Treatment of severe 2,4-D and mecoprop intoxication with alkaline diuresis.

abstract：:1 The pharmacokinetics of diazepam following intravenous administration have been investigated in six normal volunteers and nine epileptic patients receiving chronic antiepileptic drug therapy. 2 After intravenous administration, serum diazepam levels declined biexponentially in all subjects. The elimination half-life...

journal_title：British journal of clinical pharmacology

authors： Dhillon S,Richens A

更新日期：1981-12-01 00:00:00

abstract：:1. The effects of benzhexol on the absorption and pharmacokinetics of an oral dose of levodopa have been studied in 10 young healthy volunteers. Subjects were given a suspension of levodopa (250 mg) 90 min after either benzhexol (5 mg) or placebo in a randomized cross over design with doses separated by at least 1 wee...

journal_title：British journal of clinical pharmacology

authors： Roberts J,Waller DG,von Renwick AG,O'Shea N,Macklin BS,Bulling M

更新日期：1996-04-01 00:00:00

abstract：:1. The aromatic 2-hydroxylation of imipramine was studied in microsomes from three human livers. The kinetics were best described by a biphasic enzyme model. The estimated values of Vmax and Km for the high affinity site ranged from 3.2 to 5.7 nmol mg-1 h-1 and from 25 to 31 microM, respectively. 2. Quinidine was a po...

journal_title：British journal of clinical pharmacology

authors： Skjelbo E,Brøsen K

更新日期：1992-09-01 00:00:00

abstract：AIMS:Aprepitant and fosaprepitant, commonly used for the prevention of chemotherapy-induced nausea and vomiting, alter cytochrome P450 activity. This systematic review evaluates clinically significant pharmacokinetic drug interactions with aprepitant and fosaprepitant and describes adverse events ascribed to drug inter...

journal_title：British journal of clinical pharmacology

authors： Patel P,Leeder JS,Piquette-Miller M,Dupuis LL

更新日期：2017-10-01 00:00:00

abstract：:1. A double-blind, four period crossover study was undertaken to test for an interaction between single oral doses of nifedipine retard (20 mg) and lisinopril (20 mg) in normal subjects. 2. Side effects with both drugs were mild and the incidence was additive. 3. Blood pressure (BP) was lowered by nifedipine for 4 h, ...

journal_title：British journal of clinical pharmacology

authors： Lees KR,Reid JL

更新日期：1988-03-01 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions as a key regulator of cell growth, division and survival. Many haematologic malignancies exhibit elevated or aberrant mTOR activation, supporting the launch of numerous clinical trials aimed at evaluating the potential of single agent m...

journal_title：British journal of clinical pharmacology

authors： Lee JS,Vo TT,Fruman DA

更新日期：2016-11-01 00:00:00

abstract：:High consumption of irrational fixed-dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin-cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulat...

journal_title：British journal of clinical pharmacology

authors： Sayer B,Bortone B,Sharland M,Hsia Y

更新日期：2020-12-23 00:00:00

abstract：:1. N-hydroxylation is thought to be an essential step in the haemotoxicity of dapsone (DDS). To investigate both metabolism-dependent and cell-selective drug toxicity in vitro we have developed a three-compartment system in which an hepatic drug metabolizing system is contained within a central compartment separated b...

journal_title：British journal of clinical pharmacology

authors： Tingle MD,Park BK

更新日期：1993-07-01 00:00:00

abstract：AIMS:Generic products can be regarded as therapeutically equivalent and switchable with the reference product. However, switchability between generics is unknown, as direct comparisons between generics are not performed. The aim of this study was to investigate the bioequivalence between generic clopidogrel products by...

journal_title：British journal of clinical pharmacology

authors： Pejčić Z,Vučićević K,García-Arieta A,Miljković B

更新日期：2019-09-01 00:00:00

abstract：AIMS:A systematic review of the literature published in English over 10 years was undertaken in order to describe the use of electronic healthcare data in the identification of potential adverse drug reactions (ADRs) in children. METHODS:MEDLINE and EMBASE were searched using MESH headings and text words. Titles, keyw...

journal_title：British journal of clinical pharmacology

authors： Black C,Tagiyeva-Milne N,Helms P,Moir D

更新日期：2015-10-01 00:00:00

abstract：:The possibility that vigabatrin (VGB) decreases serum phenytoin (PHT) concentration by lowering the oral bioavailability of PHT was investigated in 21 patients with epilepsy. Each patient was switched from oral to intravenous PHT for 5 days before and after combined treatment with VGB. After VGB (2-3.5 g day(-1) for a...

