Visfatin/PBEF and atherosclerosis-related diseases.

Abstract:

:Visfatin is highly expressed in adipose tissue (mainly by the stromal cells), but it is also ubiquitously present in most tissues. Visfatin, which plays a role in nicotinamide adenine dinucleotide (NAD) biosynthesis, has been implicated in inflammatory states. Controversial results exist about the expression, circulating levels and the role of visfatin in atherosclerosis-related diseases. Most studies showed increased levels of visfatin in diabetes mellitus, obesity, hypertension, renal and cardiovascular disease. However, other studies reported lower levels of visfatin in these diseases. The discrepancies in clinical studies may be attributed to the multifactorial regulation of visfatin. There is evidence that visfatin expression and circulating levels are influenced by fat area and distribution, inflammatory state, renal function, iron metabolism, hormones as well as several other factors. Furthermore, discrepancies and lack of correlation between commercially available visfatin assays have been reported. More research is needed to better understand the factors that control its synthesis/release and to evaluate the role of visfatin in atherosclerosis-related disease. Large studies with homogeneous populations will probably be needed to answer these questions. Whether visfatin will eventually become a therapeutic target remains to be established.

journal_name

Curr Vasc Pharmacol

authors

Filippatos TD,Randeva HS,Derdemezis CS,Elisaf MS,Mikhailidis DP

doi

10.2174/157016110790226679

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

12-28

issue

1

eissn

1570-1611

issn

1875-6212

pii

CVP-Abs-009

journal_volume

8

pub_type

杂志文章,评审
  • Statins: Are they really all the same?

    abstract:: ...

    journal_title:Current vascular pharmacology

    pub_type: 社论

    doi:10.2174/1570161116666180713120217

    authors: Cortese F

    更新日期:2019-01-01 00:00:00

  • Recommendations for severe hypertriglyceridemia treatment, are there new strategies?

    abstract::This review considers drug combinations and newer treatment strategies for patients with severe hypertriglyceridemia. Hypertriglyceridemia is associated with an atherogenic metabolic profile and in most studies with increased cardiovascular disease risk. Patients with severe hypertriglyceridemia also have increased in...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/15701611113119990133

    authors: Filippatos TD,Elisaf MS

    更新日期:2014-01-01 00:00:00

  • Angiogenetic potential of Ad2/Hif-1α/VP16 after regional application in a preclinical pig model of chronic ischemia.

    abstract:UNLABELLED:Hif-1α, a master regulator of ischemia-responsive gene induction, controls pro-angiogenic gene expression of VEGF-A, flt-1, IGF-1 and erythropoietin, rendering its overexpression an attractive tool for therapeutic neovascularization. Utilizing an adenoviral vector system, we investigated the efficacy of sele...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章

    doi:

    authors: Hinkel R,Lebherz C,Fydanaki M,Wuchrer A,El-Aouni C,Thormann M,Thein E,Kupatt C,Boekstegers P

    更新日期:2013-01-01 00:00:00

  • Involvement of coagulation and hemostasis in inflammatory bowel diseases.

    abstract::Inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis (UC) are idiopathic, intestinal and systemic inflammatory disorders which are immunologically mediated with the activation of plasma proteolytic cascades. The activation of coagulation in IBD is related to the activity and colonic extension of t...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016112801784495

    authors: Stadnicki A

    更新日期:2012-09-01 00:00:00

  • The role of infection in carotid plaque pathogenesis and stability: the clinical evidence.

    abstract:INTRODUCTION:Chlamydia pneumoniae was the first pathogen linked with carotid atherosclerotic changes and plaque rupture. Currently, other common pathogens are also under investigation as potential contributors. METHODS:A systematic review of PubMed and Scopus databases was performed. Studies evaluating the infectious ...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016110793563889

    authors: Makris GC,Makris MC,Wilmot VV,Geroulakos G,Falagas ME

    更新日期:2010-11-01 00:00:00

  • The role of the methoxyphenol apocynin, a vascular NADPH oxidase inhibitor, as a chemopreventative agent in the potential treatment of cardiovascular diseases.

