Abstract:
:Post-transplant diabetes mellitus (PTDM) and dyslipidaemia are the most common metabolic complications in kidney transplant recipients (KTR). They are associated with a higher risk of lower graft function and survival, as well as an increased risk of cardiovascular disease (CVD). The aim of this review is to provide current data on the epidemiology, pathophysiology and optimal management of these two principal metabolic complications in KTR. Several risk factors in this metabolic milieu are either already present or emerge after renal transplantation, such as those due to immunosuppressive therapy. However, the exact pathogenic mechanisms have not been fully elucidated. Awareness of these disorders is crucial to estimate CVD risk in KTR and optimize screening and therapeutic strategies. These include lifestyle (preferably according to the Mediterranean pattern) and immunosuppressive regimen modification, as well as the best available anti-diabetic (insulin or oral hypoglycaemic agents) and hypolipidaemic (e.g. statins) regimen according to an individual's metabolic profile and medical history.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Anagnostis P,Paschou SA,Spartalis E,Sarno G,De Rosa P,Muscogiuri Gdoi
10.2174/1570161117666190619143005subject
Has Abstractpub_date
2020-01-01 00:00:00pages
273-281issue
3eissn
1570-1611issn
1875-6212pii
CVP-EPUB-99061journal_volume
18pub_type
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abstract:: ...
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-01-01 00:00:00
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更新日期:2004-10-01 00:00:00
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pub_type: 社论,评审
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pub_type: 杂志文章,多中心研究
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