Abstract:
:In end-stage renal disease patients, the leading causes of mortality are of cardiovascular (CV) origin. The underlying mechanisms are complex, given that sudden heart failure is more common than acute myocardial infarction. A contributing role of oxidative stress is postulated, which is increased even at early stages of chronic kidney disease, is gradually augmented in parallel to progression to endstage renal disease and is further accelerated by renal replacement therapy. Oxidative stress ensues when there is an imbalance between reactive pro-oxidants and physiologically occurring electron donating antioxidant defence systems. During the last decade, a close association of oxidative stress with accelerated atherosclerosis and increased risk for CV and all-cause mortality has been established. Lipid peroxidation has been identified as a trigger for endothelial dysfunction, the first step towards atherogenesis. In order to counteract the deleterious effects of free radicals and thereby ameliorate, or delay, CV disease, exogenous administration of antioxidants has been proposed. Here, we attempt to summarize existing data from studies that test antioxidants for CV protection, such as vitamins E and C, statins, omega-3 fatty acids and N-acetylcysteine.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Roumeliotis S,Roumeliotis A,Gorny X,Mertens PRdoi
10.2174/1570161118666200317151553subject
Has Abstractpub_date
2021-01-01 00:00:00pages
41-54issue
1eissn
1570-1611issn
1875-6212pii
CVP-EPUB-105324journal_volume
19pub_type
杂志文章abstract::Tertiary amine local anesthetics (LAs) are clinically valuable agents for controlling pain and for treating some cardiac arrhythmias. These drugs inhibit conduction of electrical activity by blocking voltage-gated sodium channels. Interestingly, LAs can influence the conduction of electrical activity in heart muscle w...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161033476628
更新日期:2003-10-01 00:00:00
abstract::Platelet aggregation induced by stirring of a platelet suspension after activation by the exogenous addition of stimulants, such as ADP, epinephrine and thrombin, has long been used as a platelet function test, and for the screening of antiplatelet agents. Since platelet aggregation has been demonstrated to be mediate...
journal_title:Current vascular pharmacology
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doi:10.2174/1570161043476456
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112801784486
更新日期:2012-09-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2174/1570161112666141014151858
更新日期:2015-01-01 00:00:00
abstract::Monoclonal antibodies have been developed to optimize treatment effects in various malignant and nonmalignant conditions, by selectively targeting key components of the underlying pathophysiologic processes. Rituximab, a chimeric anti-CD20 antibody has revolutionized treatment of malignant lymphomas, extending remissi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110790226651
更新日期:2010-01-01 00:00:00
abstract::Fifteen years after its discovery, NO has fully reached an established position in physiology, medicine and therapeutics. It is difficult to find a biological function or a pathological condition where NO does not play a relevant role. Discoveries in the NO field have historically evolved from cardiovascular research,...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161033476637
更新日期:2003-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161052773898
更新日期:2005-01-01 00:00:00
abstract::Epidemiological evidence supports a reduced prevalence of Thoracic Aortic Aneurysm (TAA) and Abdominal Aortic Aneurysm (AAA) in patients with Diabetes (DM). The mechanisms underlying this negative association are unknown. Some studies support that hyperglycemia has effects on the Extracellular Matrix (ECM), resulting ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180828155622
更新日期:2019-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161111666131126144025
更新日期:2014-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016112801784495
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:We described lifestyle changes one year after acute coronary syndrome (ACS) among patients in Arabian Gulf countries. METHODOLOGY:Data of patients admitted to 29 hospitals in 4 countries with the diagnosis of ACS were analysed from Gulf citizens with ACS events (Gulf COAST) registry. A total of 3565 ACS pat...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究
doi:10.2174/1570161115666170529090700
更新日期:2018-01-01 00:00:00
abstract::The "pleiotropic" effects of statins have been the centre of a considerable research activity. Among the numerous experimental and clinical studies of this field, some focused on the effects of statins on blood pressure (BP), while others reported data on BP together with other parameters. Some of the animal or human ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016107780368307
更新日期:2007-04-01 00:00:00
abstract::Chronic kidney disease (CKD) is associated with high cardiovascular morbidity and mortality. The available data suggest that efforts to reduce mortality in the CKD population should be focused on treatment and prevention of, among others, coronary artery disease and congestive heart failure. Accelerated atherosclerosi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161111311050013
更新日期:2013-09-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161116666180117102422
更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016109789043883
更新日期:2009-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::Gestational diabetes mellitus (GDM) is a syndrome compromising the health of the mother and the fetus. Endothelial damage and reduced metabolism of the vasodilator adenosine occur and fetal hyperinsulinemia associated with deficient insulin response and a metabolic rather than mitogenic phenotype is characteristic of ...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111797484062
更新日期:2011-11-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161043476410
更新日期:2004-04-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/15701611113119990006
更新日期:2015-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161114666160728093323
更新日期:2016-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016107779317251
更新日期:2007-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,实务指引,评审
doi:10.2174/1570161117666190503123911
更新日期:2019-01-01 00:00:00
abstract::Alterations of fibroblast growth factor 23 (FGF-23) and Klotho levels are considered to be the earliest biochemical abnormality of chronic kidney disease - mineral and bone disease (CKDMBD) syndrome. Moreover, emerging data suggests that the dysregulated FGF-23 and Klotho axis has many effects on the cardiovascular (C...
journal_title:Current vascular pharmacology
pub_type: 杂志文章
doi:10.2174/1570161118666200420102100
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:In various cardiac diseases, thrombembolism constitutes a major risk, and in these patients clinically silent microembolic signals (MES) are detectable within the transcranial Doppler frequency spectrum (TCD) of the major brain arteries. MES are already an accepted surrogate parameter of the future risk of s...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016108785909797
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the general population. The disease ranges from simple steatosis, to non-alcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. Several drugs are used in daily clinical practice to manage the disease. However, dat...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666170621083744
更新日期:2018-01-01 00:00:00
abstract::The pathogenesis of obesity, insulin resistance and hypertension begins with an interaction between genetic factors and environmental factors. The search for the underlying genetic basis of these conditions has yielded disappointing results. It is possible that the importance of environmental influences has been under...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016106778521661
更新日期:2006-10-01 00:00:00
abstract::In patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), 25OH-vitamin D (calcidiol) deficiency or insufficiency is a common finding with high prevalence. Numerous epidemiological studies have found an independent association of low levels of calcidiol with increased morbidity and mortality. Wi...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/15701611113119990027
更新日期:2014-03-01 00:00:00
abstract::Non-fasting triglycerides are measured at any time within up to 8 h (14 h) after any normal meal, while postprandial triglycerides are measured at a fixed time point within up to 8 h (14 h) of a standardised fat tolerance test. The simplest possible way of evaluating remnant cholesterol is non-fasting/postprandial tot...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016111795495585
更新日期:2011-05-01 00:00:00
abstract::This review considers drug combinations and newer treatment strategies for patients with severe hypertriglyceridemia. Hypertriglyceridemia is associated with an atherogenic metabolic profile and in most studies with increased cardiovascular disease risk. Patients with severe hypertriglyceridemia also have increased in...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/15701611113119990133
更新日期:2014-01-01 00:00:00