Detection of new biallelic polymorphisms in the human MxA gene.

abstract：:Intrinsic bent DNA sites were identified in the 4289 bp segment encompassing the replication zone which directs DNA amplification and transcription of the C3-22 gene of Rhynchosciara americana. Restriction fragments showed reduced electrophoretic mobility in polyacrylamide gels. The 2D modeling of the 3D DNA path and ...

journal_title：Molecular biology reports

authors： Fiorini A,de Gouveia FS,de Soares MA,Stocker AJ,Ciferri RR,Fernandez MA

更新日期：2006-03-01 00:00:00

abstract：:Molecular abnormalities in the 11p15.5 imprinted gene cluster lead to two different growth diseases: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS). They are mainly caused by epigenetic alterations in one of the two imprinting 11p15 control regions (ICR1 and ICR2). These CpG-rich regions are diffe...

journal_title：Molecular biology reports

authors： Lukova M,Todorova A,Todorov T,Mitev V

更新日期：2013-01-01 00:00:00

abstract：:Safe harbor loci allow predicable integration of a transgene into the genome without perturbing endogenous gene activity and for decades have been exploited in the mouse to investigate gene function, generate humanised models and create tissue specific reporter and Cre recombinase expressing lines. Herein, we show tha...

journal_title：Molecular biology reports

authors： Browning J,Rooney M,Hams E,Takahashi S,Mizuno S,Sugiyama F,Fallon PG,Kelly VP

更新日期：2020-02-01 00:00:00

abstract：:Complexity is one of the hallmarks that applies to C2H2 type zinc finger proteins (ZFPs). Structurally distinct clusters of zinc finger modules define an extremely large superfamily of nucleic acid binding proteins with several hundred, perhaps thousands of different members in vertebrates. Recent discoveries have pro...

journal_title：Molecular biology reports

authors： Pieler T,Bellefroid E

更新日期：1994-07-01 00:00:00

abstract：:Evidence is presented to suggest that in chick liver, xanthine dehydrogenase and aldehyde oxidase activities are associated with only one protein species. The results of SDS electrophoresis of the purified material indicate a subunit MW of 120 000. ...

journal_title：Molecular biology reports

authors： Andres R,Lebherz HG,Ursprung H

更新日期：1973-08-01 00:00:00

abstract：:The phenylalanine and the phenylalanyl-tRNAPhe binding sites on the subunits of phenylalanyl-tRNA synthetase from E. coli MRE-600 were localized using p-azidoanilidate of [14C]phenylalanine and N-bromoacetyl-[14C]phenylalanyl-tRNAPhe. The phenylalanine recognizing site was shown to be situated on the alpha subunit of ...

journal_title：Molecular biology reports

authors： Lavrik OI,Moor NA,Khodyreva SN

更新日期：1982-03-31 00:00:00

abstract：:MicroRNAs (miRNAs) may play important roles in SLE, but genetic polymorphisms of miRNAs and their relationships with various autoantibodies present in SLE patients remain unclear. Here, we report that 213 SLE patients and 209 healthy individuals of Chinese had been taken into this case-control studies, which had been ...

journal_title：Molecular biology reports

authors： Zhang J,Yang B,Ying B,Li D,Shi Y,Song X,Cai B,Huang Z,Wu Y,Wang L

更新日期：2011-03-01 00:00:00

abstract：:We report here cloning and characterization of a novel human gene, termed VMP, which is a vesicular membrane protein. RT-PCR analysis shows that VMP is expressed exclusively in brain of the 16 tissues examined, suggesting that it is a neuron-specific membrane protein. The cDNA encodes 195 amino acid with a putative mo...

journal_title：Molecular biology reports

authors： Cheng C,Xu J,Ye X,Dai J,Wu Q,Zeng L,Wang L,Zhao W,Ji C,Gu S,Xie Y,Mao Y

更新日期：2002-09-01 00:00:00

abstract：:One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major t...

journal_title：Molecular biology reports

authors： Seven M,Batar B,Unal S,Yesil G,Yuksel A,Guven M

更新日期：2014-01-01 00:00:00

abstract：:Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four diseases i.e. breast cancer, systemic lupus erythematosus (SLE), coronary ...

journal_title：Molecular biology reports

authors： Naushad SM,Vijayalakshmi SV,Rupasree Y,Kumudini N,Sowganthika S,Naidu JV,Ramaiah MJ,Rao DN,Kutala VK

更新日期：2015-07-01 00:00:00

abstract：:Insect molting is an important developmental process of metamorphosis, which is initiated by molting hormone. The molting process includes the activation of dermal cells, epidermal cells separation, molting fluid secretion, the formation of new epidermis and old epidermis excoriation etc. Polyphenol oxidases (PPOs), d...

