Endothelin and oxidative stress in the vascular system.

Abstract:

:Both endothelin(ET)-1 and oxidative stress have been the subjects of intense investigation within the cardiovascular field over the past decade and a half, yet little is known about the precise relationship between these important modulators of vascular function. There is a firm evidence that ET-1 can stimulate the production of superoxide via NADPH oxidase activation, and at the same time, reactive oxygen species appear to stimulate ET-1 production. What is less clear is how these changes participate in the pathogenesis of vascular dysfunction. There is mixed evidence on whether oxidative stress plays a role in ET-dependent hypertension, however, a specific influence of ET-induced oxidative stress to reduce vascular reactivity is more convincing. The current review summarizes recent investigations into the relationship between ET-1 and oxidative stress and highlights several areas that require further investigation.

journal_name

Curr Vasc Pharmacol

authors

Pollock DM,Pollock JS

doi

10.2174/157016105774329408

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

365-7

issue

4

eissn

1570-1611

issn

1875-6212

journal_volume

3

pub_type

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