Bioequivalence of macitentan and tadalafil given as fixed-dose combination or single-component tablets in healthy subjects.

abstract：:The effects of single oral doses of atenolol 50 mg and xamoterol 200 mg (a recently developed partial beta 1-adrenoceptor agonist) on lung function, heart rate and blood pressure were investigated in 11 patients with asthma. Xamoterol caused a significant increase in heart rate and systolic blood pressure, which chang...

journal_title：British journal of clinical pharmacology

authors： Lammers JW,Müller ME,Folgering HT,van Herwaarden CL

更新日期：1986-11-01 00:00:00

abstract：AIMS:To measure the prevalence of beta-blocker eye drop prescribing and respiratory effect of ocular beta-blocker administration in people with asthma. METHODS:We measured the prevalence of ocular beta-blocker prescribing in people with asthma and ocular hypertension, and performed a nested case-control study (NCCS) m...

journal_title：British journal of clinical pharmacology

authors： Morales DR,Dreischulte T,Lipworth BJ,Donnan PT,Jackson C,Guthrie B

更新日期：2016-09-01 00:00:00

abstract：:1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment. 2 Each patient was given a long-term supply of drug and was asked to vary their own dosage within...

journal_title：British journal of clinical pharmacology

authors： Rooney PJ,Capell HA,Paterson S,Buchanan WW,Dick WC

更新日期：1978-05-01 00:00:00

abstract：AIMS:To characterize the pharmacokinetics (PK) of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in adults with relapsed or refractory hairy cell leukaemia, we examined data from a phase 1 study (Study 1001; n = 49) and from the pivotal clinical study (Study 1053; n = 74). METHODS:Data from both studies ...

journal_title：British journal of clinical pharmacology

authors： Kuruvilla D,Chia YL,Balic K,Yao NS,Kreitman RJ,Pastan I,Li X,Standifer N,Liang M,Tseng CM,Faggioni R,Roskos L

更新日期：2020-07-01 00:00:00

abstract：:1 Cardiovascular responses to intravenous prizidilol hydrochloride (SK&F 92657) 0.86 mg/kg were studied in eight supine resting healthy volunteers. Five subjects were slow and the remaining three were fast acetylators of sulphamethazine. Compared with pre-infusion values, mean resting systolic and diastolic blood pres...

journal_title：British journal of clinical pharmacology

authors： Edmonstone WM,Manghani KK,Bell AJ,McLeod M,Milton-Thompson GJ,Burland WL

更新日期：1981-10-01 00:00:00

abstract：AIMS:The aim of this study was to compare the effects of the ACE-inhibitor lisinopril and the angiotensin II receptor antagonist losartan on insulin sensitivity in the treatment of non diabetic hypertensives. METHODS:Twenty-five non diabetic subjects with mild to moderate hypertension, 11 females and 14 males, aged 44...

journal_title：British journal of clinical pharmacology

authors： Fogari R,Zoppi A,Corradi L,Lazzari P,Mugellini A,Lusardi P

更新日期：1998-11-01 00:00:00

abstract：:1 The anticholinergic effects of atropine and two antihistamines (terfenadine and mequitazine) were investigated vs placebo in a double-blind study. 2 Salivary secretion, basal pupil diameter, pilocarpine (0.25%) induced miosis and heart rate were determined in eight healthy volunteers, seven male and one female, aged...

journal_title：British journal of clinical pharmacology

authors： Brion N,Beaumont D,Advenier C

更新日期：1988-01-01 00:00:00

abstract：:1. The pharmacokinetics of butorphanol were evaluated in 18 female volunteers with varying degrees of renal function following a single, 1 mg transnasal dose of butorphanol tartrate. The creatinine clearance (CLCR) values for subjects in the normal (NOR), moderately impaired (MI), and severely impaired (SI) groups wer...

journal_title：British journal of clinical pharmacology

authors： Shyu WC,Morgenthien EA,Barbhaiya RH

更新日期：1996-05-01 00:00:00

abstract：:1. Lisinopril and enalapril were administered as 2.5 mg single doses and as eight single daily 2.5 mg doses to separate groups of six patients with chronic renal failure. Patients were receiving regular haemodialysis. 2. In the absence of haemodialysis, the decline in plasma concentrations of lisinopril and enalaprila...

journal_title：British journal of clinical pharmacology

authors： Kelly JG,Doyle GD,Carmody M,Glover DR,Cooper WD

更新日期：1988-12-01 00:00:00

abstract：AIMS:Ibandronate, a highly potent nitrogen-containing bisphosphonate, is the subject of an ongoing clinical development programme that aims to maximize the potential of simplified, less frequent oral and intravenous (i.v.) administration in osteoporosis. A modelling and simulation project was undertaken to characterize...

