Abstract:
:Chronic venous disease (CVeD) is a debilitating condition that affects millions of individuals worldwide. The condition can result in varicose veins, or advance to severe skin changes and venous ulceration. The fundamental basis for CVeD is inflammation within the venous circulation and that it is subjected to increased hydrostatic pressure resulting in increased ambulatory venous pressure. The inflammation involves leukocytes, in particular macrophages and monocytes, inflammatory modulators and chemokines, cytokine expression, growth factors, metalloproteinase (MMP) activity, and many regulatory pathways that perpetuate inflammation. Sulodexide (SDX) is a glycosaminoglycan with pro-fibrinolytic and anti-thrombotic properties. We have previously demonstrated that SDX inhibits the secretion of pro-zymogen MMP-9 from human leukocytes without displacing high molecular complexes of MMP-9. The anti-inflammatory properties of SDX on activated leukocytes have not been well established. We hypothesized that SDX will reduce the secretion of inflammatory mediators from lipopolysaccharide (LPS)-stimulated macrophages. Therefore, we evaluated the effects of SDX on LPS-stimulated macrophage secretion of various inflammatory and anti-inflammatory cytokines, chemokines, and colony stimulating factors. We used microplatebased multiplex immunoassays. LPS-stimulated macrophages in vitro caused a substantial increase of interleukins, tumor necrosis factor, interferon, chemokines and colony stimulating factors. The addition of SDX caused both a dose-dependent and dose-independent decrease in nearly all of the inflammatory cytokines, chemokines and colony stimulating factors. These findings suggest that SDX has a significant effect on the release of inflammatory mediators from macrophages, and may be useful in the treatment of early and advanced CVeD.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Mannello F,Ligi D,Canale M,Raffetto JDdoi
10.2174/1570161111666131126144025subject
Has Abstractpub_date
2014-01-01 00:00:00pages
173-85issue
1eissn
1570-1611issn
1875-6212pii
CVP-EPUB-57656journal_volume
12pub_type
杂志文章abstract:BACKGROUND:The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. OBJECTIVE:Our study aimed to evaluate two markers of CV risk [common carotid artery intima-media thickness (cIMT) and the aortic pulse wave velocity (PWV)] in p...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
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更新日期:2020-06-09 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 社论,评审
doi:10.2174/157016109788340712
更新日期:2009-07-01 00:00:00
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更新日期:2009-07-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111795495558
更新日期:2011-05-01 00:00:00
abstract::The incidence of cardiovascular disease is low in healthy premenopausal women and increases with age especially after the menopause; this difference has been attributed to the loss of endogenous estrogen. Atherosclerosis is a chronic inflammatory condition of the vascular wall that may result in an acute clinical even...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790886974
更新日期:2010-03-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190121102323
更新日期:2020-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
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更新日期:2013-05-13 00:00:00
abstract:INTRODUCTION:Chlamydia pneumoniae was the first pathogen linked with carotid atherosclerotic changes and plaque rupture. Currently, other common pathogens are also under investigation as potential contributors. METHODS:A systematic review of PubMed and Scopus databases was performed. Studies evaluating the infectious ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110793563889
更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.2174/15701611113119990133
更新日期:2014-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112803520927
更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790226679
更新日期:2010-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111797484062
更新日期:2011-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161112666140613115813
更新日期:2014-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/1570161112666141014151858
更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190405164749
更新日期:2020-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161053586912
更新日期:2005-04-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161112666140423220628
更新日期:2014-05-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:
更新日期:2013-03-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016106777698423
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.2174/1570161115666170529090700
更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170414115705
更新日期:2017-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161113666150204142716
更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111796642689
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Dyslipidaemia is a risk factor for macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Our aim was to assess the use of lipid lowering drugs (LLDs) in patients with T2DM and co-existing dyslipidaemia. METHOD:A multicentre, non-interventional survey conducted in 6 Middle Eastern cou...
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pub_type: 杂志文章,多中心研究
doi:10.2174/1570161115666170705153815
更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 临床试验,杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
abstract::Both endothelin(ET)-1 and oxidative stress have been the subjects of intense investigation within the cardiovascular field over the past decade and a half, yet little is known about the precise relationship between these important modulators of vascular function. There is a firm evidence that ET-1 can stimulate the pr...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016105774329408
更新日期:2005-10-01 00:00:00
abstract::Obesity and Gestational Diabetes Mellitus (GDM) are the most frequent pathologies affecting mothers and offspring during pregnancy. Both conditions have shown a sustained increase in their prevalence in recent years, and they worsen the outcome of pregnancy and the long-term health of mothers. Obesity increases the ri...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666200628142353
更新日期:2021-01-01 00:00:00