Abstract:
:This essay focuses on nine important lessons learned during more than thirty years of endothelial research. They include: the danger of hiding behind a word, the confusion generated by abbreviations, the need to define the physiological role of the response studied, the local role of endothelium- dependent responses, the strength of pharmacological analyses, endothelial dysfunction as consequence and cause of disease, the importance of rigorous protocols, the primacy of in vivo studies and the importance of serendipity.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Vanhoutte PMdoi
10.2174/1570161114666151202204754subject
Has Abstractpub_date
2016-01-01 00:00:00pages
175-80issue
2eissn
1570-1611issn
1875-6212pii
CVP-EPUB-72202journal_volume
14pub_type
杂志文章,评审abstract:BACKGROUND:Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. OBJECTIVE:To investigate whether t...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161115666170609102506
更新日期:2018-01-01 00:00:00
abstract::Statins are beneficial both in the primary and secondary prevention of atherosclerotic vascular disease and acute events in a broad spectrum of patient subgroups. However, the observed clinical benefit with statin therapy is much greater than expected through the reduction of cholesterol levels alone. Clinical and exp...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043385475
更新日期:2004-10-01 00:00:00
abstract::Cardiovascular failure in sepsis involves a combination of hypovolemia, decreased vascular tone, myocardial depression and microcirculatory alterations. Fluids represent the first line therapeutic intervention, with controversy regarding the type of fluid. Recent data indicate that albumin is safe and might even be be...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:
更新日期:2013-03-01 00:00:00
abstract::This review demonstrates that oxidative stress, reactive oxygen species, and electron transfer can serve as unifying mechanistic themes for large numbers of cardiovascular toxins, both endogenous and exogenous. Lipid peroxidation is a prevalent insult. Common among the various conditions are atherosclerosis and arrhyt...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161053586912
更新日期:2005-04-01 00:00:00
abstract::Both endothelin(ET)-1 and oxidative stress have been the subjects of intense investigation within the cardiovascular field over the past decade and a half, yet little is known about the precise relationship between these important modulators of vascular function. There is a firm evidence that ET-1 can stimulate the pr...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016105774329408
更新日期:2005-10-01 00:00:00
abstract:INTRODUCTION:Obstructive Sleep Apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal Blood Pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causativ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170414115705
更新日期:2017-01-01 00:00:00
abstract::In chronic inflammatory conditions, endothelial cells actively recruit immune cells from the circulation into the underlying tissue and participate in angiogenesis to support the continuous demand for oxygen and nutrients. They do so in response to activation by cytokines and growth factors such as tumour necrosis fac...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161052773898
更新日期:2005-01-01 00:00:00
abstract::Cardiovascular disease (CVD) is among the most major causes of morbidity and mortality worldwide. Great progress has been made in the management of CVD which has been influenced by the use of experimental animal models. These models provided information at cellular and molecular levels and allowed the development of t...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161113666150212151506
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used, having numerous indications. However, despite their therapeutic role, they are associated with serious cardiovascular (CV) adverse events. Objectives-Methods: This review comprising recent observational studies and metaanalyses over the past few...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161114666160728093323
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), are major health problems worldwide. Genetics may play a role in the pathogenesis of NAFLD/NASH. AIM:To investigate the prevalence of NAFLD/NASH in 5,400 military personnel and evaluate the effect of treatme...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666201015152921
更新日期:2020-10-15 00:00:00
abstract::Obesity and Gestational Diabetes Mellitus (GDM) are the most frequent pathologies affecting mothers and offspring during pregnancy. Both conditions have shown a sustained increase in their prevalence in recent years, and they worsen the outcome of pregnancy and the long-term health of mothers. Obesity increases the ri...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666200628142353
更新日期:2021-01-01 00:00:00
abstract::A number of epidemiological studies have shown that diets rich in plant-derived phenolic compounds reduce the risk of coronary heart disease. The chronic antioxidant and hypolipidemic activities of these compounds have important roles in prevention of lipoprotein oxidation and atherosclerotic lesion development. In re...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161033476736
更新日期:2003-06-01 00:00:00
abstract::In the last decade there have been considerable advances in the understanding of the pathophysiology of malignant ventricular tachyarrhythmias (VA) and Sudden Cardiac Death (SCD). Over 80% of SCD occurs in patients with organic heart disease. However, approximately 10-15% of SCD occurs in the presence of structurally ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016109788340794
更新日期:2009-07-01 00:00:00
abstract::High-mobility group box-1 (HMGB1) is a nuclear protein that acts as a cytokine when released into the extracellular milieu by necrotic and inflammatory cells, and is involved in inflammatory responses and tissue repair. This protein is released passively during cellular necrosis by almost all cells that have a nucleus...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111797484125
