Experience with the use of a corticosteroid aerosol.

abstract：:The binding of carbamazepine and carbamazepine 10,11-epoxide to serum, albumin and alpha 1-acid glycoprotein (AAG) was determined and compared at drug concentrations ranging from 0.5 to 400 mg/l using equilibrium dialysis and liquid chromatography. The total binding of carbamazepine in serum was determined primarily b...

journal_title：British journal of clinical pharmacology

authors： MacKichan JJ,Zola EM

更新日期：1984-10-01 00:00:00

abstract：:1. Eight volunteers received in randomized order two 30 microliters drops of either 1% w/v cyclopentolate hydrochloride or a corresponding amount of cyclopentolate polygalacturonate in saline or in acetate buffer in one eye. Cyclopentolate concentrations in plasma were measured by a radioreceptor assay. 2. Peak plasma...

journal_title：British journal of clinical pharmacology

authors： Lahdes K,Huupponen R,Kaila T,Monti D,Saettone MF,Salminen L

更新日期：1993-05-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00

abstract：AIMS:The pharmacokinetics (PK) of fluconazole and micafungin differ in neonates compared with children and adults. Dosing instructions in product labels appear to be inconsistent with the emerging scientific evidence. Limited information is available on the safety profile of these agents in neonates. Our objective was ...

journal_title：British journal of clinical pharmacology

authors： Leroux S,Jacqz-Aigrain E,Elie V,Legrand F,Barin-Le Guellec C,Aurich B,Biran V,Dusang B,Goudjil S,Coopman S,Garcia Sanchez R,Zhao W,Manzoni P,FP7 TINN (Treat Infections in NeoNates) consortium.

更新日期：2018-09-01 00:00:00

abstract：:Both empirical epidemiological data on the causes of traffic accidents and conceptual models of skilled human performance stress the central role of perception and cognition. This paper examines the effects of drugs on two major components of cognitive perceptual performance, namely, concentrated attention or vigilanc...

journal_title：British journal of clinical pharmacology

authors： Moskowitz H

更新日期：1984-01-01 00:00:00

abstract：:Plasma and synovial fluid concentrations of the enantiomers of flurbiprofen were measured in 15 rheumatoid patients receiving 100 mg racemic flurbiprofen twice daily. Pharmacokinetic parameters showed considerable variability within the group of patients, although differences in S(+)/R(-) plasma concentration ratios w...

journal_title：British journal of clinical pharmacology

authors： Young MA,Aarons L,Toon S

更新日期：1991-01-01 00:00:00

abstract：:One hundred different drug advertisements from each of seven leading medical journals have been assessed. Information about drug interactions, adverse reactions, mode of action, absorption, distribution, metabolism, excretion and cost was seldom provided in UK journals. A requirement should exist that drug advertiseme...

journal_title：British journal of clinical pharmacology

authors： Morgan AH,Jeffers TA,Petrie JC,Walker W

更新日期：1976-12-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Dihydropyrimidine dehydrogenase (DPD) is the enzyme responsible for the elimination of approximately 80% of the administered dose of 5-fluorouracil (5-FU). * Mutations in the DPD-coding gene have been shown to increase the risk of severe toxicity in 5-FU treated patients. * T...

journal_title：British journal of clinical pharmacology

authors： Paré L,Paez D,Salazar J,Del Rio E,Tizzano E,Marcuello E,Baiget M

更新日期：2010-08-01 00:00:00

abstract：:Mirabegron is used for the treatment of symptoms associated with overactive bladder syndrome. It selectively stimulates the β3 -adrenoreceptor, which relaxes the detrusor muscle. This improves urine storage by distension of the bladder body. ...

journal_title：British journal of clinical pharmacology

authors： Goulooze SC,Cohen AF,Rissmann R

更新日期：2015-10-01 00:00:00

abstract：AIMS:Variability in responsiveness to clopidogrel is a clinical problem in secondary prevention after cerebral ischaemia which has been suggested to be linked to competitive metabolization of clopidogrel and cytochrome P450 (CYP) 3A4-oxidated statins such as simvastatin. We assessed the hypothesis that simvastatin, in ...

journal_title：British journal of clinical pharmacology

authors： Siepmann T,Heinke D,Kepplinger J,Barlinn K,Gehrisch S,Grählert X,Schwanebeck U,Reichmann H,Puetz V,Bodechtel U,Gahn G

更新日期：2014-11-01 00:00:00

abstract：:1. Potential therapies for ischaemic stroke include agents to reduce oedema, to improve cerebral perfusion, to reduce excitotoxic damage, to minimise free-radical induced injury and to reduce complications such as deep venous thrombosis. 2. Of the anti-oedema drugs, steroids are ineffective and possibly dangerous; int...

