当前位置： SCI文献检索 > BRITISH JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.

Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.

Abstract：

AIMS:In man a neurokinin-1 (NK1) receptor antagonist has previously been shown to be ineffective in the prevention of motion-induced nausea. The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist. Hence the efficacy of the NK1 antagonist GR205171 in combination with the 5-HT3 antagonist ondansetron (Zofrantrade mark) was assessed in motion-induced nausea. METHODS:GR205171 25 mg i.v., with and without concomitant administration of ondansetron 8 mg i.v., and hyoscine hydrobromide 0. 6 mg orally (positive control) were compared with placebo in a model of motion-induced nausea. The study was performed to a four-period, randomized, balanced, double-blind, crossover design in 16 healthy subjects. The end-point was the exposure to the motion stimulus required to produce moderate nausea in the subjects. RESULTS:The motion stimulus required to produce moderate nausea was significantly greater for the positive control than placebo (P < 0. 001). There was no significant difference between either GR205171 or GR205171 plus ondansetron and placebo (P = 0.648 and 0.342, respectively). CONCLUSIONS:The enhancement of NK1 receptor antagonist antiemetic activity through combination with a 5-HT3 receptor antagonist is not replicated in motion-induced nausea.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Reid K,Palmer JL,Wright RJ,Clemes SA,Troakes C,Somal HS,House F,Stott JR

doi

10.1046/j.1365-2125.2000.00221.x

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

61-4

issue

1

eissn

0306-5251

issn

1365-2125

pii

bcp221

journal_volume

50

pub_type

临床试验,杂志文章,随机对照试验

相关文献

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Cyclosporin-erythromycin interaction in renal transplant patients.

    abstract：:1. The interaction between cyclosporin (CyA) and erythromycin was studied in renal transplant patients following oral and intravenous administration of CyA. 2. Blood and plasma CyA concentrations and blood concentrations of metabolite 17 were measured by h.p.l.c. 3. Erythromycin produced almost a two-fold increase in ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1989.tb05396.x

    authors： Gupta SK,Bakran A,Johnson RW,Rowland M

    更新日期：1989-04-01 00:00:00

  • The effect of selective and non-selective beta-adrenoceptor blockade, and of naloxone infusion, on the hormonal mechanisms of recovery from insulin-induced hypoglycaemia in man.

    abstract：:The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective beta-adrenoceptor blockade but unaffected by selective beta 1-adrenoceptor blockade. This implies that the rise is secondary to beta 2-adrenoceptor stimulatio...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1983.tb02248.x

    authors： Armitstead JG,Lightman SL,Brown MJ,Causon RC,Vaughan NJ

    更新日期：1983-12-01 00:00:00

  • A regulatory perspective of clinical trial applications for biological products with particular emphasis on Advanced Therapy Medicinal Products (ATMPs).

    abstract：:The safety of trial subjects is the tenet that guides the regulatory assessment of a Clinical Trial Authorization application and applies equally to trials involving small molecules and those with biological/biotechnological products, including Advanced Therapy Medicinal Products. The objective of a regulator is to en...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.12057

    authors： Jones DR,McBlane JW,McNaughton G,Rajakumaraswamy N,Wydenbach K

    更新日期：2013-08-01 00:00:00

  • Inhibition of bradykinin-induced vasodilation in human forearm vasculature by icatibant, a potent B2-receptor antagonist.

    abstract：:1. The effect of icatibant (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8] bradykinin) a potent B2-kinin receptor antagonist, was studied on bradykinin-induced vasodilation in the human forearm. 2. Eight healthy normotensive men were studied in a rising dose random-placebo controlled study. Placebo and icatibant (20, 50 and 100 mic...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1994.tb04360.x

    authors： Cockcroft JR,Chowienczyk PJ,Brett SE,Bender N,Ritter JM

    更新日期：1994-10-01 00:00:00

  • Relation between changes in blood pressure and serum ACE activity after a single dose of enalapril and ACE genotype in healthy subjects.

    abstract：:1. The effects of a single oral dose of enalapril 10 mg on serum ACE activity and blood pressure in relation to the ACE genotype were studied in 27 healthy men, n = 9 each of genotype DD, ID and II, in a parallel group study design. 2. Before treatment serum ACE activity differed significantly between the genotypes, w...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1995.tb04419.x

    authors： Todd GP,Chadwick IG,Higgins KS,Yeo WW,Jackson PR,Ramsay LE

    更新日期：1995-02-01 00:00:00

  • Under-reporting of adverse drug reactions in general practice.

