Evaluation of the antimuscarinic activity of atropine, terfenadine and mequitazine in healthy volunteers.

abstract：:Ten patients with mild to moderate hypertension were treated for 9 weeks with a tablet formulation of pinacidil. Mean supine blood pressure fell from 174/100 to 148/84 mm Hg and mean supine pulse increased by 3 beats/min. Daily dosage was 40-100 mg, given in two or three divided doses. Plasma urea increased significan...

journal_title：British journal of clinical pharmacology

authors： Ward JW

更新日期：1984-08-01 00:00:00

abstract：:1. A novel formulation of nicardipine (50% standard (short acting), 50% sustained release) was evaluated in mild hypertension in a double-blind, randomized, placebo-controlled study, using clinic measurements (Hawksley) augmented by home recorded blood pressures (Copal UA 251). 2. Nicardipine 60 mg twice daily for 28 ...

journal_title：British journal of clinical pharmacology

authors： Webster J,Witte K,Rawles J,Petrie JC,Jeffers TA

更新日期：1989-05-01 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulator of cell growth, division and survival. Many haematologic malignancies exhibit elevated or aberrant mTOR activation, supporting the launch of numerous clinical trials aimed at evaluating the potential of single agent m...

journal_title：British journal of clinical pharmacology

authors： Lee JS,Vo TT,Fruman DA

更新日期：2016-11-01 00:00:00

abstract：:The fall in blood pressure produced by captopril is not accompanied by a compensatory tachycardia. Angiotensin converting enzyme may participate in the metabolism of endogenous opioids and these substances can lower blood pressure without reflex tachycardia. It is therefore possible that the hypotensive effect of capt...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Millar JA,Sturani S,Lawrie C,Reid JL

更新日期：1984-06-01 00:00:00

abstract：:A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the foll...

journal_title：British journal of clinical pharmacology

authors： Tjandra-Maga TB,van Hecken A,van Melle P,Verbesselt R,de Schepper PJ

更新日期：1986-07-01 00:00:00

abstract：:The metabolism of [3H]ethinyloestradiol (EE2) was investigated in six male subjects who had been phenotyped with respect to sparteine metabolism (three metabolizers and three non-metabolizers). Urinary metabolite profiles of EE2 were virtually identical. Following enzyme hydrolysis of sulphate and glucuronide conjugat...

journal_title：British journal of clinical pharmacology

authors： Back DJ,Maggs JL,Purba HS,Newby S,Park BK

更新日期：1984-10-01 00:00:00

abstract：:1 The effect of an intravenous bolus of labetalol (0.6-1.6 mg/kg body weight) on central and peripheral haemodynamics was studied in nine subjects with essential hypertension and in eleven subjects with chronic renal disease and hypertension. 2 The BP reduction amounting to 20/13 mmHg was entirely due to the lowering ...

journal_title：British journal of clinical pharmacology

authors： Bahlmann J,Brod J,Hubrich W,Cachovan M,Pretschner P

更新日期：1979-04-01 00:00:00

abstract：AIMS:Mycophenolic acid (MPA) suppresses lymphocyte proliferation through inosine monophosphate dehydrogenase (IMPDH) inhibition. Two formulations have been approved: mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS). Pantoprazole (PAN) inhibits gastric acid secretion, which may alter MPA expo...

journal_title：British journal of clinical pharmacology

authors： Rissling O,Glander P,Hambach P,Mai M,Brakemeier S,Klonower D,Halleck F,Singer E,Schrezenmeier EV,Dürr M,Neumayer HH,Budde K

更新日期：2015-11-01 00:00:00

abstract：AIMS:SAR247799 is a selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist with potential to restore endothelial function in vascular pathologies. SAR247799, a first-in-class molecule differentiated from previous S1P1 -desensitizing molecules developed for multiple sclerosis, can activate S1P1 wi...

journal_title：British journal of clinical pharmacology

authors： Bergougnan L,Armani S,Golor G,Tardat A,Vitse O,Hurbin F,Scemama M,Poitiers F,Radzik D,Gaudin C,Hovsepian L,Muslin AJ,Kirkesseli S,Deutsch P,Parkar AA

更新日期：2020-06-10 00:00:00

abstract：AIMS:Angiotensin II is a putative mediator in bronchial asthma. There have been very few studies investigating the involvement of angiotensin II receptors in bronchial hyper-responsiveness in asthmatic patients. We examined the effect of candesartan cilexetil, a specific angiotensin II type 1 (AT1) receptor antagonist,...

journal_title：British journal of clinical pharmacology

authors： Myou S,Fujimura M,Kamio Y,Kita T,Watanabe K,Ishiura Y,Hashimoto T,Nakao S

