High dose methotrexate chemotherapy: pharmacokinetics, folate and toxicity in osteosarcoma patients.

abstract：:Activated platelets stimulate thrombus formation in response to rupture of an atherosclerotic plaque or endothelial cell erosion, promoting atherothrombotic disease. Multiple pathways contribute to platelet activation. Aspirin, an irreversible inhibitor of thromboxane A2 synthesis, in combination with clopidogrel, an ...

journal_title：British journal of clinical pharmacology

authors： Tello-Montoliu A,Tomasello SD,Ueno M,Angiolillo DJ

更新日期：2011-10-01 00:00:00

abstract：AIMS:To assess the age-associated changes over time of plasma paraxanthine/caffeine (PAX/CAF) ratios used as a probe for CYP1A2 activity. METHODS:Intraindividual and interindividual variabilities in PAX/CAF ratio were compared by phenotyping with caffeine, 16 young and 16 elderly healthy subjects on five occasions. R...

journal_title：British journal of clinical pharmacology

authors： Simon T,Becquemont L,Hamon B,Nouyrigat E,Chodjania Y,Poirier JM,Funck-Brentano C,Jaillon P

更新日期：2001-11-01 00:00:00

abstract：:1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1. 2. Resting heart rate fell from 78 to 74 beats min-1 (P less than 0.0...

journal_title：British journal of clinical pharmacology

authors： Virk SJ,Davies MK

更新日期：1989-01-01 00:00:00

abstract：:1. The inhibitory effect of sufotidine, a new histamine H2-receptor antagonist, on gastric secretion of acid and pepsin was studied in six healthy male volunteers. This was a three-way, cross-over, randomized, double-blind study. On each of 3 study days, the drug in a dose of 600 mg, or placebo, was administered eithe...

journal_title：British journal of clinical pharmacology

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：:1. A double-blind placebo-controlled study was conducted on the effects of oral terbutaline (beta 2-adrenoceptor agonist) and propranolol (beta 1 beta 2-adrenoceptor antagonist) on basal heat production of skeletal muscle, measured ex vivo by direct microcalorimetry. Terbutaline slow-release 7.5 mg, propranolol 80 mg,...

journal_title：British journal of clinical pharmacology

authors： Fagher B,Liedholm H,Sjögren A,Monti M

更新日期：1993-06-01 00:00:00

abstract：:1 The concentrations of cyclophosphamide in plasma and saliva were determined in seven patients following administration of single doses of cyclophosphamide during chemotherapy for lymphoma. 2 The saliva/plasma ratio was 0.77 +/- 0.24 (s.d.) and showed no time-dependence being rapidly established following intravenous...

journal_title：British journal of clinical pharmacology

authors： Juma FD,Rogers HJ,Trounce JR

更新日期：1979-11-01 00:00:00

abstract：:The kinetics of a single 0.5 mg oral dose of the triazolobenzodiazepine hypnotic triazolam, were studied in 54 healthy young men aged 20-44 years, with a mean body weight of 77 kg. Triazolam kinetics were determined from multiple plasma concentrations measured during 14 h post-dose. The overall mean +/- s.e. mean (wit...

journal_title：British journal of clinical pharmacology

authors： Friedman H,Greenblatt DJ,Burstein ES,Harmatz JS,Shader RI

更新日期：1986-12-01 00:00:00

abstract：:Simultaneous cerebrospinal fluid (CSF), total and free plasma valproic acid (VPA) concentrations were measured in 17 patients receiving two weight-adjusted VPA doses as seizure prophylaxis prior to diagnostic myelography or cisternography. Free drug concentrations were similar when measured by equilibrium dialysis (ED...

journal_title：British journal of clinical pharmacology

authors： Rapeport WG,Mendelow AD,French G,MacPherson P,Teasdale E,Agnew E,Thompson GG,Brodie MJ

更新日期：1983-10-01 00:00:00

abstract：AIMS:Inhaled corticosteroids alone or in combination with long acting beta2-agonists are indicated for use in mild persistent asthmatics. We set out to evaluate effects on airway hyperresponsiveness (AHR) and airway calibre using hydrofluoroalkane fluticasone/salmeterol (FP/SM) vs. double the dose of fluticasone alone ...

journal_title：British journal of clinical pharmacology

authors： Currie GP,Stenback S,Lipworth BJ

更新日期：2003-07-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:* The interindividual variability of the pharmacokinetic parameters of cilostazol is relatively large. * Cilostazol undergoes extensive hepatic metabolism via the P450 enzymes, primarily CYP3A and, to a lesser extent, CYP2C19. * Indeed, <1% of the administered dose of cilostazol...

