Abstract:
INTRODUCTION:Obstructive Sleep Apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal Blood Pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causative role of OSA in the development of hypertension, the evidence is not fully consistent. Nasal continuous positive airway pressure (nCPAP) applied during sleep is well documented and a highly efficient therapeutic aid to eliminate OSA. It has been repeatedly shown that nCPAP-therapy is also associated with modest BP lowering effect in hypertensive OSA-patients, and the magnitude of the observed effect correlates with the severity of OSA. However, it is unlikely that nCPAP would normalize BP. CONCLUSION:There are few studies which tested the interplay between OSA, nCPAP and certain BPlowering drug classes. Angiotensin receptor blockers may show synergistic hypotensive effect with nCPAP, whereas mineralocorticoid receptor blocker has been shown to modestly attenuate the severity of OSA. Additionally, the application of chronotherapy may be of special use in such patients. The current evidence is sufficient to promote persistent and effective nCPAP-therapy as a standard in all eligible OSA-patients with difficult-to-control hypertension.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Wolf J,Narkiewicz Kdoi
10.2174/1570161115666170414115705subject
Has Abstractpub_date
2017-01-01 00:00:00pages
44-53issue
1eissn
1570-1611issn
1875-6212pii
CVP-EPUB-82822journal_volume
16pub_type
杂志文章,评审abstract::Postprandial hypertriglyceridaemia, defined as an increase in plasma triglyceride-containing lipoproteins following a fat meal, is a potential risk predictor of atherosclerotic cardiovascular disease and other chronic diseases. Several non-modifiable factors (genetics, age, sex and menopausal status) and lifestyle fac...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,实务指引,评审
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Current vascular pharmacology
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journal_title:Current vascular pharmacology
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更新日期:2008-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2006-10-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161117666190621150725
更新日期:2020-01-01 00:00:00
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journal_title:Current vascular pharmacology
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abstract::This review considers drug combinations and newer treatment strategies for patients with severe hypertriglyceridemia. Hypertriglyceridemia is associated with an atherogenic metabolic profile and in most studies with increased cardiovascular disease risk. Patients with severe hypertriglyceridemia also have increased in...
journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Current vascular pharmacology
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doi:10.2174/157016110792006923
更新日期:2010-09-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2012-11-01 00:00:00
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journal_title:Current vascular pharmacology
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abstract::Matrix metalloproteinases (MMP) comprise a family of at least 25 zinc-dependent endopeptidases that play a pivotal role in the physiopathology of the mammalian central nervous system. In the first phases after stroke, the dysregulation of MMPs has been described to increase acute neurovascular disruption and cerebral ...
journal_title:Current vascular pharmacology
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abstract::Normal pregnancy is associated with increased insulin resistance as a metabolic adaptation to the nutritional demands of the placenta and fetus, and this is amplified in obese mothers. Insulin resistance is normally compensated for by an adaptive increase in pancreatic β-cell mass together with enhanced glucose-stimul...
journal_title:Current vascular pharmacology
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abstract::Central arterial systolic blood pressure is a very important factor in the pathophysiology of cardiovascular diseases. Central arterial pressure is a better predictor of cardiovascular risk than peripheral brachial blood pressure. Measurement of central blood pressure is useful for a diagnosis of spurious systolic hyp...
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journal_title:Current vascular pharmacology
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更新日期:2012-07-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2014-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Current vascular pharmacology
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更新日期:2016-01-01 00:00:00
abstract::Revascularization procedures used for the treatment of cardiovascular disease can be associated with restenosis, although drug-coated stents have greatly reduced this complication. Both type 2 diabetes (T2DM) and metabolic syndrome (MetS) are associated with a high risk for atherosclerosis and restenosis. Insulin resi...
journal_title:Current vascular pharmacology
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更新日期:2011-05-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/1570161115666171013153750
更新日期:2018-01-01 00:00:00
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journal_title:Current vascular pharmacology
pub_type: 杂志文章,评审
doi:10.2174/157016110793563889
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