Abstract:
:Several lines of evidence suggest a detrimental effect of aldosterone excess on the development of metabolic alterations. Glucose metabolism derangements due to aldosterone action are frequently observed not only in patients with primary aldosteronism but also in patients with obesity. A contribution to the hyperaldosteronism observed in obese subjects can be attributed, at least in part, to the action of still unidentified adipocyte-derived factor. Aldosterone, through genomic and non-genomic actions contributes to induce several abnormalities: pancreatic fibrosis, impaired beta cell function, as well as reduced skeletal muscle and adipose tissue insulin sensitivity. Oxidative stress, systemic inflammation, together with these metabolic alterations may explain the appearance of the cardiometabolic syndrome and the progression of cardiovascular and renal diseases, in the presence of inappropriate aldosterone levels. The biological actions of aldosterone are mediated by mineralocorticoid receptor (MR), although MR can be activated through an aldosterone independent fashion. Besides salt-water homeostasis, MR activation promotes inflammation, endothelial dysfunction, cardiovascular remodelling and affects adipose tissue differentiation and function. Clinical and experimental studies have shown that MR blockade is able to suppress inflammation, to improve endothelium- dependent vasorelaxation, but most interestingly, to improve pancreatic insulin release as well as insulin-mediated glucose utilization. These actions indicate MR antagonists as a useful therapeutic tool able not only to reduce cardiovascular risk and renal damage, but also to improve metabolic sequaelae.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Ronconi V,Turchi F,Appolloni G,di Tizio V,Boscaro M,Giacchetti Gdoi
10.2174/157016112799304969subject
Has Abstractpub_date
2012-03-01 00:00:00pages
238-46issue
2eissn
1570-1611issn
1875-6212pii
BSP/CVP/E-Pub/0000177journal_volume
10pub_type
杂志文章,评审abstract::Aldosterone, a steroid hormone with mineralocorticoid activity, is far more than merely a salt-and-water hormone. Aldosterone has a number of non-classical, mineralocorticoid receptor (MR)-mediated actions, including tissue remodeling, modulation of vascular tone and stimulating inflammation and fibrosis, which may fu...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111796642689
更新日期:2011-09-01 00:00:00
abstract::Bladder outlet obstruction (BOO) is a common disorder that is associated with urinary tract symptoms. Nitric oxide (NO), synthesized by NO synthase (NOS) is a potent vasodilator that is present throughout the urinary tract and the corpus cavernosum. Endothelin-1 (ET-1) conversely is a potent vasoconstrictor peptide th...
journal_title:Current vascular pharmacology
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doi:10.2174/1570161033386600
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND:Single-pill fixed dose combination (FDC) therapies are widely used in the treatment of arterial hypertension. OBJECTIVE:This pilot study aimed to evaluate the effects of a FDC therapy combined with therapeutic drug monitoring (TDM) on blood pressure (BP) in patients with treatment resistant hypertension. M...
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更新日期:2018-01-26 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the general population. The disease ranges from simple steatosis, to non-alcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. Several drugs are used in daily clinical practice to manage the disease. However, dat...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170621083744
更新日期:2018-01-01 00:00:00
abstract::Chronic kidney disease (CKD), and particularly kidney failure, is associated with accelerated atherosclerosis and approximately a 20-fold increased risk of cardiovascular death. The majority of these patients die from complications directly attributed to atherosclerosis and their life expectancy is decreased. Establis...
journal_title:Current vascular pharmacology
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doi:10.2174/157016108783955374
更新日期:2008-04-01 00:00:00
abstract::Non-fasting triglycerides are measured at any time within up to 8 h (14 h) after any normal meal, while postprandial triglycerides are measured at a fixed time point within up to 8 h (14 h) of a standardised fat tolerance test. The simplest possible way of evaluating remnant cholesterol is non-fasting/postprandial tot...
journal_title:Current vascular pharmacology
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doi:10.2174/157016111795495585
更新日期:2011-05-01 00:00:00
abstract::Arterial stiffness (AS) is considered an independent predictor of cardiovascular disease (CVD) events. Among lipid lowering drugs, statins have a beneficial effect on AS, independent of their hypolipidaemic effect. Based on 3 meta-analyses and other studies, this effect is compound- and doserelated. Potent statins at ...