更新日期：2002-12-01 00:00:00

abstract：AIMS:Previous isobolographic analysis revealed that coadministration of morphine and oxycodone produces synergistic antinociception in laboratory rodents. As both opioids can produce ventilatory depression, this study was designed to determine whether their ventilatory effects were synergistic when coadministered to he...

journal_title：British journal of clinical pharmacology

authors： Ladd LA,Kam PC,Williams DB,Wright AW,Smith MT,Mather LE

更新日期：2005-05-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Desmopressin is a known haemostatic agent and is also being used, albeit at lower doses, during the diagnostic work-up of Cushing's syndrome, a condition characterized by excess cortisol concentrations and frequent thromboembolic events. No study has yet evaluated whether admini...

journal_title：British journal of clinical pharmacology

authors： Pecori Giraldi F,Ambrogio AG,Fatti LM,Rubini V,Cozzi G,Scacchi M,Federici AB,Cavagnini F

更新日期：2011-01-01 00:00:00

abstract：AIMS:The pharmacokinetics of voriconazole show a nonlinear dose-exposure relationship caused by inhibition of its own CYP3A-dependent metabolism. Because the magnitude of autoinhibition also depends on voriconazole concentrations, infusion rate might modulate voriconazole exposure. The impact of four different infusion...

journal_title：British journal of clinical pharmacology

authors： Hohmann N,Kreuter R,Blank A,Weiss J,Burhenne J,Haefeli WE,Mikus G

更新日期：2017-09-01 00:00:00

abstract：AIMS:Paracetamol is frequently involved in intended self-poisoning, and concomitant overdosing of other drugs is commonly reported. The purpose of the study was to investigate further concomitant drug overdose in patients with paracetamol poisoning and to evaluate its effects on the outcome of the paracetamol intoxicat...

journal_title：British journal of clinical pharmacology

authors： Schmidt LE,Dalhoff K

更新日期：2002-05-01 00:00:00

abstract：:1 Isoxicam was found to inhibit monocyte and neutrophil cell chemotaxis at therapeutic concentrations. 2 The effect was observed after in vitro incubation of normal cells and in vivo in patients with rheumatoid arthritis. 3 Compared to other NSAIDs studied in our laboratory, isoxicam was shown to have a broader spectr...

journal_title：British journal of clinical pharmacology

authors： Martinez JG,Murakami SI,Scheinberg MA

更新日期：1986-01-01 00:00:00

abstract：:A double-blind, crossover study was carried out on the acceptability of three doses of brotizolam (0.125, 0.25 and 0.5 mg) in chronic insomniacs aged between 21 and 75 years (33 men: 42 women). Patients reported a shorter time to fall asleep and less nocturnal awakenings. Improvement in sleep was evident during the fi...

journal_title：British journal of clinical pharmacology

authors： Fritz-Osner A,Arias-Ortiz JL,Dorantes JF,Rabago-Sánchez J,Rodríguez-Tenorio A,Sánchez-Martinez J

更新日期：1983-01-01 00:00:00

abstract：:1 The pharmacokinetics of single oral doses of nortriptyline were studied in twenty patients with chronic renal failure, eight of whom were receiving treatment with haemodialysis. 2 The median nortriptyline half-life was 25.2 h (range 14.5-140.0 h) and the median nortriptyline clearance was 32.3 l/h (range 8.1-122.0 l...

journal_title：British journal of clinical pharmacology

authors： Dawlilng S,Lynn K,Rosser R,Braithwaite R

更新日期：1981-07-01 00:00:00

abstract：AIMS:To assess the utility of human hepatic microsomes for predicting in vivo intrinsic clearance (CLint ) via the use of four cytochrome P450 2C9 substrates: phenytoin, tolbutamide (S)-ibuprofen (two pathways) and diclofenac, and to examine the role of exogenous albumin within the microsomal incubation. METHODS:V max...

journal_title：British journal of clinical pharmacology

authors： Carlile DJ,Hakooz N,Bayliss MK,Houston JB

更新日期：1999-06-01 00:00:00

abstract：:Twelve healthy volunteers were given orally placebo, itraconazole 100 mg or terbinafine 250 mg for 4 days. Midazolam 7.5 mg was ingested on the fourth day, after which plasma samples were collected and psychomotor performance tests carried out for 17 h. Itraconazole increased the area under the midazolam concentration...

journal_title：British journal of clinical pharmacology

authors： Ahonen J,Olkkola KT,Neuvonen PJ

更新日期：1995-09-01 00:00:00

abstract：:1. The localisation and distribution of cytochrome P-450 in human tissues has been studied by immunocytochemistry using a monoclonal antibody to a major form of human hepatic cytochrome P-450, P-450hA7, which is closely related to cytochromes P-450 HLp and P-450NF. 2. Strong immunoreactivity was identified in hepatocy...

