Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.

abstract：:The mouse double minute 2 (MDM2) gene encodes a phosphoprotein that interacts with P53 and negatively regulates its activity. SNP309 polymorphism (T-G) in the promoter of MDM2 gene has been reported to be associated with enhanced MDM2 expression and tumor development. Many published studies have evaluated the associat...

journal_title：Molecular biology reports

authors： Zhao E,Cui D,Yuan L,Lu W

更新日期：2012-04-01 00:00:00

abstract：:Circadian rhythms are endogenous and self-sustained oscillations of multiple biological processes with approximately 24-h rhythmicity. Circadian genes and their protein products constitute the molecular components of the circadian oscillator that form positive/negative feedback loops and generate circadian rhythms. Th...

journal_title：Molecular biology reports

authors： Rana S,Munawar M,Shahid A,Malik M,Ullah H,Fatima W,Mohsin S,Mahmood S

更新日期：2014-01-01 00:00:00

abstract：:Protein profile of the skeletal muscle of Takifugu rubripes, a kind of pufferfish, was carried out with two-dimensional polyacrylamide gel electrophoresis (2-DE). Among the 112 protein spots detected in a silver-stained 2-D polyacrylamide gel, 33 were analyzed by Matrix Assisted Laser Desorption Ionisation tandem time...

journal_title：Molecular biology reports

authors： Lu J,Zheng J,Liu H,Li J,Chen H,Chen K

更新日期：2010-06-01 00:00:00

abstract：:The programmed cell death (PCD) is important in maintaining the cell number homoeostasis of tissues and organs in metazoan. This process is regulated by the inhibitors of apoptosis proteins (IAPs). The function and mechanism of IAPs have been well studied in animal embryonic development and human cancers. However, the...

journal_title：Molecular biology reports

authors： He HJ,Hou L,Wang JX,Zhao XF

更新日期：2012-02-01 00:00:00

abstract：:We studied the distribution of the D/D, I/D, and I/I genotypes of the angiotensin-converting enzyme (ACE) in a sample of healthy Lebanese individuals to assess their prevalence and compare them with other populations. ACE genotypes were determined using the Cardiovascular Disease (CVD) StripAssay, which is based on a ...

journal_title：Molecular biology reports

authors： Sabbagh AS,Otrock ZK,Mahfoud ZR,Zaatari GS,Mahfouz RA

更新日期：2007-03-01 00:00:00

abstract：:The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer (HNC) were investigated in many published studies; however, the currently available results are inconclusive. Therefore, we conducted this meta-analysis for deriving a more precise estimation of associ...

journal_title：Molecular biology reports

authors： Leng WD,He MN,Chen QL,Gong H,Zhang L,Zeng XT

更新日期：2013-10-01 00:00:00

abstract：:Protein phosphorylation is one of the most fundamental types of post-translational modifications and it plays a vital role in various cellular processes of eukaryotes. Among three types of phosphorylation i.e. serine, threonine and tyrosine phosphorylation, tyrosine phosphorylation is one of the most frequent and it i...

journal_title：Molecular biology reports

authors： Khan YD,Rasool N,Hussain W,Khan SA,Chou KC

更新日期：2018-12-01 00:00:00

abstract：:In this study, we cloned and sequenced genomic sequences from a Fenneropenaeus chinensis transcriptional repressor gene, FcTR. The FcTR gene is 2,671 bp in length and has four exons and three introns. The 873 bp promoter contains several transcription factor binding sites, including a TATA box and a cyclic AMP-respons...

journal_title：Molecular biology reports

authors： Lai X,Shen S,Gao H,Yan B

更新日期：2015-02-01 00:00:00

abstract：:microRNAs are short, non-coding RNAs, that exert a posttranscriptional control on protein synthesis by mRNA interference. They are involved in normal and pathological embryologic development, as well as in adult life pathology, from myocardial infarction to cancer. There are several brain-specific species of microRNA,...

journal_title：Molecular biology reports

authors： Enciu AM,Popescu BO,Gheorghisan-Galateanu A

更新日期：2012-03-01 00:00:00

abstract：:The q11.2 region on chromosome 22 contains numerous low-copy repeats that lead to deleted or duplicated regions in the chromosome, thereby resulting in different syndromes characterized by intellectual disabilities or congenital anomalies. The association between patient phenotypes and 22q11.2 copy number abnormalitie...

journal_title：Molecular biology reports

authors： Cai M,Lin N,Su L,Wu X,Xie X,Li Y,Lin Y,Huang H,Xu L

更新日期：2020-10-01 00:00:00

abstract：:Penicillin V is a bacteriolytic β-lactam antibiotic drug. In the present work, we investigated the inhibitory effect of Penicillin V on the activity of mushroom tyrosinase for the first time. The molecular mechanism for the inhibition of tyrosinase by Penicillin V was investigated by means of kinetics analysis, fluore...

