Abstract:
:Platelet adhesion on vascular wall is the first step following vascular injury. Differential platelet secretion supports angiogenesis and vascular homeostasis. Progenitor cells are pluripotent cells responsible for tissue regeneration and wound healing. Upon ischemia bone marrow-derived progenitor cells are mobilized into peripheral circulation and domiciliate into peripheral organ vasculature and either give birth to a series of cardiovascular cells, including endothelial cells, macrophages, smooth muscle cells, or support in a paracrinic way the angiogenic capacity of local tissue cells. Mobilization, chemotaxis, adhesion, differentiation and interaction with vascular cells are essential steps of progenitor cell-mediated tissue repair. This review summarizes the recent advances in our understanding of platelet function with focus on interaction with progenitor cells and its role in cardiovascular homeostasis. Moreover, the role of platelet microparticles in progenitor cell function is separately addressed. Understanding the mechanisms of platelet interaction with progenitor cells provides us with new insights in the mechanisms of vascular homeostasis and possible new therapeutical targets supporting vascular repair.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Sopova K,Tatsidou P,Stellos Kdoi
10.2174/157016112801784486subject
Has Abstractpub_date
2012-09-01 00:00:00pages
555-62issue
5eissn
1570-1611issn
1875-6212pii
CVP-EPUB-20120215-006journal_volume
10pub_type
杂志文章,评审abstract::Cardiovascular failure in sepsis involves a combination of hypovolemia, decreased vascular tone, myocardial depression and microcirculatory alterations. Fluids represent the first line therapeutic intervention, with controversy regarding the type of fluid. Recent data indicate that albumin is safe and might even be be...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:
更新日期:2013-03-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666200420102100
更新日期:2021-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 评论,社论
doi:10.2174/157016112803520783
更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666181005122339
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Vitamin D is a fat soluble vitamin involved in calcium and bone metabolism; recently its deficiency has been related to cardiovascular disease. In cardiac tissue, vitamin D suppresses metalloproteinases (MMPs) expression, enzymes directly associated with vulnerable plaque. OBJECTIVE:To investigate whether t...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161115666170609102506
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used, having numerous indications. However, despite their therapeutic role, they are associated with serious cardiovascular (CV) adverse events. Objectives-Methods: This review comprising recent observational studies and metaanalyses over the past few...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161114666160728093323
更新日期:2016-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161052773870
更新日期:2005-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161113666150204142716
更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016108783331295
更新日期:2008-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111795495585
更新日期:2011-05-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110792006923
更新日期:2010-09-01 00:00:00
abstract::We evaluated the effects of the glycosaminoglycan sulodexide (SDX; antithrombotic/profibrinolytic drug) on the activity and release of matrix metalloproteinases (MMPs) in human blood. This was a prospective non-randomized study, analyzing by zymography and ELISA the in vitro effects of SDX on pro-enzyme, complexed, an...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161111311030010
更新日期:2013-05-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790886992
更新日期:2010-03-01 00:00:00
abstract::Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161111311050013
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:We described lifestyle changes one year after acute coronary syndrome (ACS) among patients in Arabian Gulf countries. METHODOLOGY:Data of patients admitted to 29 hospitals in 4 countries with the diagnosis of ACS were analysed from Gulf citizens with ACS events (Gulf COAST) registry. A total of 3565 ACS pat...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究
doi:10.2174/1570161115666170529090700
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Add-on therapy with the Mineralocorticoid-Receptor-Antagonists (MRAs) spironolactone and eplerenone was shown to enhance the cardioprotective action of angiotensinconverting- enzyme-inhibitors (ACEIs), angiotensin-receptor-blockers (ARBs) and/or β-blockers in nondialysis patients with congestive heart failur...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170201113817
更新日期:2017-01-01 00:00:00
abstract::Obesity and Gestational Diabetes Mellitus (GDM) are the most frequent pathologies affecting mothers and offspring during pregnancy. Both conditions have shown a sustained increase in their prevalence in recent years, and they worsen the outcome of pregnancy and the long-term health of mothers. Obesity increases the ri...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666200628142353
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), are major health problems worldwide. Genetics may play a role in the pathogenesis of NAFLD/NASH. AIM:To investigate the prevalence of NAFLD/NASH in 5,400 military personnel and evaluate the effect of treatme...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666201015152921
更新日期:2020-10-15 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790226651
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Chlamydia pneumoniae was the first pathogen linked with carotid atherosclerotic changes and plaque rupture. Currently, other common pathogens are also under investigation as potential contributors. METHODS:A systematic review of PubMed and Scopus databases was performed. Studies evaluating the infectious ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110793563889
更新日期:2010-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111201140327163302
更新日期:2014-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/157016112803520765
更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111794519273
更新日期:2011-03-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043385673
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:In the era of dual antiplatelet therapy of aspirin and clopidogrel and systematic stent implantation, Glycoprotein IIb/IIIa Inhibitors (GPI), including abciximab, eptifibatide and tirofiban, proved beneficial in improving early outcome of Percutaneous Coronary Intervention (PCI), especially in higher risk cl...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180117102422
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. OBJECTIVE:Our study aimed to evaluate two markers of CV risk [common carotid artery intima-media thickness (cIMT) and the aortic pulse wave velocity (PWV)] in p...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1389450121666200609151555
更新日期:2020-06-09 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190619143005
更新日期:2020-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112799304969
更新日期:2012-03-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161115666170830141852
更新日期:2018-01-01 00:00:00
abstract:: ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161117999190403163922
更新日期:2019-01-01 00:00:00