Recommendations for severe hypertriglyceridemia treatment, are there new strategies?

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the general population. The disease ranges from simple steatosis, to non-alcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. Several drugs are used in daily clinical practice to manage the disease. However, dat...

journal_title：Current vascular pharmacology

authors： Imprialos K,Stavropoulos K,Bouloukou S,Kerpiniotis G,Karagiannis A,Doumas M

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Obstructive Sleep Apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal Blood Pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causativ...

journal_title：Current vascular pharmacology

authors： Wolf J,Narkiewicz K

更新日期：2017-01-01 00:00:00

abstract：:Paraoxonase-1 (PON-1) is a calcium-dependent enzyme that is synthesized in the liver and then secreted in blood where it is bound to high density lipoprotein (HDL). PON-1 is a hydrolase with a wide range of substrates, including lipid peroxides. It is considered responsible for many of the antiatherogenic properties o...

journal_title：Current vascular pharmacology

authors： Lioudaki S,Verikokos C,Kouraklis G,Ioannou C,Chatziioannou E,Perrea D,Klonaris C

更新日期：2019-01-01 00:00:00

abstract：:Normal pregnancy is associated with increased insulin resistance as a metabolic adaptation to the nutritional demands of the placenta and fetus, and this is amplified in obese mothers. Insulin resistance is normally compensated for by an adaptive increase in pancreatic β-cell mass together with enhanced glucose-stimul...

journal_title：Current vascular pharmacology

authors： Szlapinski SK,Hill DJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Volatile Anaesthetics (VA) are commonly used worldwide for induction and/or maintenance of general anaesthesia. They act in the central nervous system to reduce sensation and motor response during surgical and invasive diagnostic procedures. VAs also have some non-anaesthetic properties in the brain when adm...

journal_title：Current vascular pharmacology

authors： Krzych LJ,Szczepanska AJ

更新日期：2018-01-01 00:00:00

abstract：:Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variatio...

journal_title：Current vascular pharmacology

authors： Franks PW,Poveda A

更新日期：2011-07-01 00:00:00

abstract：:Initially, the progression of chronic venous insufficiency is related to venous hypertension. The earliest complaints or symptoms, as well as vessel wall deterioration, valve restructuring, and, eventually, varicose veins, result not only from elevation of pressure, but also from a cascade of biochemical events relate...

journal_title：Current vascular pharmacology

authors： Katsenis K

更新日期：2005-01-01 00:00:00

abstract：: ...

journal_title：Current vascular pharmacology

authors： Guerrero Orriach JL,Ramirez-Fernandez A

更新日期：2019-01-01 00:00:00

abstract：:Aldosterone, a steroid hormone with mineralocorticoid activity, is far more than merely a salt-and-water hormone. Aldosterone has a number of non-classical, mineralocorticoid receptor (MR)-mediated actions, including tissue remodeling, modulation of vascular tone and stimulating inflammation and fibrosis, which may fu...

journal_title：Current vascular pharmacology

authors： Waanders F,de Vries LV,van Goor H,Hillebrands JL,Laverman GD,Bakker SJ,Navis G

更新日期：2011-09-01 00:00:00

abstract：:During the last decades survival has significantly improved and centenarians are becoming a fast-growing group of the population. Human life span is mainly dependent on environmental and genetic factors. Favourable modifications of lifestyle factors (e.g. physical activity, diet and not smoking) and healthcare (e.g. e...

journal_title：Current vascular pharmacology

authors： Kolovou G,Barzilai N,Caruso C,Sikora E,Capri M,Tzanetakou IP,Bilianou H,Avery P,Katsiki N,Panotopoulos G,Franceschi C,Benetos A,Mikhailidis DP

更新日期：2014-01-01 00:00:00

abstract：:Hypercoagulability is widely associated with sepsis, inflammation, diabetes, cancers, aging, and many pathological conditions, resulting in life-threatening disseminated intravascular coagulation (DIC), venous thrombosis, thromboembolism, cardiovascular complications, or even deadly multiple organ failure. Relieving c...