journal_title：British journal of clinical pharmacology

authors： Pillai G,Gieschke R,Goggin T,Jacqmin P,Schimmer RC,Steimer JL

更新日期：2004-12-01 00:00:00

abstract：AIMS:To investigate the impact of the specific red blood cell binding on the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine after i.v. administration at various infusion rates. It was also aimed to relate the red blood cell (RBC) occupancy of draflazine to the ex vivo measured ad...

journal_title：British journal of clinical pharmacology

authors： Snoeck E,Piotrovskij V,Jacqmin P,Van Peer A,Danhof M,Ver Donck K,Woestenborghs R,Van Belle H,Van Bortel L,Van Gool R,Dupont AG,Heykants J

更新日期：1997-06-01 00:00:00

abstract：AIMS:This study was conducted to determine whether atenolol was able to decrease BP level and mitigate BP increase during dynamic resistance exercise performed at three different intensities in hypertensives. METHODS:Ten essential hypertensives (systolic/diastolic BP between 140/90 and 160/105mmHg) were blindly studie...

journal_title：British journal of clinical pharmacology

authors： Gomides RS,Costa LA,Souza DR,Queiroz AC,Fernandes JR,Ortega KC,Junior DM,Tinucci T,Forjaz CL

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:Maraviroc, a noncompetitive antagonist of the CCR5 coreceptor, was recently approved in the USA as a treatment of HIV infection. For antiretroviral agents that target the virus, antiviral effect can be related to some extent to plasma drug concentrations. For CCR5 antagonists that target the host cells, rece...

journal_title：British journal of clinical pharmacology

authors： Rosario MC,Jacqmin P,Dorr P,James I,Jenkins TM,Abel S,van der Ryst E

更新日期：2008-04-01 00:00:00

abstract：:1 Daily treatment of two-kidney clipped renal hypertensive rats with hydrallazine, hydrochlorothiazide (HCTZ) and a new orally active inhibitor of the angiotensin-converting enzyme, captopril (SQ14,225), was correlated with survival rates for up to 9 months. 2 The groups of rats given captopril alone or captopril plus...

journal_title：British journal of clinical pharmacology

authors： Horovitz ZP,Antonaccio MJ,Rubin B,Panasevich RE

更新日期：1979-01-01 00:00:00

abstract：:1 The influence of cimetidine (1000 mg daily) on propranolol steady state plasma levels has been studied in seven normal volunteers. Cimetidine was used as a 200 mg normal release tablet whereas propranolol was given as a 160 mg slow release formulation once daily. 2 After 1 day of cimetidine treatment (day 9 of the s...

journal_title：British journal of clinical pharmacology

authors： Reimann IW,Klotz U,Siems B,Frölich J

更新日期：1981-12-01 00:00:00

abstract：:1 The disposition in urine of debrisoquine and its hydroxylated metabolites has been studied in subjects of the 'extensive metabolizer' (EM; n = 5) and 'poor metabolizer' (PM; n = 5) phenotypes. The 4-hydroxylation of debrisoquine by PM subjects following a 10 mg oral dose was capacity-limited and displayed significan...

journal_title：British journal of clinical pharmacology

authors： Sloan TP,Lancaster R,Shah RR,Idle JR,Smith RL

更新日期：1983-04-01 00:00:00

abstract：:It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population-based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient ...

journal_title：British journal of clinical pharmacology

authors： Chan EW,Liu KQ,Chui CS,Sing CW,Wong LY,Wong IC

更新日期：2015-10-01 00:00:00

abstract：:1. The pharmacokinetics, bioavailability and metabolism of nitrendipine were studied in six healthy volunteers (three females, three males) using [13C4]-nitrendipine as a biological internal standard. In the first study the drug was administered simultaneously by the i.v. [13C4] and p.o. (solution) routes and in a sec...

journal_title：British journal of clinical pharmacology

authors： Mikus G,Fischer C,Heuer B,Langen C,Eichelbaum M

更新日期：1987-11-01 00:00:00

abstract：AIMS:The pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear to be inconsistent with the emerging scientific evidence. Limited information is available on the safety profile of these agents in neonates. Our objective was ...

journal_title：British journal of clinical pharmacology

authors： Leroux S,Jacqz-Aigrain E,Elie V,Legrand F,Barin-Le Guellec C,Aurich B,Biran V,Dusang B,Goudjil S,Coopman S,Garcia Sanchez R,Zhao W,Manzoni P,FP7 TINN (Treat Infections in NeoNates) consortium.

