Lack of effect of moderate hepatic impairment on the pharmacokinetics of oral oseltamivir and its metabolite oseltamivir carboxylate.

abstract：AIMS:To investigate uptake of fluconazole into the interstitial fluid of human subcutaneous tissue using the microdialysis and suction blister techniques. METHODS:A sterile microdialysis probe (CMA/60) was inserted subcutaneously into the upper arm of five healthy volunteers following an overnight fast. Blisters were ...

journal_title：British journal of clinical pharmacology

authors： Sasongko L,Williams KM,Day RO,McLachlan AJ

更新日期：2003-11-01 00:00:00

abstract：:1 In a double-blind cross-over study, nine healthy male students received placebo, brompheniramine 12 mg), carbinoxamine (12 mg), clemastine (1 mg), and phenylpropanolamine (50 mg) orally. Three doses of each drug were given: at 08.30 h and 21.00 h on the first day of treatment and at 08.30 h on the following day. 2 P...

journal_title：British journal of clinical pharmacology

authors： Seppälä T,Nuotto E,Korttila K

更新日期：1981-08-01 00:00:00

abstract：:1. The human isolated basilar artery has been used as a model to investigate the aetiology of cerebral arterial spasm associated with rupture of intracranial aneurysms. 2. The isolated artery is contracted by 5-hydroxytryptamine, noradrenaline, six prostaglandins and cerebrospinal fluid from patients with ruptured ane...

journal_title：British journal of clinical pharmacology

authors： Boullin DJ,Mohan J

更新日期：1977-02-01 00:00:00

abstract：AIMS:Although genetic, clinical and demographic factors have been shown to explain approximately half of the inter-individual variability in warfarin dose requirement in adults, less is known about causes of dose variability in children. This study aimed to identify and quantify major genetic, clinical and demographic ...

journal_title：British journal of clinical pharmacology

authors： Hamberg AK,Wadelius M,Friberg LE,Biss TT,Kamali F,Jonsson EN

更新日期：2014-07-01 00:00:00

abstract：:We have traced the historical link between the Law of Mass Action and clinical pharmacology. The Law evolved from the work of the French chemist Claude Louis Berthollet, was first formulated by Cato Guldberg and Peter Waage in 1864 and later clarified by the Dutch chemist Jacobus van 't Hoff in 1877. It has profoundly...

journal_title：British journal of clinical pharmacology

authors： Ferner RE,Aronson JK

更新日期：2016-01-01 00:00:00

abstract：AIMS:To compare the airway potency, systemic activity and therapeutic index of three inhaled corticosteroids that differ in glucocorticoid receptor binding affinity, physicochemical and pharmacokinetic properties. METHODS:This escalating-dose, placebo-controlled, cross-over study randomised adults with asthma to 1 or ...

journal_title：British journal of clinical pharmacology

authors： Daley-Yates P,Brealey N,Thomas S,Austin D,Shabbir S,Harrison T,Singh D,Barnes N

更新日期：2020-06-02 00:00:00

abstract：AIMS:To individualize treatment, phenytoin doses are adjusted based on free concentrations, either measured or calculated from total concentrations. As a mechanistic protein binding model may more accurately reflect the protein binding of phenytoin than the empirical Winter-Tozer equation that is routinely used for cal...

journal_title：British journal of clinical pharmacology

authors： Ter Heine R,Kane SP,Huitema ADR,Krasowski MD,van Maarseveen EM

更新日期：2019-10-01 00:00:00

abstract：:Ethanol aggravates benzodiazepine-induced central nervous depression by pharmacokinetic and/or pharmacodynamic interactions and Ro 15-1788 reverses promptly the hypnotic effects of benzodiazepines. We therefore studied the acute effects of Ro 15-1788 on the ethanol-induced sedation in six healthy male subjects. Subseq...

journal_title：British journal of clinical pharmacology

authors： Klotz U,Ziegler G,Rosenkranz B,Mikus G

更新日期：1986-11-01 00:00:00

abstract：AIMS:To examine the influence of a pharmaceutical care programme on disease control and health-related quality of life in Type 2 diabetes patients in the United Arab Emirates. METHODS:A total of 240 Type 2 diabetes patients were recruited into a randomized, controlled, prospective clinical trial with a 12-month follow...

journal_title：British journal of clinical pharmacology

authors： Al Mazroui NR,Kamal MM,Ghabash NM,Yacout TA,Kole PL,McElnay JC

更新日期：2009-05-01 00:00:00

abstract：AIMS:Thiazolidinediones (TZDs) not only enhance cellular glucose transport but are reported to have potent anti-inflammatory effects. These effects may play an important role in the insulin sensitizing mechanism, and possibly precede the effects on parameters of glucoregulation. We sought to investigate whether these a...

