A comparison of the pharmacokinetics of nisoldipine in elderly and young subjects.

abstract：AIMS:Grapefruit juice inhibits CYP3A4 in the intestinal wall leading to a reduced intestinal first pass metabolism and thereby an increased oral bioavailability of certain drugs. For example, it has been shown that the oral bioavailability of midazolam, a CYP3A4 substrate, increased by 52% in healthy subjects after ing...

journal_title：British journal of clinical pharmacology

authors： Andersen V,Pedersen N,Larsen NE,Sonne J,Larsen S

更新日期：2002-08-01 00:00:00

abstract：:1. Apomorphine (1 and 5 micrograms kg-1) and placebo were given to nine normal volunteers, using a Latin-square design and double-blind procedures. The visual perception of static and moving patterns (static and motion contrast sensitivity) was evaluated before and 15 min after the dose administration. 2. Apomorphine ...

journal_title：British journal of clinical pharmacology

authors： Blin O,Mestre D,Masson G,Serratrice G

更新日期：1991-11-01 00:00:00

abstract：AIMS:To compare the pharmacokinetics of oseltamivir and oseltamivir carboxylate in hepatically impaired patients and healthy subjects. METHODS:Hepatically impaired patients (n = 11) and healthy subjects (n = 11) were individually paired on the basis of gender, age (+/-10 years) and body weight (+/-20%) and administere...

journal_title：British journal of clinical pharmacology

authors： Snell P,Dave N,Wilson K,Rowell L,Weil A,Galitz L,Robson R

更新日期：2005-05-01 00:00:00

abstract：:1 To assess the potential hazards of nitrazepam therapy of insomnia in the elderly, adverse reactions to nitrazepam were studied in 2111 hospitalized medical patients who received the drug. 2 Manifestations of unwanted central nervous system (CNS) depression (such as drowsiness or 'hangover') were reported in 49 nitra...

journal_title：British journal of clinical pharmacology

authors： Greenblatt DJ,Allen MD

更新日期：1978-05-01 00:00:00

abstract：:1. We have utilised a new non-imaging echo-Doppler cardiac output device, using the principle of attenuated compensated volume flow (ACVF), to assess the cardiovascular effects of atenolol and buccal nitroglycerin (NTG) in a placebo-controlled study of 30 patients with coronary disease. 2. Atenolol (4 mg i.v.) reduced...

journal_title：British journal of clinical pharmacology

authors： Silke B,Verma SP,Taylor SH

更新日期：1990-06-01 00:00:00

abstract：OBJECTIVE:To establish weight-based dose bands for commonly used oral medicines, given in liquid forms, for children in the UK that could be used for prescribing and administering accurate and safe drug doses. METHODS:A list of commonly prescribed, oral liquid medications was established from the medication dispensing...

journal_title：British journal of clinical pharmacology

authors： Rashed AN,Tomlin S

更新日期：2020-12-10 00:00:00

abstract：:A free lignocaine index was developed on the basis of measurements of plasma lignocaine and its principle binding protein, alpha 1-acid glycoprotein (AAG) in 80 samples from 16 patients admitted to the coronary care unit and given prophylactic lignocaine therapy. The free drug fraction, fu, of lignocaine was determine...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,Lazar JD,Barchowsky A,Stargel WW,Wagner GS,Shand DG

更新日期：1985-12-01 00:00:00

abstract：:The excretion of diazepam, N-desmethyldiazepam, temazepam and oxazepam in breast milk was studied during withdrawal of a 22-year-old patient from combined high dose diazepam and oxazepam therapy. Concentrations of these benzodiazepines in plasma from both the woman and her nursing infant (1 year old) were also documen...

journal_title：British journal of clinical pharmacology

authors： Dusci LJ,Good SM,Hall RW,Ilett KF

更新日期：1990-01-01 00:00:00

abstract：:1 Self-poisoning with a selective weedkiller containing 2,4-D and mecoprop in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxaemia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. 2 The admission plasma concentrations of 2,4-D and me...