    abstract::Oxidative stress has been linked to the origin and progression of cardiovascular diseases. Nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase is a multi-component, NADPH-dependent enzyme that generates superoxide anion in the presence of molecular oxygen. The enzyme has been identified and chara...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016108784911984

    authors: Yu J,Weïwer M,Linhardt RJ,Dordick JS

    更新日期:2008-07-01 00:00:00

  • Use of Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Relation to Cardiovascular Events. A Systematic Pharmacoepidemiological Review.

    abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used, having numerous indications. However, despite their therapeutic role, they are associated with serious cardiovascular (CV) adverse events. Objectives-Methods: This review comprising recent observational studies and metaanalyses over the past few...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161114666160728093323

    authors: Kontogiorgis C,Valikeserlis I,Hadjipavlou-Litina D,Nena E,Constantinidis TC

    更新日期:2016-01-01 00:00:00

  • Natural phenolic compounds as cardiovascular therapeutics: potential role of their antiinflammatory effects.

    abstract::A number of epidemiological studies have shown that diets rich in plant-derived phenolic compounds reduce the risk of coronary heart disease. The chronic antioxidant and hypolipidemic activities of these compounds have important roles in prevention of lipoprotein oxidation and atherosclerotic lesion development. In re...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161033476736

    authors: Jiang F,Dusting GJ

    更新日期:2003-06-01 00:00:00

  • Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease.

    abstract::Atherosclerosis (also known as arteriosclerotic vascular disease) is a chronic inflammatory disease of the arterial wall, characterized by the formation of lipid-laden lesions. The activation of endothelial cells at atherosclerotic lesion-prone sites in the arterial tree results in the up-regulation of cell adhesion m...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章

    doi:

    authors: Araldi E,Chamorro-Jorganes A,van Solingen C,Fernández-Hernando C,Suárez Y

    更新日期:2013-05-13 00:00:00

  • Clopidogrel Hypersensitivity: Pathogenesis, Presentation and Diagnosis.

    abstract::This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanis...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161116666181031143628

    authors: Ford MK,Cohn JR

    更新日期:2019-01-01 00:00:00

  • Acute coronary syndromes in patients with chronic kidney disease.

    abstract::Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosi...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161111311050013

    authors: Franczyk-Skóra B,Gluba A,Banach M,Rozentryt P,Poloński L,Rysz J

    更新日期:2013-09-01 00:00:00

  • Antenatal hypoxia and pulmonary vascular function and remodeling.

    abstract::This review provides evidence that antenatal hypoxia, which represents a significant and worldwide problem, causes prenatal programming of the lung. A general overview of lung development is provided along with some background regarding transcriptional and signaling systems of the lung. The review illustrates that ant...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161111311050006

    authors: Papamatheakis DG,Blood AB,Kim JH,Wilson SM

    更新日期:2013-09-01 00:00:00

  • Effects of insulin on the vasculature.

    abstract::Revascularization procedures used for the treatment of cardiovascular disease can be associated with restenosis, although drug-coated stents have greatly reduced this complication. Both type 2 diabetes (T2DM) and metabolic syndrome (MetS) are associated with a high risk for atherosclerosis and restenosis. Insulin resi...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016111795495558

    authors: Breen DM,Giacca A

    更新日期:2011-05-01 00:00:00

  • Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment. METHODS:Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2174/1570161112666141014151858

    authors: Wang LY,Tang JY,Liu J,Lu W,Yu YN,Chen BW,Wu HL,Su LY,Jing ZW,Hu SY,Liu XL,Yang XY,Li GX,Dong B,Wang DH,Xue J,Wang XF,Li ZM,Liu SR,Liu SS,Chen QG,Zhang L,Wang Z,Shen CT,Wang YY

    更新日期:2015-01-01 00:00:00

  • Treatment of Diabetic Cardiovascular Autonomic, Peripheral and Painful Neuropathy. Focus on the Treatment of Cardiovascular Autonomic Neuropathy with ACE Inhibitors.

    abstract::Neuropathies of the peripheral and autonomic nervous systems affect up to half of all people with diabetes mellitus, and are major risk factors for foot ulceration, amputation and cardiovascular dysfunction. Peripheral neuropathies manifest with either painful or painless symptoms, but many patients experience both. O...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161117666190521101342

    authors: Didangelos T,Veves A

    更新日期:2020-01-01 00:00:00

  • Cardiotoxic and antiarrhythmic tertiary amine local anesthetics: sodium channel affinity vs. sodium channel gating.

