Abstract：
:Sepsis is one of the major health problems all over the world. Early diagnostic of sepsis is an attractive strategy to decrease the mortality of septic patients. However, an effective biomarker that fulfills all the necessary requirements for the accurate characterization of sepsis is still unavailable until now. In this study, the 2-DE technique followed by mass spectrometry and a database search was used for searching and identifying the differential expressed proteins in platelets between septic patients and paired healthy controls. Platelet 2-DE profiles of septic patients and paired healthy controls with high resolution and reproducibility were obtained. Differential platelet 2-DE profiles between septic patients and paired healthy controls were established. Differential protein spots between normal healthy volunteers and septic patients from platelet 2-DE profiles were identified by 2-DE followed with mass spectrometry and a database search. Five proteins with increased expression were identified between septic patients and healthy controls from platelet samples. These up-expressed proteins were EF-hand calcium-binding domain-containing protein 7, actin, interleukin-1β, glycoprotein IX, and glycoprotein IIB. Sepsis induces a complex regulation of platelet protein changes. Our study highlights the important role of these differential expressed proteins in sepsis, which deserve further research as potential candidates for therapeutic strategies. Furthermore, our research is beneficial for the future developments of sepsis diagnosis and therapy.
journal_name
Mol Biol Repjournal_title
Molecular biology reportsauthors
Liu J,Li J,Deng Xdoi
10.1007/s11033-014-3177-7subject
Has Abstractpub_date
2014-05-01 00:00:00pages
3179-85issue
5eissn
0301-4851issn
1573-4978journal_volume
41pub_type
杂志文章abstract：:Cerebral aneurysm affects 2-5% of the population and posterior inferior cerebellar artery (PICA) aneurysms account for 1-3% of all intracranial aneurysms. Oxidative stress is known to contribute to the progression of cerebrovascular disease and it may be increased by inflammation, a key contributor to cerebral aneurys...
journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4374-6
更新日期：2018-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3476-z
更新日期：2014-09-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-014-3355-7
更新日期：2014-07-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-0497-0
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1329-6
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s11033-010-0173-4
更新日期：2011-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-006-0009-4
更新日期：2006-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11033-011-1006-9
更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s11033-011-1431-9
更新日期：2012-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1373-2
更新日期：2012-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-009-9496-4
更新日期：2010-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1709-6
更新日期：2012-08-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1635-7
更新日期：2012-08-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-010-9984-6
更新日期：2011-06-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-016-3996-9
更新日期：2016-06-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s11033-013-2908-5
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pub_type： 杂志文章
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更新日期：2012-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-012-1814-6
更新日期：2012-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章,meta分析
doi：10.1007/s11033-013-2708-y
更新日期：2013-10-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00417593
更新日期：1986-01-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-018-4487-y
更新日期：2019-02-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-011-1146-y
更新日期：2012-04-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/s11033-013-2803-0
更新日期：2013-12-01 00:00:00
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journal_title：Molecular biology reports
pub_type： 杂志文章
doi：10.1007/BF00775964
更新日期：1978-06-16 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/BF00988728
更新日期：1995-01-01 00:00:00
