Abstract:
:We examined genetic associations of previously identified sequence variants with bone mineral density and their heterogeneity by gender. Large-scale cohort data were used including a total of 8,419 subjects (4,034 males and 4,385 females) from the Korean Association REsource (KARE) cohort. Bone speed of sound (SOS) values were measured at distal radius or mid-shaft tibia by quantitative ultrasound. Genotypic associations of SOS were tested with each of nucleotide sequence variants identified by previous studies. The genetic association analysis revealed that 2 out of 11 nucleotide sequence variants were associated with SOS (rs1721400, rs7776725, P < 7.58 × 10(-4)). Further analysis with partitioning data by gender showed that the mid-shaft tibia phenotypes were associated with the rs1721400 and rs7776725 in females (P < 3.79 × 10(-4)), but not in males (P > 3.79 × 10(-4)). The current study suggested female-specific associations of rs1721400 and rs7776725 with bone mineral density and heterogeneity of genetic association by skeletal site measured for bone mineral density.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Woo J,Kim Y,Lee Cdoi
10.1007/s11033-011-0975-zsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
2259-65issue
3eissn
0301-4851issn
1573-4978journal_volume
39pub_type
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