    abstract::Tertiary amine local anesthetics (LAs) are clinically valuable agents for controlling pain and for treating some cardiac arrhythmias. These drugs inhibit conduction of electrical activity by blocking voltage-gated sodium channels. Interestingly, LAs can influence the conduction of electrical activity in heart muscle w...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161033476628

    authors: Wright SN

    更新日期:2003-10-01 00:00:00

  • Aldosterone, mineralocorticoid receptor and the metabolic syndrome: role of the mineralocorticoid receptor antagonists.

    abstract::Several lines of evidence suggest a detrimental effect of aldosterone excess on the development of metabolic alterations. Glucose metabolism derangements due to aldosterone action are frequently observed not only in patients with primary aldosteronism but also in patients with obesity. A contribution to the hyperaldos...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016112799304969

    authors: Ronconi V,Turchi F,Appolloni G,di Tizio V,Boscaro M,Giacchetti G

    更新日期:2012-03-01 00:00:00

  • Metabolic Complications and Kidney Transplantation: Focus on Glycaemia and Dyslipidaemia.

    abstract::Post-transplant diabetes mellitus (PTDM) and dyslipidaemia are the most common metabolic complications in kidney transplant recipients (KTR). They are associated with a higher risk of lower graft function and survival, as well as an increased risk of cardiovascular disease (CVD). The aim of this review is to provide c...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161117666190619143005

    authors: Anagnostis P,Paschou SA,Spartalis E,Sarno G,De Rosa P,Muscogiuri G

    更新日期:2020-01-01 00:00:00

  • Tetrahydrobiopterin: a vascular redox target to improve endothelial function.

    abstract::Loss of normal endothelial function and bioactivity of nitric oxide (NO), associated with increased production of reactive oxygen species (ROS), are characteristics of cardiovascular disease states. There is good experimental evidence that these abnormalities are causally related to cardiovascular disease pathogeneses...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016112803520819

    authors: Channon KM

    更新日期:2012-11-01 00:00:00

  • Lifestyle Changes among ACS Survivors in Arabian Gulf Countries (Gulf COAST Registry).

    abstract:BACKGROUND:We described lifestyle changes one year after acute coronary syndrome (ACS) among patients in Arabian Gulf countries. METHODOLOGY:Data of patients admitted to 29 hospitals in 4 countries with the diagnosis of ACS were analysed from Gulf citizens with ACS events (Gulf COAST) registry. A total of 3565 ACS pat...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.2174/1570161115666170529090700

    authors: Al-Roomi F,Khesroh A,Al-Zakwani I,Attur S,Rashed W,Zubaid M

    更新日期:2018-01-01 00:00:00

  • New Insights into the Role of FGF-23 and Klotho in Cardiovascular Disease in Chronic Kidney Disease Patients.

    abstract::Alterations of fibroblast growth factor 23 (FGF-23) and Klotho levels are considered to be the earliest biochemical abnormality of chronic kidney disease - mineral and bone disease (CKDMBD) syndrome. Moreover, emerging data suggests that the dysregulated FGF-23 and Klotho axis has many effects on the cardiovascular (C...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1570161118666200420102100

    authors: Memmos E,Papagianni A

    更新日期:2021-01-01 00:00:00

  • Diabetes Mellitus, Hypertension and Hypercholesterolemia in Relation to the 10-Year ACS Prognosis; the GREECS Study.

    abstract::Although hypertension, hypercholesterolemia and diabetes mellitus (DM) are recognized as major cardio-metabolic risk factors in primary Acute Coronary Syndrome (ACS) prevention, studies focusing on secondary ACS incidence are scarce. In the present study, the association between the aforementioned factors and 10-year ...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1570161113666150916093451

    authors: Notara V,Panagiotakos DB,Michalopoulou M,Kouvari M,Tsompanaki E,Verdi M,Vassileiou N,Kalli E,Mantas Y,Kogias Y,Stravopodis P,Papanagnou G,Zombolos S,Pitsavos C,Greecs Study Investigators.