    abstract：AIMS:In post-marketing setting, spontaneous reporting by physicians is a mode of surveillance of adverse effects associated with drug use. The objective of this study was to quantitatively assess under-reporting of adverse drug reactions (ADRs) in general practice. METHODS:A random sample of 100 general practitioners ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.1997.05417.x

    authors： Moride Y,Haramburu F,Requejo AA,Bégaud B

    更新日期：1997-02-01 00:00:00

  • Scientifically based combination therapies with immuno-oncology checkpoint inhibitors.

    abstract：:The discovery of immune checkpoints and their role in modulating immune response have revolutionised cancer treatment in recent years. The immune checkpoints, cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 and its ligand, programmed cell death-ligand 1, have been extensively studied. Curr...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1111/bcp.14338

    authors： Chew HY,Dolcetti R,Simpson F

    更新日期：2020-09-01 00:00:00

  • Lack of effect of moderate hepatic impairment on the pharmacokinetics of oral oseltamivir and its metabolite oseltamivir carboxylate.

    abstract：AIMS:To compare the pharmacokinetics of oseltamivir and oseltamivir carboxylate in hepatically impaired patients and healthy subjects. METHODS:Hepatically impaired patients (n = 11) and healthy subjects (n = 11) were individually paired on the basis of gender, age (+/-10 years) and body weight (+/-20%) and administere...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/j.1365-2125.2005.02340.x

    authors： Snell P,Dave N,Wilson K,Rowell L,Weil A,Galitz L,Robson R

    更新日期：2005-05-01 00:00:00

  • Intrinsic heart rate on exercise and the measurement of beta-adrenoceptor blockade.

    abstract：:Methods of expressing the effects of beta-adrenoceptor blocking drugs on exercise heart rate have been evaluated using a standardised exercise test. In six normal subjects given atropine (0.04 mg/kg) on two separate occasions, the mean +/- s.e. mean exercise heart rate rose by 10.3 +/- 1.8 beats/min and by 11.0 +/- 1....

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1976.tb00348.x

    authors： Carruthers SG,Shanks RG,McDevitt DG

    更新日期：1976-12-01 00:00:00

  • Effect of food on the absorption of frusemide and bumetanide in man.

    abstract：:1. The influence of food on the absorption of frusemide and bumetanide was compared in two separate randomized crossover studies. 2. On three separate occasions frusemide 40 mg was administered to eight healthy male volunteers intravenously, orally in the fasting state and orally after a standard breakfast. Blood and ...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1996.00494.x

    authors： McCrindle JL,Li Kam Wa TC,Barron W,Prescott LF

    更新日期：1996-12-01 00:00:00

  • Blood-brain barrier transport of morphine in patients with severe brain trauma.

    abstract：AIMS:In experimental studies, morphine pharmacokinetics is different in the brain compared with other tissues due to the properties of the blood-brain barrier, including action of efflux pumps. It was hypothesized in this clinical study that active efflux of morphine occurs also in human brain, and that brain injury wo...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2125.2003.02032.x

    authors： Ederoth P,Tunblad K,Bouw R,Lundberg CJ,Ungerstedt U,Nordström CH,Hammarlund-Udenaes M

    更新日期：2004-04-01 00:00:00

  • Quantitative comparison of aldosterone antagonists in normal human subjects: prediction of therapeutic potency.

    abstract：:1 The potency of single doses of the aldosterone antagonist SC8109 relative to spironolactone in reversing the urinary electrolyte effects of fludrocortisone was examined in a double-blind, balanced, crossover study in six healthy volunteers. 2 For the urinary ratio log10 10Na/K, the relative potency of SC8109; spiron...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1981.tb01299.x

    authors： McInnes GT,Harrison IR,Shelton JR,Perkins RM

    更新日期：1981-11-01 00:00:00

  • Short-term sucralfate administration alters potassium diclofenac absorption in healthy male volunteers.

    abstract：AIMS:Since patients who regularly take NSAIDS may use sucralfate because of its cytoprotective properties, we examined the influence of this compound on the pharmacokinetics of diclofenac. METHODS:Potassium diclofenac (105 mg) was administered orally to eighteen healthy male volunteers with or without a 5-day pre-trea...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1997.tb00040.x

    authors： Pedrazzoli Júnior J,Pierossi Mde A,Muscará MN,Dias HB,da Silva CM,Mendes FD,de Nucci G

    更新日期：1997-01-01 00:00:00

  • Adenosine-induced respiratory and heart rate changes in young and elderly adults.