journal_title：Molecular biology reports

authors： Wang MX,Lu Y,Cai ZZ,Liang S,Niu YS,Miao YG

更新日期：2013-05-01 00:00:00

abstract：:Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure forma...

journal_title：Molecular biology reports

authors： Schmidt M,Schmidtke G,Kloetzel PM

更新日期：1997-03-01 00:00:00

abstract：:The present study brings out the preventive role of (-)-epigallocatechin-gallate (EGCG) on cardiac mitochondrial metabolism and apoptosis in cigarette smoke (CS)-exposed rats. The CS-exposed rats showed significantly decreased activities of TCA cycle enzymes and mitochondrial enzymatic antioxidants, on the other hand,...

journal_title：Molecular biology reports

authors： Adikesavan G,Vinayagam MM,Abdulrahman LA,Chinnasamy T

更新日期：2013-12-01 00:00:00

abstract：:De novo assemblies of transcriptome sequence of F(1) interspecies hybrids between Mandarin fish Siniperca chuatsi (Basilewsky) (♀) and Golden mandarin fish Siniperca scherzeri Steindachner (♂) were generated using Illumina sequencing. In the present study, 64 microsatellite primer pairs were designed on basis of the t...

journal_title：Molecular biology reports

authors： Huang W,Liang X,Qu C,Cao J,Zhao C,Cao L

更新日期：2013-02-01 00:00:00

abstract：:Late-embryogenesis abundant (LEA) proteins have been reported to be closely correlated with the acquisition of desiccation tolerance during seed development and response of plant to drought, salinity, and freezing, etc. In this study, a LEA gene, CarLEA4 (GenBank accession no. GU247511), was isolated from chickpea bas...

journal_title：Molecular biology reports

authors： Gu H,Jia Y,Wang X,Chen Q,Shi S,Ma L,Zhang J,Zhang H,Ma H

更新日期：2012-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are autoimmune, inflammatory diseases with substantial genetic contributions. Matrix metalloproteinase (MMP)-2, tumor necrosis factor (TNF)-α and NLR family pyrin domain-containing 1 (NLRP1) play important roles in the immune response. We studied the MMP-2 rs24...

journal_title：Molecular biology reports

authors： Sun R,Huang Y,Zhang H,Liu R

更新日期：2013-11-01 00:00:00

abstract：:The association between vitamin D receptor (VDR) gene polymorphisms and risk of benign prostatic hyperplasia (BPH) has been investigated in numerous publications, but published results remain inconclusive. Hence, we conducted this meta-analysis to derive a more precise conclusion. Four polymorphisms (Taq-I, Bsm-I, Apa...

journal_title：Molecular biology reports

authors： Zeng XT,Yao QS,Weng H,Li S,Huang JY,Wang XH

更新日期：2014-10-01 00:00:00

abstract：:This study was designed to examine the interactions of ergosterol with bovine serum albumin (BSA) and human serum albumin (HSA) under physiological conditions with the drug concentrations in the range of 2.99-105.88 μM and the concentration of proteins was fixed at 5.0 μM. The analysis of emission spectra quenching at...

journal_title：Molecular biology reports

authors： Cheng Z

更新日期：2012-10-01 00:00:00

abstract：:We report the characterization of VvIAA9, an auxin/indole-3-acetic acid (Aux/IAA) protein, in grapevine (Vitis vinifera L.). VvIAA9 was expressed abundantly in leaves and berries. VvIAA9 transcription was drastically upregulated from anthesis to onset of ripening (termed véraison), in which berry diameter rapidly incr...

journal_title：Molecular biology reports

authors： Fujita K,Horiuchi H,Takato H,Kohno M,Suzuki S

更新日期：2012-07-01 00:00:00

abstract：:The leaf primordium derives from the peripheral zone of shoot apical meristem. During the formation of leaf primordia, they need to establish the proximodistal, mediolateral, and ab/adaxial axes. Among these axes, the ab/adaxial axis might be the most important. ASYMMETRIC LEAVES2 (AS2) gene is a member of AS2/LATERAL...

journal_title：Molecular biology reports

authors： Sun SB,Song JP,Meng LS

更新日期：2012-04-01 00:00:00

abstract：:Azotobacter chroococcum and A. salinestris do not possess significant and distinct morphological and physiological differences and are often mistaken with each other in microbiological research. In this study, 12 isolates of Azotobacter isolated by standard protocol from soils were identified morphologically and physi...

