当前位置： SCI文献检索 > BRITISH JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Pharmacokinetics of co-administered didanosine and stavudine in HIV-seropositive male patients.

Pharmacokinetics of co-administered didanosine and stavudine in HIV-seropositive male patients.

Abstract：

:The pharmacokinetics of single and co-administered didanosine and stavudine were evaluated in 10 HIV-seropositive subjects in an open, within subject design in which each subject received each of three treatments. Single doses of didanosine 100 mg were alternated randomly with single doses of stavudine 40 mg on days 1 and 2. Beginning on day 3, subjects received the same doses of both drugs simultaneously every 12 h for nine doses. Serial blood and urine samples were obtained on single dose days 1 and 2, first simultaneous dose day 3, and last simultaneous dose day 7. The average maximum plasma concentrations of didanosine and stavudine before and after simultaneous administration were 422 +/- 184 (s.d.) ng ml-1 and 603 +/- 160 (s.d.) ng ml-1, and 419 +/- 153 (s.d.) ng ml-1 and 726 +/- 188 (s.d.) ng ml-1, respectively. Didanosine and stavudine AUC values before and after simultaneous administration were 615 +/- 170 (s.d.) ng ml-1 h and 1246 +/- 230 (s.d.) ng ml-1 h, 637 +/- 155 (s.d.) ng ml-1 h and 1326 +/- 267 (s.d.) ng ml-1 h, respectively. No significant changes in maximum plasma concentration, AUC elimination half-life, or renal clearance of didanosine and stavudine were observed when the drugs were administered simultaneously. Co-administration of didanosine 100 mg and stavudine 40 mg is well tolerated and the drugs do not interact pharmacokinetically.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Seifert RD,Stewart MB,Sramek JJ,Conrad J,Kaul S,Cutler NR

doi

10.1111/j.1365-2125.1994.tb04374.x

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

405-10

issue

5

eissn

0306-5251

issn

1365-2125

journal_volume

38

pub_type

临床试验,杂志文章,随机对照试验

相关文献

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Mexiletine disposition: individual variation in response to urine acidification and alkalinisation.

    abstract：:The disposition of mexiletine has been studied in five subjects on two occasions with urine pH controlled at 5.0 and at 8.0. With acid urine total plasma clearance was similar in all subjects (462 to 497 ml min-1) and the plasma half-life ranged from 3.8 to 9.2 h (mean 6.7 h). With alkaline urine the total plasma clea...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1983.tb02162.x

    authors： Mitchell BG,Clements JA,Pottage A,Prescott LF

    更新日期：1983-09-01 00:00:00

  • The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple-dose trial.

    abstract：AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14300

    authors： Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

    更新日期：2020-10-01 00:00:00

  • UK medicines policy: the role of clinical pharmacologists.

    abstract：:Clinical pharmacologists are the only medical specialists whose training focuses specifically on the safe, effective and cost-effective use of medicines, underpinned by an understanding of drug discovery, drug regulation, pharmacology, translational medicine and the performance of clinical trials. This unique perspect...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2012.04244.x

    authors： Webb DJ

    更新日期：2012-06-01 00:00:00

  • Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

    abstract：AIMS:Oral L-arginine supplementation has been used in several studies to improve endothelium-dependent, nitric oxide (NO)-mediated vasodilation. L-Arginine treatment is hampered by extensive presystemic elimination due to intestinal arginase activity. In contrast, L-citrulline is readily absorbed and at least in part c...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2007.02990.x

    authors： Schwedhelm E,Maas R,Freese R,Jung D,Lukacs Z,Jambrecina A,Spickler W,Schulze F,Böger RH

    更新日期：2008-01-01 00:00:00

  • The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and ther

    abstract：:1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocyte 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of various groups of patients--those who have not received digoxin, those during the early phases of treatment, those...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1979.tb05811.x

    authors： Ford AR,Aronson JK,Grahame-Smith DG,Carver JG

    更新日期：1979-08-01 00:00:00

  • The effect on motion sickness and oculomotor function of GR 38032F, a 5-HT3-receptor antagonist with anti-emetic properties.

    abstract：:1. The 5-hydroxytryptamine (5-HT3) receptor antagonist, GR 38032F, which possesses potent anti-emetic properties in vomiting induced by cancer chemotherapeutic drugs, has been tested to determine its value in the prophylaxis of motion sickness induced by cross-coupled stimulation. The double-blind trial compared GR 38...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1989.tb05345.x

    authors： Stott JR,Barnes GR,Wright RJ,Ruddock CJ

    更新日期：1989-02-01 00:00:00

  • Pharmacokinetics and safety of fluconazole and micafungin in neonates with systemic candidiasis: a randomized, open-label clinical trial.

