1-Deoxynojirimycin modulates glucose homeostasis by regulating the combination of IR-GlUT4 and ADIPO-GLUT4 pathways in 3T3-L1 adipocytes.

abstract：:Growing data supported that epigenetic modifications, including altered DNA methylation have a potential role in the pathogenesis of autoimmune thyroid diseases (AITD). In the present study we aimed to investigate the methylation status of ICAM-1 gene promoter in patients with AITD. Forty patients with Graves' disease...

journal_title：Molecular biology reports

authors： Shalaby SM,Mackawy AMH,Atef DM,Atef RM,Saeed J

更新日期：2019-10-01 00:00:00

abstract：:The lily-of-the-valley Convallaria (Asparagaceae) consists of three herbaceous perennial species. The plants are commonly found in northern hemisphere, and are best-known for their ornamental and pharmaceutical value. In order to assess the genetic structure, diversity and demographic history of Convallaria species, 1...

journal_title：Molecular biology reports

authors： Lu QX,Gao J,Wu JJ,Zhou X,Wu X,Li MD,Wei YK,Wang RH,Qi ZC,Li P

更新日期：2020-04-01 00:00:00

abstract：:High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, me...

journal_title：Molecular biology reports

authors： Du D,Shi YH,Le GW

更新日期：2010-12-01 00:00:00

abstract：:Many studies have examined the association between the GSTP1 Ile105Val (rs 1695) gene polymorphism and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The PubMed and CNKI database was searched for case-control...

journal_title：Molecular biology reports

authors： Xu CH,Wang Q,Zhan P,Qian Q,Yu LK

更新日期：2014-07-01 00:00:00

abstract：:It has been demonstrated that ACSL3 and ACSL5 play important roles in fat metabolism. To investigate the primary functions of ACSL3 and ACSL5 and to evaluate their expression levels during goose fatty liver development, we cloned the ACSL3 and ACSL5 coding domain sequences (CDSs) of geese using RT-PCR and analyzed the...

journal_title：Molecular biology reports

authors： He H,Liu HH,Wang JW,Lv J,Li L,Pan ZX

更新日期：2014-01-01 00:00:00

abstract：:India has a rich heritage of rearing cattle where farmers selected native cattle suitable to their local agro-ecological conditions for centuries. It is reflected in 50 indigenous breeds of cattle, besides many lesser known populations not explored so far. It is the need of the hour to characterize such populations to...

journal_title：Molecular biology reports

authors： Sharma R,Ahlawat S,Sharma H,Bhagat RL,Singh PK,Tantia MS

更新日期：2020-08-01 00:00:00

abstract：:Alterations in expression of the DFF40 gene have been reported in some cancers. This study is an in vitro study of the therapeutic effects of gene transfer that lead to elevation in DFF40 expression within T-47D cells in the presence of sulfonamide drugs. In this study, we have constructed a eukaryotic expression vect...

journal_title：Molecular biology reports

authors： Bagheri F,Safarian S,Eslaminejad MB,Sheibani N

更新日期：2014-11-01 00:00:00

abstract：:Mollusks lack an adaptive immune system and rely solely on the innate immune response. The nuclear factor-kappa B (NF-κB) signaling pathway is one of the most important components of the innate immune system and its activity is regulated by physical interaction with the inhibitor of NF-κB (IκB) protein. The manila cla...

journal_title：Molecular biology reports

authors： Lee Y,Wickamarachchi WD,Whang I,Oh M,Umasuthan N,De Zoysa M,Oh C,Kang DH,Lee J

更新日期：2013-02-01 00:00:00

abstract：:The MinION is a miniaturized high-throughput next generation sequencing platform of novel conception. The use of nucleic acids derived from formalin-fixed paraffin-embedded samples is highly desirable, but their adoption for molecular assays is hurdled by the high degree of fragmentation and by the chemical-induced mu...

journal_title：Molecular biology reports

authors： Vacca D,Cancila V,Gulino A,Lo Bosco G,Belmonte B,Di Napoli A,Florena AM,Tripodo C,Arancio W

更新日期：2018-02-01 00:00:00

abstract：:It has been suggested that the allele frequency of thrombophilic mutations is affected by glucose-6-phosphate dehydrogenase (G6PD) deficiency. The prevalence of thrombophilic mutations were studied in sixty G6PD deficient individuals including 57 males and three females with the mean age of 15 +/- 3.08 and 110 age and...

journal_title：Molecular biology reports

authors： Mozafari H,Rahimi Z,Heidarpour A,Fallahi M,Muniz A

更新日期：2009-11-01 00:00:00

abstract：:The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collecte...

