Attention tasks as skills performance measures of drug effects.

abstract：:1 Cumulative dose-response curves (FEV1) to pressurized aerosol salbutamol were established in 17 patients admitted to hospital with acute severe asthma. After the maximal pressurized aerosol effect had been achieved, a further dose (5 mg) of salbutamol was given by wet nebulizer and any further increment recorded. 2 ...

journal_title：British journal of clinical pharmacology

authors： Tarala RA,Madsen BW,Paterson JW

更新日期：1980-10-01 00:00:00

abstract：:1. Nitric oxide is recognised as an important biological mediator, which is thought to be involved in cardiovascular homeostasis. The purpose of this study was to investigate the effects of basal nitric oxide synthesis on cardiac function in man, by blocking nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA...

journal_title：British journal of clinical pharmacology

authors： Clarkson PB,Lim PO,MacDonald TM

更新日期：1995-10-01 00:00:00

abstract：:1. Six healthy volunteers received single doses of either nomifensine 100 mg, nomifensine 50 mg or placebo at weekly intervals in a randomized double-blind crossover study. 2. Subjects were subjected to a simulated test of car driving at night. 3. Testing lasted about 1.5 h and consisted of measuring responses to ligh...

journal_title：British journal of clinical pharmacology

authors： Hindmarch I

更新日期：1977-01-01 00:00:00

abstract：:1 Measurements have been made of steady state serum phenytoin concentration, serum half-life of (14)C-labelled phenytoin, and the urinary ratio of the major metabolite of phenytoin to the unchanged drug (p-HPPH: DPH ratio) in epileptic patients on and off sulthiame therapy. 2 Starting sulthiame treatment produced an i...

journal_title：British journal of clinical pharmacology

authors： Houghton GW,Richens A

更新日期：1974-02-01 00:00:00

abstract：:1. Oxycodone hydrochloride (0.1 mg kg-1) was given by intravenous bolus to 18 children after ophthalmic surgery. Plasma was sampled for up to 8 h. Blood pressure, heart rate, peripheral arteriolar oxygen saturation, end-tidal carbon dioxide and halothane concentrations and ventilatory rate were also recorded. 2. Mean ...

journal_title：British journal of clinical pharmacology

authors： Olkkola KT,Hamunen K,Seppälä T,Maunuksela EL

更新日期：1994-07-01 00:00:00

abstract：AIMS:We performed a prospective cohort study to gain more insight into risk factors for neuropsychiatric effects of mefloquine among tourists travelling to tropical areas. METHODS:We enrolled all patients who consulted the Travel Clinic of the Havenziekenhuis & Institute for Tropical Diseases Rotterdam for mefloquine ...

journal_title：British journal of clinical pharmacology

authors： van Riemsdijk MM,Sturkenboom MC,Ditters JM,Tulen JH,Ligthelm RJ,Overbosch D,Stricker BH

更新日期：2004-04-01 00:00:00

abstract：:A possible route of metabolism of beta-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the beta-adrenoceptor agonists were ...

journal_title：British journal of clinical pharmacology

authors： Sodha RJ,Schneider H

更新日期：1984-01-01 00:00:00

abstract：:The effects of intravenous boluses of adenosine on respiration and heart rate were compared in young and elderly individuals. Respiratory stimulation and biphasic changes in heart rate were confirmed. The dose-response relationship for the effects of adenosine on respiration and heart-rate did not differ significantly...

journal_title：British journal of clinical pharmacology

authors： Watt AH,Bayer A,Routledge PA,Swift CG

更新日期：1989-02-01 00:00:00

abstract：:The effect of a high potency antacid and food on the bioavailability of famotidine was studied in 17 healthy volunteers in an open randomized three-way cross-over trial. After an overnight fast, famotidine was administered to each subject as follows: 40 mg famotidine orally alone; 40 mg orally with antacid; and 40 mg ...

journal_title：British journal of clinical pharmacology

authors： Lin JH,Chremos AN,Kanovsky SM,Schwartz S,Yeh KC,Kann J

更新日期：1987-10-01 00:00:00

abstract：:1. Hydrochlorothiazide (HCT, 50-75 mg) was administered orally to seven patients with cardiac failure. 2. Plasma levels and urinary concentration of HCT were determined by GLC. 3. The gastrointestinal uptake of the diuretic in three patients was reduced to approximately half that seen in healthy controls. 4. Plasma ha...