journal_title：British journal of clinical pharmacology

authors： Yoo HD,Cho HY,Lee YB

更新日期：2010-01-01 00:00:00

abstract：:1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 ...

journal_title：British journal of clinical pharmacology

authors： Gazzard BG,Willison RA,Weston MJ,Thompson RP,Williams R

更新日期：1974-06-01 00:00:00

abstract：AIMS:A recent case report had suggested a citrus soft drink (Sun Drop) may have caused clinically relevant elevations in ciclosporin levels through a grapefruit juice-like mechanism via inactivation of intestinal cytochrome P450 3A4 (CYP3A4). This study was conducted to investigate the effect of grapefruit juice and ci...

journal_title：British journal of clinical pharmacology

authors： Schwarz UI,Johnston PE,Bailey DG,Kim RB,Mayo G,Milstone A

更新日期：2006-10-01 00:00:00

abstract：AIMS:Post licensing, the evaluation of drug safety relies heavily on the collation of sporadic, spontaneous reports on adverse effects. The aim was to assess the potential utility of a more systematic approach to the detection of adverse events that utilizes routinely collected clinical data from a large primary care p...

journal_title：British journal of clinical pharmacology

authors： Grosso A,Douglas I,Hingorani A,MacAllister R,Smeeth L

更新日期：2008-11-01 00:00:00

abstract：AIMS:The efflux transporter P-glycoprotein (ABCB1) acts at the blood-brain barrier (BBB) to restrict the distribution of many different drugs from blood to the brain. Previous data suggest an age-associated decrease in the expression and function of ABCB1 at the BBB. In the present study, we investigated the influence ...

journal_title：British journal of clinical pharmacology

authors： Bauer M,Wulkersdorfer B,Karch R,Philippe C,Jäger W,Stanek J,Wadsak W,Hacker M,Zeitlinger M,Langer O

更新日期：2017-09-01 00:00:00

abstract：:Infections due to resistant and multidrug resistant (MDR) organisms in haematology patients and haematopoietic stem cell transplant recipients are an increasingly complex problem of global concern. We outline the burden of illness and epidemiology of resistant organisms such as gram-negative pathogens, vancomycin-resi...

journal_title：British journal of clinical pharmacology

authors： Trubiano JA,Worth LJ,Thursky KA,Slavin MA

更新日期：2015-02-01 00:00:00

abstract：:The present study was designed to evaluate the potential anti-ischaemic activity of R 56865 in patients with coronary artery disease, scheduled to undergo percutaneous transluminal coronary angioplasty (PTCA). At baseline a complete haemodynamic profile, including cardiac output and coronary sinus blood flow (CSBF) wa...

journal_title：British journal of clinical pharmacology

authors： Pijl AJ,Van Wezel HB,Koolen JJ,Piek JJ,Koch K,Swaan A,David GK,Visser CA,Van Zwieten PA

更新日期：1995-05-01 00:00:00

abstract：:1. The relative bioavailability of cyclosporin was studied in 11 healthy volunteers after single oral capsule doses of cyclosporin on three separate occasions; fasting, with breakfast and with breakfast together with bile acid tablets (400 mg of cholic acid and 100 mg of dehydrocholic acid). 2. There was a significant...

journal_title：British journal of clinical pharmacology

authors： Lindholm A,Henricsson S,Dahlqvist R

更新日期：1990-05-01 00:00:00

abstract：:The influence of cimetidine pretreatment on the pharmacokinetics of 5-fluorouracil (5FU) has been studied in 15 ambulant patients with carcinoma. Neither pretreatment with a single dose of cimetidine (400 mg) nor with daily treatment at 1000 mg for 1 week altered 5FU pharmacokinetics. Pretreatment with cimetidine for ...

journal_title：British journal of clinical pharmacology

authors： Harvey VJ,Slevin ML,Dilloway MR,Clark PI,Johnston A,Lant AF

更新日期：1984-09-01 00:00:00

abstract：:1. Oxycodone hydrochloride (0.1 mg kg-1) was given by intravenous bolus to 18 children after ophthalmic surgery. Plasma was sampled for up to 8 h. Blood pressure, heart rate, peripheral arteriolar oxygen saturation, end-tidal carbon dioxide and halothane concentrations and ventilatory rate were also recorded. 2. Mean ...

journal_title：British journal of clinical pharmacology

authors： Olkkola KT,Hamunen K,Seppälä T,Maunuksela EL

更新日期：1994-07-01 00:00:00

abstract：AIM:The large inter-individual variability in clopidogrel response is attributed to pharmacokinetics. Although, it has been used since the late 1990s the pharmacokinetic fate of clopidogrel and its metabolites are poorly explained. The variable response to clopidogrel is believed to be multi-factorial, caused both by g...

