Abstract:
:Nowadays long-term outcome of heart transplantation is limited by a peculiar type of coronary atherosclerosis, known as cardiac allograft vasculopathy (CAV). Although the exact pathogenesis of CAV remains unclear, emerging evidence indicates that the endothelium plays a significant role in the onset and progression of this disease. Nitric oxide (NO) is the principal mediator of all endothelial protective effects, due to its antinflammatory, antiproliferative, immunomodulatory and vasorelaxant properties. CAV involves immunologic mechanisms operating in the context of common cardiovascular risk factors which lead to impaired endothelial function, mainly as a consequence of decreased NO bioavailability and excessive oxidative stress. Once dysfunctional, the endothelium promotes CAV lesion progression towards the diffuse narrowing of the coronary vasculature which characterizes advanced allograft vasculopathy. Recently, many studies showed the possibility to restore endothelial dysfunction with an associated potential improvement in clinical cardiovascular outcome. Therefore, growing interest deserves the possibility to exert an endothelial protective role shown by some currently used cardiovascular and immunosuppressive drugs, as well as the future development of new pharmacological compounds with selective endothelial protective properties as a target for successful prevention and therapy of CAV.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Osto E,Tona F,De Bon E,Iliceto S,Cella Gdoi
10.2174/157016110790886992subject
Has Abstractpub_date
2010-03-01 00:00:00pages
169-88issue
2eissn
1570-1611issn
1875-6212pii
CVP-Abs-019journal_volume
8pub_type
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journal_title:Current vascular pharmacology
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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