journal_title：British journal of clinical pharmacology

authors： Beermann B,Groschinsky-Grind M

更新日期：1979-06-01 00:00:00

abstract：:The present study was designed to evaluate the potential anti-ischaemic activity of R 56865 in patients with coronary artery disease, scheduled to undergo percutaneous transluminal coronary angioplasty (PTCA). At baseline a complete haemodynamic profile, including cardiac output and coronary sinus blood flow (CSBF) wa...

journal_title：British journal of clinical pharmacology

authors： Pijl AJ,Van Wezel HB,Koolen JJ,Piek JJ,Koch K,Swaan A,David GK,Visser CA,Van Zwieten PA

更新日期：1995-05-01 00:00:00

abstract：:Ten healthy normal volunteers received an intravenous infusion of erythromycin lactobionate over 60 min to a total dose of 800 mg (n = 9), and 524 mg (n = 1). Blood samples were collected at 10 min intervals for 100 min and gastric contents aspirated, via a nasogastric tube, from pre-dose to 105 min after start of inf...

journal_title：British journal of clinical pharmacology

authors： Downey KM,Chaput de Saintonge DM

更新日期：1986-03-01 00:00:00

abstract：AIMS:Previously published pharmacokinetic (PK) models for sunitinib and its active metabolite SU12662 were based on a limited dataset or lacked important elements such as correlations between sunitinib and its metabolite. The current study aimed to develop an improved PK model that circumvented these limitations and to...

journal_title：British journal of clinical pharmacology

authors： Yu H,Steeghs N,Kloth JS,de Wit D,van Hasselt JG,van Erp NP,Beijnen JH,Schellens JH,Mathijssen RH,Huitema AD

更新日期：2015-05-01 00:00:00

abstract：AIM:To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of the highly selective oral p38alpha/beta mitogen-activated protein (MAP) kinase inhibitor Org 48,775-0 in a first-in-human study. METHODS:In the single ascending dosing (SAD) study, an oral dose of Org 48,775-0 (0.3-600 mg) was evalua...

journal_title：British journal of clinical pharmacology

authors： Moerland M,Kales AJ,Broekhuizen K,Nässander U,Nelissen R,de Kam ML,Peeters PAM,Burggraaf J

更新日期：2020-11-17 00:00:00

abstract：AIMS:This study compares physicians' recall of the claims of benefits on cardiovascular disease and diabetes made by pharmaceutical sales representatives for drugs approved on the basis of a surrogate outcome, i.e., an off-label claim, compared with those approved on the basis of a serious morbidity or mortality (clini...

journal_title：British journal of clinical pharmacology

authors： Habibi R,Lexchin J,Mintzes B,Holbrook A

更新日期：2017-11-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rosiglitazone is able to increase serum adiponectin levels significantly in Type 2 diabetic patients. :The role of genetic factors that determine the marked interindividual variability in glucose-lowering efficacy of rosiglitazone in Chinese patients is not known. The current st...

journal_title：British journal of clinical pharmacology

authors： Sun H,Gong ZC,Yin JY,Liu HL,Liu YZ,Guo ZW,Zhou HH,Wu J,Liu ZQ

更新日期：2008-06-01 00:00:00

abstract：:1. Quinidine is a potent inhibitor of the genetically-determined debrisoquine 4-hydroxylation. Oxidation reactions of several other drugs, including the 5-hydroxylation of the new antiarrhythmic drug propafenone, depend on the isozyme responsible for debrisoquine 4-hydroxylation. 2. The effect of quinidine on the debr...

journal_title：British journal of clinical pharmacology

authors： Funck-Brentano C,Kroemer HK,Pavlou H,Woosley RL,Roden DM

更新日期：1989-04-01 00:00:00

abstract：:1. In order to assess attitudes of patients to participation in therapeutic trials 197 patients underwent structured interviews conducted by a single observer. Of these patients 66 were previous or current participants in clinical trials (group A), 12 had declined participation in a trial (group B), and 119 had never ...

journal_title：British journal of clinical pharmacology

authors： Bevan EG,Chee LC,McGhee SM,McInnes GT

更新日期：1993-02-01 00:00:00

abstract：AIMS:Increased exposure to fondaparinux, as observed in patients with renal impairment, may increase bleeding risk. This study aims to determine the time course of major bleeding after major orthopaedic surgery, identify predictors of bleeding and simulate the effect of a reduced dose of fondaparinux on bleeding for pa...