journal_title：Current vascular pharmacology

authors： Chu AJ

更新日期：2004-07-01 00:00:00

abstract：:Obesity is a risk factor for complications of atherosclerotic vascular disease such as myocardial infarction and stroke. Recent studies have demonstrated that the vascular risk associated with obesity is correlated particularly with visceral adiposity. These clinical observations indicate that various adipose tissue d...

journal_title：Current vascular pharmacology

authors： Ohman MK,Wright AP,Wickenheiser KJ,Luo W,Eitzman DT

更新日期：2009-04-01 00:00:00

abstract：:Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model....

journal_title：Current vascular pharmacology

authors： Uemura M,Kasahara Y,Nagatsuka K,Taguchi A

更新日期：2012-05-01 00:00:00

abstract：:This review demonstrates that oxidative stress, reactive oxygen species, and electron transfer can serve as unifying mechanistic themes for large numbers of cardiovascular toxins, both endogenous and exogenous. Lipid peroxidation is a prevalent insult. Common among the various conditions are atherosclerosis and arrhyt...

journal_title：Current vascular pharmacology

authors： Kovacic P,Thurn LA

更新日期：2005-04-01 00:00:00

abstract：:It is well known that solid cancers are associated with thromboembolic complications, but recent studies have shown that the incidence of thrombosis may be as high (or even higher) in patients with malignant haematological disorders. However, this may be obscured by the significant morbidity and mortality due to other...

journal_title：Current vascular pharmacology

authors： Castelli R,Ferrari B,Cortelezzi A,Guariglia A

更新日期：2010-07-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an essential role in fluid and electrolyte homeostasis and the regulation of vascular tone; however, dysregulation and over-activation of the RAS lead to the pathogenesis of various cardiovascular diseases. The RAS is closely associated with NADPH oxidase, a major enzymatic sou...

journal_title：Current vascular pharmacology

authors： Honjo T,Yamaoka-Tojo M,Inoue N

更新日期：2011-03-01 00:00:00

abstract：: ...

journal_title：Current vascular pharmacology

authors： Cortese F

更新日期：2019-01-01 00:00:00

abstract：:Post-transplant diabetes mellitus (PTDM) and dyslipidaemia are the most common metabolic complications in kidney transplant recipients (KTR). They are associated with a higher risk of lower graft function and survival, as well as an increased risk of cardiovascular disease (CVD). The aim of this review is to provide c...

journal_title：Current vascular pharmacology

authors： Anagnostis P,Paschou SA,Spartalis E,Sarno G,De Rosa P,Muscogiuri G

更新日期：2020-01-01 00:00:00

abstract：:Nowadays long-term outcome of heart transplantation is limited by a peculiar type of coronary atherosclerosis, known as cardiac allograft vasculopathy (CAV). Although the exact pathogenesis of CAV remains unclear, emerging evidence indicates that the endothelium plays a significant role in the onset and progression of...

journal_title：Current vascular pharmacology

authors： Osto E,Tona F,De Bon E,Iliceto S,Cella G

更新日期：2010-03-01 00:00:00

abstract：:Recent updates in the field of echocardiography have resulted in improvements in both image quality and techniques allowing echocardiography to maintain its position as the primary non-invasive imaging modality. In particular, the development of new ultrasound contrast agents and imaging techniques have now made possi...

journal_title：Current vascular pharmacology

authors： Dwivedi G,Hayat SA,Janardhanan R,Senior R

更新日期：2006-07-01 00:00:00

abstract：:Aspirin plays a pivotal role in the management of patients with Coronary Artery Disease (CAD) with well-recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing Percutaneous Coronary Intervention (PCI). Dual antiplatelet therapy is mandated for pa...