journal_title：British journal of clinical pharmacology

authors： Ganesan S,Williams C,Maslen CL,Cherala G

更新日期：2013-06-01 00:00:00

abstract：:1 Prolactin levels in response to sulpiride were studied in healthy volunteers. 2 Oral doses of 1 mg-50 mg sulpiride or placebo were given. 3 A 3 mg sulpiride dose produced similar levels to those achieved with both 10 mg and 50 mg. 4 Circadian effects were studied showing no significant differences in the prolactin r...

journal_title：British journal of clinical pharmacology

authors： McMurdo ME,Howie PW,Lewis M,Marnie M,McEwen J,McNeilly AS

更新日期：1987-08-01 00:00:00

abstract：:1. The interaction between cyclosporin (CyA) and erythromycin was studied in renal transplant patients following oral and intravenous administration of CyA. 2. Blood and plasma CyA concentrations and blood concentrations of metabolite 17 were measured by h.p.l.c. 3. Erythromycin produced almost a two-fold increase in ...

journal_title：British journal of clinical pharmacology

authors： Gupta SK,Bakran A,Johnson RW,Rowland M

更新日期：1989-04-01 00:00:00

abstract：AIMS:The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate the publicly available data on pregnancy/lactation before and after marketing authorization in Europe of biologics ...

journal_title：British journal of clinical pharmacology

authors： Ghalandari N,Dolhain RJEM,Hazes JMW,Siezen CLE,van der Laan JW,Crijns HJMJ,van Puijenbroek EP,van der Woude CJ

更新日期：2020-03-01 00:00:00

abstract：:1 Improvement in physical performance, based on exercise tolerance, self-assessed work and physician-rated functional capacities, is proposed as a measure of efficacy of anti-anginal therapy in the rehabilitation of the cardiac patient. 2 Improved physical performance parallels changes in frequency of anginal attacks ...

journal_title：British journal of clinical pharmacology

authors： Ling AS,Groel JT

更新日期：1979-01-01 00:00:00

abstract：:1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hyperte...

journal_title：British journal of clinical pharmacology

authors： Lamming GD,Symonds EB

更新日期：1979-04-01 00:00:00

abstract：:1 The effect of pregnancy on the binding of phenytoin and phenobarbitone to serum proteins was studied in normal women and in drug treated epileptic women. 2 The binding of both drugs was reduced during pregnancy. The reduction correlated positively with the gestational age and negatively with the serum albumin concen...

journal_title：British journal of clinical pharmacology

authors： Chen SS,Perucca E,Lee JN,Richens A

更新日期：1982-04-01 00:00:00

abstract：AIMS:Adrenomedullin (ADM) is an important regulator of endothelial barrier function and vascular tone, and may represent a novel treatment target in sepsis. The non-neutralizing ADM antibody adrecizumab has shown promising results in preclinical sepsis models. In the present study, we investigated the safety, tolerabil...

journal_title：British journal of clinical pharmacology

authors： Geven C,van Lier D,Blet A,Peelen R,Ten Elzen B,Mebazaa A,Kox M,Pickkers P

更新日期：2018-09-01 00:00:00

abstract：AIMS:To compare the pharmacokinetics of oseltamivir and oseltamivir carboxylate in hepatically impaired patients and healthy subjects. METHODS:Hepatically impaired patients (n = 11) and healthy subjects (n = 11) were individually paired on the basis of gender, age (+/-10 years) and body weight (+/-20%) and administere...

journal_title：British journal of clinical pharmacology

authors： Snell P,Dave N,Wilson K,Rowell L,Weil A,Galitz L,Robson R

更新日期：2005-05-01 00:00:00

abstract：AIMS:Pravastatin is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, which is widely used both in primary and secondary prevention of coronary heart disease (CHD). Pravastatin is not subject to metabolism by cytochrome P450s, but it is actively transported from blood into target tissues (e.g. hepa...

journal_title：British journal of clinical pharmacology

authors： Zhang W,Chen BL,Ozdemir V,He YJ,Zhou G,Peng DD,Deng S,Xie QY,Xie W,Xu LY,Wang LC,Fan L,Wang A,Zhou HH

更新日期：2007-09-01 00:00:00

abstract：:Cefpiramide is a new parenteral cephalosporin mainly excreted in the bile. Eight patients with cholestasis and 11 healthy subjects received a single 1 g i.v. dose. Cefpiramide concentrations in plasma and urine were measured by h.p.l.c. and plasma binding was determined by ultrafiltration. Total clearance of cefpirami...

journal_title：British journal of clinical pharmacology

authors： Demontes-Mainard F,Vinçon G,Labat L,Amouretti M,Necciari J,Kieffer G,Bannwarth B

更新日期：1994-03-01 00:00:00