journal_title:Current vascular pharmacology
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abstract::Visfatin is highly expressed in adipose tissue (mainly by the stromal cells), but it is also ubiquitously present in most tissues. Visfatin, which plays a role in nicotinamide adenine dinucleotide (NAD) biosynthesis, has been implicated in inflammatory states. Controversial results exist about the expression, circulat...
journal_title:Current vascular pharmacology
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doi:10.2174/157016110790226679
更新日期:2010-01-01 00:00:00
abstract::Initially, the progression of chronic venous insufficiency is related to venous hypertension. The earliest complaints or symptoms, as well as vessel wall deterioration, valve restructuring, and, eventually, varicose veins, result not only from elevation of pressure, but also from a cascade of biochemical events relate...
journal_title:Current vascular pharmacology
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更新日期:2005-01-01 00:00:00
abstract::Platelet activation induces rapid thrombus formation at a ruptured atherosclerotic plaque leading to acute vessel occlusion and a fatal or non-fatal cardiovascular event. More recent evidence suggests that activated platelets play an additional central role during the initiation of atherosclerosis, essentially facilit...
journal_title:Current vascular pharmacology
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更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Aging-associated vascular dysfunction promotes cardiovascular diseases. Recently, Ginkgo biloba extract (GBE) has attracted considerable attention in the prevention of aged vasculature. METHODS:This review discusses the pathophysiological alterations in aged vasculature and the underlying mechanisms of GBE ...
journal_title:Current vascular pharmacology
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doi:10.2174/1570161117666190621150725
更新日期:2020-01-01 00:00:00
abstract::Platelet adhesion on vascular wall is the first step following vascular injury. Differential platelet secretion supports angiogenesis and vascular homeostasis. Progenitor cells are pluripotent cells responsible for tissue regeneration and wound healing. Upon ischemia bone marrow-derived progenitor cells are mobilized ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
abstract::A number of epidemiological studies have shown that diets rich in plant-derived phenolic compounds reduce the risk of coronary heart disease. The chronic antioxidant and hypolipidemic activities of these compounds have important roles in prevention of lipoprotein oxidation and atherosclerotic lesion development. In re...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161033476736
更新日期:2003-06-01 00:00:00
abstract::In this issue of Curr Vasc Pharmacol, Pfeiffer et al. [1] and Glorioso et al. [2] report the efficacy and tolerability of aliskiren/amlodipine single-pill combinations (SPCs) in patients with inadequate blood pressure (BP) response to amlodipine or aliskiren monotherapy, respectively. ...
journal_title:Current vascular pharmacology
pub_type: 评论,社论
doi:10.2174/157016112803520783
更新日期:2012-11-01 00:00:00
abstract::There is growing evidence that Rho-kinase contributes to cardiovascular disease, which has made Rho-kinase a target for the treatment of human diseases. To date, the only Rho-kinase inhibitor employed clinically in humans is fasudil, which has been used for the prevention of cerebral vasospasm and subsequent ischemic ...
journal_title:Current vascular pharmacology
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doi:10.2174/1570161112666140613115813
更新日期:2014-01-01 00:00:00
abstract::Several cellular and molecular mechanisms have been implicated in the development of myocardial dysfunction and low cardiac output in pediatric patients undergoing heart surgery. Ischemia- reperfusion injury with alterations in calcium homeostasis as well as mitochondrial function has been strongly related to myocyte ...
journal_title:Current vascular pharmacology
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doi:10.2174/1570161113666151014122557
更新日期:2016-01-01 00:00:00
abstract::High density lipoprotein (HDL) is recognized as the major negative risk factor of cardiovascular disease and number of anti-atherogenic functions has been ascribed to HDL. HDL is an assembly of a neutral lipid core and an outer shell consisting of polar lipids and proteins. It has been defined many different ways base...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112800812755
更新日期:2012-07-01 00:00:00
abstract::Aspirin plays a pivotal role in the management of patients with Coronary Artery Disease (CAD) with well-recognised benefits of reducing recurrent myocardial infarction and minimising the risk of stent thrombosis for those undergoing Percutaneous Coronary Intervention (PCI). Dual antiplatelet therapy is mandated for pa...