journal_title：Current vascular pharmacology

authors： Kassimis G,Raina T,Alexopoulos D

更新日期：2019-01-01 00:00:00

abstract：:Platelet activation induces rapid thrombus formation at a ruptured atherosclerotic plaque leading to acute vessel occlusion and a fatal or non-fatal cardiovascular event. More recent evidence suggests that activated platelets play an additional central role during the initiation of atherosclerosis, essentially facilit...

journal_title：Current vascular pharmacology

authors： Schäfer A,Bauersachs J

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), are major health problems worldwide. Genetics may play a role in the pathogenesis of NAFLD/NASH. AIM:To investigate the prevalence of NAFLD/NASH in 5,400 military personnel and evaluate the effect of treatme...

journal_title：Current vascular pharmacology

authors： Sfikas G,Psallas M,Koumaras C,Imprialos K,Perdikakis E,Doumas M,Giouleme O,Karagiannis A,Athyros VG

更新日期：2020-10-15 00:00:00

abstract：:The pathogenesis of obesity, insulin resistance and hypertension begins with an interaction between genetic factors and environmental factors. The search for the underlying genetic basis of these conditions has yielded disappointing results. It is possible that the importance of environmental influences has been under...

journal_title：Current vascular pharmacology

authors： Sharma V,McNeill JH

更新日期：2006-10-01 00:00:00

abstract：:Epidemiological evidence supports a reduced prevalence of Thoracic Aortic Aneurysm (TAA) and Abdominal Aortic Aneurysm (AAA) in patients with Diabetes (DM). The mechanisms underlying this negative association are unknown. Some studies support that hyperglycemia has effects on the Extracellular Matrix (ECM), resulting ...

journal_title：Current vascular pharmacology

authors： Krizhanovskii C,Franco-Cereceda A

更新日期：2019-01-01 00:00:00

abstract：:Loss of normal endothelial function and bioactivity of nitric oxide (NO), associated with increased production of reactive oxygen species (ROS), are characteristics of cardiovascular disease states. There is good experimental evidence that these abnormalities are causally related to cardiovascular disease pathogeneses...

journal_title：Current vascular pharmacology

authors： Channon KM

更新日期：2012-11-01 00:00:00

abstract：:Prostaglandins (PGs) belong to the family of prostanoids together with thromboxanes and are produced mainly from arachadonic acid by the enzyme cyclooxygenase. PGs are known to stimulate platelet aggregation, mediate inflammation and edema, play a role in bone metabolism and in biological adaptation of connective tiss...

journal_title：Current vascular pharmacology

authors： Boushel R,Langberg H,Risum N,Kjaer M

更新日期：2004-04-01 00:00:00

abstract：:A number of epidemiological studies have shown that diets rich in plant-derived phenolic compounds reduce the risk of coronary heart disease. The chronic antioxidant and hypolipidemic activities of these compounds have important roles in prevention of lipoprotein oxidation and atherosclerotic lesion development. In re...

journal_title：Current vascular pharmacology

authors： Jiang F,Dusting GJ

更新日期：2003-06-01 00:00:00

abstract：:Matrix metalloproteinases (MMP) comprise a family of at least 25 zinc-dependent endopeptidases that play a pivotal role in the physiopathology of the mammalian central nervous system. In the first phases after stroke, the dysregulation of MMPs has been described to increase acute neurovascular disruption and cerebral ...

journal_title：Current vascular pharmacology

authors： Lenglet S,Montecucco F,Mach F

更新日期：2015-01-01 00:00:00

abstract：:This review provides evidence that antenatal hypoxia, which represents a significant and worldwide problem, causes prenatal programming of the lung. A general overview of lung development is provided along with some background regarding transcriptional and signaling systems of the lung. The review illustrates that ant...

journal_title：Current vascular pharmacology

authors： Papamatheakis DG,Blood AB,Kim JH,Wilson SM

更新日期：2013-09-01 00:00:00