Disopyramide and lignocaine. A comparison of cardiac effects using echocardiography.

abstract：:1 The plasma levels of disopyramide and mono-N-dealkyldisopyramide were measured from 118 patients, and the protein binding of both drugs from 50 patients during chronic oral disopyramide therapy. 2 No significant correlation was seen between the daily dose of disopyramide and the achieved plasma drug concentration. 3...

journal_title：British journal of clinical pharmacology

authors： Aitio ML

更新日期：1981-04-01 00:00:00

abstract：:1 Two antitussive agents (+/-)-glaucine phosphate and codeine phosphate have been compared with placebo with respect to ventilation, ventilatory response to carbon dioxide, pulse, blood pressure, digit symbol substitution, sedation score and the Zahlen-Verbindung test performance in ten healthy volunteers (22-36 years...

journal_title：British journal of clinical pharmacology

authors： Redpath JB,Pleuvry BJ

更新日期：1982-10-01 00:00:00

abstract：:1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of 'active' renin and angiotensin II together with an increase of 'inactive' renin and unchanged 'total' renin. The significant exercise-provoked increases in angiotensin II, plasma renin activity and 'active', 'inactiv...

journal_title：British journal of clinical pharmacology

authors： Lijnen PJ,Amery AK,Fagard RH,Reybrouck TM,Moerman EJ,De Schaepdryver AF

更新日期：1979-02-01 00:00:00

abstract：:The effect of acute migraine attack and rectally given metoclopramide on the absorption of orally given tolfenamic acid (300 mg) was investigated in seven female patients in a crossover study consisting of four phases, two without migraine and two during migraine. Metoclopramide hydrochloride (20 mg) or placebo was gi...

journal_title：British journal of clinical pharmacology

authors： Tokola RA,Neuvonen PJ

更新日期：1984-01-01 00:00:00

abstract：:Early clinical features of lead toxicity are non-specific and an occupational history is particularly valuable. Lead in the body comprises 2% in the blood (t1/2 35 days) and 95% in bone and dentine (t1/2 20-30 years). Blood lead may remain elevated for years after cessation from long exposure, due to redistribution fr...

journal_title：British journal of clinical pharmacology

authors： Gordon JN,Taylor A,Bennett PN

更新日期：2002-05-01 00:00:00

abstract：AIMS:Angiotensin receptor blockers (ARBs) are renoprotective and targeted to blood pressure. However, ARBs have multiple other (off-target) effects which may affect renal outcome. It is unknown whether on-target and off-target effects are congruent within individuals. If not, this variation in short term effects may ha...

journal_title：British journal of clinical pharmacology

authors： Schievink B,de Zeeuw D,Parving HH,Rossing P,Lambers Heerspink HJ

更新日期：2015-10-01 00:00:00

abstract：:1. Apomorphine (1 and 5 micrograms kg-1) and placebo were given to nine normal volunteers, using a Latin-square design and double-blind procedures. The visual perception of static and moving patterns (static and motion contrast sensitivity) was evaluated before and 15 min after the dose administration. 2. Apomorphine ...

journal_title：British journal of clinical pharmacology

authors： Blin O,Mestre D,Masson G,Serratrice G

更新日期：1991-11-01 00:00:00

abstract：:1 The potency of single doses of the aldosterone antagonist SC8109 relative to spironolactone in reversing the urinary electrolyte effects of fludrocortisone was examined in a double-blind, balanced, crossover study in six healthy volunteers. 2 For the urinary ratio log10 10Na/K, the relative potency of SC8109; spiron...

journal_title：British journal of clinical pharmacology

authors： McInnes GT,Harrison IR,Shelton JR,Perkins RM

更新日期：1981-11-01 00:00:00

abstract：AIMS:To test the feasibility of a novel rivastigmine nasal spray as prospective treatment for dementia. METHODS:A single dose, crossover absolute bioavailability and safety study was conducted with rivastigmine intravenous solution (1 mg) and nasal spray (3.126 mg) in eight healthy elderly individuals, aged 58-75 year...

journal_title：British journal of clinical pharmacology

authors： Morgan TM,Soh B

更新日期：2017-03-01 00:00:00

abstract：AIMS:Statins have been suggested to prevent haematological malignancies. Several epidemiological studies have evaluated this association, while randomized controlled trials (RCTs) on cardiovascular outcomes have provided relevant data as secondary end-points. Our aim was to examine the strength of this association thro...

