyay S,Das S,Rana T,Das SK,Bandyopadhyay S,Manna B,Bhattacharya D

    更新日期:2011-03-01 00:00:00

  • Xanthine dehydrogenase and aldehyde oxidase in chicken liver: Molecular identity?

    abstract::Evidence is presented to suggest that in chick liver, xanthine dehydrogenase and aldehyde oxidase activities are associated with only one protein species. The results of SDS electrophoresis of the purified material indicate a subunit MW of 120 000. ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00357585

    authors: Andres R,Lebherz HG,Ursprung H

    更新日期:1973-08-01 00:00:00

  • Association of interleukin-8 gene polymorphisms with the risk of hepatocellular carcinoma.

    abstract::Interleukin-8 (IL8) polymorphisms have been implicated in several cancers, but their roles in the pathogenesis of hepatocellular carcinoma (HCC) are largely unknown. The present study was designed to explore the association between IL8 polymorphism and the risk of HCC in a Chinese population. Four single nucleotide po...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2993-5

    authors: Wang JL,Nong LG,Wei YS,Tang YJ,Wang JC,Wang CF

    更新日期:2014-03-01 00:00:00

  • Optimizing mechanical stretching protocols for hypertrophic and anti-apoptotic responses in cardiomyocyte-like H9C2 cells.

    abstract::Cardiomyocytes possess the ability to respond to mechanical stimuli by reprogramming their gene expression. This study investigated the effects of different loading protocols on signaling and expression responses of myogenic, anabolic, inflammatory, atrophy and pro-apoptotic genes in cardiomyocyte-like H9C2 cells. Dif...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-020-06112-z

    authors: Zevolis E,Philippou A,Moustogiannis A,Chatzigeorgiou A,Koutsilieris M

    更新日期:2021-01-04 00:00:00

  • Identification, characterization, and expression analysis of a serotonin receptor involved in the reproductive process of the Pacific abalone, Haliotis discus hannai.

    abstract::Serotonin receptor (5-HT) is a biogenic amine acting as a neurotransmitter and neuromodulator that mediates various aspects of reproduction and gametogenesis. The full-length nucleotide sequence of Haliotis discus hannai encodes a protein of 417 amino acids with a predicted molecular mass of 46.54 kDa and isoelectric ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-019-05162-2

    authors: Sharker MR,Sukhan ZP,Kim SC,Lee WK,Kho KH

    更新日期:2020-01-01 00:00:00

  • Systematic investigation of interactions between papain and MPA-capped CdTe quantum dots.

    abstract::Fluorescent quantum dots (QDs) have been widely applied in biological and biomedical areas, but relatively little is known about the interaction of QDs with some natural enzymes. Herein, the interactions between 3-mercaptopropionic acid-capped CdTe QDs (MPA-QDs) and papain were systematically investigated by UV-Vis ab...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2681-5

    authors: Xiao Q,Qiu H,Huang S,Huang C,Su W,Hu B,Liu Y

    更新日期:2013-10-01 00:00:00

  • High frequency production of rapeseed transgenic plants via combination of microprojectile bombardment and secondary embryogenesis of microspore-derived embryos.

    abstract::Transgenic doubled haploid rapeseed (Brassica napus L. cvs. Global and PF(704)) plants were obtained from microspore-derived embryo (MDE) hypocotyls using the microprojectile bombardment. The binary vector pCAMBIA3301 containing the gus and bar genes under control of CaMV 35S promoter was used for bombardment experime...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0158-3

    authors: Abdollahi MR,Moieni A,Mousavi A,Salmanian AH

    更新日期:2011-02-01 00:00:00

  • SNPs of MYPN and TTN genes are associated to meat and carcass traits in Italian Large White and Italian Duroc pigs.

    abstract::Myopalladin (MYPN) and titin (TTN) play key roles in skeletal muscle structural organisation and for this reason they may be functional candidates for meat production traits in pigs. We analysed by PCR-RFLP two polymorphisms previously identified and described in the 3'UTR of MYPN and TTN genes in a group of Italian L...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-2812-z

    authors: Braglia S,Davoli R,Zappavigna A,Zambonelli P,Buttazzoni L,Gallo M,Russo V