journal_title：Molecular biology reports

authors： Dong X,Wang S,Xu L,Lin J,Xu X

更新日期：2020-02-01 00:00:00

abstract：:MAPK kinase 1 interacting protein 1 (MAP2K1ip1) is an important scaffold proteins of the mitogen-activated protein kinase (MAPK) pathway that form an active signaling module and enhance the specificity and spatiality of MAPK signaling. In the present study, we identified and characterized a MAP2K1ip1 cDNA from tiger s...

journal_title：Molecular biology reports

authors： Yang L,Liu X,Huang J,Yang Q,Qiu L,Liu W,Jiang S

更新日期：2012-05-01 00:00:00

abstract：:The purpose of our research is to elucidate whether oxLDL activates P2X7R in cultured human podocytes and if the activation of P2X7R leads to podocyte apoptosis. Additionally, we explore the underlying mechanism involved in podocyte apoptosis. Immortalized human podocytes were incubated with oxLDL (80 µg/ml), P2X7R an...

journal_title：Molecular biology reports

authors： Zhu Y,Li Q,Xun W,Chen Y,Zhang C,Sun S

更新日期：2019-08-01 00:00:00

abstract：:Evidence indicates that both S-adenosylmethionine (SAMe) metabolism and intramuscular fat are associated with insulin resistance and type II diabetes. However, it is still unknown whether SAMe have effects on intramuscular adipogenesis. The present study investigated the roles of SAMe in the adipogenic differentiation...

journal_title：Molecular biology reports

authors： Yue T,Fang Q,Yin J,Li D,Li W

更新日期：2010-10-01 00:00:00

abstract：:We report here a cDNA and its deduced amino acid sequence encoding a cathepsin D-like, aspartic protease from Chlamys farreri (denoted as CfCD) by expressed sequence tag and rapid amplification of cDNA ends techniques. The cDNA of CfCD consisted of 1,810 nucleotides with a canonical polyadenylation signal sequence AAT...

journal_title：Molecular biology reports

authors： Li C,Zhang H,Li L,Song L

更新日期：2010-03-01 00:00:00

abstract：:Sepsis is one of the major health problems all over the world. Early diagnostic of sepsis is an attractive strategy to decrease the mortality of septic patients. However, an effective biomarker that fulfills all the necessary requirements for the accurate characterization of sepsis is still unavailable until now. In t...

journal_title：Molecular biology reports

authors： Liu J,Li J,Deng X

更新日期：2014-05-01 00:00:00

abstract：:The genes of E. coli are located on a circular chromosome of 4.6 million basepairs. This 1.6 mm long molecule is compressed into a nucleoid to fit inside the 1-2 microm cell in a functional format. To examine the role of DNA supercoiling as nucleoid compaction force we modulated the activity of DNA gyrase by electroni...

journal_title：Molecular biology reports

authors： Stuger R,Woldringh CL,van der Weijden CC,Vischer NO,Bakker BM,van Spanning RJ,Snoep JL,Westerhoff HV

更新日期：2002-01-01 00:00:00

abstract：:In attempting to produce the HAP, endoplasmic reticulum (ER) targeted apoptosis-inducing protein, as a GST-fusion protein we found that the expression of HAP, but not GST alone, induced bacterial cell death. The HAP protein inhibited the bacterial growth within 30 min after inducting HAP expression. The transmission e...

journal_title：Molecular biology reports

authors： Gan M,Qi Y,Wan Q,Kuang E,Liu Q,Liu X

更新日期：2004-09-01 00:00:00

abstract：:Serotonin receptor (5-HT) is a biogenic amine acting as a neurotransmitter and neuromodulator that mediates various aspects of reproduction and gametogenesis. The full-length nucleotide sequence of Haliotis discus hannai encodes a protein of 417 amino acids with a predicted molecular mass of 46.54 kDa and isoelectric ...

journal_title：Molecular biology reports

authors： Sharker MR,Sukhan ZP,Kim SC,Lee WK,Kho KH

更新日期：2020-01-01 00:00:00

abstract：:Induction and break of bud dormancy are important features for perennial plants surviving extreme seasonal variations in climate. However, the molecular mechanism of the dormancy regulation, still remain poorly understood. To better understand the molecular basis of poplar bud dormancy, we used a label-free quantitati...