    abstract：AIMS:The pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear to be inconsistent with the emerging scientific evidence. Limited information is available on the safety profile of these agents in neonates. Our objective was ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/bcp.13628

    authors： Leroux S,Jacqz-Aigrain E,Elie V,Legrand F,Barin-Le Guellec C,Aurich B,Biran V,Dusang B,Goudjil S,Coopman S,Garcia Sanchez R,Zhao W,Manzoni P,FP7 TINN (Treat Infections in NeoNates) consortium.

    更新日期：2018-09-01 00:00:00

  • Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.

    abstract：AIMS:In man a neurokinin-1 (NK1) receptor antagonist has previously been shown to be ineffective in the prevention of motion-induced nausea. The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist. Hence the efficacy of...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.2000.00221.x

    authors： Reid K,Palmer JL,Wright RJ,Clemes SA,Troakes C,Somal HS,House F,Stott JR

    更新日期：2000-07-01 00:00:00

  • Drug management in acute kidney disease - Report of the Acute Disease Quality Initiative XVI meeting.

    abstract：AIMS:To summarize and extend the main conclusions and recommendations relevant to drug management during acute kidney disease (AKD) as agreed at the 16th Acute Disease Quality Initiative (ADQI) consensus conference. METHODS:Using a modified Delphi method to achieve consensus, experts attending the 16th ADQI consensus ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.13449

    authors： Ostermann M,Chawla LS,Forni LG,Kane-Gill SL,Kellum JA,Koyner J,Murray PT,Ronco C,Goldstein SL,ADQI 16 workgroup.

    更新日期：2018-02-01 00:00:00

  • N-acetylcysteine fails to attenuate haemodynamic tolerance to glyceryl trinitrate in healthy volunteers.

    abstract：:1. The effects of chronic dosing with N-acetylcysteine (NAC), on nitrate-induced haemodynamic changes during the acute and chronic treatment of healthy volunteers with glyceryl trinitrate (GTN) patches (Transiderm nitro) has been investigated. 2. Seven volunteers were treated in a double-blind randomised crossover man...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1989.tb03522.x

    authors： Hogan JC,Lewis MJ,Henderson AH

    更新日期：1989-10-01 00:00:00

  • Effect of midazolam on sleep of insomniacs.

    abstract：:We studied in a sleep laboratory the effects of bedtime 15 mg midazolam and 20 mg midazolam on the sleep and morning performance of healthy subjects with polygraphically verified sleep onset insomnia. Six subjects received 15 mg midazolam and six subjects received 20 mg midazolam for 14 consecutive nights which were p...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1983.tb02279.x

    authors： Vogel GW,Vogel F

    更新日期：1983-01-01 00:00:00

  • Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine.

    abstract：AIMS:Using human liver microsomes from donors of the CYP2D6 poor and extensive metabolizer genotypes, the role of individual cytochromes P-450 in the oxidative metabolism of dihydrocodeine was investigated. METHODS:The kinetics of formation of N- and O-demethylated metabolites, nordihydrocodeine and dihydromorphine, w...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.1997.t01-1-00626.x

    authors： Kirkwood LC,Nation RL,Somogyi AA

    更新日期：1997-12-01 00:00:00

  • Pharmacokinetic-pharmacodynamic analysis of mnesic effects of lorazepam in healthy volunteers.

    abstract：AIMS:To describe the pharmacokinetic-pharmacodynamic modelling of the psychomotor and mnesic effects of a single 2 mg oral dose of lorazepam in healthy volunteers. METHODS:This was a randomized double-blind, placebo-controlled two-way cross-over study. The effect of lorazepam was examined with the following tasks: cho...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1999.00047.x

    authors： Blin O,Jacquet A,Callamand S,Jouve E,Habib M,Gayraud D,Durand A,Bruguerolle B,Pisano P

    更新日期：1999-10-01 00:00:00

  • Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA).