journal_title：British journal of clinical pharmacology

authors： Lees KR

更新日期：1992-12-01 00:00:00

abstract：AIMS:To compare the pharmacokinetics of oseltamivir and oseltamivir carboxylate in hepatically impaired patients and healthy subjects. METHODS:Hepatically impaired patients (n = 11) and healthy subjects (n = 11) were individually paired on the basis of gender, age (+/-10 years) and body weight (+/-20%) and administere...

journal_title：British journal of clinical pharmacology

authors： Snell P,Dave N,Wilson K,Rowell L,Weil A,Galitz L,Robson R

更新日期：2005-05-01 00:00:00

abstract：:1. Labetalol, a new drug combining alpha-and beta-adrenoceptor blocking properties, has been compared with placebo in a double-blind crossover study of a group of patients with mild to moderate essential hypertension (blood pressure 150/100 to 189/114 mmHg). 2. Labetalol and propranolol lowered blood pressure satisfac...

journal_title：British journal of clinical pharmacology

authors： Pugsley DJ,Nassim M,Armstrong BK,Beilin L

更新日期：1979-01-01 00:00:00

abstract：AIMS:Paracetamol-containing combination analgesics are widely prescribed but the use of paracetamol/dextropropoxyphene (co-proxamol) is particularly controversial. We aim to examine the prescribing patterns of the paracetamol-containing analgesics in Ireland. METHODS:A national primary care prescribing database was us...

journal_title：British journal of clinical pharmacology

authors： Usher C,Teeling M,Bennett K,McGowan B,Feely J

更新日期：2005-12-01 00:00:00

abstract：AIMS:To determine the induction effect of rifampicin on the activity of 4'-hydroxylase in poor metabolizers (PMs) with m1 mutation of S-mephenytoin 4'-hydroxylation and the relationship of the effect with gene dose. METHODS:Seven extensive metabolizers (EMs) of S-mephenytoin 4'-hydroxylation and five PMs with m1 mutat...

journal_title：British journal of clinical pharmacology

authors： Feng HJ,Huang SL,Wang W,Zhou HH

更新日期：1998-01-01 00:00:00

abstract：ADVERSE EVENT:A drug interaction leading to higher exposure to cyclosporine. DRUGS IMPLICATED:Cyclosporine and ticagrelor. THE PATIENT:A 49-year-old man with a stable renal graft, managed with cyclosporine with stable trough blood concentrations for several years, was treated with ticagrelor for unstable angina pecto...

journal_title：British journal of clinical pharmacology

authors： van Sloten TT,de Klaver PAG,van den Wall Bake AWL

更新日期：2018-01-01 00:00:00

abstract：:Many studies from around the world show a correlation between increasing age and adverse drug reaction (ADR) rate, at least for some medical conditions. More than 80% of ADRs causing admission or occurring in hospital are type A (dose-related) in nature, and thus predictable from the known pharmacology of the drug and...

journal_title：British journal of clinical pharmacology

authors： Routledge PA,O'Mahony MS,Woodhouse KW

更新日期：2004-02-01 00:00:00

abstract：:1. The objective of this study was to investigate the efficacy of home-medicated non-steroidal anti-inflammatory (NSAID) analgesics, using an electronic patient diary. Single doses of ketoprofen 25 mg and ketoprofen 50 mg were compared with ibuprofen 200 mg and placebo in the treatment of a single occasion of episodic...

journal_title：British journal of clinical pharmacology

authors： van Gerven JM,Schoemaker RC,Jacobs LD,Reints A,Ouwersloot-van der Meij MJ,Hoedemaker HG,Cohen AF

更新日期：1996-10-01 00:00:00

abstract：:The prevalence of putative poor metaboliser (PM) phenotypes of proguanil oxidation in Caucasian populations is 3-10%. The PM frequency in Oriental populations is unknown. In this study the plasma metabolic ratios of proguanil and dapsone to their principal metabolites cycloguanil and monoacetyldapsone were determined ...

journal_title：British journal of clinical pharmacology

authors： Edstein MD,Shanks GD,Teja-Isavadharm P,Rieckmann KH,Webster HK

更新日期：1994-01-01 00:00:00

abstract：AIMS:Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy s...

journal_title：British journal of clinical pharmacology

authors： Singh D,Tal-Singer R,Faiferman I,Lasenby S,Henderson A,Wessels D,Goosen A,Dallow N,Vessey R,Goldman M

