Abstract:
BACKGROUND:Aging-associated vascular dysfunction promotes cardiovascular diseases. Recently, Ginkgo biloba extract (GBE) has attracted considerable attention in the prevention of aged vasculature. METHODS:This review discusses the pathophysiological alterations in aged vasculature and the underlying mechanisms of GBE in vascular aging suppression. RESULTS:Both arterial stiffening and endothelial dysfunction are critical aging-related vascular phenotypes that result in the progression of cardiovascular diseases in the general population. Consistent oxidative stress and inflammatory reaction lead to vascular dysfunction. GBE ameliorates aging-related vascular dysfunction, due to its antioxidant and anti-inflammatory properties. The main effects of GBE in aged vasculature might be associated with the longevity signaling pathways. GBE also attenuates the progression of vascular aging in diabetes mellitus via regulation of glucose and lipid metabolism. CONCLUSION:GBE plays an important role in the prevention of vascular aging process. It is a promising therapeutic approach to ameliorate aging-related vascular dysfunction and cardiovascular diseases.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Li X,Lu L,Chen J,Zhang C,Chen H,Huang Hdoi
10.2174/1570161117666190621150725subject
Has Abstractpub_date
2020-01-01 00:00:00pages
334-345issue
4eissn
1570-1611issn
1875-6212pii
CVP-EPUB-99159journal_volume
18pub_type
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 评论,社论
doi:10.2174/157016112803520783
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016106778521661
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pub_type: 杂志文章
doi:10.2174/1570161118666201015152921
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Current vascular pharmacology
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pub_type: 杂志文章,评审
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