    abstract：:1. Blood and urine concentrations of the macrolide immunosuppressant FK506 and its metabolites were measured in seven orthotopic liver transplant patients after the first oral dose of FK506 (0.04 +/- 0.02 mg kg-1) used as primary immunosuppressant. A specific h.p.l.c.-MS assay was used, allowing the measurement of par...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1994.tb04398.x

    authors： Gonschior AK,Christians U,Braun F,Winkler M,Linck A,Baumann J,Sewing KF

    更新日期：1994-12-01 00:00:00

  • The pharmacokinetics of ziprasidone in subjects with normal and impaired hepatic function.

    abstract：AIMS:To assess whether hepatic impairment influences the pharmacokinetics of ziprasidone. METHODS:Thirty subjects with normal hepatic function or a primary diagnosis of clinically significant cirrhosis (Child-Pugh A or B) were enrolled into an open-label, multicentre, multiple-dose study. The subjects with chronic, st...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1046/j.1365-2125.2000.00149.x

    authors： Everson G,Lasseter KC,Anderson KE,Bauer LA,Carithens RL Jr,Wilner KD,Johnson A,Anziano RJ,Smolarek TA,Turncliff RZ

    更新日期：2000-01-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects.

    abstract：AIM:To evaluate safety, tolerability and pharmacokinetics of oral PF-05190457, an oral ghrelin receptor inverse agonist, in healthy adults. METHODS:Single (SAD) and multiple ascending dose (MAD) studies were randomised, placebo-controlled, double-blind studies. Thirty-five healthy men (age 38.2 ± 10.4 years; body mass...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/bcp.13127

    authors： Denney WS,Sonnenberg GE,Carvajal-Gonzalez S,Tuthill T,Jackson VM

    更新日期：2017-02-01 00:00:00

  • Establishing dose bands for commonly prescribed oral medications for children in the UK: Results of a Delphi study.

    abstract：OBJECTIVE:To establish weight-based dose bands for commonly used oral medicines, given in liquid forms, for children in the UK that could be used for prescribing and administering accurate and safe drug doses. METHODS:A list of commonly prescribed, oral liquid medications was established from the medication dispensing...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14698

    authors： Rashed AN,Tomlin S

    更新日期：2020-12-10 00:00:00

  • Direct oral anticoagulants for stroke prevention in patients with atrial fibrillation: meta-analysis by geographic region with a focus on European patients.

    abstract：AIMS:To analyse clinical outcomes with direct oral anticoagulants in patients with atrial fibrillation according to geographic region. METHODS:We systematically searched MEDLINE, CENTRAL, websites of regulatory agencies, clinical trials registers and conference proceedings for randomized controlled trials of direct or...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/bcp.13005

    authors： Gómez-Outes A,Terleira-Fernández AI,Calvo-Rojas G,Suárez-Gea ML,Vargas-Castrillón E

    更新日期：2016-09-01 00:00:00

  • In vitro immunosuppressive potency of deflazacort, a new bone-sparing corticosteroid on T lymphocytes, NK and K cells.

    abstract：:The in vitro immunosuppressive effect of deflazacort, a new bone-sparing glucocorticoid, and its biologically active metabolite, 21-deacetyl-deflazacort, was examined on phytohaemagglutinin (PHA) stimulated human peripheral blood lymphocytes (PBL) as well as on natural killer (NK) and killer (K) cell activity. Deflaza...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1986.tb05165.x

    authors： Langhoff E,Olgaard K

    更新日期：1986-02-01 00:00:00

  • Decreased systemic clearance of caffeine due to cimetidine.

    abstract：:1 Five normal subjects received pre-treatment with cimetidine 200 mg three times daily and 400 mg at night for 6 days, or matching placebo. 2 Caffeine (300 mg) was given orally before any treatment and at the beginning of the last day of each treatment course. Treatments were randomly allocated and separated by at lea...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1981.tb01194.x

    authors： Broughton LJ,Rogers HJ

    更新日期：1981-08-01 00:00:00

  • Factors influencing the activity and fate of benzodiazepines in the body.

    abstract：:1 The clinical pharmacokinetics of the many benzodiazepines used to treat numerous and varied clinical conditions can be influenced by many factors. 2 Combinations of drugs efficacious in the central nervous system can change the onset, intensity and duration of effect as a result of pharmacological, physiological and...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1981.tb01843.x

    authors： van der Kleijn E,Vree TB,Baars AM,Wijsman R,Edmunds LC,Knop HJ

    更新日期：1981-01-01 00:00:00

  • Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro.