更新日期:2011-11-01 00:00:00
abstract::The vascular endothelium is a monolayer of cells between the vessel lumen and the vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized from the amino acid L-arginine in endothelial cells by the constitutive calcium-calmodulin-dependent enzyme nitric oxide synthase (NOS). This subst...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112798829760
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Volatile Anaesthetics (VA) are commonly used worldwide for induction and/or maintenance of general anaesthesia. They act in the central nervous system to reduce sensation and motor response during surgical and invasive diagnostic procedures. VAs also have some non-anaesthetic properties in the brain when adm...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666171013153750
更新日期:2018-01-01 00:00:00
abstract::Platelet activation induces rapid thrombus formation at a ruptured atherosclerotic plaque leading to acute vessel occlusion and a fatal or non-fatal cardiovascular event. More recent evidence suggests that activated platelets play an additional central role during the initiation of atherosclerosis, essentially facilit...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016108783331295
更新日期:2008-01-01 00:00:00
abstract::There is growing evidence that Rho-kinase contributes to cardiovascular disease, which has made Rho-kinase a target for the treatment of human diseases. To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161112666140613115813
更新日期:2014-01-01 00:00:00
abstract::Platelet aggregation induced by stirring of a platelet suspension after activation by the exogenous addition of stimulants, such as ADP, epinephrine and thrombin, has long been used as a platelet function test, and for the screening of antiplatelet agents. Since platelet aggregation has been demonstrated to be mediate...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043476456
更新日期:2004-01-01 00:00:00
abstract::Obesity is a risk factor for complications of atherosclerotic vascular disease such as myocardial infarction and stroke. Recent studies have demonstrated that the vascular risk associated with obesity is correlated particularly with visceral adiposity. These clinical observations indicate that various adipose tissue d...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016109787455680
更新日期:2009-04-01 00:00:00
abstract::Aspirin plays a pivotal role in the management of patients with Coronary Artery Disease (CAD) with well-recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing Percutaneous Coronary Intervention (PCI). Dual antiplatelet therapy is mandated for pa...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180604100220
更新日期:2019-01-01 00:00:00
abstract::An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk o...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161113666150529125127
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:In the era of dual antiplatelet therapy of aspirin and clopidogrel and systematic stent implantation, Glycoprotein IIb/IIIa Inhibitors (GPI), including abciximab, eptifibatide and tirofiban, proved beneficial in improving early outcome of Percutaneous Coronary Intervention (PCI), especially in higher risk cl...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180117102422
更新日期:2018-01-01 00:00:00
abstract::The pathogenesis of obesity, insulin resistance and hypertension begins with an interaction between genetic factors and environmental factors. The search for the underlying genetic basis of these conditions has yielded disappointing results. It is possible that the importance of environmental influences has been under...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016106778521661
更新日期:2006-10-01 00:00:00
abstract:: ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161117999190403163922
更新日期:2019-01-01 00:00:00
abstract::Reactive oxygen species (ROS) are important signaling molecules in the vasculature. However, when there is imbalance between their occurrence and antioxidant defense mechanisms, ROS can contribute to the vascular abnormalities that lead to hypertension. Evidence accumulated in the last decade strongly supports the not...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161054368643
更新日期:2005-07-01 00:00:00
abstract:UNLABELLED:Hif-1α, a master regulator of ischemia-responsive gene induction, controls pro-angiogenic gene expression of VEGF-A, flt-1, IGF-1 and erythropoietin, rendering its overexpression an attractive tool for therapeutic neovascularization. Utilizing an adenoviral vector system, we investigated the efficacy of sele...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::Hypercoagulability is widely associated with sepsis, inflammation, diabetes, cancers, aging, and many pathological conditions, resulting in life-threatening disseminated intravascular coagulation (DIC), venous thrombosis, thromboembolism, cardiovascular complications, or even deadly multiple organ failure. Relieving c...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043385673
更新日期:2004-07-01 00:00:00
abstract::The aim of this review is to present, critically appraise and qualitatively synthesize current evidence on the risk of type 2 diabetes mellitus (T2DM) development during menopause, the management of climacteric symptoms in women with T2DM and the management of T2DM in postmenopausal women. Menopause represents the end...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180625124405
更新日期:2019-01-01 00:00:00
abstract::Many patients with hypertension will require multiple antihypertensive drugs to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combinations (SPCs) in patients with mild-to-moderate hypertension who were non-responsive to aliskiren mono...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/157016112803520765
更新日期:2012-11-01 00:00:00