journal_title：Molecular biology reports

authors： Santos B,Delgadinho M,Ferreira J,Germano I,Miranda A,Arez AP,Faustino P,Brito M

更新日期：2020-07-01 00:00:00

abstract：:Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are common syndromes characterized by diffuse, acute injury to the alveolar epithelium and pulmonary vascular endothelial cells, with high mortality rate for there are no effective pharmacological therapies. Peroxisome proliferators-activated recept...

journal_title：Molecular biology reports

authors： Xiao B,Xu J,Wang G,Jiang P,Fang F,Huang J,Wang J

更新日期：2011-11-01 00:00:00

abstract：:The treatment of anaplastic astrocytoma (AA) is controversial. New chemotherapeutic approaches are needed for AA treatment. Temozolomide (TMZ) is one of the chemotherapeutic drugs for the treatment of AA. The cytotoxic effects of TMZ can be removed by the MGMT (O(6)-methylguanine-DNA methyltransferase) enzyme. Then, c...

journal_title：Molecular biology reports

authors： Ugur HC,Taspinar M,Ilgaz S,Sert F,Canpinar H,Rey JA,Castresana JS,Sunguroglu A

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study is to evaluate which dysregulated angiomiRs compose the specific proangiogenic microRNA signature of advanced laryngeal cancer and review the literature. Thirty-six samples from twelve patients with advanced laryngeal carcinoma were collected. Total RNA was extracted and microRNA global profiling...

journal_title：Molecular biology reports

authors： Popov TM,Giragosyan S,Petkova V,Stancheva G,Marinov T,Belitova M,Rangachev J,Popova D,Kaneva RP

更新日期：2020-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that function in transcriptional and post-transcriptional regulation of gene expression. Several miRNAs have been implicated in regulating prostate cancer (PCa) progression. Deregulations of miRNA regulatory networks have been reported in ERG positive PCa, which accounts fo...

journal_title：Molecular biology reports

authors： Bakkar A,Alshalalfa M,Petersen LF,Abou-Ouf H,Al-Mami A,Hegazy SA,Feng F,Alhajj R,Bijian K,Alaoui-Jamali MA,Bismar TA

更新日期：2016-04-01 00:00:00

abstract：:The study was done to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms that contribute to Parkinson's disease (PD) susceptibility and to generate a SNP to ene to pathway hypothesis using an analytical pathway-based approach. We used a PD genome-wide association study...

journal_title：Molecular biology reports

authors： Song GG,Lee YH

更新日期：2013-03-01 00:00:00

abstract：:Fatty acid-binding proteins (FABPs), small cytosolic proteins that function in the uptake and utilization of fatty acids, have been extensively studied in higher vertebrates while invertebrates have received little attention despite similar nutritional requirements during periods of reproductive activity. Therefore, a...

journal_title：Molecular biology reports

authors： Li WW,Jin XK,He L,Gong YN,Jiang H,Wang Q

更新日期：2011-11-01 00:00:00

abstract：:The phosphoenolpyruvate (PEP) carboxylase is regulated at the levels of transcription and post-translation in C4 plants in light and abundantly accumulates in leaf mesophyll cells. We report here developmental and photosynthetic regulation of stably accumulated Bacillus thuringiensis δ-endotoxin under the control of P...

journal_title：Molecular biology reports

authors： Khan MS,Ali S,Iqbal J

更新日期：2011-04-01 00:00:00

abstract：:A number of regions designated as RD1-RD16 (region of difference) and encompassing 129 open reading frames have been identified between Mycobacterium tuberculosis and Mycobacterium bovis on the one hand and Bacillus Calmette-Guérin on the other. Identification of T cell epitopes from this set of proteins may serve to ...

journal_title：Molecular biology reports

authors： Wang J,Zhang H,Wang H

更新日期：2010-04-01 00:00:00

abstract：:To explore the relationship of Notch1 mutation in T-ALL with the survival rate of T-ALL patients. The PubMed database, the Cochrane Library, conference proceedings, EMBASE databases, and references of published trials and review articles were searched. Two reviewers independently assessed the quality of the trials and...

journal_title：Molecular biology reports

authors： Ma J,Wu M

更新日期：2012-05-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (LP-PLA2) may play an important role in the pathophysiology of coronary heart disease (CHD). The polymorphism of LP-PLA2 gene caused LP-PLA2 enzyme activity depressing or lost. But there is not a definite conclusion for the association of between the LP-PLA2 gene polymorphism an...

