Abstract：
:The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder concordant with the expression profile of SOX9 during embryogenesis. The mechanistic understanding of development has revealed roles for SOX9 in regulating cartilage extracellular matrix (ECM) production and cell proliferation, among others. More recently, it transpires that SOX9 becomes expressed and induces destructive ECM components in organ fibrosis and related disorders. Although commonly absent from the parent cell type, SOX9 is expressed in a wide range of cancers, where it regulates cell proliferation. These data have potential diagnostic, prognostic and therapeutic relevance, suggesting that disease mechanisms might result from re-expressing this developmental transcription factor in ectopic locations.
journal_name
Trends Mol Medjournal_title
Trends in molecular medicineauthors
Pritchett J,Athwal V,Roberts N,Hanley NA,Hanley KPdoi
10.1016/j.molmed.2010.12.001subject
Has Abstractpub_date
2011-03-01 00:00:00pages
166-74issue
3eissn
1471-4914issn
1471-499Xpii
S1471-4914(10)00186-3journal_volume
17pub_type
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