journal_title：British journal of clinical pharmacology

authors： Zufferey PJ,Ollier E,Delavenne X,Laporte S,Mismetti P,Duffull SB

更新日期：2018-10-01 00:00:00

abstract：AIMS:To investigate the extent of dose-related off-label antibiotic paediatric prescribing in primary care and to identify any potential clinical effects, particularly of lower than recommended dose prescribing. METHODS:Assessment of antibiotic prescribing in 168 396 children aged 0-16 years for the year 1999-2000 fro...

journal_title：British journal of clinical pharmacology

authors： Ekins-Daukes S,McLay JS,Taylor MW,Simpson CR,Helms PJ

更新日期：2003-07-01 00:00:00

abstract：:1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose rela...

journal_title：British journal of clinical pharmacology

authors： Clark RA,Holdsworth CD,Rees MR,Howlett PJ

更新日期：1980-12-01 00:00:00

abstract：:1. Dilevalol (R,R-labetalol) is a non-selective beta-adrenoceptor antagonist with beta 2-adrenoceptor agonist activity. Its effects after 1 month's administration on heart rate, blood pressure and muscle blood flow were studied in a double-blind crossover comparison with nifedipine in 16 hypertensive patients. 2. Dile...

journal_title：British journal of clinical pharmacology

authors： Walley T,Tsao Y,Scott A,Mackay E,Vandenburg M,Breckenridge A

更新日期：1993-06-01 00:00:00

abstract：:The safety of trial subjects is the tenet that guides the regulatory assessment of a Clinical Trial Authorization application and applies equally to trials involving small molecules and those with biological/biotechnological products, including Advanced Therapy Medicinal Products. The objective of a regulator is to en...

journal_title：British journal of clinical pharmacology

authors： Jones DR,McBlane JW,McNaughton G,Rajakumaraswamy N,Wydenbach K

更新日期：2013-08-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:The dominant health economic units upon which new treatment funding decisions are made are the incremental cost per life year gained (LYG) or the cost per quality-adjusted life year (QALY) gained. Neither of these units modifies the amount of health gained, by the amount of heal...

journal_title：British journal of clinical pharmacology

authors： Camidge DR,Oliver JJ,Skinner C,Attwood B,Nussey F,Jodrell D,Webb DJ

更新日期：2008-02-01 00:00:00

abstract：:1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxy...

journal_title：British journal of clinical pharmacology

authors： Leonard BE

更新日期：1978-01-01 00:00:00

abstract：AIMS:Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head-to-head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors. METHODS:Using an appropriate search strategy, randomized controlled trial...

journal_title：British journal of clinical pharmacology

authors： Sridharan K,Sivaramakrishnan G

更新日期：2018-03-01 00:00:00

abstract：AIMS:The aim of this study was to compare the effects of the ACE-inhibitor lisinopril and the angiotensin II receptor antagonist losartan on insulin sensitivity in the treatment of non diabetic hypertensives. METHODS:Twenty-five non diabetic subjects with mild to moderate hypertension, 11 females and 14 males, aged 44...

journal_title：British journal of clinical pharmacology

authors： Fogari R,Zoppi A,Corradi L,Lazzari P,Mugellini A,Lusardi P

更新日期：1998-11-01 00:00:00

abstract：:1. We have measured [3H]-ouabain binding to lymphocyte membranes in eight healthy volunteers before and after they had taken lithium carbonate for 14 days in doses which maintained the serum lithium concentration in the range 0.5-1.0 mmol 1-1. 2. There was a statistically significant increase in the [3H]-ouabain bindi...

journal_title：British journal of clinical pharmacology

authors： Antia IJ,Dorkins CE,Wood AJ,Aronson JK

更新日期：1992-12-01 00:00:00

abstract：AIMS:The aim of this work is to understand the process of drug administration and identify points in the workflow that resulted in interventions by clinical information systems in order to improve patient safety. METHODS:To identify a generic way to structure the drug administration process we performed peer-group dis...

journal_title：British journal of clinical pharmacology

authors： Seidling HM,Lampert A,Lohmann K,Schiele JT,Send AJ,Witticke D,Haefeli WE

更新日期：2013-09-01 00:00:00

abstract：AIMS:To test the existence of an association between reports of hypoglycaemia and angiotensin converting enzyme inhibitors, in a spontaneous reports database. METHODS:The French Pharmacovigilance database was examined for an association between adverse drug reaction reports mentioning hypoglycaemia, and angiotensin co...

journal_title：British journal of clinical pharmacology

authors： Moore N,Kreft-Jais C,Haramburu F,Noblet C,Andrejak M,Ollagnier M,Bégaud B

更新日期：1997-11-01 00:00:00