    abstract：:The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1989.tb05360.x

    authors： Watt AH,Bayer A,Routledge PA,Swift CG

    更新日期：1989-02-01 00:00:00

  • Cimetidine, but not oxmetidine, penetrates into the cerebrospinal fluid after a single intravenous dose.

    abstract：:1 Thirty-six patients with various neurological diseases or symptoms received single intravenous doses of either cimetidine 400 mg (n = 19) or oxmetidine 200 mg (n = 17), 15 or 60 min before a diagnostic lumbar puncture. 2 In the 15 min CSF samples concentrations of cimetidine were detectable but not measurable in 5 a...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1982.tb02042.x

    authors： Jönsson KA,Eriksson SE,Kagevi I,Norlander B,Bodemar G,Walan A

    更新日期：1982-12-01 00:00:00

  • Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma.

    abstract：AIMS:Adenosine monophosphate (AMP) acts indirectly via primed airway mast cells to induce bronchial hyper-responsiveness, which in turn correlates with eosinophilic asthmatic inflammation and atopic disease expression. We evaluated single and short-term dosing effects of a modern histamine H1-receptor antagonist, levoc...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2004.02110.x

    authors： Lee DK,Gray RD,Wilson AM,Robb FM,Soutar PC,Lipworth BJ

    更新日期：2004-07-01 00:00:00

  • Flavonoids inhibit the platelet TxA(2) signalling pathway and antagonize TxA(2) receptors (TP) in platelets and smooth muscle cells.

    abstract：AIMS:Flavonoids may affect platelet function by several mechanisms, including antagonism of TxA(2) receptors (TP). These TP are present in many tissues and modulate different signalling cascades. We explored whether flavonoids affect platelet TP signalling, and if they bind to TP expressed in other cell types. METHODS...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2007.02881.x

    authors： Guerrero JA,Navarro-Nuñez L,Lozano ML,Martínez C,Vicente V,Gibbins JM,Rivera J

    更新日期：2007-08-01 00:00:00

  • Pharmacokinetic and pharmacodynamic profile of donepezil HCl following evening administration.

    abstract：AIMS:The primary objective of this study was to characterize the pharmacokinetics and pharmacodynamics of single daily doses of donepezil (5 and 10 mg) each evening for 28 consecutive days. A secondary objective was to measure the plasma protein binding of donepezil at steady state. METHODS:This was a double-blind, ra...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2125.1998.0460s1013.x

    authors： Tiseo PJ,Rogers SL,Friedhoff LT

    更新日期：1998-11-01 00:00:00

  • The negative inotropic and chronotropic effects of intravenous R 56865 during percutaneous transluminal coronary angioplasty.

    abstract：:The present study was designed to evaluate the potential anti-ischaemic activity of R 56865 in patients with coronary artery disease, scheduled to undergo percutaneous transluminal coronary angioplasty (PTCA). At baseline a complete haemodynamic profile, including cardiac output and coronary sinus blood flow (CSBF) wa...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2125.1995.tb04491.x

    authors： Pijl AJ,Van Wezel HB,Koolen JJ,Piek JJ,Koch K,Swaan A,David GK,Visser CA,Van Zwieten PA

    更新日期：1995-05-01 00:00:00

  • Perturbation of paracetamol urinary metabolic ratios by urine flow rate.

    abstract：:The effects of high and low urine flow rates on the urinary metabolic ratios for paracetamol glucuronidation, sulphation and oxidation were determined at steady-state in seven healthy young adult volunteers. Metabolic partial clearances were unaffected by urine flow rate, but individual paracetamol metabolic ratios va...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1992.tb05643.x

    authors： Miners JO,Osborne NJ,Tonkin AL,Birkett DJ

    更新日期：1992-10-01 00:00:00

  • Influence of basal nitric oxide secretion on cardiac function in man.

    abstract：:1. Nitric oxide is recognised as an important biological mediator, which is thought to be involved in cardiovascular homeostasis. The purpose of this study was to investigate the effects of basal nitric oxide synthesis on cardiac function in man, by blocking nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1995.tb04550.x

    authors： Clarkson PB,Lim PO,MacDonald TM

    更新日期：1995-10-01 00:00:00

  • Pharmacist-led, video-stimulated feedback to reduce prescribing errors in doctors-in-training: A mixed methods evaluation.

    abstract：AIMS:To develop and evaluate a feasible, authentic pharmacist-led prescribing feedback intervention for doctors-in-training, to reduce prescribing errors. METHODS:This was a mixed methods study. Sixteen postgraduate doctors-in training, rotating though the surgical assessment unit of 1 UK hospital, were filmed taking ...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14065

    authors： Parker H,Farrell O,Bethune R,Hodgetts A,Mattick K

    更新日期：2019-10-01 00:00:00

  • Limited predictability of amikacin clearance in extreme premature neonates at birth.