更新日期：2018-09-01 00:00:00

abstract：AIMS:Therapeutic drug monitoring of infliximab can guide clinical decisions in patients with loss of response and in those who can benefit from a de-intensification. The aim of this study was to determine the impact of therapeutic drug monitoring combined with Bayesian forecasting methodology on clinical response in a ...

journal_title：British journal of clinical pharmacology

authors： Santacana Juncosa E,Rodríguez-Alonso L,Padullés Zamora A,Guardiola J,Rodríguez-Moranta F,Serra Nilsson K,Bas Minguet J,Morandeira Rego F,Colom Codina H,Padullés Zamora N

更新日期：2020-06-03 00:00:00

abstract：AIMS:To assess the antihistaminic activity of levocetirizine and fexofenadine 2 h and 24 h after drug administration using facial thermography and to compare the results with those using well-established parameters of antihistaminic activity in the nose and skin. METHODS:This was a randomized, double-blind, three-trea...

journal_title：British journal of clinical pharmacology

authors： Larbig M,Burtin B,Martin L,Stamm H,Luettig B,Hohlfeld JM,Krug N

更新日期：2006-08-01 00:00:00

abstract：:A single oral dose of sotalol (160 mg) was administered to control subjects with normal renal function and patients with chronic renal failure in the interdialysis period to estimate the elimination kinetics of the drug. Sotalol concentrations in body fluids were measured fluorimetrically using a modified Garrett and ...

journal_title：British journal of clinical pharmacology

authors： Tjandramaga TB,Verbeeck R,Thomas J,Verbesselt R,Verberckmoes R,Schepper PJ

更新日期：1976-04-01 00:00:00

abstract：:In a double-blind trial the effects on ventilatory function (FEV1), heart rate and blood pressure of oral pirbuterol and oral salbutamol in various single doses were studied in ten patients with chronic asthma. Pirbuterol (15 mg) and salbutamol (4 mg) produced equal peak levels of bronchodilatation. There was no signi...

journal_title：British journal of clinical pharmacology

authors： Willey RF,Grant IW,Pocock SJ

更新日期：1976-08-01 00:00:00

abstract：AIMS:The aims of the study were to determine the effect of advice from the Scottish Medicines Consortium (SMC) on the use of medicines within Scotland's National Health Service (NHS) and generate hypotheses that may explain differences in the impact of advice on the use of individual medicines. METHODS:A retrospective...

journal_title：British journal of clinical pharmacology

authors： Bennie M,Dear J,Hems S,Black C,McIver L,Webb DJ

更新日期：2011-02-01 00:00:00

abstract：:1. The pharmacokinetics of recombinant erythropoietin, r-Epo, were evaluated after intravenous and subcutaneous administration of 50 u kg-1 to six healthy male volunteers. 2. The calculated mean values (+/- s.d.) for volume of distribution at steady state and clearance after an i.v. dose were 76 (+/- 33) ml kg-1 and 1...

journal_title：British journal of clinical pharmacology

authors： Salmonson T,Danielson BG,Wikström B

更新日期：1990-06-01 00:00:00

abstract：:The disposition of mexiletine has been studied in five subjects on two occasions with urine pH controlled at 5.0 and at 8.0. With acid urine total plasma clearance was similar in all subjects (462 to 497 ml min-1) and the plasma half-life ranged from 3.8 to 9.2 h (mean 6.7 h). With alkaline urine the total plasma clea...

journal_title：British journal of clinical pharmacology

authors： Mitchell BG,Clements JA,Pottage A,Prescott LF

更新日期：1983-09-01 00:00:00

abstract：AIM:To use non-linear mixed effects modelling and simulation techniques to predict whether PF-04878691, a toll-like receptor 7 (TLR7) agonist, would produce sufficient antiviral efficacy while maintaining an acceptable side effect profile in a 'proof of concept' (POC) study in chronic hepatitis C (HCV) patients. METHO...

journal_title：British journal of clinical pharmacology

authors： Jones HM,Chan PL,van der Graaf PH,Webster R

更新日期：2012-01-01 00:00:00

abstract：:1. The aromatic 2-hydroxylation of imipramine was studied in microsomes from three human livers. The kinetics were best described by a biphasic enzyme model. The estimated values of Vmax and Km for the high affinity site ranged from 3.2 to 5.7 nmol mg-1 h-1 and from 25 to 31 microM, respectively. 2. Quinidine was a po...

journal_title：British journal of clinical pharmacology

authors： Skjelbo E,Brøsen K

更新日期：1992-09-01 00:00:00

abstract：:The effects of epanolol (200 mg once daily) and diltiazem (60 mg three times daily) on the response of atrial natriuretic peptide (ANP) to exercise were investigated in a double-blind placebo-controlled crossover study in 16 patients with angina pectoris. Exercise tolerance as assessed by peak oxygen consumption was s...

journal_title：British journal of clinical pharmacology

authors： Riley M,Elborn JS,Onuoha G,Erwin C,Shaw C,Khan MM,Stanford CF,Nicholls DP

更新日期：1993-02-01 00:00:00

abstract：:The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Still, the optimal use and the value of pharmacological personalization of the taxanes is still controversial. We give an overview on the pharmacologica...

journal_title：British journal of clinical pharmacology

authors： Muth M,Ojara FW,Kloft C,Joerger M

更新日期：2020-11-28 00:00:00