Clopidogrel Hypersensitivity: Pathogenesis, Presentation and Diagnosis.

Abstract:

:This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanism. Clopidogrel reactions most commonly present as a mild delayed maculopapular erythematous rash 5 to 10 days after introduction of the drug, and do not always require discontinuation of the drug. Severe cutaneous, systemic, and immediate adverse reactions to clopidogrel are rare. For the diagnosis of clopidogrel hypersensitivity, drug causality can be determined using patch testing, or for mild reactions, recurrence of symptoms after drug reintroduction, although neither are required for diagnosis.

journal_name

Curr Vasc Pharmacol

authors

Ford MK,Cohn JR

doi

10.2174/1570161116666181031143628

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

110-112

issue

2

eissn

1570-1611

issn

1875-6212

pii

CVP-EPUB-94163

journal_volume

17

pub_type

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