Hypertension: quo vadis?

abstract：:The saphenous vein is the most commonly used conduit in patients undergoing coronary artery bypass surgery. However, a high proportion of vein grafts occlude within the first year and over 50% patients require further grafting within 10 years. Using conventional harvesting techniques the saphenous vein is damaged due ...

journal_title：Current vascular pharmacology

authors： Dashwood MR,Loesch A

更新日期：2009-01-01 00:00:00

abstract：:Chronic venous disease (CVeD) is a debilitating condition that affects millions of individuals worldwide. The condition can result in varicose veins, or advance to severe skin changes and venous ulceration. The fundamental basis for CVeD is inflammation within the venous circulation and that it is subjected to increas...

journal_title：Current vascular pharmacology

authors： Mannello F,Ligi D,Canale M,Raffetto JD

更新日期：2014-01-01 00:00:00

abstract：:High-mobility group box-1 (HMGB1) is a nuclear protein that acts as a cytokine when released into the extracellular milieu by necrotic and inflammatory cells, and is involved in inflammatory responses and tissue repair. This protein is released passively during cellular necrosis by almost all cells that have a nucleus...

journal_title：Current vascular pharmacology

authors： Biscetti F,Ghirlanda G,Flex A

更新日期：2011-11-01 00:00:00

abstract：:Normal pregnancy is associated with increased insulin resistance as a metabolic adaptation to the nutritional demands of the placenta and fetus, and this is amplified in obese mothers. Insulin resistance is normally compensated for by an adaptive increase in pancreatic β-cell mass together with enhanced glucose-stimul...

journal_title：Current vascular pharmacology

authors： Szlapinski SK,Hill DJ

更新日期：2021-01-01 00:00:00

abstract：:Post-transplant diabetes mellitus (PTDM) and dyslipidaemia are the most common metabolic complications in kidney transplant recipients (KTR). They are associated with a higher risk of lower graft function and survival, as well as an increased risk of cardiovascular disease (CVD). The aim of this review is to provide c...

journal_title：Current vascular pharmacology

authors： Anagnostis P,Paschou SA,Spartalis E,Sarno G,De Rosa P,Muscogiuri G

更新日期：2020-01-01 00:00:00

abstract：:Several cellular and molecular mechanisms have been implicated in the development of myocardial dysfunction and low cardiac output in pediatric patients undergoing heart surgery. Ischemia- reperfusion injury with alterations in calcium homeostasis as well as mitochondrial function has been strongly related to myocyte ...

journal_title：Current vascular pharmacology

authors： Bautista-Hernandez V,Karamanlidis G,McCully JD,Del Nido PJ

更新日期：2016-01-01 00:00:00

abstract：:Many patients with hypertension will require multiple antihypertensive drugs to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combinations (SPCs) in patients with mild-to-moderate hypertension who were non-responsive to aliskiren mono...

journal_title：Current vascular pharmacology

authors： Glorioso N,Thomas M,Troffa C,Argiolas G,Patel S,Baek I,Zhang J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Dyslipidaemia is a risk factor for macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Our aim was to assess the use of lipid lowering drugs (LLDs) in patients with T2DM and co-existing dyslipidaemia. METHOD:A multicentre, non-interventional survey conducted in 6 Middle Eastern cou...

journal_title：Current vascular pharmacology

authors： Shehab A,Al-Rasadi K,Arafah M,Al-Hinai AT,Al Mahmeed W,Bhagavathula AS,Al Tamimi O,Al Herz S,Al Anazi F,Al Nemer K,Metwally O,Alkhadra A,Fakhry M,Elghetany H,Medani AR,Yusufali AH,Al Jassim O,Al Hallaq O,Baslaib FOAS

更新日期：2018-01-01 00:00:00

abstract：:The "pleiotropic" effects of statins have been the centre of a considerable research activity. Among the numerous experimental and clinical studies of this field, some focused on the effects of statins on blood pressure (BP), while others reported data on BP together with other parameters. Some of the animal or human ...

journal_title：Current vascular pharmacology

authors： Sarafidis PA,Kanaki AI,Lasaridis AN

更新日期：2007-04-01 00:00:00

abstract：:Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variatio...

journal_title：Current vascular pharmacology

authors： Franks PW,Poveda A

更新日期：2011-07-01 00:00:00

abstract：:Arterial stiffness (AS) is considered an independent predictor of cardiovascular disease (CVD) events. Among lipid lowering drugs, statins have a beneficial effect on AS, independent of their hypolipidaemic effect. Based on 3 meta-analyses and other studies, this effect is compound- and doserelated. Potent statins at ...

journal_title：Current vascular pharmacology

authors： Reklou A,Katsiki N,Karagiannis A,Athyros V

更新日期：2020-01-01 00:00:00

abstract：:Initially, the progression of chronic venous insufficiency is related to venous hypertension. The earliest complaints or symptoms, as well as vessel wall deterioration, valve restructuring, and, eventually, varicose veins, result not only from elevation of pressure, but also from a cascade of biochemical events relate...

journal_title：Current vascular pharmacology

authors： Katsenis K

更新日期：2005-01-01 00:00:00

abstract：:Loss of normal endothelial function and bioactivity of nitric oxide (NO), associated with increased production of reactive oxygen species (ROS), are characteristics of cardiovascular disease states. There is good experimental evidence that these abnormalities are causally related to cardiovascular disease pathogeneses...

journal_title：Current vascular pharmacology

authors： Channon KM

更新日期：2012-11-01 00:00:00

abstract：:Hypercoagulability is widely associated with sepsis, inflammation, diabetes, cancers, aging, and many pathological conditions, resulting in life-threatening disseminated intravascular coagulation (DIC), venous thrombosis, thromboembolism, cardiovascular complications, or even deadly multiple organ failure. Relieving c...