    abstract：AIMS:The aim of this study was to investigate the effect of policosanol on the susceptibility of LDL-C to in vitro lipid peroxidation in human healthy volunteers. METHODS:The effect of policosanol (5 and 10 mg day(-1) on LDL-C oxidation was studied in a double-blind, randomized, placebo-controlled trial conducted in 6...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2125.2000.00250.x

    authors： Menéndez R,Más R,Amor AM,González RM,Fernández JC,Rodeiro I,Zayas M,Jiménez S

    更新日期：2000-09-01 00:00:00

  • Residual effects of flurazepam and brotizolam on psychomotor performance.

    abstract：:Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reactio...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1983.tb02309.x

    authors： Krueger H,Müller-Limmroth W

    更新日期：1983-01-01 00:00:00

  • Preliminary assessment of RX 72601, a new anticholinesterase in man: reversal of competitive neuromuscular blockade.

    abstract：:1 The effect of RX 72601, neostigmine plus atropine, or saline on neuromuscular blockade with (+)-tubocurarine was studied in a double blind trial in four healthy male volunteers. 2 The methods used to assess neuromuscular function were voluntary grip strength and indirectly evoked muscle twitches. The muscarinic acti...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1974.tb00239.x

    authors： Dettmar PW,Metcalf G,Smith MH,Gillett GB,Hedges A,Richens A

    更新日期：1974-06-01 00:00:00

  • Growth factors for diabetic foot ulcers: mixed treatment comparison analysis of randomized clinical trials.

    abstract：AIMS:Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head-to-head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS:Using an appropriate search strategy, randomized controlled trial...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1111/bcp.13470

    authors： Sridharan K,Sivaramakrishnan G

    更新日期：2018-03-01 00:00:00

  • Lessons learned from the clinical development of oral peptides.

    abstract：:The oral delivery of peptides and proteins has been hampered by an array of obstacles. However, several promising novel oral delivery systems have been developed. This paper reviews the most advanced oral formulation technologies, and highlights key lessons and implications from studies undertaken to date with these o...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.12557

    authors： Karsdal MA,Riis BJ,Mehta N,Stern W,Arbit E,Christiansen C,Henriksen K

    更新日期：2015-05-01 00:00:00

  • Reports of hypoglycaemia associated with the use of ACE inhibitors and other drugs: a case/non-case study in the French pharmacovigilance system database.

    abstract：AIMS:To test the existence of an association between reports of hypoglycaemia and angiotensin converting enzyme inhibitors, in a spontaneous reports database. METHODS:The French Pharmacovigilance database was examined for an association between adverse drug reaction reports mentioning hypoglycaemia, and angiotensin co...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.1997.00615.x

    authors： Moore N,Kreft-Jais C,Haramburu F,Noblet C,Andrejak M,Ollagnier M,Bégaud B

    更新日期：1997-11-01 00:00:00

  • A placebo-controlled study of interaction between nabumetone and acenocoumarol.

    abstract：AIMS:The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients treated with oral anticoagulants is generally discouraged due to the risk of interactions that could increase the risk of bleeding complications. Available data suggest the NSAID, nabumetone, does not produce such an interaction. We investigated ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1999.00916.x

    authors： Pardo A,García-Losa M,Fernández-Pavón A,del Castillo S,Pascual-García T,García-Méndez E,Dal-Ré R

    更新日期：1999-04-01 00:00:00

  • First-time-in-human randomized clinical trial in healthy volunteers and haemodialysis patients with SNF472, a novel inhibitor of vascular calcification.

    abstract：AIMS:SNF472 is a calcification inhibitor being developed for the treatment of cardiovascular calcification in haemodialysis (HD) and in calciphylaxis patients. This study investigated the safety, tolerability and pharmacokinetics (PK) of intravenous (IV) SNF472 in healthy volunteers (HV) and HD patients. METHODS:This ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/bcp.13752

    authors： Perelló J,Joubert PH,Ferrer MD,Canals AZ,Sinha S,Salcedo C

    更新日期：2018-12-01 00:00:00

  • Correlation between plasma quinidine and cardiac effect.

    abstract：:1 The relationship between serum quinidine levels and rate-corrected QT (QTc) interval after administration of single identical doses of quinidine was assessed. Quinidine concentrations were determined by a modification of Hamfelt & Malers' (1963) method. The significance and clinical application of our findings is di...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1974.tb01694.x

    authors： Edwards IR,Hancock BW,Saynor R

    更新日期：1974-12-01 00:00:00