    更新日期:2016-01-01 00:00:00

  • Occurrence and clinical impact of microembolic signals (MES) in patients with chronic cardiac diseases and atheroaortic plaques--a systematic review.

    abstract:BACKGROUND:In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of s...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016108785909797

    authors: Dittrich R,Ringelstein EB

    更新日期:2008-10-01 00:00:00

  • Current and Potential Future Pharmacological Approaches for Non- Alcoholic Fatty Liver Disease.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the general population. The disease ranges from simple steatosis, to non-alcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. Several drugs are used in daily clinical practice to manage the disease. However, dat...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161115666170621083744

    authors: Imprialos K,Stavropoulos K,Bouloukou S,Kerpiniotis G,Karagiannis A,Doumas M

    更新日期:2018-01-01 00:00:00

  • Diabetes, Incretin Therapy and Thoracic Aortic Aneurysm - What Does the Evidence Show?

    abstract::Epidemiological evidence supports a reduced prevalence of Thoracic Aortic Aneurysm (TAA) and Abdominal Aortic Aneurysm (AAA) in patients with Diabetes (DM). The mechanisms underlying this negative association are unknown. Some studies support that hyperglycemia has effects on the Extracellular Matrix (ECM), resulting ...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161116666180828155622

    authors: Krizhanovskii C,Franco-Cereceda A

    更新日期:2019-01-01 00:00:00

  • Paget's Disease of Bone and Cardiovascular Risk: a Pilot Study.

    abstract:BACKGROUND:The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. OBJECTIVE:Our study aimed to evaluate two markers of CV risk [common carotid artery intima-media thickness (cIMT) and the aortic pulse wave velocity (PWV)] in p...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章

    doi:10.2174/1389450121666200609151555

    authors: Gaudio A,Zanoli L,Xourafa A,Rapisarda R,Catalano A,Signorelli SS,Castellino P

    更新日期:2020-06-09 00:00:00

  • Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage.

    abstract::Aldosterone, a steroid hormone with mineralocorticoid activity, is far more than merely a salt-and-water hormone. Aldosterone has a number of non-classical, mineralocorticoid receptor (MR)-mediated actions, including tissue remodeling, modulation of vascular tone and stimulating inflammation and fibrosis, which may fu...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/157016111796642689

    authors: Waanders F,de Vries LV,van Goor H,Hillebrands JL,Laverman GD,Bakker SJ,Navis G

    更新日期:2011-09-01 00:00:00

  • Heart Failure Models: Traditional and Novel Therapy.

    abstract::Cardiovascular disease (CVD) is among the most major causes of morbidity and mortality worldwide. Great progress has been made in the management of CVD which has been influenced by the use of experimental animal models. These models provided information at cellular and molecular levels and allowed the development of t...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161113666150212151506

    authors: Haidara MA,Assiri AS,Yassin HZ,Ammar HI,Obradovic MM,Isenovic ER

    更新日期:2015-01-01 00:00:00

  • Excess Metabolic and Cardiovascular Risk is not Manifested in all Phenotypes of Polycystic Ovary Syndrome: Implications for Diagnosis and Treatment.

    abstract:AIM:To assess the potential differences in the metabolic and cardiovascular disease (CVD) risk between the distinct phenotypes of the Polycystic Ovary Syndrome (PCOS) according to the Rotterdam definition regardless of body mass index (BMI). PATIENTS-METHODS:The study included 300 women; 240 women with PCOS, according...

    journal_title:Current vascular pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.2174/1567201812666150120163025

    authors: Daskalopoulos G,Karkanaki A,Piouka A,Prapas N,Panidis D,Gkeleris P,Athyros VG

    更新日期:2015-01-01 00:00:00

  • Mechanisms of Cardioprotection of Halogenated Agents During Extracorporeal Circulation in Cardiac Surgery.

    abstract::The implementation of cardioprotective strategies involving pre-, intra-, and postoperative interventions is key during cardiac surgery requiring extracorporeal circulation (ECC). The primary goal of this study was to review the physiopathology and protection strategies against myocardial damage secondary to ECC durin...

    journal_title:Current vascular pharmacology

    pub_type: 杂志文章,评审

    doi:10.2174/1570161115666171116170806

    authors: Ramirez-Aliaga M,Escalona-Belmonte JJ,Ramirez-Fernandez A,Rubio-Navarro M,Cruz-Manas J

    更新日期:2018-01-01 00:00:00