journal_title：British journal of clinical pharmacology

authors： van Doorn M,Kemme M,Ouwens M,van Hoogdalem EJ,Jones R,Romijn H,de Kam M,Schoemaker R,Burggraaf K,Cohen A

更新日期：2006-10-01 00:00:00

abstract：:Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative ...

journal_title：British journal of clinical pharmacology

authors： Ashton H,Millman JE,Telford R,Thompson JW,Davies TF,Hall R

更新日期：1976-08-01 00:00:00

abstract：:The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Still, the optimal use and the value of pharmacological personalization of the taxanes is still controversial. We give an overview on the pharmacologica...

journal_title：British journal of clinical pharmacology

authors： Muth M,Ojara FW,Kloft C,Joerger M

更新日期：2020-11-28 00:00:00

abstract：AIMS:To study the delivery of 15 mg beclomethasone 17,21-dipropionate (BDP) to the distal part of the small bowel for three oral sustained-release formulations (I-III) and a reference capsule in volunteer ileostomists, and to compare these findings with the in vitro dissolution profiles. METHODS:Two groups of nine ile...

journal_title：British journal of clinical pharmacology

authors： Burggraaf J,van Haarst AD,Fockens P,Schoemaker HC,Krauwinkel WJ,Cohen AF

更新日期：1998-09-01 00:00:00

abstract：:Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P les...

journal_title：British journal of clinical pharmacology

authors： Rae SA,Williams IA,English J,Baylis EM

更新日期：1982-09-01 00:00:00

abstract：AIMS:Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss of response and in those who can benefit from a de-intensification. The aim of this study was to determine the impact of therapeutic drug monitoring combined with Bayesian forecasting methodology on clinical response in a ...

journal_title：British journal of clinical pharmacology

authors： Santacana Juncosa E,Rodríguez-Alonso L,Padullés Zamora A,Guardiola J,Rodríguez-Moranta F,Serra Nilsson K,Bas Minguet J,Morandeira Rego F,Colom Codina H,Padullés Zamora N

更新日期：2020-06-03 00:00:00

abstract：AIMS:The main goal of the study was to describe the pharmacokinetics of maternal zidovudine (ZDV) administration during pregnancy and labour and to evaluate their impact on fetal concentrations and exposures. METHODS:A total of 195 HIV-infected pregnant and non-pregnant women aged 16-59 years were included and 273 mat...

journal_title：British journal of clinical pharmacology

authors： Fauchet F,Treluyer JM,Valade E,Benaboud S,Pannier E,Firtion G,Foissac F,Bouazza N,Urien S,Hirt D

更新日期：2014-12-01 00:00:00

abstract：:1 Twelve-week courses of oxprenolol and methyldopa were administered in a randomised, double-blind cross over study to ten insulin dependent hypertensive diabetics. 2 Prior to treatment, and at the end of each period of drug administration, fasting levels of high density lipoprotein, triglycerides, free fatty acids an...

journal_title：British journal of clinical pharmacology

authors： Benfield GF,Hunter KR

更新日期：1982-02-01 00:00:00

abstract：:1. Preliminary results are reported from a long-term study aimed at recording the concentrations of serum lipids and lipoproteins at 6, 12 and 24 months of treatment with pindolol in young/middle-aged males with moderate hypertension. 2. Seventy-three patients have been recruited, of whom 47 have completed 6 months tr...

journal_title：British journal of clinical pharmacology

authors： Carlson LA,Ribacke M,Terent A

更新日期：1987-01-01 00:00:00

abstract：AIM:Experimental pain models may help to evaluate the mechanisms of analgesics and target the clinical indications for their use. This review, the second in a series of two, addresses how the efficacy of non-opioid analgesics have been assessed in human volunteers using experimental pain models. METHODS:A literature s...

journal_title：British journal of clinical pharmacology

authors： Staahl C,Olesen AE,Andresen T,Arendt-Nielsen L,Drewes AM

更新日期：2009-09-01 00:00:00

abstract：:1 In a preliminary double-blind trial the effects of ephedrine and pseudoephedrine on the blood pressure and heart rate of resting healthy volunteers were compared. Ephedrine 60 or 90 mg were required to raise the diastolic blood pressure above 90 mmHg, whereas 210 or 240 mg pseudoephedrine were required to produce th...