journal_title：British journal of clinical pharmacology

authors： Bonovas S,Filioussi K,Tsantes A,Sitaras NM

更新日期：2007-09-01 00:00:00

abstract：:1 Aspirin is partly hydrolyzed to salicylic acid during absorption. Absorbed aspirin is rapidly hydrolyzed systemically. Salicylic acid elimination kinetics are dependent on drug concentration due to the limited capacity of two major biotransformation pathways: formation of salicyluric acid and of salicylphenolic gluc...

journal_title：British journal of clinical pharmacology

authors： Levy G

更新日期：1980-10-01 00:00:00

abstract：:The coming of age of molecular biology has resulted in an explosion in our understanding of the pathogenesis of virus related diseases. New pathogens have been identified and characterized as being responsible for old diseases. Empirical clinical evaluation of morbidity and mortality as outcome measures after a therap...

journal_title：British journal of clinical pharmacology

authors： Shaunak S,Davies DS

更新日期：2002-07-01 00:00:00

abstract：:1. We compare the sensitivity and specificity of chosen outcome criteria in a placebo-controlled, randomised cross-over study of the efficacy of maintenance therapy with the levodopa/carbidopa combination (Sinemet Plus) alone. Patients were characterised by having idiopathic Parkinsonism with no overt fluctuations in ...

journal_title：British journal of clinical pharmacology

authors： Bowes SG,Clark PK,Charlett A,O'Neill CJ,Leeman AL,Weller C,Nicholson PW,Deshmukh AA,Dobbs SM,Dobbs RJ

更新日期：1991-03-01 00:00:00

abstract：AIMS:The aims of the present study were to evaluate the pharmacokinetic properties of dihydroartemisinin (DHA) and piperaquine, potential drug-drug interactions with concomitant primaquine treatment, and piperaquine effects on the electrocardiogram in healthy volunteers. METHODS:The population pharmacokinetic properti...

journal_title：British journal of clinical pharmacology

authors： Chotsiri P,Wattanakul T,Hoglund RM,Hanboonkunupakarn B,Pukrittayakamee S,Blessborn D,Jittamala P,White NJ,Day NPJ,Tarning J

更新日期：2017-12-01 00:00:00

abstract：:1 Data from a comprehensive drug surveillance programme are analysed to provide details of procainamide use and toxicity in medical wards of teaching hospitals in five countries. 2 Out of a total of 488 recipients 9.2% had one or more adverse effect attributed to the drug; common effects being arrhythmias, gastro-inte...

journal_title：British journal of clinical pharmacology

authors： Lawson DH,Jick H

更新日期：1977-10-01 00:00:00

abstract：:Little is known about the administration of direct-acting oral anticoagulants (DOACs) and the occurrence of alopecia. Our aim was to analyse the reports of alopecia following DOAC administration received until 2 May 2018 from VigiBase, the World Health Organization database. A descriptive analysis of age, sex, serious...

journal_title：British journal of clinical pharmacology

authors： Bonaldo G,Vaccheri A,Motola D

更新日期：2020-08-01 00:00:00

abstract：:1 Twelve-week courses of oxprenolol and methyldopa were administered in a randomised, double-blind cross over study to ten insulin dependent hypertensive diabetics. 2 Prior to treatment, and at the end of each period of drug administration, fasting levels of high density lipoprotein, triglycerides, free fatty acids an...

journal_title：British journal of clinical pharmacology

authors： Benfield GF,Hunter KR

更新日期：1982-02-01 00:00:00

abstract：:1. The new intravenous bisphosphonate drug aminohydroxypropylidine bisphosphonate (APD) is effective in treating the hypercalcaemia of malignant disease, but the optimum dose regimen is not yet established. We have treated twenty-seven patients with malignant hypercalcaemia (corrected calcium greater than 3.00 mmol l-...

journal_title：British journal of clinical pharmacology

authors： Davis JR,Heath DA

更新日期：1989-09-01 00:00:00

abstract：:Since hepatic clearance of ICG is reduced by H2-receptor antagonists in normal subjects, it has been suggested that they reduce liver blood flow. We have studied the effect of intravenous ranitidine on ICG clearance in twelve patients with chronic liver disease. Wedged and free hepatic venous pressure were measured be...

