Abstract:
:Both endothelin(ET)-1 and oxidative stress have been the subjects of intense investigation within the cardiovascular field over the past decade and a half, yet little is known about the precise relationship between these important modulators of vascular function. There is a firm evidence that ET-1 can stimulate the production of superoxide via NADPH oxidase activation, and at the same time, reactive oxygen species appear to stimulate ET-1 production. What is less clear is how these changes participate in the pathogenesis of vascular dysfunction. There is mixed evidence on whether oxidative stress plays a role in ET-dependent hypertension, however, a specific influence of ET-induced oxidative stress to reduce vascular reactivity is more convincing. The current review summarizes recent investigations into the relationship between ET-1 and oxidative stress and highlights several areas that require further investigation.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Pollock DM,Pollock JSdoi
10.2174/157016105774329408keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
365-7issue
4eissn
1570-1611issn
1875-6212journal_volume
3pub_type
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journal_title:Current vascular pharmacology
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