A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

abstract：:Children are not small adults. However, the main thesis of this review will be that children's responses to drugs have much in common with the responses in adults and indeed in other mammals. Often, it is assumed that drug effects differ in children but in reality this perception often arises because the drugs have no...

journal_title：British journal of clinical pharmacology

authors： Stephenson T

更新日期：2005-06-01 00:00:00

abstract：:1 To compare the haemodynamic effects of secondary characteristics of beta-adrenoceptor blockers with an angiotensin converting enzyme inhibitor forty patients with previously untreated mild to moderate hypertension were prescribed either atenolol 50-100 mg day-1, labetalol 200-800 mg day-1, pindolol 10-30 mg day-1 or...

journal_title：British journal of clinical pharmacology

authors： Roberts DH,Tsao Y,Grimmer SF,Winstanley PA,Orme ML,Breckenridge AM

更新日期：1987-08-01 00:00:00

abstract：AIMS:To investigate the relationships between pretreatment folate concentrations, MTX pharmacokinetics and acute toxicities following high dose methotrexate (HD MTX) therapy. METHODS:MTX and its major extracellular metabolite 7-OH-MTX were measured in eight serum samples per HD MTX cycle in 65 consecutive osteosarcoma...

journal_title：British journal of clinical pharmacology

authors： Holmboe L,Andersen AM,Mørkrid L,Slørdal L,Hall KS

更新日期：2012-01-01 00:00:00

abstract：AIMS:It is estimated that two-thirds of cancer patients will at some point during their illness experience breakthrough pain. In this study, the pharmacokinetics of a novel sublingual dosage form of fentanyl developed for breakthrough pain was evaluated. METHODS:Eleven Caucasian patients (seven male and 4 female, aged...

journal_title：British journal of clinical pharmacology

authors： Lennernäs B,Hedner T,Holmberg M,Bredenberg S,Nyström C,Lennernäs H

更新日期：2005-02-01 00:00:00

abstract：AIMS:The objective of this study was to estimate the number of fractures attributed to oral corticosteroid use. METHODS:Information was obtained from the General Practice Research Database which contains medical records of general practitioners in the UK. The total number of corticosteroid-related fractures during a c...

journal_title：British journal of clinical pharmacology

authors： van Staa TP,Abenhaim L,Cooper C,Zhang B,Leufkens HG

更新日期：2001-06-01 00:00:00

abstract：:Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reactio...

journal_title：British journal of clinical pharmacology

authors： Krueger H,Müller-Limmroth W

更新日期：1983-01-01 00:00:00

abstract：:1 A treatment group comprising 635 hypertensive men (casual SBP greater than 175 or DBP greater than 115 twice) was compared with a reference group (n = 391 men; casual SBP greater than 175 or DBP greater than 115 only at screening). All men belonged to the same population sample of 7,455 men aged 47-54 yr. 2 The two ...

journal_title：British journal of clinical pharmacology

authors： Wilhelmsen L,Berglund G,Sannerstedt R,Hansson L,Andersson O,Sievertsson R,Wikstrand J

更新日期：1979-01-01 00:00:00

abstract：:1 Self-poisoning with a selective weedkiller containing 2,4-D and mecoprop in a 39 year old man resulted in prolonged deep coma, pyrexia, hyperventilation, hypoxaemia, myotonia, skeletal muscle damage and electrocardiographic changes consistent with cardiomyopathy. 2 The admission plasma concentrations of 2,4-D and me...

journal_title：British journal of clinical pharmacology

authors： Prescott LF,Park J,Darrien I

更新日期：1979-01-01 00:00:00

abstract：AIMS:To determine whether topical ocular chloramphenicol increases the risk of aplastic anaemia and to estimate the magnitude of this risk, if any. METHODS:Population-based prospective case-control surveillance of aplastic anaemia in a community of 4.2 million inhabitants from 1980 to 1995 (67.2 million person-years) ...

journal_title：British journal of clinical pharmacology

authors： Laporte JR,Vidal X,Ballarín E,Ibáñez L

更新日期：1998-08-01 00:00:00

abstract：AIMS:Rifampicin profoundly reduces lopinavir concentrations. Doubled doses of lopinavir/ritonavir compensate for the effect of rifampicin in adults, but fail to provide adequate lopinavir concentrations in young children on rifampicin-based antituberculosis therapy. The objective of this study was to develop a populati...