更新日期：2006-04-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Nitrates may facilitate syncope through various pathways, but the precise mechanism of nitrate-induced syncope is still under debate. The purpose of the present study was to compare the underlying haemodynamic mechanisms in subjects without and with presyncopal symptoms during a...

journal_title：British journal of clinical pharmacology

authors： Tahvanainen A,Koskela J,Leskinen M,Ilveskoski E,Nordhausen K,Kähönen M,Kööbi T,Mustonen J,Pörsti I

更新日期：2011-01-01 00:00:00

abstract：AIMS:The aims of the study were to characterize the pharmacokinetics (PK) of selumetinib (AZD6244; ARRY-142886), a mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor in clinical development for various indications, and its N-desmethyl metabolite in healthy volunteers, and evaluate clinically important covariat...

journal_title：British journal of clinical pharmacology

authors： Patel P,Howgate E,Martin P,Carlile DJ,Aarons L,Zhou D

更新日期：2018-01-01 00:00:00

abstract：AIMS:Increased exposure to fondaparinux, as observed in patients with renal impairment, may increase bleeding risk. This study aims to determine the time course of major bleeding after major orthopaedic surgery, identify predictors of bleeding and simulate the effect of a reduced dose of fondaparinux on bleeding for pa...

journal_title：British journal of clinical pharmacology

authors： Zufferey PJ,Ollier E,Delavenne X,Laporte S,Mismetti P,Duffull SB

更新日期：2018-10-01 00:00:00

abstract：AIMS:To study reporting of hypoglycaemia in angiotensin receptor blocker (ARB) users, and to investigate the possibility of confounding. METHODS:The French pharmacovigilance database was examined for an association between hypoglycaemia and ARBs or other drugs using reports notified between 1996 and 2005. This associa...

journal_title：British journal of clinical pharmacology

authors： Grégoire F,Pariente A,Fourrier-Reglat A,Haramburu F,Bégaud B,Moore N

更新日期：2008-07-01 00:00:00

abstract：:1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar ...

journal_title：British journal of clinical pharmacology

authors： McNeil JJ,Louis WJ

更新日期：1979-04-01 00:00:00

abstract：:A double-blind, placebo-controlled, cross-over trial of quinine in leg cramps occurring at rest was conducted in 22 elderly cramp sufferers. Despite demonstration of impaired quinine elimination in the elderly, prescription of the traditional dose of 300 mg quinine bisulphate at night failed to produce a significant (...

journal_title：British journal of clinical pharmacology

authors： Warburton A,Royston JP,O'Neill CJ,Nicholson PW,Jee RD,Denham MJ,Dobbs SM,Dobbs RJ

更新日期：1987-04-01 00:00:00

abstract：:Scientific advice (SA) is an important tool offered by regulators to help developers generate robust evidence on a medicine's benefits and risks. Drawing on accumulated experience and looking at the SA provided by the European Medicines Agency in 2018 to advanced therapy medicinal products originally developed by publ...

journal_title：British journal of clinical pharmacology

authors： Tavridou A,Rogers D,Bonelli M,Schiel A,Hidalgo-Simon A

更新日期：2020-11-25 00:00:00

abstract：AIMS:The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate the publicly available data on pregnancy/lactation before and after marketing authorization in Europe of biologics ...

journal_title：British journal of clinical pharmacology

authors： Ghalandari N,Dolhain RJEM,Hazes JMW,Siezen CLE,van der Laan JW,Crijns HJMJ,van Puijenbroek EP,van der Woude CJ

更新日期：2020-03-01 00:00:00

abstract：:1 In an open, randomized cross-over investigation of thirteen patients (nine and four women, aged 37-67 years) with mild or moderate essential hypertension a comparison between atenolol and metoprolol was carried out in order to study the effects of 50, 100 and 200 mg given once daily on blood pressure and heart rate ...

journal_title：British journal of clinical pharmacology

authors： Rasmussen S,Arnung K,Eskildsen PC,Nielsen PE

更新日期：1981-12-01 00:00:00

abstract：:1. Mizolastine, a new benzimidazole derivative with potent selective, non-sedative H1-histamine antagonist activity was compared with terfenadine, cetirizine and loratadine using the histamine-induced wheal and flare model in healthy volunteers. 2. Study design was a five way double-blind crossover design using a sing...

journal_title：British journal of clinical pharmacology

authors： Rosenzweig P,Caplain H,Chaufour S,Ulliac N,Cabanis MJ,Thebault JJ

更新日期：1995-11-01 00:00:00