    abstract：AIM:Identify and quantify factors describing variability of amikacin clearance in preterm neonates at birth. METHODS:Population pharmacokinetics of amikacin were estimated in a cohort of 205 extreme preterm neonates [post conception age (PCA) 27.8, SD 1.8, range 24-30 weeks; weight 1.07, SD 0.34, range 0.45-1.98 kg, p...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.2005.02530.x

    authors： Allegaert K,Anderson BJ,Cossey V,Holford NH

    更新日期：2006-01-01 00:00:00

  • Potassium supplements during long-term thiazide therapy for essential hypertension.

    abstract：:Increasing doses of a slow-release potassium supplement were given to nine hypertensive patients previously treated for at least 18 months with bendrofluazide 10 mg daily. Serum potassium and total body potassium (TBK) were measured after 2 months on each dose. No significant increase in serum potassium or TBK occurre...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2125.1982.tb01975.x

    authors： Wilkinson PR,Tait C,Hesp R,Raftery EB

    更新日期：1982-08-01 00:00:00

  • Surrogacy in antiviral drug development.

    abstract：:The coming of age of molecular biology has resulted in an explosion in our understanding of the pathogenesis of virus related diseases. New pathogens have been identified and characterized as being responsible for old diseases. Empirical clinical evaluation of morbidity and mortality as outcome measures after a therap...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2125.2002.01623.x

    authors： Shaunak S,Davies DS

    更新日期：2002-07-01 00:00:00

  • Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone.

    abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Oxycodone is an opioid analgesic that is metabolized mainly in the liver by cytochrome P450 (CYP) 2D6 and 3A4 enzymes. So far, the effects of CYP2D6 or CYP3A4 inhibitors on the pharmacokinetics of oxycodone in humans have not been systematically studied. WHAT THIS STUDY ADDS:Dr...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.2010.03653.x

    authors： Grönlund J,Saari TI,Hagelberg NM,Neuvonen PJ,Olkkola KT,Laine K

    更新日期：2010-07-01 00:00:00

  • Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritis.

    abstract：AIMS:Inflammation reduces hepatic clearance of many drugs with unknown therapeutic consequences. This study was carried out to examine the effect of rheumatoid arthritis (RA) on the pharmacokinetics and pharmacodynamics of verapamil. METHODS:Eight RA patients were age- and sex-matched with eight healthy volunteers. Th...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2125.2000.00314.x

    authors： Mayo PR,Skeith K,Russell AS,Jamali F

    更新日期：2000-12-01 00:00:00

  • The renal protective effect of angiotensin receptor blockers depends on intra-individual response variation in multiple risk markers.

    abstract：AIMS:Angiotensin receptor blockers (ARBs) are renoprotective and targeted to blood pressure. However, ARBs have multiple other (off-target) effects which may affect renal outcome. It is unknown whether on-target and off-target effects are congruent within individuals. If not, this variation in short term effects may ha...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/bcp.12655

    authors： Schievink B,de Zeeuw D,Parving HH,Rossing P,Lambers Heerspink HJ

    更新日期：2015-10-01 00:00:00

  • Effects of dazoxiben on exercise performance in chronic stable angina.

    abstract：:1 We have performed a double-blind, randomized, 7-d cross-over study of the thromboxane synthetase inhibitor dazoxiben (UK 37248) in 20 patients with stable coronary heart disease. 2 All patients had a history of exertional angina of greater than two years duration and no patient had suffered a myocardial infarction i...

    journal_title：British journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2125.1983.tb02114.x

    authors： Reuben SR,Kuan P,Cairns J,Gyde OH

    更新日期：1983-01-01 00:00:00

  • Bioequivalence of macitentan and tadalafil given as fixed-dose combination or single-component tablets in healthy subjects.

    abstract：AIMS:To demonstrate the bioequivalence of macitentan/tadalafil fixed-dose combination (FDC) tablets with single-component tablets of macitentan and tadalafil in healthy subjects. METHODS:Studies AC-077-101 and AC-077-103 were single-centre, open-label, single-dose, 2-period, randomized, crossover Phase 1 studies condu...

    journal_title：British journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1111/bcp.14347

    authors： Grill S,Bruderer S,Sidharta PN,Antonova M,Globig S,Carlson J,Schultz A,Csonka D

    更新日期：2020-12-01 00:00:00