    更新日期:2013-12-01 00:00:00

  • NHE1 gene associated with avian leukosis virus subgroup J infection in chicken.

    abstract::As a kind of binding protein, the type 1 Na(+)/H(+) exchanger (NHE1) is a receptor for the highly pathogenic Avian leukosis viruses-J subgroup (ALV-J) in chicken. In order to investigate the potential effect of chicken NHE1 gene on leukosis, we compared its expression between ALV-J-affected and -unaffected chicken, sc...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-014-3535-5

    authors: Chen B,Pan W,Zhang L,Liu J,Ouyang H,Nie Q,Zhang X

    更新日期:2014-10-01 00:00:00

  • Effect of Sevoflurane postconditioning on gene expression in brain tissue of the middle cerebral artery occlusion rat model.

    abstract::Ischemic postconditioning has been described in both heart and brain. The first aim of this study was to evaluate the effects of Sevoflurane postconditioning (SP) on brain biochemical parameters, Bcl-2, Bax, c-Fos and Caspase-3 protein levels and Bcl-2, Bax, TNF-α and Caspase-3 mRNA expression in the middle cerebral a...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1935-y

    authors: Liu HG,Hua Z,Zhang Y,Wang YX,Meng C,Liang Y,Tian SY,Ma YP,Wang L,Wang WS

    更新日期:2012-12-01 00:00:00

  • Identification of a cathepsin D potentially involved in H2A cleavage from scallop Chlamys farreri.

    abstract::We report here a cDNA and its deduced amino acid sequence encoding a cathepsin D-like, aspartic protease from Chlamys farreri (denoted as CfCD) by expressed sequence tag and rapid amplification of cDNA ends techniques. The cDNA of CfCD consisted of 1,810 nucleotides with a canonical polyadenylation signal sequence AAT...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9534-2

    authors: Li C,Zhang H,Li L,Song L

    更新日期:2010-03-01 00:00:00

  • Molecular and biochemical analysis of the beta class carbonic anhydrases in Caenorhabditis elegans.

    abstract::The beta class of the carbonic anhydrase (CA) enzyme family has been found in plants, yeast, bacteria and algae, but not in animals. Also, little is known concerning the CAs of C. elegans. Genes possibly encoding beta-CAs were revealed by in silico analysis of the C. elegans genome. Amino acid sequence and 3D structur...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9857-z

    authors: Fasseas MK,Tsikou D,Flemetakis E,Katinakis P

    更新日期:2010-07-01 00:00:00

  • Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.

    abstract::The aim of this study was to explore candidate single nucleotide polymorphisms (SNPs) and candidate mechanisms of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Two SLE genome-wide association studies (GWASs) datasets were included in this study. Meta-analysis was conducted using 737,984 SNPs in 1,5...

    journal_title:Molecular biology reports

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11033-012-1952-x

    authors: Lee YH,Bae SC,Choi SJ,Ji JD,Song GG

    更新日期:2012-12-01 00:00:00

  • Effect of ketamine administration on memory consolidation, p-CREB and c-fos expression in the hippocampal slices of minor rats.

    abstract::To investigate the effect of ketamine administration on memory consolidation, p-CREB and c-fos expression in hippocampus of infant rats and the possible mechanism. Ninety-six SD rats of 21 days old were divided into seven groups, Y-maze was used to test the ability of learning and memory for minor rats. p-CREB and c-f...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-010-0374-x

    authors: Peng S,Zhang Y,Ren B,Zhang J,Wang H

    更新日期:2011-04-01 00:00:00

  • Rapid and simple methodology for isolation of high quality genomic DNA from coniferous tissues (Taxus baccata).

