Abstract：
:1 Two antitussive agents (+/-)-glaucine phosphate and codeine phosphate have been compared with placebo with respect to ventilation, ventilatory response to carbon dioxide, pulse, blood pressure, digit symbol substitution, sedation score and the Zahlen-Verbindung test performance in ten healthy volunteers (22-36 years). The study was double-blind and the two doses of each antitussive agent and the placebo were administered as a syrup. 2 Both codeine phosphate and (+/-)-glaucine phosphate displaced the ventilatory response to carbon dioxide to the right. 3 The effect of codeine phosphate on the ventilatory response to carbon dioxide was not dose dependent: 30 mg produced greater effects than the 60 mg dose. 4 Only the highest dose of (+/-)-glaucine phosphate (60 mg) caused respiratory depression and this was associated with sedation and decreased performance in the digit symbol substitution test. 5 Neither antitussive agent had significant effects upon pulse or blood pressure and codeine phosphate had no detectable sedative activity.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Redpath JB,Pleuvry BJdoi
10.1111/j.1365-2125.1982.tb02028.xsubject
Has Abstractpub_date
1982-10-01 00:00:00pages
555-8issue
4eissn
0306-5251issn
1365-2125journal_volume
14pub_type
临床试验,杂志文章abstract：AIMS:The aim of this work is to understand the process of drug administration and identify points in the workflow that resulted in interventions by clinical information systems in order to improve patient safety. METHODS:To identify a generic way to structure the drug administration process we performed peer-group dis...
journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/bcp.12191
更新日期：2013-09-01 00:00:00
abstract：:1 The effects of oxprenolol 80 mg and propranolol 80 mg on resting forearm blood flow (RFBF) and skin temperature were compared in seven normotensive subjects, for 4 h after an oral dose. 2 There was a significant fall of RFBF after propranolol (mean +/- s.e. mean 0.74 +/- 0.24 ml 100 g-1 min-1) compared to a smaller ...
journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2125.1981.tb01154.x
更新日期：1981-05-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,评审
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
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更新日期：1983-02-01 00:00:00
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更新日期：2008-03-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1979-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-06-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,评审
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