journal_title：Molecular biology reports

authors： Zheng GH,Chen HY,Xiong SQ,Chu JF

更新日期：2011-08-01 00:00:00

abstract：:Male Breast Cancer (MBC) is a rare and aggressive disease that is associated with genetic factors. Mutations in BRCA1 and BRCA2 account for 10% of all MBC cases suggesting that other genetic factors are involved. The aim of the present study is to screen whole BRCA1 and BRCA2 exons using the Ampliseq BRCA panel in Tun...

journal_title：Molecular biology reports

authors： Ben Kridis-Rejeb W,Ben Ayed-Guerfali D,Ammous-Boukhris N,Ayadi W,Kifagi C,Charfi S,Saguem I,Sellami-Boudawara T,Daoud J,Khanfir A,Mokdad-Gargouri R

更新日期：2020-09-01 00:00:00

abstract：:CENP-A locates at nucleosome as histone H3-like proteins, and is phosphorylated during mitosis. We investigated the dynamic distribution of p-CENP-A to explore the details of its function. We found that p-CENP-A was phosphorylated at late prophase, and the signal of p-CENP-A arranged at equatorial plate along with nuc...

journal_title：Molecular biology reports

authors： Li D,Liu R,Song L,Zhou H,Chen J,Huang X

更新日期：2008-12-01 00:00:00

abstract：:Disorders in the proliferation and apoptosis of thyrocytes may induce goitre, adenoma and carcinoma in the thyroid. The Wnt/beta-catenin pathway has been demonstrated to be involved in the regulation of cell proliferation, differentiation and apoptosis in various cell lines. The regulatory mechanism on the proliferati...

journal_title：Molecular biology reports

authors： Chen G,Jiang Q,You Z,Yao J,Mou L,Lin X,Shen X,You T,Lin Q,Wen J,Lin L

更新日期：2010-07-01 00:00:00

abstract：:One of the most crucial steps for preventing viral pandemics is the early detection of the causative virus on site. Various molecular and immunological approaches have been developed for virus detection. In this study, we investigated the utility of the recently introduced convection polymerase chain reaction (cPCR) p...

journal_title：Molecular biology reports

authors： Lee MH,Song KY,Hwang HJ,Kim JH,Hwang I

更新日期：2019-10-01 00:00:00

abstract：:Allele frequencies for the high polymorphic short tandem repeats (STR) loci PentaE, PentaD, D18S51, D21S11, TH01, D3S1358, FGA, D16S539, D7820, D13S317, vWA and D81179 were analysed in an native Amerindian population from Mato Grosso do Sul state named Terena. Deviations from Hardy-Weinberg expectations were evaluated...

journal_title：Molecular biology reports

authors： Manta FS,Silva DA,Sánchez-Diz P,Aguiar JI,Cabello PH,Carvalho EF

更新日期：2012-04-01 00:00:00

abstract：:p53 helps in maintaining genomic stability by undergoing cellular arrest, DNA repair or cellular apoptosis during DNA damage. So, as to find the association of p53Arg 72 Pro towards lung carcinogenesis and overall survival of North Indian lung cancer patients, single nucleotide polymorphic variant (rs1042522) was anal...

journal_title：Molecular biology reports

authors： Kumari A,Bahl C,Singh N,Behera D,Sharma S

更新日期：2016-12-01 00:00:00

abstract：:Identifying patients at high risk of metastasis is a major challenge in lung adenocarcinoma (ADC) therapy, therefore discovery of noninvasive biomarkers and therapeutic targets is urgent. We found significant differences between the secretomes of differentially expressed proteins in lung ADC cell lines, clinical tissu...

journal_title：Molecular biology reports

authors： Liu Z,Gao Y,Hao F,Lou X,Zhang X,Li Y,Wu D,Xiao T,Yang L,Li Q,Qiu X,Wang E

更新日期：2014-11-01 00:00:00

abstract：:Dipeptidyl peptidase III (DPP III) is an emerging biomarker of human cancers. Expression, specificity, and function of human DPP III (hDPP III) mRNA variant I (V-I), II (V-II), and III (V-III) are poorly understood. Here, we investigated expression of these variants in multiple human tumor derived cell lines. DNA sequ...

journal_title：Molecular biology reports

authors： Prajapati SC,Chauhan SS

更新日期：2016-06-01 00:00:00

abstract：:Biochemical networks comprise many diverse components and interactions between them. It has intracellular signaling, metabolic and gene regulatory pathways which are highly integrated and whose responses are elicited by extracellular actions. Previous modeling techniques mostly consider each pathway independently with...

journal_title：Molecular biology reports

authors： Tomar N,Choudhury O,Chakrabarty A,De RK

更新日期：2013-02-01 00:00:00