    abstract::Various investigations have been so far performed for extraction of genomic DNA from plant tissues, in which the extracted intact DNA can be exploited for a diverse range of biological studies. Extraction of high quality DNA from leathery plant tissues (e.g., coniferous organs) appears to be a critical stage. Moreover...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-009-9634-z

    authors: Barzegari A,Vahed SZ,Atashpaz S,Khani S,Omidi Y

    更新日期:2010-02-01 00:00:00

  • Cloning and characterization of Na+/H+ antiporter (LfNHX1) gene from a halophyte grass Leptochloa fusca for drought and salt tolerance.

    abstract::Abiotic stresses such as salinity and drought have adverse effects on plants. In the present study, a Na(+)/H(+) antiporter gene homologue (LfNHX1) has been cloned from a local halophyte grass (Leptochloa fusca). The LfNHX1 cDNA contains an open reading frame of 1,623 bp that encodes a polypeptide chain of 540 amino a...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-013-3015-3

    authors: Rauf M,Shahzad K,Ali R,Ahmad M,Habib I,Mansoor S,Berkowitz GA,Saeed NA

    更新日期:2014-03-01 00:00:00

  • High fat diet administration leads to the mitochondrial dysfunction and selectively alters the expression of class 1 GLUT protein in mice.

    abstract::Metabolic syndrome is an agglomeration of disorders including obesity, diabetes and cardiovascular diseases and characterized as chronic mild inflammation which elevates the circulatory inflammatory markers. This could be due to mitochondrial dysfunction, oxidative stress and hypoxia as a consequence of high fat diet ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-019-04623-y

    authors: Jha D,Mitra Mazumder P

    更新日期:2019-04-01 00:00:00

  • Glutathione S-transferase M1, T1, and P1 polymorphisms and risk of glioma: a meta-analysis.

    abstract::The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However these studies report inconsistent results. In order to quantitatively summarise the evidence for such a relationship, a meta-analysis is conduc...

    journal_title:Molecular biology reports

    pub_type: 杂志文章,meta分析

    doi:10.1007/s11033-012-2213-8

    authors: Fan Z,Wu Y,Shen J,Zhan R

    更新日期:2013-02-01 00:00:00

  • Isolation and characterization of microsatellite markers for conservation management of the endangered Great-billed Seed-finch, Sporophila maximiliani (Aves, Passeriformes), and cross-amplification in other congeners.

    abstract::The Great-billed Seed-finch, Sporophila maximiliani, is a threatened neotropical bird that has declined mainly due to illegal trapping, with very few records in the wild in the last two decades. Despite the existence of a considerable captive population that could be used for reintroductions into the wild, many indivi...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-018-4377-3

    authors: Medolago CAB,Costa MC,Ubaid FK,Glenn TC,Silveira LF,Francisco MR

    更新日期:2018-12-01 00:00:00

  • EGY2, a chloroplast membrane metalloprotease, plays a role in hypocotyl elongation in Arabidopsis.

    abstract::Intramembrane proteases control many important processes in a wide variety of organisms through regulated intramembrane proteolysis (RIP). However, very few intramembrane proteases have been characterized in plants. Intriguingly, EGY2 in Arabidopsis belongs to the Site-2 protease (S2P) family that performs RIP. It con...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-0962-4

    authors: Chen G,Law K,Ho P,Zhang X,Li N

    更新日期:2012-03-01 00:00:00

  • Expression analysis of turkey (Meleagris gallopavo) toll-like receptors and molecular characterization of avian specific TLR15.

    abstract::Toll-like receptors (TLRs) constitute a multi-gene family, which plays a pivotal role in sensing invading pathogens by virtue of conserved microbial patterns. TLR repertoire of chicken and zebra finch has been well studied. However TLR family of other avian species is yet to be characterized. In the present study, we ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1709-6

    authors: Ramasamy KT,Reddy MR,Verma PC,Murugesan S

    更新日期:2012-08-01 00:00:00

  • A comparative study on the two classes of heterogeneous nuclear ribonucleoprotein particles separated in metrizamide density gradient, by electrophoresis of proteins and chase experiments. Evidence for two distinct subfractions of HnRNP in mammalian nucle

    abstract::Heterogeneous nuclear ribonucleoprotein particles (HnRNP) were separated in metrizamide density gradients, into two fractions migrating to 1.31 g ml-1 and 1.18 g ml-1, respectively. Proteins associated with each of these fractions were analysed by SDS-acrylamide gel electrophoresis. It is shown that the whole proteins...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00643481

    authors: Houssais JF

    更新日期:1977-03-01 00:00:00

  • Differentially expressed three non-coding alternate exons at 5' UTR of regulatory type I beta subunit gene of mouse.