journal_title：British journal of clinical pharmacology

authors： Gatti G,Bartoli A,Marchiselli R,Michelucci R,Tassinari CA,Pisani F,Zaccara G,Timmings P,Richens A,Perucca E

更新日期：1993-12-01 00:00:00

abstract：AIMS:The aim of this study was to examine the use of potentially inappropriate medication (PIM) in relation to time before death, to explore whether PIMs are discontinued at the end of life, and the factors associated with this discontinuation. METHODS:We conducted a retrospective register-based mortality cohort study...

journal_title：British journal of clinical pharmacology

authors： Paque K,De Schreye R,Elseviers M,Vander Stichele R,Pardon K,Dilles T,Christiaens T,Deliens L,Cohen J

更新日期：2019-04-01 00:00:00

abstract：:The effects of epanolol (200 mg once daily) and diltiazem (60 mg three times daily) on the response of atrial natriuretic peptide (ANP) to exercise were investigated in a double-blind placebo-controlled crossover study in 16 patients with angina pectoris. Exercise tolerance as assessed by peak oxygen consumption was s...

journal_title：British journal of clinical pharmacology

authors： Riley M,Elborn JS,Onuoha G,Erwin C,Shaw C,Khan MM,Stanford CF,Nicholls DP

更新日期：1993-02-01 00:00:00

abstract：:1 The absorption of effervescent aspirin was studied in normal volunteers of both sexes under varied conditions of activity in both fasting and non-fasting states. 2 Moderate activity resulted in no significant changes in absorption compared with that at rest. 3 In non-fasting subjects the absorption was reduced but t...

journal_title：British journal of clinical pharmacology

authors： Volans GN

更新日期：1974-04-01 00:00:00

abstract：AIMS:6-mercaptopurine (6-MP) is used in the treatment of childhood acute lymphoblastic leukaemia (ALL). Its red blood cell (RBC) metabolite concentrations (6-thioguanine [6-TGN] and 6-methylmercaptopurine nucleotides [6-MMPN]) are related to drug response. We investigated the impact of non-genetic covariates and pharma...

journal_title：British journal of clinical pharmacology

authors： Adam de Beaumais T,Fakhoury M,Medard Y,Azougagh S,Zhang D,Yakouben K,Jacqz-Aigrain E

更新日期：2011-04-01 00:00:00

abstract：AIMS:To evaluate putative associations between drugs and dilated cardiomyopathy. METHODS:We used the case/noncase method in the French PharmacoVigilance Database (FPVD). Cases were all the observations with dilated cardiomyopathy registered into the FPVD between 1 January 1990 and 30 June 2007. Noncases were all other...

journal_title：British journal of clinical pharmacology

authors： Montastruc G,Favreliere S,Sommet A,Pathak A,Lapeyre-Mestre M,Perault-Pochat MC,Montastruc JL,French Association of Regional PharmacoVigilance Centres.

更新日期：2010-03-01 00:00:00

abstract：:1. Mono(ADP-ribosyl)transferase activity has been identified on the external surface of human polymorphonuclear neutrophil leucocytes (PMNs). The enzyme is released from the plasma membrane by phosphoinositide-specific phospholipase C, suggesting a glycosylphosphatidylinositol (GPI) linkage of the enzyme to the plasma...

journal_title：British journal of clinical pharmacology

authors： Allport JR,Donnelly LE,Kefalas P,Lo G,Nunn A,Yadollahi-Farsani M,Rendell NB,Murray S,Taylor GW,MacDermot J

更新日期：1996-07-01 00:00:00

abstract：:1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxida...

journal_title：British journal of clinical pharmacology

authors： Richens A,Nawishy S,Trimble M

更新日期：1983-01-01 00:00:00

abstract：:We define a me-too drug as a pharmacologically active compound that is structurally related to a first-in-class compound, regarded as belonging to the same therapeutic class as the original compound, and used for the same therapeutic purposes, but which may differ in some respects, such as specificity of pharmacologic...