journal_title：Molecular biology reports

authors： Khosravi H,Dolatabad HK

更新日期：2020-01-01 00:00:00

abstract：:Mouse U26 has been defined as a 2-aminoadipic 6-semialdehyde dehydrogenase. It was speculated to be a PQQ-dependent AAS dehydrogenase due to the research of demonstrating PQQ as a new B vitamin. We isolated a novel human cDNA from the human fetal brain cDNA library we constructed. Its deduced protein was most related ...

journal_title：Molecular biology reports

authors： Wang L,Jil C,Xu Y,Xu J,Dai J,Wu Q,Wu M,Zou X,Sun L,Gu S,Xie Y,Mao Y

更新日期：2005-03-01 00:00:00

abstract：:Apolipoprotein AV (apoAV) modulates plasma triglyceride levels, which is an independent risk factor for cardiovascular disease. ApoAV is also involved in atherosclerosis lesion formation. In order to systematically evaluate the apolipoprotein-related gene profile in tree shrew, a model for its insusceptibility to athe...

journal_title：Molecular biology reports

authors： Li G,Luo H,Sun G,Wu G,Wu G,Wang Y,Man Y,Wang S,Li J,Chen B

更新日期：2013-09-01 00:00:00

abstract：:Fluorescent proteins related to and derived from green fluorescent protein (GFP) are widely used as tools for investigating a wide range of biological processes. In particular, GFP and its relatives have been used extensively as qualitative reporters of gene expression in many different organisms, but relatively few s...

journal_title：Molecular biology reports

authors： Lissemore JL,Bayes J,Calvey M,Reineke L,Colagiavanni A,Tscheiner M,Mascotti DP

更新日期：2009-05-01 00:00:00

abstract：:The purpose of this study was to assess the value of cytokeratin 19 (CK19) and matrix metalloproteinase 2 (MMP-2) in predicting lymph node metastasis (LNM) and survival after curative resection in hepatocellular carcinoma (HCC) patients. Expression of CK19 and MMP-2 in tumor tissue was assessed through immunohistochem...

journal_title：Molecular biology reports

authors： Xiang ZL,Zeng ZC,Tang ZY,Fan J,Sun HC,Tan YS

更新日期：2011-06-01 00:00:00

abstract：:Micro-RNAs (miRNAs) play key roles in regulating genes of the immune system. The aim of this study was to examine the expression of miR-1, 21 and 125a in the immune cells taken from the peripheral blood of patients suffering from chronic HBV infection (CHB). This cross-sectional study was performed on 60 CHB patients ...

journal_title：Molecular biology reports

authors： Momeni M,Hassanshahi G,Arababadi MK,Kennedy D

更新日期：2014-07-01 00:00:00

abstract：:In the present work, Site-directed mutagenesis to insert the Glu50Lys amino acid substitution was achieved by PCR using plasmid pBluescript-OPTN. Mutated human OPTN(E50K) gene-driven mouse c-kit promoter was constructed and confirmed by endonuclease digestion and sequence analysis. Transgenic mice were generated via t...

journal_title：Molecular biology reports

authors： Meng Q,Xiao Z,Yuan H,Xue F,Zhu Y,Zhou X,Yang B,Sun J,Meng B,Sun X,Cheng F

更新日期：2012-02-01 00:00:00

abstract：:Syndecan-1 has been implicated in tumorigenesis and progression of various human malignancies. Recent studies have demonstrated that syndecan-1 may have a different function and biological activity depending on the specific tumor type. Therefore, the aim of this study was to investigate the clinical significance of sy...

journal_title：Molecular biology reports

authors： Xu Y,Yuan J,Zhang Z,Lin L,Xu S

更新日期：2012-09-01 00:00:00

abstract：:The CRISPR/Cas9 system now allows for unprecedented possibilities of genome editing. However, there are some limitations, including achieving efficient one-step multiple genome targeting to save costs, time, and ensure high quality. In the present study, we investigated the efficiency of one-step multiple gene modific...

journal_title：Molecular biology reports

authors： Hirata M,Wittayarat M,Namula Z,Le QA,Lin Q,Nguyen NT,Takebayashi K,Sato Y,Tanihara F,Otoi T

更新日期：2020-07-01 00:00:00

abstract：:The stem cells in freshwater flatworms (planarian) are called neoblasts. Neoblasts are capable of proliferation and differentiation into every cell type, including the gametes. For the investigation of the mechanisms of stem cells proliferation and differentiation the proper evaluation of changes in the cell cycle of ...

journal_title：Molecular biology reports

authors： Ermakov AM,Ermakova ON,Kudravtsev AA,Kreshchenko ND

更新日期：2012-03-01 00:00:00