Cardiac side effects of chemotherapy: state of art and strategies for a correct management.

Abstract:

:In recent years, the development of more effective drugs has provided a better prognosis and an increase in life expectancy for patients at all-stages of cancer. On the other hand, the price for the improving effectiveness of therapies against malignant tumors is the development of severe and potentially life-threatening drug reactions. Among these, cardiac toxic effects have recently gained particular attention. The term cardiotoxicity includes many possible pathological manifestations, but the most frequent is the reduction in cardiac function, potentially leading to heart failure and death. Importantly, the development of cardiac dysfunction may occur immediately after drug administration, or after years. The purpose of this review is to discuss the clinical features of cardiotoxicity, its molecular basis and novel possible strategies to reduce the likelihood of serious cardiac complications.

journal_name

Curr Vasc Pharmacol

authors

Perrino C,Schiattarella GG,Magliulo F,Ilardi F,Carotenuto G,Gargiulo G,Serino F,Ferrone M,Scudiero F,Carbone A,Trimarco B,Esposito G

doi

10.2174/157016111201140327163302

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

106-16

issue

1

eissn

1570-1611

issn

1875-6212

pii

CVP-EPUB-20120508-001

journal_volume

12

pub_type

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