    abstract::Prkar1b gene encodes regulatory type I, beta subunit (RIβ) of cAMP dependent protein kinase A in mouse. Among the various isoforms of regulatory and catalytic subunits that comprise mammalian PKA, RIβ subunit is considered to be one of the important subunits for neuronal functions. This is involved in multiple forms o...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-011-1108-4

    authors: Banday AR,Azim S,Tabish M

    更新日期:2012-04-01 00:00:00

  • Ribosome-membrane interactions: characterization of ribosomal proteins from loose and tight bound ribosomes.

    abstract::Membrane-bound ribosomes were isolated from a post-mitochondrial supernatant fraction of mouse liver homogenate by sedimentation in a sucrose density gradient, Loose ribosomes were released from the membrane fragments with 0.5 M KCl, while tight bound ribosomes were not released. After purification of the loose and ti...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00778433

    authors: Hoffman WL,Dowben RM

    更新日期:1980-07-31 00:00:00

  • Proteasome inactivation upon aging and on oxidation-effect of HSP 90.

    abstract::Increases of oxidatively modified protein in the cell have been associated with the aging process. Such an accumulation of damaged protein may be the result of increase in the rate of protein oxidation and/or decrease in the rate of degradation of oxidized protein. The multicatalytic proteinase or proteasome is known ...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1023/a:1006852506884

    authors: Conconi M,Friguet B

    更新日期:1997-03-01 00:00:00

  • Anomalous refractivity changes of gramicidin A in ethanol solutions.

    abstract::Studies of the refractive properties of Gramicidin A in absolute ethanol and in ethanol water mixtures showed that this peptide in solution undergoes a conformational transition resulting in species with different refractivity. Accordingly, the folded form of this peptide shows a lower specific refractive index increm...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/BF00357540

    authors: Derechin M,Jordan BE

    更新日期:1975-07-01 00:00:00

  • Effects of magnetic field on cell dedifferentiation and callus induction derived from embryo culture in bread wheat (Triticum aestivum. L) genotypes.

    abstract::Current study was conducted to investigation of effect of magnetic field on cell dedifferentiation and follow it callus induction derived from mature embryo culture in bread wheat genotypes. For this purpose, a factorial experiment based on completely randomized design was carried out with two wheat genotypes and thre...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-2214-7

    authors: Kahrizi D,Cheghamirza K,Akbari L,Rostami-Ahmadvandi H

    更新日期:2013-02-01 00:00:00

  • MicroRNA signature associated with osteogenic lineage commitment.

    abstract::Cell-based approaches offer a potential therapeutic strategy for appropriate bone manufacturing. Capable of differentiating into multiple cell types especially osteoblasts spontaneously, unrestricted somatic stem cell (USSC) seems to be a suitable candidate. Recent studies have shown the involvement of microRNAs in se...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-1591-2

    authors: Bakhshandeh B,Soleimani M,Hafizi M,Paylakhi SH,Ghaemi N

    更新日期:2012-07-01 00:00:00

  • An integrated pathway system modeling of Saccharomyces cerevisiae HOG pathway: a Petri net based approach.

    abstract::Biochemical networks comprise many diverse components and interactions between them. It has intracellular signaling, metabolic and gene regulatory pathways which are highly integrated and whose responses are elicited by extracellular actions. Previous modeling techniques mostly consider each pathway independently with...

    journal_title:Molecular biology reports

    pub_type: 杂志文章

    doi:10.1007/s11033-012-2153-3

    authors: Tomar N,Choudhury O,Chakrabarty A,De RK

    更新日期:2013-02-01 00:00:00