journal_title：Current vascular pharmacology

authors： Chu AJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Kallistatin (KS) is a serine proteinase. The result of KS on 'Renal Ischemia- Reperfusion Injury' (IRI) has not clearly been researched. In this study, investigative research has been conducted to draw results on the administration of human KS on kidney response conducted within a mouse model of IRI. MATERI...

journal_title：Current vascular pharmacology

authors： Zhou S,Sun Y,Zhuang Y,Zhao W,Chen Y,Jiang B,Guo C,Zhang Z,Peng H,Chen Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Volatile Anaesthetics (VA) are commonly used worldwide for induction and/or maintenance of general anaesthesia. They act in the central nervous system to reduce sensation and motor response during surgical and invasive diagnostic procedures. VAs also have some non-anaesthetic properties in the brain when adm...

journal_title：Current vascular pharmacology

authors： Krzych LJ,Szczepanska AJ

更新日期：2018-01-01 00:00:00

abstract：:There is growing evidence that Rho-kinase contributes to cardiovascular disease, which has made Rho-kinase a target for the treatment of human diseases. To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic ...

journal_title：Current vascular pharmacology

authors： Satoh S,Ikegaki I,Kawasaki K,Asano T,Shibuya M

更新日期：2014-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosi...

journal_title：Current vascular pharmacology

authors： Franczyk-Skóra B,Gluba A,Banach M,Rozentryt P,Poloński L,Rysz J

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of s...

journal_title：Current vascular pharmacology

authors： Dittrich R,Ringelstein EB

更新日期：2008-10-01 00:00:00

abstract：:Preeclampsia (PE), gestational diabetes mellitus (GDM), and maternal supraphysiological hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic disruptions leading to alterations of the mother, fetus and neonate health. These syndromes result in fetoplacental vascular dysfunction, where nitr...

journal_title：Current vascular pharmacology

authors： Leiva A,Fuenzalida B,Barros E,Sobrevia B,Salsoso R,Sáez T,Villalobos R,Silva L,Chiarello I,Toledo F,Gutiérrez J,Sanhueza C,Pardo F,Sobrevia L

更新日期：2016-01-01 00:00:00

abstract：:Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to high density lipoprotein (HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antiatherogenic properties o...

journal_title：Current vascular pharmacology

authors： Lioudaki S,Verikokos C,Kouraklis G,Ioannou C,Chatziioannou E,Perrea D,Klonaris C

更新日期：2019-01-01 00:00:00

abstract：:This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanis...

journal_title：Current vascular pharmacology

authors： Ford MK,Cohn JR

更新日期：2019-01-01 00:00:00

abstract：:In chronic inflammatory conditions, endothelial cells actively recruit immune cells from the circulation into the underlying tissue and participate in angiogenesis to support the continuous demand for oxygen and nutrients. They do so in response to activation by cytokines and growth factors such as tumour necrosis fac...

journal_title：Current vascular pharmacology

authors： Kułdo JM,Ogawara KI,Werner N,Asgeirsdóttir SA,Kamps JA,Kok RJ,Molema G

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), are major health problems worldwide. Genetics may play a role in the pathogenesis of NAFLD/NASH. AIM:To investigate the prevalence of NAFLD/NASH in 5,400 military personnel and evaluate the effect of treatme...

journal_title：Current vascular pharmacology

authors： Sfikas G,Psallas M,Koumaras C,Imprialos K,Perdikakis E,Doumas M,Giouleme O,Karagiannis A,Athyros VG

更新日期：2020-10-15 00:00:00

abstract：:Aspirin plays a pivotal role in the management of patients with Coronary Artery Disease (CAD) with well-recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing Percutaneous Coronary Intervention (PCI). Dual antiplatelet therapy is mandated for pa...

journal_title：Current vascular pharmacology

authors： Kassimis G,Raina T,Alexopoulos D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. OBJECTIVE:Our study aimed to evaluate two markers of CV risk [common carotid artery intima-media thickness (cIMT) and the aortic pulse wave velocity (PWV)] in p...

journal_title：Current vascular pharmacology

authors： Gaudio A,Zanoli L,Xourafa A,Rapisarda R,Catalano A,Signorelli SS,Castellino P

更新日期：2020-06-09 00:00:00

abstract：:Oxidative stress has been linked to the origin and progression of cardiovascular diseases. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase is a multi-component, NADPH-dependent enzyme that generates superoxide anion in the presence of molecular oxygen. The enzyme has been identified and chara...

journal_title：Current vascular pharmacology

authors： Yu J,Weïwer M,Linhardt RJ,Dordick JS

更新日期：2008-07-01 00:00:00

abstract：:An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk o...

journal_title：Current vascular pharmacology

authors： Radak D,Tanaskovic S,Katsiki N,Isenovic ER

更新日期：2016-01-01 00:00:00

abstract：:Urocortin comprises a group of endogenously produced peptide hormones that belong to the corticotropinreleasing factor (CRF) family with promising future as potential drugs for the treatment of heart disease. Members of the urocortin family are known to act as potent regulators of cardiac and vascular functions, throu...

journal_title：Current vascular pharmacology

authors： Díaz I,Smani T

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. OBJECTIVE:To investigate whether t...

journal_title：Current vascular pharmacology

authors： Machulsky NF,Barchuk M,Gagliardi J,Gonzalez D,Lombardo M,Escudero AG,Gigena G,Blanco F,Schreier L,Fabre B,Berg G

更新日期：2018-01-01 00:00:00