journal_title：British journal of clinical pharmacology

authors： Prescott LF,Park J,Darrien I

更新日期：1979-01-01 00:00:00

abstract：AIMS:To evaluate the potential ethnic differences in the pharmacokinetics (PK) and pharmacodynamics (PD) of evolocumab in Caucasian and Asian populations using population PK/PD modelling analysis. METHODS:Data from different ethnic groups in 5 Phase I clinical trials, including two American studies, one Japanese study...

journal_title：British journal of clinical pharmacology

authors： Wang C,Zheng Q,Zhang M,Lu H

更新日期：2019-01-01 00:00:00

abstract：:1 Roth et al. (1972) have proposed that within the affective disorders there are two distinct syndromes--anxiety and depression--differentiated by the relative predominance of these symptoms, the presence or absence of premorbid maladaptive traits, and the natural outcome of the disorder. 2 Goldberg (1982) on the othe...

journal_title：British journal of clinical pharmacology

authors： Russell GF,De Silva P

更新日期：1983-01-01 00:00:00

abstract：:Cefpiramide is a new parenteral cephalosporin mainly excreted in the bile. Eight patients with cholestasis and 11 healthy subjects received a single 1 g i.v. dose. Cefpiramide concentrations in plasma and urine were measured by h.p.l.c. and plasma binding was determined by ultrafiltration. Total clearance of cefpirami...

journal_title：British journal of clinical pharmacology

authors： Demontes-Mainard F,Vinçon G,Labat L,Amouretti M,Necciari J,Kieffer G,Bannwarth B

更新日期：1994-03-01 00:00:00

abstract：:We define a me-too drug as a pharmacologically active compound that is structurally related to a first-in-class compound, regarded as belonging to the same therapeutic class as the original compound, and used for the same therapeutic purposes, but which may differ in some respects, such as specificity of pharmacologic...

journal_title：British journal of clinical pharmacology

authors： Aronson JK,Green AR

更新日期：2020-11-01 00:00:00

abstract：AIMS:In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury wo...

journal_title：British journal of clinical pharmacology

authors： Ederoth P,Tunblad K,Bouw R,Lundberg CJ,Ungerstedt U,Nordström CH,Hammarlund-Udenaes M

更新日期：2004-04-01 00:00:00

abstract：AIMS:To assess the prevalence of potentially inappropriate medications (PIMs) use in a population of community-based multicompartment compliance aid (MCA) users in north-east Scotland. METHODS:Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1st June to 31st October 2014, together ...

journal_title：British journal of clinical pharmacology

authors： Counter D,Stewart D,MacLeod J,McLay JS

更新日期：2017-07-01 00:00:00

abstract：:1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hyperte...

journal_title：British journal of clinical pharmacology

authors： Lamming GD,Symonds EB

更新日期：1979-04-01 00:00:00

abstract：AIMS:To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians. METHODS:Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 :...

journal_title：British journal of clinical pharmacology

authors： Chan C,Yeo KP,Pan AX,Lim M,Knadler MP,Small DS

更新日期：2007-03-01 00:00:00

abstract：AIMS:To determine whether repeated once daily administration of grapefruit juice altered the pharmacokinetics or pharmacodynamics of the calcium antagonist amlodipine. METHOD:S The effects of grapefruit juice on the pharmacokinetics and pharmacodynamics of oral and intravenous amlodipine were assessed in 20 healthy me...

journal_title：British journal of clinical pharmacology

authors： Vincent J,Harris SI,Foulds G,Dogolo LC,Willavize S,Friedman HL

更新日期：2000-11-01 00:00:00

abstract：AIM:To assess the effect of Schisandra sphenanthera extract (SchE) on the pharmacokinetics of tacrolimus in healthy volunteers. METHODS:Twelve healthy male volunteers were orally treated with SchE, three capsules twice daily for 13 days. Pharmacokinetic investigations of oral tacrolimus administration at 2 mg were per...

journal_title：British journal of clinical pharmacology

authors： Xin HW,Wu XC,Li Q,Yu AR,Zhu M,Shen Y,Su D,Xiong L

更新日期：2007-10-01 00:00:00

abstract：AIMS:To evaluate putative associations between drugs and dilated cardiomyopathy. METHODS:We used the case/noncase method in the French PharmacoVigilance Database (FPVD). Cases were all the observations with dilated cardiomyopathy registered into the FPVD between 1 January 1990 and 30 June 2007. Noncases were all other...

journal_title：British journal of clinical pharmacology

authors： Montastruc G,Favreliere S,Sommet A,Pathak A,Lapeyre-Mestre M,Perault-Pochat MC,Montastruc JL,French Association of Regional PharmacoVigilance Centres.

