Abstract:
:This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanism. Clopidogrel reactions most commonly present as a mild delayed maculopapular erythematous rash 5 to 10 days after introduction of the drug, and do not always require discontinuation of the drug. Severe cutaneous, systemic, and immediate adverse reactions to clopidogrel are rare. For the diagnosis of clopidogrel hypersensitivity, drug causality can be determined using patch testing, or for mild reactions, recurrence of symptoms after drug reintroduction, although neither are required for diagnosis.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Ford MK,Cohn JRdoi
10.2174/1570161116666181031143628subject
Has Abstractpub_date
2019-01-01 00:00:00pages
110-112issue
2eissn
1570-1611issn
1875-6212pii
CVP-EPUB-94163journal_volume
17pub_type
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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更新日期:2012-07-01 00:00:00
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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更新日期:2012-01-01 00:00:00