journal_title:Current vascular pharmacology
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更新日期:2019-01-01 00:00:00
abstract::Although hypertension, hypercholesterolemia and diabetes mellitus (DM) are recognized as major cardio-metabolic risk factors in primary Acute Coronary Syndrome (ACS) prevention, studies focusing on secondary ACS incidence are scarce. In the present study, the association between the aforementioned factors and 10-year ...
journal_title:Current vascular pharmacology
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更新日期:2016-01-01 00:00:00
abstract::Angiogenesis is central to cardiac repair following myocardial infarction (MI). Cardiac angiotensin converting enzyme (ACE)2 significantly increased postMI, which is coincident with activated angiogenesis. The function of ACE2 is to generate angiotensin (Ang)1-7, an active peptide with cellular actions mediated by Mas...
journal_title:Current vascular pharmacology
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更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is a multifactorial inflammatory disease of the cardiovascular system. It has been suggested that periodontitis, an infectious disease of oral cavity caused by gramnegative anaerobic bacteria, could be linked to atherosclerosis. OBJECTIVE:The objective of this systematic review was to assess...
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更新日期:2018-01-01 00:00:00
abstract::Prostaglandins (PGs) belong to the family of prostanoids together with thromboxanes and are produced mainly from arachadonic acid by the enzyme cyclooxygenase. PGs are known to stimulate platelet aggregation, mediate inflammation and edema, play a role in bone metabolism and in biological adaptation of connective tiss...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043476410
更新日期:2004-04-01 00:00:00
abstract::In end-stage renal disease patients, the leading causes of mortality are of cardiovascular (CV) origin. The underlying mechanisms are complex, given that sudden heart failure is more common than acute myocardial infarction. A contributing role of oxidative stress is postulated, which is increased even at early stages ...
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更新日期:2021-01-01 00:00:00
abstract::Platelet aggregation induced by stirring of a platelet suspension after activation by the exogenous addition of stimulants, such as ADP, epinephrine and thrombin, has long been used as a platelet function test, and for the screening of antiplatelet agents. Since platelet aggregation has been demonstrated to be mediate...
journal_title:Current vascular pharmacology
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doi:10.2174/1570161043476456
更新日期:2004-01-01 00:00:00
abstract::Urocortin comprises a group of endogenously produced peptide hormones that belong to the corticotropinreleasing factor (CRF) family with promising future as potential drugs for the treatment of heart disease. Members of the urocortin family are known to act as potent regulators of cardiac and vascular functions, throu...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161111311040009
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of s...
journal_title:Current vascular pharmacology
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doi:10.2174/157016108785909797
更新日期:2008-10-01 00:00:00
abstract::Cardiovascular failure in sepsis involves a combination of hypovolemia, decreased vascular tone, myocardial depression and microcirculatory alterations. Fluids represent the first line therapeutic intervention, with controversy regarding the type of fluid. Recent data indicate that albumin is safe and might even be be...
journal_title:Current vascular pharmacology
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doi:
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:The primary objective of this study was to evaluate the impact of polypharmacy on primary and secondary adherence to evidence-based medication (EBM) and to measure factors associated with non-adherence among patients who underwent percutaneous coronary intervention (PCI). METHODS:We conducted a retrospectiv...
journal_title:Current vascular pharmacology
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更新日期:2016-01-01 00:00:00
abstract::Matrix metalloproteinases (MMP) comprise a family of at least 25 zinc-dependent endopeptidases that play a pivotal role in the physiopathology of the mammalian central nervous system. In the first phases after stroke, the dysregulation of MMPs has been described to increase acute neurovascular disruption and cerebral ...
journal_title:Current vascular pharmacology
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更新日期:2015-01-01 00:00:00
abstract::This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanis...
journal_title:Current vascular pharmacology
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更新日期:2019-01-01 00:00:00