Cellular and Molecular Mechanisms of Low Cardiac Output Syndrome after Pediatric Cardiac Surgery.

Abstract:

:Several cellular and molecular mechanisms have been implicated in the development of myocardial dysfunction and low cardiac output in pediatric patients undergoing heart surgery. Ischemia- reperfusion injury with alterations in calcium homeostasis as well as mitochondrial function has been strongly related to myocyte damage and heart failure in this population. In this article, we will review the main mechanisms of postoperative cardiac dysfunction at cellular and molecular levels and the subsequent protective strategies. In addition, we will describe cellular features of the neonatal or immature myocardium and will suggest possible protective management strategies. This article addresses the first of eight topics comprising the special issue entitled "Pharmacologic strategies with afterload reduction in low cardiac output syndrome after pediatric cardiac surgery".

journal_name

Curr Vasc Pharmacol

authors

Bautista-Hernandez V,Karamanlidis G,McCully JD,Del Nido PJ

doi

10.2174/1570161113666151014122557

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

5-13

issue

1

eissn

1570-1611

issn

1875-6212

pii

CVP-EPUB-71073

journal_volume

14

pub_type

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