journal_title：British journal of clinical pharmacology

authors： Zhang C,Denti P,Decloedt EH,Ren Y,Karlsson MO,McIlleron H

更新日期：2013-11-01 00:00:00

abstract：:A potential kinetic interaction between cimetidine and flecainide has been studied in eight healthy males receiving flecainide (200 mg) orally on three occasions: before any treatment and on day 2 and day 7 of 8 days' cimetidine maintenance treatment at 1 g daily. Six days pretreatment with cimetidine induced the foll...

journal_title：British journal of clinical pharmacology

authors： Tjandra-Maga TB,van Hecken A,van Melle P,Verbesselt R,de Schepper PJ

更新日期：1986-07-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate whether differences in total and peak drug exposure upon generic substitution are due to differences between formulations or to intrasubject pharmacokinetic variability of the active substance. METHODS:The study was designed as a retrospective reanalysis of existing...

journal_title：British journal of clinical pharmacology

authors： Yu Y,Teerenstra S,Neef C,Burger D,Maliepaard M

更新日期：2016-04-01 00:00:00

abstract：AIMS:Major bleeding complications with low-molecular-weight heparin (LMWH) treatment have been reported both in clinical studies and during postmarketing surveillance. Monitoring of antifactor Xa (anti-Xa) activities is therefore recommended in special populations often predisposed to renal impairment. The PROPHRE.75 s...

journal_title：British journal of clinical pharmacology

authors： Berges A,Laporte S,Epinat M,Zufferey P,Alamartine E,Tranchand B,Decousus H,Mismetti P,PROPHRE.75 Study Group.

更新日期：2007-10-01 00:00:00

abstract：:1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose rela...

journal_title：British journal of clinical pharmacology

authors： Clark RA,Holdsworth CD,Rees MR,Howlett PJ

更新日期：1980-12-01 00:00:00

abstract：AIMS:Canagliflozin is a recently approved drug for use in the treatment of type 2 diabetes. The potential for canagliflozin to cause clinical drug-drug interactions (DDIs) was assessed. METHODS:DDI potential of canagliflozin was investigated using in vitro test systems containing drug metabolizing enzymes or transport...

journal_title：British journal of clinical pharmacology

authors： Mamidi RNVS,Dallas S,Sensenhauser C,Lim HK,Scheers E,Verboven P,Cuyckens F,Leclercq L,Evans DC,Kelley MF,Johnson MD,Snoeys J

更新日期：2017-05-01 00:00:00

abstract：AIMS:To investigate the pharmacokinetics of enterally administered cisapride suspension in young infants being treated for gastro-oesophageal reflux disease. METHODS:Plasma cisapride concentrations in 49 subjects (weight: 825-5010 g; n=108 samples, median two per patient; concentration: 14.8-170 ng ml-1 ) were fitted ...

journal_title：British journal of clinical pharmacology

authors： Preechagoon Y,Charles B,Piotrovskij V,Donovan T,Van Peer A

更新日期：1999-11-01 00:00:00

abstract：:1. Nitric oxide is recognised as an important biological mediator, which is thought to be involved in cardiovascular homeostasis. The purpose of this study was to investigate the effects of basal nitric oxide synthesis on cardiac function in man, by blocking nitric oxide synthesis with NG-monomethyl-L-arginine (L-NMMA...

journal_title：British journal of clinical pharmacology

authors： Clarkson PB,Lim PO,MacDonald TM

更新日期：1995-10-01 00:00:00

abstract：AIMS:To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). METHODS:In Part 1 of this Phase I, randomized, double-blind, placebo-c...

journal_title：British journal of clinical pharmacology

authors： Nnane I,Frederick B,Yao Z,Raible D,Shu C,Badorrek P,van den Boer M,Branigan P,Duffy K,Baribaud F,Fink D,Yang TY,Xu Z

更新日期：2020-12-01 00:00:00

abstract：:1. Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. ...

journal_title：British journal of clinical pharmacology

authors： Habermann W

更新日期：1977-01-01 00:00:00

abstract：AIMS:There are no specific criteria for a step-down or withdrawal dose of omalizumab (OMA). Our purpose was to evaluate the viability of a protocol for OMAlizumab DOse REduction (the OMADORE study) in severe allergic asthma (SAA). METHODS:The study population included 35 SAA patients treated during a minimum period of...

journal_title：British journal of clinical pharmacology

authors： Domingo C,Pomares X,Navarro A,Amengual MJ,Montón C,Sogo A,Mirapeix RM

更新日期：2018-02-01 00:00:00

abstract：AIMS:To study the pharmacokinetics and bioavailability of the prodrug bambuterol and its bronchodilator moiety terbutaline in healthy subjects. METHODS:Eight healthy subjects (four women) received intravenous doses of bambuterol and terbutaline. On a third occasion, they, plus another four subjects, ingested oral bamb...

