Abstract:
:Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people with diabetes mellitus, and are major risk factors for foot ulceration, amputation and cardiovascular dysfunction. Peripheral neuropathies manifest with either painful or painless symptoms, but many patients experience both. Once diagnosed appropriately, painful diabetic neuropathy management presents a unique challenge for physicians and should be considered as a syndrome, clinically distinct from diabetic peripheral neuropathy. The aetiology is multifactorial: metabolic changes in diabetes may directly affect neural tissue and neurodegenerative changes are precipitated by compromised nerve vascular supply. Metabolic changes include the elevated polyol pathway activity, the increased oxidative stress, the formation of advanced glycation and lipoxidation end products, and various pro-inflammatory changes. These mechanisms work in combination and interact in a mutually facilitatory fashion. This review focuses on the current therapies for the management of peripheral and cardiovascular autonomic neuropathy and of painful neuropathy as a distinct entity, based on the current knowledge of diabetic neuropathy. Moreover, the role of ACE inhibition has been explored in the treatment of Cardiovascular Autonomic Neuropathy.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Didangelos T,Veves Adoi
10.2174/1570161117666190521101342subject
Has Abstractpub_date
2020-01-01 00:00:00pages
158-171issue
2eissn
1570-1611issn
1875-6212pii
CVP-EPUB-98557journal_volume
18pub_type
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journal_title:Current vascular pharmacology
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doi:10.2174/157016109788340794
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666171013153750
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journal_title:Current vascular pharmacology
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更新日期:2009-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 社论,评审
doi:10.2174/157016109788340712
更新日期:2009-07-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016106778521661
更新日期:2006-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161111311030010
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2004-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043476456
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