journal_title：British journal of clinical pharmacology

authors： Dunk AA,Jenkins WJ,Burroughs AK,Walt RP,Osuafor TO,Sherlock S,Mackie S,Dick R

更新日期：1983-08-01 00:00:00

abstract：AIMS:The therapeutic action of tricyclic agents may be accompanied by unwanted effects on the cardiovascular system. The evidence for the effects on vascular and nonvascular smooth muscle comes from animal studies. Whether these studies can be extrapolated to human vessels remains to be determined. Therefore, the prese...

journal_title：British journal of clinical pharmacology

authors： Vila JM,Medina P,Segarra G,Lluch P,Pallardó F,Flor B,Lluch S

更新日期：1999-08-01 00:00:00

abstract：:The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to ...

journal_title：British journal of clinical pharmacology

authors： Treloar AJ,Assin M,Macdonald AJ

更新日期：1996-03-01 00:00:00

abstract：AIM:To investigate the effect of the P-glycoprotein inhibitor verapamil on the pharmacokinetics and pharmacodynamics of dabigatran etexilate (DE). METHOD:In this two part multiple crossover trial in 40 healthy subjects, DE 150 mg was given alone or with verapamil at different doses, duration of treatment (single vs. m...

journal_title：British journal of clinical pharmacology

authors： Härtter S,Sennewald R,Nehmiz G,Reilly P

更新日期：2013-04-01 00:00:00

abstract：AIMS:To investigate presence or absence of clinically relevant drug interactions (pharmacokinetic and safety/tolerability) of OBE022 with standard-of-care medicines for preterm labour, enabling coadministration and further clinical development. METHODS:Part A: open-label, randomized, 3-period crossover assessing coadm...

journal_title：British journal of clinical pharmacology

authors： Pohl O,Marchand L,Gotteland JP,Coates S,Täubel J,Lorch U

更新日期：2019-07-01 00:00:00

abstract：:1. Labetalol, a new drug combining alpha-and beta-adrenoceptor blocking properties, has been compared with placebo in a double-blind crossover study of a group of patients with mild to moderate essential hypertension (blood pressure 150/100 to 189/114 mmHg). 2. Labetalol and propranolol lowered blood pressure satisfac...

journal_title：British journal of clinical pharmacology

authors： Pugsley DJ,Nassim M,Armstrong BK,Beilin L

更新日期：1979-01-01 00:00:00

abstract：AIMS:To determine whether enzyme-inducing antiseizure drugs (ASDs) affect the risk of developing chronic obstructive pulmonary disease (COPD) or lung cancer in smokers. METHODS:Cases of COPD and lung cancer and matched controls without these conditions were identified from a population of smokers with ≥1 prescription ...

journal_title：British journal of clinical pharmacology

authors： Leuppi-Taegtmeyer AB,Reinau D,Yilmaz S,Rüegg S,Krähenbühl S,Jick SS,Leuppi JD,Meier CR

更新日期：2020-08-01 00:00:00

abstract：:1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its effects after 1 month's administration on heart rate, blood pressure and muscle blood flow were studied in a double-blind crossover comparison with nifedipine in 16 hypertensive patients. 2. Dile...

journal_title：British journal of clinical pharmacology

authors： Walley T,Tsao Y,Scott A,Mackay E,Vandenburg M,Breckenridge A

更新日期：1993-06-01 00:00:00

abstract：:Calcium subserves a ubiquitous role in the organisation of cell function. Ca2+ channels which control influx may be modified in disease states. Animal models of cerebral ischaemia do present some problems when investigating potential therapies involving Ca2+ channels. However, it is important not to be too rigid in se...

journal_title：British journal of clinical pharmacology

authors： Alps BJ

更新日期：1992-09-01 00:00:00

abstract：:1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were...

journal_title：British journal of clinical pharmacology

authors： Hayes MJ,Langman MJ,Short AH

更新日期：1975-02-01 00:00:00

abstract：:1. Preliminary results are reported from a long-term study aimed at recording the concentrations of serum lipids and lipoproteins at 6, 12 and 24 months of treatment with pindolol in young/middle-aged males with moderate hypertension. 2. Seventy-three patients have been recruited, of whom 47 have completed 6 months tr...

journal_title：British journal of clinical pharmacology

authors： Carlson LA,Ribacke M,Terent A

更新日期：1987-01-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00