Abstract:
:Chromatin from guinea pig hepatocytes has been studied by electron microscopy using the spreading technique. Among DNP fibers with nucleosomal organization numerous structures with different organization have been observed. The structures consist of the main axial fiber from which the lateral fibrils branch off normal to the axis. The distances between the bases of lateral fibrils vary to a considerable extent. The lateral fibrils are composed of regular granules with an average diameter of 257 A, and the axial fiber of irregularly and rarely arranged granules. The structures described are thought to be nonribosomal transcription complexes, and the granules of lateral fibrils--nuclear informosomes. The longest lateral fibril may have up to 80 granules (informosomes), which corresponds to a pre-mRNA chain of about 15-17 x 10(6) daltons.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Bandrina IN,Manteifel VM,Zelenin AVdoi
10.1007/BF00775408subject
Has Abstractpub_date
1980-10-31 00:00:00pages
149-51issue
3eissn
0301-4851issn
1573-4978journal_volume
6pub_type
杂志文章abstract::Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diagnoses seen by primary care providers and gastroenterologists. Proinflammatory cytokines interleukin (IL)-6 and IL-8 have been found increased in IBS patients. Cytokine gene single nucleotide polymorphisms (SNPs) of IL-8 and IL-10 have not be...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-1745-2
更新日期:2012-09-01 00:00:00
abstract::Inflammatory cytokine, adipokine and adhesion molecules are known to play a key role in pathogenesis of diabetic kidney disease (DKD). In this study, our aim was to investigate the role of fetuin-A in relation with pro-inflammatory cytokines (IL-6, IL-18), adipokines (adiponectin, leptin), chemokine (MCP-1), and adhes...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04592-2
更新日期:2019-02-01 00:00:00
abstract::Circulating long noncoding RNAs as biomarkers of diseases have attracted increasing attention recently. However, circulating lncRNAs in hypertension is still unexplored niche. The levels of lncRNAs GAS5, NR024118, MRAK134679, AX765700 and MRNR026574 were measured in the serum and myocardium of hypertensive rats and no...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05086-x
更新日期:2019-12-01 00:00:00
abstract::Acute and chronic viral hepatitis infections are corresponding to increase the risk of different types of hematological malignancies especially with leukemia. In this study the serological and molecular markers of hepatitis viruses were evaluated in patients with different types of leukemia in comparing with control g...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0851-x
更新日期:2012-02-01 00:00:00
abstract::The aim of this study is to evaluate which dysregulated angiomiRs compose the specific proangiogenic microRNA signature of advanced laryngeal cancer and review the literature. Thirty-six samples from twelve patients with advanced laryngeal carcinoma were collected. Total RNA was extracted and microRNA global profiling...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05250-8
更新日期:2020-07-01 00:00:00
abstract::A full length spermidine synthase (PgSPD) cDNA was isolated and characterized from the root of Panax ginseng C. A. Meyer. The cDNA was 1,188 nucleotides long and had an open reading frame of 1,002 bp with a deduced amino acid sequence of 333 residues. The calculated molecular mass of the matured protein is approximate...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9725-x
更新日期:2010-02-01 00:00:00
abstract::Steroid administration, which is commonly performed for the treatment of autoimmune inflammatory diseases, cancers or organ transplantation, has been a leading cause of nontraumatic osteonecrosis of the femoral head (ONFH). Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-014-3173-y
更新日期:2014-05-01 00:00:00
abstract::TCF7L2 and SLC30A8 have been found to be associated with type 2 diabetes mellitus (T2DM) as well as with impaired proinsulin processing recently, enzymes encoded by PCSK1 and PCSK2 are reported to play an important role in the process of proinsulin conversion. To investigate whether the single nucleotide polymorphisms...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0705-6
更新日期:2012-01-01 00:00:00
abstract::The aim of this work was to study β-defensin 1 (SBD1) and β-defensin 2 (SBD2) genes in Valle del Belice dairy sheep in order to identify polymorphisms that can be utilized as markers of the analyzed genes, and search for the functional effects and roles of the identified polymorphisms (variation of the amino acid sequ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-011-0694-5
更新日期:2011-11-01 00:00:00
abstract::Echinococcus granulosus is a parasitic helminth which affects both man and animals. During infection with larval stage of the organism secretory and membrane-bound (S/M) proteins play a meaningful role for evasion of immune system. Antigen B (AgB) is one of them. Present investigation has defined sequence diversity of...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-010-0332-7
更新日期:2011-03-01 00:00:00
abstract::The interleukin (IL)-1β-511 C/T polymorphism has been shown to be functional and to contribute to the risk of gastric cancer. However, the relationship between the IL-1β-511 C/T polymorphism and gastric carcinogenesis remains inconclusive. A systematical electronic search was conducted of the MEDLINE, EMBASE, and CENT...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-014-3748-7
更新日期:2015-01-01 00:00:00
abstract::The protease activity of gp63 from L. major was studied in relation to tunicamycin induced N-deglycosylation. It was found that after tunicamycin treatment, a N-deglycosylated product of gp63 with protease activity is present at the cell surface of Leishmania promastigote. ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00419752
更新日期:1992-05-01 00:00:00
abstract::The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collecte...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05628-8
更新日期:2020-07-01 00:00:00
abstract::Cotton fiber cells elongate without dividing to form economically valuable spinnable fiber. Reports of the ploidy level of fiber cells are variable. Early reports indicated an increase in nuclear DNA content in young fibers; however, subsequent reports failed to observe such a significant increase in ploidy level. Eva...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9496-4