journal_title：British journal of clinical pharmacology

authors： Drew CD,Knight GT,Hughes DT,Bush M

更新日期：1978-09-01 00:00:00

abstract：AIMS:We investigated the effect of angiotensin converting enzyme inhibitors (ACEIs) on postsynaptic adrenoceptor sensitivity and compared the effect of the lipophilic ACEI, quinapril, and that of hydrophilic agent, enalapril in human vessels. METHODS:Alpha-adrenoceptor sensitivity was evaluated using the dorsal hand v...

journal_title：British journal of clinical pharmacology

authors： Kimura M,Umemura K,Kosuge K,Nishimoto M,Ohashi K,Nakashima M

更新日期：1998-12-01 00:00:00

abstract：AIMS:Kisangani is an area with intense malaria transmission and sulfadoxine-pyrimethamine resistance. Alternative antimalaria prophylaxis medication and protocols are needed, particularly with pregnant individuals. In this study, we compare the tolerance and effectiveness of mefloquine regimen as a split dose with a me...

journal_title：British journal of clinical pharmacology

authors： Labama Otuli N,Marini Djang'eing'a R,Losimba Likwela J,Bosenge Nguma JD,Maindo Alongo MA,Ahuka Ona Longombe A,Mbutu Mango B,M N Bono D,L Mokili J,Manga Okenge JP

更新日期：2021-01-04 00:00:00

abstract：:1. In order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews conducted by a single observer. Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a trial (group B), and 119 had never ...

journal_title：British journal of clinical pharmacology

authors： Bevan EG,Chee LC,McGhee SM,McInnes GT

更新日期：1993-02-01 00:00:00

abstract：:1 Apparent Vmax and Km for phenytoin were estimated in 40 children (aged 8--33 months) and 21 adults (aged 18--66 years). 2 The derived values of Vmax and Km were used to predict the plasma and salivary concentrations of phenytoin following a change in dose. There was a highly significant correlation between observed ...

journal_title：British journal of clinical pharmacology

authors： Blain PG,Mucklow JC,Bacon CJ,Rawlins MD

更新日期：1981-11-01 00:00:00

abstract：:1. The cardiovascular responses to handgrip exercise have been studied in ten patients with uncomplicated essential hypertension in a randomized crossover study of propranolol and prazosin. 2. Isometric handgrip exercise was performed with a calibrated strain gauge dynamometer at 30% of maximum voluntary contraction f...

journal_title：British journal of clinical pharmacology

authors： Reuben SR,Gale EV,Blake P

更新日期：1979-10-01 00:00:00

abstract：:1. The effect of nomifensine on the uptake of 5-hydroxytryptamine (5-HT) and dopamine (DA) into human platelet-rich plasma has been studied. 2. A significant inhibition of DA uptake was observed at nomifensine 10(-6) M. 3. 5-HT uptake was significantly inhibited only at nomifensine 10(-4) M or more. 4. These results a...

journal_title：British journal of clinical pharmacology

authors： Ehsanullah RS,Turner P

更新日期：1977-01-01 00:00:00

abstract：AIMS:To investigate the effect of multiple dosing with montelukast, a selective leukotriene-receptor antagonist, on the pharmacokinetics of rosiglitazone, a CYP2C8 substrate, in humans. METHODS:A two-period, randomized crossover study was conducted in 10 healthy subjects. After administration of oral doses of placebo ...

journal_title：British journal of clinical pharmacology

authors： Kim KA,Park PW,Kim KR,Park JY

更新日期：2007-03-01 00:00:00

abstract：AIMS:To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians. METHODS:Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 :...

journal_title：British journal of clinical pharmacology

authors： Chan C,Yeo KP,Pan AX,Lim M,Knadler MP,Small DS

更新日期：2007-03-01 00:00:00

abstract：:1 The cardiac effects of disopyramide (D) and lignocaine (L) were measured and compared in normal volunteers (D n=4; L n=3) following the establishment of a series of three steady-state drug plasma concentrations spanning the therapeutic range (1.5-5 micrograms base ml-1). 2 During control and steady-state periods mul...

journal_title：British journal of clinical pharmacology

authors： Martin MA,Bax ND,Tucker GT,Ward JW

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Develop a translational assay of Transient Receptor Potential Ankyrin 1 (TRPA1) activity for use as a preclinical and clinical biomarker. EXPERIMENTAL APPROACH:Allyl isothiocyanate (AITC), capsaicin or citric acid were applied to ears of wildtype and Trpa1-knock out (Trpa1 KO) rats, and changes ...

journal_title：British journal of clinical pharmacology

authors： Joseph V,Yang X,Gao SS,Elstrott J,Weimer RM,Theess W,Thrasher C,Singh N,Lin J,Bauer RN

更新日期：2021-01-01 00:00:00