journal_title：British journal of clinical pharmacology

authors： Aronson JK,Green AR

更新日期：2020-11-01 00:00:00

abstract：:1. The pharmacokinetics of recombinant erythropoietin, r-Epo, were evaluated after intravenous and subcutaneous administration of 50 u kg-1 to six healthy male volunteers. 2. The calculated mean values (+/- s.d.) for volume of distribution at steady state and clearance after an i.v. dose were 76 (+/- 33) ml kg-1 and 1...

journal_title：British journal of clinical pharmacology

authors： Salmonson T,Danielson BG,Wikström B

更新日期：1990-06-01 00:00:00

abstract：:1. In order to investigate accurately the biochemical effects of renin inhibition in man, we have developed a sensitive assay to measure angiotensin I (1-10) decapeptide. 2. Angiotensins were extracted from plasma by adsorption to phenylsilylsilica, and angiotensin I (Ang I) was quantified by radioimmunoassay. The det...

journal_title：British journal of clinical pharmacology

authors： Chauveau D,Guyenne TT,Cumin F,Chatellier G,Corvol P,Ménard J

更新日期：1992-03-01 00:00:00

abstract：AIMS:Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results in preclinical sepsis models. In the present study, we investigated the safety, tolerabil...

journal_title：British journal of clinical pharmacology

authors： Geven C,van Lier D,Blet A,Peelen R,Ten Elzen B,Mebazaa A,Kox M,Pickkers P

更新日期：2018-09-01 00:00:00

abstract：:1. Changes in undergraduate medical education will involve the development of a core curriculum of material of essential knowledge and of the skills for self directed learning both as a student and a postgraduate. A survey of departments or individuals teaching clinical pharmacology and therapeutics was conducted to c...

journal_title：British journal of clinical pharmacology

authors： Walley T,Bligh J,Orme M,Breckenridge A

更新日期：1994-02-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effect of policosanol on the susceptibility of LDL-C to in vitro lipid peroxidation in human healthy volunteers. METHODS:The effect of policosanol (5 and 10 mg day(-1) on LDL-C oxidation was studied in a double-blind, randomized, placebo-controlled trial conducted in 6...

journal_title：British journal of clinical pharmacology

authors： Menéndez R,Más R,Amor AM,González RM,Fernández JC,Rodeiro I,Zayas M,Jiménez S

更新日期：2000-09-01 00:00:00

abstract：:1 Cardiovascular responses to intravenous prizidilol hydrochloride (SK&F 92657) 0.86 mg/kg were studied in eight supine resting healthy volunteers. Five subjects were slow and the remaining three were fast acetylators of sulphamethazine. Compared with pre-infusion values, mean resting systolic and diastolic blood pres...

journal_title：British journal of clinical pharmacology

authors： Edmonstone WM,Manghani KK,Bell AJ,McLeod M,Milton-Thompson GJ,Burland WL

更新日期：1981-10-01 00:00:00

abstract：:1. We have compared acute gastric bleeding caused by a new slow release preparation of indomethacin (indomethacin Continus) with that caused by aspirin and other indomethacin preparations. 2. In a randomized crossover study, blood loss into timed gastric aspirates was determined in 20 healthy volunteers after receivin...

journal_title：British journal of clinical pharmacology

authors： Prichard PJ,Poniatowska TJ,Willars JE,Ravenscroft AT,Hawkey CJ

更新日期：1988-08-01 00:00:00

abstract：:The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-blind crossover trial using an automated psychomotor test battery (APT), postural sway (PS), blood pressure (BP) and puls...

journal_title：British journal of clinical pharmacology

authors： Kinirons MT,Jackson SH,Kalra L,Trevit RT,Swift CG

更新日期：1993-10-01 00:00:00

abstract：:1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar ...

journal_title：British journal of clinical pharmacology

authors： McNeil JJ,Louis WJ

更新日期：1979-04-01 00:00:00

abstract：:1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 ...

journal_title：British journal of clinical pharmacology

authors： Gazzard BG,Willison RA,Weston MJ,Thompson RP,Williams R

更新日期：1974-06-01 00:00:00

abstract：AIMS:The aim of the present study was to investigate whether differences in total and peak drug exposure upon generic substitution are due to differences between formulations or to intrasubject pharmacokinetic variability of the active substance. METHODS:The study was designed as a retrospective reanalysis of existing...

journal_title：British journal of clinical pharmacology

authors： Yu Y,Teerenstra S,Neef C,Burger D,Maliepaard M

更新日期：2016-04-01 00:00:00