journal_title：British journal of clinical pharmacology

authors： Murray GI,Barnes TS,Sewell HF,Ewen SW,Melvin WT,Burke MD

更新日期：1988-04-01 00:00:00

abstract：:1. In order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews conducted by a single observer. Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a trial (group B), and 119 had never ...

journal_title：British journal of clinical pharmacology

authors： Bevan EG,Chee LC,McGhee SM,McInnes GT

更新日期：1993-02-01 00:00:00

abstract：:1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1. 2. Resting heart rate fell from 78 to 74 beats min-1 (P less than 0.0...

journal_title：British journal of clinical pharmacology

authors： Virk SJ,Davies MK

更新日期：1989-01-01 00:00:00

abstract：:1. In 48 patients with chronic asthma who had been receiving treatment with beclomethasone dipropionate aerosol (BDA) at a daily dose of 400 microgram for several years, observations were made on the effect of increasing the dose to 800 microgram daily for 6 months. 2. There was subjective improvement in 37 of the 48 ...

journal_title：British journal of clinical pharmacology

authors： Chatterjee SS

更新日期：1977-01-01 00:00:00

abstract：:Since platelet activation has been incriminated in the pathogenesis of asthma, we have investigated the effect of one of its major granule-derived mediators, 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in normal (12), atopic non-asthmatic (12) and atopic asthmatic subjects (16). On separate days subjects i...

journal_title：British journal of clinical pharmacology

authors： Cushley MJ,Wee LH,Holgate ST

更新日期：1986-10-01 00:00:00

abstract：:1. Potential therapies for ischaemic stroke include agents to reduce oedema, to improve cerebral perfusion, to reduce excitotoxic damage, to minimise free-radical induced injury and to reduce complications such as deep venous thrombosis. 2. Of the anti-oedema drugs, steroids are ineffective and possibly dangerous; int...

journal_title：British journal of clinical pharmacology

authors： Lees KR

更新日期：1992-12-01 00:00:00

abstract：AIMS:Case reports and small case series suggest increased central nervous system (CNS) toxicity, especially convulsions, after overdose of mefenamic acid, compared with other nonsteroidal anti-inflammatory drugs (NSAIDs), although comparative epidemiological studies have not been conducted. The current study compared r...

journal_title：British journal of clinical pharmacology

authors： Kamour A,Crichton S,Cooper G,Lupton DJ,Eddleston M,Vale JA,Thompson JP,Thomas SH

更新日期：2017-04-01 00:00:00

abstract：AIMS:To examine the effects of salbutamol and L-arginine, two compounds acting largely on the endothelium, and the endothelium-independent agent nitroglycerin on blood pressure, arterial compliance, cardiac function and vascular resistance. METHODS:Continuous radial pulse wave analysis, whole-body impedance cardiograp...

journal_title：British journal of clinical pharmacology

authors： Tahvanainen A,Leskinen M,Koskela J,Ilveskoski E,Alanko J,Kähönen M,Kööbi T,Lehtimäki L,Moilanen E,Mustonen J,Pörsti I

更新日期：2009-07-01 00:00:00

abstract：:The plasma concentration-response relationships of oral and intravenous pindolol and propranolol have been studied in a group of eight healthy male subjects who received each dosage form in a randomized single-blind cross-over manner. Despite similar elimination half-lives, the duration of action of pindolol was longe...

journal_title：British journal of clinical pharmacology

authors： Carruthers SG,Pacha WL,Aellig WH

更新日期：1985-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:• The topical second generation anti-histamine azelastine hydrochloride (AZE) and the potent corticosteroid fluticasone propionate (FP) are well established first-line treatments in allergic rhinitis (AR). • MP29-02, a novel intranasal AZE and FP formulation, has been shown to c...

journal_title：British journal of clinical pharmacology

authors： Derendorf H,Munzel U,Petzold U,Maus J,Mascher H,Hermann R,Bousquet J

更新日期：2012-07-01 00:00:00

abstract：:1 A double-blind entry to a trial of an active non-steroidal anti-inflammatory drug, flurbiprofen against placebo was undertaken until 100 patients with classical rheumatoid arthritis had been allocated to each treatment. 2 Each patient was given a long-term supply of drug and was asked to vary their own dosage within...

journal_title：British journal of clinical pharmacology

authors： Rooney PJ,Capell HA,Paterson S,Buchanan WW,Dick WC

更新日期：1978-05-01 00:00:00