更新日期:2010-02-01 00:00:00
abstract::Current study was conducted to investigation of effect of magnetic field on cell dedifferentiation and follow it callus induction derived from mature embryo culture in bread wheat genotypes. For this purpose, a factorial experiment based on completely randomized design was carried out with two wheat genotypes and thre...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-012-2214-7
更新日期:2013-02-01 00:00:00
abstract::Membrane-bound ribosomes were isolated from a post-mitochondrial supernatant fraction of mouse liver homogenate by sedimentation in a sucrose density gradient, Loose ribosomes were released from the membrane fragments with 0.5 M KCl, while tight bound ribosomes were not released. After purification of the loose and ti...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/BF00778433
更新日期:1980-07-31 00:00:00
abstract::Curcumin is a polyphenolic bioactive compound found in the spice turmeric endowed with diverse pharmacological and biological activities. In this study, fluorescence spectroscopy in combination with UV-Vis absorbance spectroscopy was employed to investigate the high affinity binding of curcumin to herring sperm DNA (h...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2530-6
更新日期:2013-07-01 00:00:00
abstract::In attempting to produce the HAP, endoplasmic reticulum (ER) targeted apoptosis-inducing protein, as a GST-fusion protein we found that the expression of HAP, but not GST alone, induced bacterial cell death. The HAP protein inhibited the bacterial growth within 30 min after inducting HAP expression. The transmission e...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1023/b:mole.0000043551.84883.c8
更新日期:2004-09-01 00:00:00
abstract::The association between vitamin D receptor (VDR) gene polymorphisms and risk of benign prostatic hyperplasia (BPH) has been investigated in numerous publications, but published results remain inconclusive. Hence, we conducted this meta-analysis to derive a more precise conclusion. Four polymorphisms (Taq-I, Bsm-I, Apa...
journal_title:Molecular biology reports
pub_type: 杂志文章,meta分析
doi:10.1007/s11033-014-3554-2
更新日期:2014-10-01 00:00:00
abstract::The disturbed immune homeostasis is involved in the pathogenesis of an array of autoimmune diseases like rheumatoid arthritis (RA). The adenosine monophosphate-activated protein kinase (AMPK) with a pivotal role in immunometabolism process, also plays a regulatory function in the immune system. This study aims to eval...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05078-x
更新日期:2019-12-01 00:00:00
abstract::p53 helps in maintaining genomic stability by undergoing cellular arrest, DNA repair or cellular apoptosis during DNA damage. So, as to find the association of p53Arg 72 Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic variant (rs1042522) was anal...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-016-4072-1
更新日期:2016-12-01 00:00:00
abstract::Dengue virus and Zika virus are arthropod-borne flaviviruses that cause millions of infections worldwide. The co-circulation of both viruses makes serological diagnosis difficult as they share high amino acid similarities in viral proteins. Antigens are one of the key reagents in the differential diagnosis of these vi...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-020-05772-1
更新日期:2020-10-01 00:00:00
abstract::A number of regions designated as RD1-RD16 (region of difference) and encompassing 129 open reading frames have been identified between Mycobacterium tuberculosis and Mycobacterium bovis on the one hand and Bacillus Calmette-Guérin on the other. Identification of T cell epitopes from this set of proteins may serve to ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9613-4
更新日期:2010-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) incidence is fast-growing especially in countries highly prevalent with viral hepatitis. Its poor prognosis has driven the research toward the discovery of sensitive markers for early detection. We investigated the usefulness of serum Transforming growth factor-beta1 (TGF-β1), Glypican-3...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2829-3
更新日期:2013-12-01 00:00:00
abstract::Interleukin-8 (IL8) polymorphisms have been implicated in several cancers, but their roles in the pathogenesis of hepatocellular carcinoma (HCC) are largely unknown. The present study was designed to explore the association between IL8 polymorphism and the risk of HCC in a Chinese population. Four single nucleotide po...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2993-5
更新日期:2014-03-01 00:00:00
abstract::The Cichlid fish Sarotherodon melanotheron is typically found in West and Central African estuaries and lagoons. It represents a good candidate for promoting tilapia farming in brackish waters. Understanding the genetic diversity in its populations from the hydrographical basins of Southern Benin is primordial before ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-018-4354-x
更新日期:2018-12-01 00:00:00
abstract::The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes...
journal_title:Molecular biology reports
pub_type: 杂志文章,评审
doi:10.1007/s11033-014-3079-8
更新日期:2014-01-01 00:00:00
abstract::Deprivation of cytokines induces cell cycle arrest and apoptosis in cytokine-dependent hematopoietic progenitors. Previous studies have indicated that in Baf-3, interleukin (IL)-3-dependent cells, apoptosis is caused predominantly by Bim, a BH3-only cell death activator that belongs to the Bcl-2 superfamily. Because B...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-004-7656-0
更新日期:2005-06-01 00:00:00
abstract::Evidence indicates that both S-adenosylmethionine (SAMe) metabolism and intramuscular fat are associated with insulin resistance and type II diabetes. However, it is still unknown whether SAMe have effects on intramuscular adipogenesis. The present study investigated the roles of SAMe in the adipogenic differentiation...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-009-9893-8
更新日期:2010-10-01 00:00:00
abstract::The present was carried out to evaluate the toxicity of methanolic leaf extract of Rhizophora mucronata (MERM) under in vivo and in vitro conditions. Mutagenicity of MERM (up to 4,000 μg/plate) evaluated by Salmonella/microsome assay (TA98, TA100, TA1535 and TA1538 strains), with or without metabolic activation showed...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-013-2981-9
更新日期:2014-03-01 00:00:00