Abstract:
:Revascularization procedures used for the treatment of cardiovascular disease can be associated with restenosis, although drug-coated stents have greatly reduced this complication. Both type 2 diabetes (T2DM) and metabolic syndrome (MetS) are associated with a high risk for atherosclerosis and restenosis. Insulin resistance, defined as the inability of insulin to exert its metabolic actions, characterizes both T2DM and MetS. Recent data suggest that insulin resistance is directly implicated in atherosclerosis/restenosis, because of the unresponsiveness to the vasculoprotective action of insulin, including its phosphoinositide 3-kinase (PI3K)-Akt-endothelial nitric oxide synthase mediated enhancement of endothelial function. However, insulin also has 'atherogenic' actions, including enhancement of vascular smooth muscle cell (VSMC) proliferation, which are mitogen-activated protein kinase-mediated. These 'atherogenic' actions are less affected by insulin resistance, which mainly involves the PI3K pathway. The role of insulin in the atherosclerotic disease process is still highly controversial, where some investigators view insulin as a growth factor with pro-atherogenic effects while some others believe insulin resistance to be pro-atherogenic rather than insulin itself. We attempt to produce a balanced review with a focus on the effect of insulin in vivo, in animal models of atherosclerosis and restenosis.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Breen DM,Giacca Adoi
10.2174/157016111795495558subject
Has Abstractpub_date
2011-05-01 00:00:00pages
321-32issue
3eissn
1570-1611issn
1875-6212pii
BSP/CVP/E-Pub/0000102journal_volume
9pub_type
杂志文章,评审abstract:BACKGROUND:The primary objective of this study was to evaluate the impact of polypharmacy on primary and secondary adherence to evidence-based medication (EBM) and to measure factors associated with non-adherence among patients who underwent percutaneous coronary intervention (PCI). METHODS:We conducted a retrospectiv...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161113666151030105805
更新日期:2016-01-01 00:00:00
abstract::A considerable amount of data supports a 1.8-7.4-fold increased mortality associated with Cushing's syndrome (CS). This is attributed to a high occurrence of several cardiovascular disease (CVD) risk factors in CS [e.g. adiposity, arterial hypertension (AHT), dyslipidaemia and type 2 diabetes mellitus (T2DM)]. Therefo...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666181005122339
更新日期:2020-01-01 00:00:00
abstract::Initially, the progression of chronic venous insufficiency is related to venous hypertension. The earliest complaints or symptoms, as well as vessel wall deterioration, valve restructuring, and, eventually, varicose veins, result not only from elevation of pressure, but also from a cascade of biochemical events relate...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161052773870
更新日期:2005-01-01 00:00:00
abstract::Nowadays long-term outcome of heart transplantation is limited by a peculiar type of coronary atherosclerosis, known as cardiac allograft vasculopathy (CAV). Although the exact pathogenesis of CAV remains unclear, emerging evidence indicates that the endothelium plays a significant role in the onset and progression of...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790886992
更新日期:2010-03-01 00:00:00
abstract::Monoclonal antibodies have been developed to optimize treatment effects in various malignant and nonmalignant conditions, by selectively targeting key components of the underlying pathophysiologic processes. Rituximab, a chimeric anti-CD20 antibody has revolutionized treatment of malignant lymphomas, extending remissi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790226651
更新日期:2010-01-01 00:00:00
abstract::It is well known that solid cancers are associated with thromboembolic complications, but recent studies have shown that the incidence of thrombosis may be as high (or even higher) in patients with malignant haematological disorders. However, this may be obscured by the significant morbidity and mortality due to other...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110791330799
更新日期:2010-07-01 00:00:00
abstract::Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161111311050013
更新日期:2013-09-01 00:00:00
abstract::The implementation of cardioprotective strategies involving pre-, intra-, and postoperative interventions is key during cardiac surgery requiring extracorporeal circulation (ECC). The primary goal of this study was to review the physiopathology and protection strategies against myocardial damage secondary to ECC durin...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666171116170806
更新日期:2018-01-01 00:00:00
abstract:AIM:To assess the potential differences in the metabolic and cardiovascular disease (CVD) risk between the distinct phenotypes of the Polycystic Ovary Syndrome (PCOS) according to the Rotterdam definition regardless of body mass index (BMI). PATIENTS-METHODS:The study included 300 women; 240 women with PCOS, according...
journal_title:Current vascular pharmacology
pub_type: 临床试验,杂志文章
doi:10.2174/1567201812666150120163025
更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00
abstract::This review provides evidence that antenatal hypoxia, which represents a significant and worldwide problem, causes prenatal programming of the lung. A general overview of lung development is provided along with some background regarding transcriptional and signaling systems of the lung. The review illustrates that ant...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161111311050006
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. OBJECTIVE:Our study aimed to evaluate two markers of CV risk [common carotid artery intima-media thickness (cIMT) and the aortic pulse wave velocity (PWV)] in p...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1389450121666200609151555
更新日期:2020-06-09 00:00:00
abstract::Many patients with hypertension will require multiple antihypertensive drugs to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combinations (SPCs) in patients with mild-to-moderate hypertension who were non-responsive to aliskiren mono...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/157016112803520765
更新日期:2012-11-01 00:00:00
abstract:INTRODUCTION:Obstructive Sleep Apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal Blood Pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causativ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170414115705
更新日期:2017-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180625124405
更新日期:2019-01-01 00:00:00
abstract::Hypercoagulability is widely associated with sepsis, inflammation, diabetes, cancers, aging, and many pathological conditions, resulting in life-threatening disseminated intravascular coagulation (DIC), venous thrombosis, thromboembolism, cardiovascular complications, or even deadly multiple organ failure. Relieving c...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043385673
更新日期:2004-07-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170621083744
更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161112666140423220628
更新日期:2014-05-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
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更新日期:2013-05-13 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016105774329408
更新日期:2005-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2003-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190405164749
更新日期:2020-01-01 00:00:00
abstract::Visfatin is highly expressed in adipose tissue (mainly by the stromal cells), but it is also ubiquitously present in most tissues. Visfatin, which plays a role in nicotinamide adenine dinucleotide (NAD) biosynthesis, has been implicated in inflammatory states. Controversial results exist about the expression, circulat...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790226679
更新日期:2010-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161113666150204142716
更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666200317151553
更新日期:2021-01-01 00:00:00
abstract::Urocortin comprises a group of endogenously produced peptide hormones that belong to the corticotropinreleasing factor (CRF) family with promising future as potential drugs for the treatment of heart disease. Members of the urocortin family are known to act as potent regulators of cardiac and vascular functions, throu...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
abstract::Cardiovascular failure in sepsis involves a combination of hypovolemia, decreased vascular tone, myocardial depression and microcirculatory alterations. Fluids represent the first line therapeutic intervention, with controversy regarding the type of fluid. Recent data indicate that albumin is safe and might even be be...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
abstract::Several lines of evidence suggest a detrimental effect of aldosterone excess on the development of metabolic alterations. Glucose metabolism derangements due to aldosterone action are frequently observed not only in patients with primary aldosteronism but also in patients with obesity. A contribution to the hyperaldos...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112799304969
更新日期:2012-03-01 00:00:00
abstract::Obstructive sleep apnoea (OSA) is characterized by repetitive interruptions of breathing, causing Chronic Intermittent Hypoxia (CIH) that can be involved in the development and progression of cardiovascular diseases. There is evidence showing a close relationship between OSA and atherosclerosis, even in patients who d...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161114666161007164112
更新日期:2017-01-01 00:00:00