Abstract:
BACKGROUND:The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. OBJECTIVE:Our study aimed to evaluate two markers of CV risk [common carotid artery intima-media thickness (cIMT) and the aortic pulse wave velocity (PWV)] in patients with PDB. METHODS:We enrolled 12 patients with PDB and 58 control subjects, matched for age. Diagnosis of PDB was based on clinical, radiological and biochemical parameters. RESULTS:Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased. CONCLUSION:These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or to the high levels of oxidative stress that characterize this population.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Gaudio A,Zanoli L,Xourafa A,Rapisarda R,Catalano A,Signorelli SS,Castellino Pdoi
10.2174/1389450121666200609151555subject
Has Abstractpub_date
2020-06-09 00:00:00eissn
1570-1611issn
1875-6212pii
CVP-EPUB-107221pub_type
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