journal_title：British journal of clinical pharmacology

authors： Nyberg L,Rosenborg J,Weibull E,Jönsson S,Kennedy BM,Nilsson M

更新日期：1998-05-01 00:00:00

abstract：AIMS:This double-blind, randomized, four-period, two-way crossover study was conducted to evaluate the acute effects of oral sildenafil (100-mg single dose) on sperm motility, count, density, morphology and vitality as well as ejaculate volume and viscosity in healthy male subjects. The concentrations of sildenafil and...

journal_title：British journal of clinical pharmacology

authors： Purvis K,Muirhead GJ,Harness JA

更新日期：2002-01-01 00:00:00

abstract：:Small GTPases of the Rho family and their down-stream effectors Rho associated kinases (ROCKs) are the molecules that converge a spectrum of pathophysiological signals triggered by the diabetic milieu and represent promising molecular targets for nephroprotective treatment in diabetes. The review discusses recent stud...

journal_title：British journal of clinical pharmacology

authors： Komers R

更新日期：2013-10-01 00:00:00

abstract：AIMS:To characterize milk/plasma (M/P) ratio and infant dose, for venlafaxine (V) and its O-desmethyl metabolite (ODV), in breastfeeding women taking venlafaxine for the treatment of depression, and to determine the plasma concentration and effects of these drugs in their infants. METHODS:Six women (mean age 34.5 year...

journal_title：British journal of clinical pharmacology

authors： Ilett KF,Kristensen JH,Hackett LP,Paech M,Kohan R,Rampono J

更新日期：2002-01-01 00:00:00

abstract：:1 A study was carried out to investigate the possible contribution of prostaglandins in captopril-induced hypotension. 2 Healthy volunteers and patients with essential hypertension were given single oral doses of 25 mg and 50 mg captopril respectively before and after cyclo-oxygenase inhibition with indomethacin. 3 Th...

journal_title：British journal of clinical pharmacology

authors： Silberbauer K,Stanek B,Templ H

更新日期：1982-01-01 00:00:00

abstract：:Paracetamol overdose prior to the introduction of acetylcysteine was associated with significant morbidity. Acetylcysteine is now the mainstay of treatment for paracetamol poisoning and has effectively reduced rates of hepatotoxicity and death. The current three-bag intravenous regimen with an initial high loading dos...

journal_title：British journal of clinical pharmacology

authors： Chiew AL,Isbister GK,Duffull SB,Buckley NA

更新日期：2016-03-01 00:00:00

abstract：:The possibility that vigabatrin (VGB) decreases serum phenytoin (PHT) concentration by lowering the oral bioavailability of PHT was investigated in 21 patients with epilepsy. Each patient was switched from oral to intravenous PHT for 5 days before and after combined treatment with VGB. After VGB (2-3.5 g day(-1) for a...

journal_title：British journal of clinical pharmacology

authors： Gatti G,Bartoli A,Marchiselli R,Michelucci R,Tassinari CA,Pisani F,Zaccara G,Timmings P,Richens A,Perucca E

更新日期：1993-12-01 00:00:00

abstract：:It is recognised that randomised controlled trials are not feasible for capturing rare adverse events. There is an increasing trend towards observational research methodologies using large population-based health databases. These databases offer more scope for adequate sample sizes, allowing for comprehensive patient ...

journal_title：British journal of clinical pharmacology

authors： Chan EW,Liu KQ,Chui CS,Sing CW,Wong LY,Wong IC

更新日期：2015-10-01 00:00:00

abstract：:Ouabain inhibits endothelium-dependent vascular relaxation in vitro, but has not been studied in this regard in vivo. We have therefore measured blood flow responses to carbachol, bradykinin and sodium nitroprusside (endothelium-dependent and endothelium-independent vasodilators) infused into the brachial artery with ...

journal_title：British journal of clinical pharmacology

authors： Woolfson RG,Benjamin N,Todd SD,Poston L,Ritter JM

更新日期：1991-12-01 00:00:00

abstract：AIMS:In man a neurokinin-1 (NK1) receptor antagonist has previously been shown to be ineffective in the prevention of motion-induced nausea. The antiemetic efficacy of NK1 receptor antagonists against chemotherapy-induced emesis is, however, enhanced when combined with a 5-HT3 receptor antagonist. Hence the efficacy of...

journal_title：British journal of clinical pharmacology

authors： Reid K,Palmer JL,Wright RJ,Clemes SA,Troakes C,Somal HS,House F,Stott JR

更新日期：2000-07-01 00:00:00