Abstract：
:HMG proteins were extracted with 5% PCA or 0.35 M NaCl from whole tissue, nuclei or chromatin of the liver of young (19 weeks) and old (118 weeks) male rats. They were resolved on acetic acid-urea polyacrylamide gel. The electrophoretic patterns of the major HMG proteins 1, 2, 14 and 17 of both ages are similar. The in vitro synthesis of HMG 1 and 2 decreases, but that of HMG 14 and 17 increases considerably in the liver of old rats. The synthesis of different HMG proteins is modulated differentially by spermine, butyrate, dexamethasone and 3-aminobenzamide in the liver of young and old rats. These findings suggest that HMG proteins contribute to alterations in the organization of chromatin and expression of genes during aging.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Thakur MK,Prasad Sdoi
10.1007/BF00369896subject
Has Abstractpub_date
1991-02-01 00:00:00pages
19-24issue
1eissn
0301-4851issn
1573-4978journal_volume
15pub_type
杂志文章abstract：:Steroid administration, which is commonly performed for the treatment of autoimmune inflammatory diseases, cancers or organ transplantation, has been a leading cause of nontraumatic osteonecrosis of the femoral head (ONFH). Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3173-y
更新日期：2014-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析
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abstract：:Schizophrenia is a chronic and neuropsychiatric disease that affects about 0.5-1% of the world's population. An increase in dopamine and dopamine D2 receptor (DRD2) gene products has been well described in schizophrenic patients. Several groups have studied the relationship between dopaminergic hyperactivity and cellu...
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journal_title：Molecular biology reports
pub_type： 杂志文章,评审
doi：10.1007/BF00988718
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-020-05934-1
更新日期：2020-11-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章,评审
doi：10.1007/s11033-006-9013-y
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-10-12 00:00:00
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更新日期：2020-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章,meta分析,评审
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journal_title：Molecular biology reports
pub_type： 杂志文章
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journal_title：Molecular biology reports
pub_type： 杂志文章
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