Abstract:
INTRODUCTION:Diabetes mellitus (DM) is one of the most common diseases worldwide. Its adverse effects on several body organs, have made treatment of DM a priority. One of the most serious complications of DM is diabetic nephropathy (DN). OBJECTIVE:The aim of this review is to critically discuss available data on the pharmacological management of DN. METHODS:A comprehensive review of the literature was performed to identify studies assessing the impact of several drug classes on DN. RESULTS:Several studies have been conducted in order to find a novel and effective treatment of DN. So far, the cornerstone therapy of DN consists of renin-angiotensin system (RAS) inhibitors, agents that decrease the synthesis of intrarenal angiotensin II or block its receptors. Their antiproteinuric and antihypertensive effects can not only decelerate the progress of DN but prevent its onset as well. Novel antidiabetic drugs, such as sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and glucagon-like peptide- 1 receptor agonists (GLP-1 RA), are promising agents in the therapy of DN, due to their positive effect on renal and cardiovascular adverse events. From lipid-lowering agents, atorvastatin improves DN up to stage 3 and substantially reduces CVD. CONCLUSION:RAS inhibitors, SGLT-2i and GLP-1 agonists were found to be beneficial for the treatment of DN. Larger renal trials are needed in order to incorporate these drugs into the first line treatment of DN.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Papademetriou V,Alataki S,Stavropoulos K,Papadopoulos C,Bakogiannis K,Tsioufis Kdoi
10.2174/1570161117666190405164749subject
Has Abstractpub_date
2020-01-01 00:00:00pages
139-147issue
2eissn
1570-1611issn
1875-6212pii
CVP-EPUB-97858journal_volume
18pub_type
杂志文章,评审abstract::Aldosterone, a steroid hormone with mineralocorticoid activity, is far more than merely a salt-and-water hormone. Aldosterone has a number of non-classical, mineralocorticoid receptor (MR)-mediated actions, including tissue remodeling, modulation of vascular tone and stimulating inflammation and fibrosis, which may fu...
journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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更新日期:2013-03-01 00:00:00
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 评论,社论
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更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
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abstract:: ...
journal_title:Current vascular pharmacology
pub_type: 社论
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journal_title:Current vascular pharmacology
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更新日期:2011-03-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2010-03-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2021-01-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2020-10-15 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,实务指引,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Current vascular pharmacology
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更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
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pub_type: 杂志文章
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journal_title:Current vascular pharmacology
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更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2013-05-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2005-07-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2012-09-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2011-11-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2009-01-01 00:00:00