journal_title：Molecular biology reports

authors： Ning DL,Liu CC,Liu JW,Shen Z,Chen S,Liu F,Wang BC,Yang CP

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to explore whether the cytotoxic T lymphocyte antigen-4 (CTLA-4) +49 A/G polymorphism confers susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between CTLA-4 +49 A/G polymorphism and RA using; 1) allele contrast, 2) the recessive model, 3) the dom...

journal_title：Molecular biology reports

authors： Lee YH,Bae SC,Choi SJ,Ji JD,Song GG

更新日期：2012-05-01 00:00:00

abstract：:C2H2 proteins belong to a group of transcription factors (TFs) existing as a superfamily that plays important roles in defense responses and various other physiological processes in plants. The present study aimed to screen for and identify C2H2 proteins associated with defense responses to abiotic and biotic stresses...

journal_title：Molecular biology reports

authors： Jiang L,Pan LJ

更新日期：2012-06-01 00:00:00

abstract：:Chloroplast microsatellites for two Korean endemic species, Eranthis byunsanensis and E. pungdoensis (Ranunculaceae), were isolated to address the questions of their distributional patterns and evolutionary relationships, using next-generation sequencing. Twenty-four polymorphic chloroplast microsatellite markers for ...

journal_title：Molecular biology reports

authors： Oh A,Oh BU

更新日期：2017-08-01 00:00:00

abstract：:Finger millet (Eleusine coracana L.) is an important crop used for food, forage, and industrial products. Three DNA marker techniques, random amplified polymorphic DNA (RAPD), simple sequence repeat (SSR) and cytochrome P(450) gene based markers were used for the detection of genetic polymorphism in 83 accessions of f...

journal_title：Molecular biology reports

authors： Panwar P,Saini RK,Sharma N,Yadav D,Kumar A

更新日期：2010-12-01 00:00:00

abstract：:As-ClC (chloride channels protein from Artemia sinica), a member from the chloride channels protein family, is a α-helical membrane protein predicted to traverse the cell membrane 11 times. It is important for several physiological functions such as cell volume regulation, cell proliferation, growth and differentiatio...

journal_title：Molecular biology reports

authors： Zhang Q,Hou M,Li Q,Han L,Yuan Z,Tan J,Du B,Zou X,Hou L

更新日期：2013-05-01 00:00:00

abstract：:The objective of this study was to determine hepatic expression levels of GHR, IGF1R, IGF1 and IGF2 genes in young growing gilts at different developmental ages (60-210 days) in five pig breeds: Polish Large White (PLW), Polish Landrace (PL), Pulawska (Pul), Duroc (Dur) and Pietrain (Pie). We studied the differences a...

journal_title：Molecular biology reports

authors： Pierzchała M,Pareek CS,Urbański P,Goluch D,Kamyczek M,Różycki M,Smoczynski R,Horbańczuk JO,Kurył J

更新日期：2012-03-01 00:00:00

abstract：:Experiments with 5'-azacytidine and hematopoietic growth factor approved for the transformation of human mesenchymal cells into hematopoietic cells have demonstrated that cell fate can be dramatically altered by changing the epigenetic state of cells. Here, we demonstrate that umbilical cord-derived human mesenchymal ...

journal_title：Molecular biology reports

authors： Hu K,Xu C,Ni H,Xu Z,Wang Y,Xu S,Ji K,Xiong J,Liu H

更新日期：2014-07-01 00:00:00

abstract：:We report here cloning and characterization of a novel human gene, termed VMP, which is a vesicular membrane protein. RT-PCR analysis shows that VMP is expressed exclusively in brain of the 16 tissues examined, suggesting that it is a neuron-specific membrane protein. The cDNA encodes 195 amino acid with a putative mo...

journal_title：Molecular biology reports

authors： Cheng C,Xu J,Ye X,Dai J,Wu Q,Zeng L,Wang L,Zhao W,Ji C,Gu S,Xie Y,Mao Y

更新日期：2002-09-01 00:00:00

abstract：:Ribonuclease P (RNase P) is a key enzyme involved in tRNA biosynthesis. It catalyses the endonucleolytic cleavage of nearly all tRNA precursors to produce 5'-end matured tRNA. RNase P activity has been found in all organisms examined, from bacteria to mammals. Eubacterial RNase RNA is the only known RNA enzyme which f...

journal_title：Molecular biology reports

authors： Drainas D

更新日期：1995-01-01 00:00:00

abstract：:The immunity and health status of ornamental fish is an important aspect, as they are kept in a confined environment and various stressful conditions which lead to depletion of overall colourful appearance and mortality. The carotenoids can act as immunity boosters in captive aquarium system and may be supplemented in...

journal_title：Molecular biology reports

authors： Tripathy PS,Khatei A,Parhi J,Choudhury TG,Sahoo L,Mandal SC

更新日期：2019-12-01 00:00:00