更新日期：2010-03-01 00:00:00

abstract：:1 Measurements have been made of steady state serum phenytoin concentration, serum half-life of (14)C-labelled phenytoin, and the urinary ratio of the major metabolite of phenytoin to the unchanged drug (p-HPPH: DPH ratio) in epileptic patients on and off sulthiame therapy. 2 Starting sulthiame treatment produced an i...

journal_title：British journal of clinical pharmacology

authors： Houghton GW,Richens A

更新日期：1974-02-01 00:00:00

abstract：:1 The rate of methaqualone metabolism in women was shown to be significantly increased at the time of ovulation. 2 The apparent first order rate constants for the formation of five C-monohydroxy metabolites of methaqualone on day 15 of the menstrual cycle were approximately double that on day 1. 3 The N-oxidation of m...

journal_title：British journal of clinical pharmacology

authors： Wilson K,Oram M,Horth CE,Burnett D

更新日期：1982-09-01 00:00:00

abstract：AIMS:To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. METHODS:Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. R...

journal_title：British journal of clinical pharmacology

authors： Simon T,Becquemont L,Hamon B,Nouyrigat E,Chodjania Y,Poirier JM,Funck-Brentano C,Jaillon P

更新日期：2001-11-01 00:00:00

abstract：:1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and, in the standing position, dose-related reductions in blood pressure during treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes were not related to dose but reduced compared with pre-treatment values. 3 No postur...

journal_title：British journal of clinical pharmacology

authors： Andersson O,Berglund G,Hansson L

更新日期：1976-08-01 00:00:00

abstract：:1. Blood and urine concentrations of the macrolide immunosuppressant FK506 and its metabolites were measured in seven orthotopic liver transplant patients after the first oral dose of FK506 (0.04 +/- 0.02 mg kg-1) used as primary immunosuppressant. A specific h.p.l.c.-MS assay was used, allowing the measurement of par...

journal_title：British journal of clinical pharmacology

authors： Gonschior AK,Christians U,Braun F,Winkler M,Linck A,Baumann J,Sewing KF

更新日期：1994-12-01 00:00:00

abstract：:Twelve healthy volunteers were given orally placebo, itraconazole 100 mg or terbinafine 250 mg for 4 days. Midazolam 7.5 mg was ingested on the fourth day, after which plasma samples were collected and psychomotor performance tests carried out for 17 h. Itraconazole increased the area under the midazolam concentration...

journal_title：British journal of clinical pharmacology

authors： Ahonen J,Olkkola KT,Neuvonen PJ

更新日期：1995-09-01 00:00:00

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：:Plasma concentrations of isoniazid and N-acetylisoniazid were measured at varying times after addition of both compounds to plasma (5 micrograms/ml) and storage at several different temperatures (-70 degrees C, -20 degrees C, 4 degrees C and 20 degrees C). The concentration of both compounds declined log-linearly with...

journal_title：British journal of clinical pharmacology

authors： Hutchings A,Monie RD,Spragg B,Routledge PA

更新日期：1983-02-01 00:00:00

abstract：:1. The pharmacokinetics of butorphanol were evaluated in 18 female volunteers with varying degrees of renal function following a single, 1 mg transnasal dose of butorphanol tartrate. The creatinine clearance (CLCR) values for subjects in the normal (NOR), moderately impaired (MI), and severely impaired (SI) groups wer...

journal_title：British journal of clinical pharmacology

authors： Shyu WC,Morgenthien EA,Barbhaiya RH

更新日期：1996-05-01 00:00:00

abstract：:Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r ...

journal_title：British journal of clinical pharmacology

authors： van Dongen RT,Crul BJ,Koopman-Kimenai PM,Vree TB

更新日期：1994-09-01 00:00:00