The kinetics of salivary elimination of cyclophosphamide in man.

abstract：:1 The effects of propranolol and atenolol given in random order in a cross-over study to fifteen patients with essential hypertension have been studied. 2 Both drugs were effective in lowering blood pressure and side effects were not markedly different. 3 There was no change in exchangeable sodium or potassium or in t...

journal_title：British journal of clinical pharmacology

authors： Wilkinson R,Stevens IM,Pickering M,Robson V,Hawkins T,Kerr DN,Harry JD

更新日期：1980-07-01 00:00:00

abstract：UNLABELLED:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT?: * Two chemically diverse CCK1 receptor antagonists have been shown clinically to inhibit CCK-evoked contraction of human gallbladder [2, 3]. These studies have not examined the relationship between plasma concentration and effect, the latter usually considered to be...

journal_title：British journal of clinical pharmacology

authors： Gerskowitch VP,Hodge J,Hull RA,Shankley NP,Kalindjian SB,McEwen J,Black JW

更新日期：2007-05-01 00:00:00

abstract：AIMS:Aldosterone has been found to influence cancer cell growth, cell cycle regulation and cell migration, including in prostate cancer cells. Spironolactone is an aldosterone antagonist used for managing chronic heart failure (HF) with known antiandrogenic effects. We examined the effect of spironolactone exposure amo...

journal_title：British journal of clinical pharmacology

authors： Hiebert BM,Janzen BW,Sanjanwala RM,Ong AD,Feldman RD,Kim JO

更新日期：2020-09-28 00:00:00

abstract：:1 The relationship between serum quinidine levels and rate-corrected QT (QTc) interval after administration of single identical doses of quinidine was assessed. Quinidine concentrations were determined by a modification of Hamfelt & Malers' (1963) method. The significance and clinical application of our findings is di...

journal_title：British journal of clinical pharmacology

authors： Edwards IR,Hancock BW,Saynor R

更新日期：1974-12-01 00:00:00

abstract：:Darunavir is an efficacious drug; however, pharmacokinetic variability has been reported. The objective of this study was to find predisposing factors for low darunavir plasma concentrations in patients starting the once- or twice-daily dosage. Darunavir plasma concentrations from January 2010 till December 2014 of hu...

journal_title：British journal of clinical pharmacology

authors： Daskapan A,Stienstra Y,Kosterink JGW,Bierman WFW,van der Werf TS,Touw DJ,Alffenaar JC

更新日期：2018-03-01 00:00:00

abstract：AIM:The aim was to examine patients' stated preferences to persist with medicines and to explore the influence of psychosocial and sociocognitive factors. METHODS:Community-dwelling, hypertensive patients recruited from nine European countries were invited to complete a discrete choice experiment (DCE) with attributes...

journal_title：British journal of clinical pharmacology

authors： Holmes EA,Morrison VL,Hughes DA

更新日期：2016-08-01 00:00:00

abstract：:1. The three dimensional requirements for inhibition of ACE (angiotensin converting enzyme) were investigated in order to facilitate design of a more potent and selective antihypertensive agent. 2. All compounds designed possessed a bicyclic unit incorporating carboxylate and amidic carbonyl groups together with a thi...

journal_title：British journal of clinical pharmacology

authors： Attwood MR

更新日期：1989-01-01 00:00:00

abstract：:Ten healthy volunteers were treated for 4 days with 160 mg propranolol HCl and placebo in random order. At the end of each treatment salivary antipyrine kinetics and the plasma kinetics and urinary excretion of paracetamol and its major metabolites were measured following a 1500 mg oral dose. Propranolol prolonged the...

journal_title：British journal of clinical pharmacology

authors： Baraka OZ,Truman CA,Ford JM,Roberts CJ

更新日期：1990-02-01 00:00:00

abstract：:The renal response to a challenge of maximal water diuresis has been studied in seven subjects pretreated over 48 h with either placebo, probenecid, indomethacin or piroxicam. Probenecid did not alter the excretion of water and sodium chloride when compared with placebo responses, but increased both phosphate and urat...

journal_title：British journal of clinical pharmacology

authors： Dixey JJ,Noormohamed FH,Lant AF,Brewerton DA

更新日期：1988-05-01 00:00:00

abstract：:The discovery of immune checkpoints and their role in modulating immune response have revolutionised cancer treatment in recent years. The immune checkpoints, cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 and its ligand, programmed cell death-ligand 1, have been extensively studied. Curr...

journal_title：British journal of clinical pharmacology

authors： Chew HY,Dolcetti R,Simpson F

更新日期：2020-09-01 00:00:00

abstract：:WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The population pharmacokinetics and limited sampling strategies for ciclosporin monitoring have been extensively studied in renal and liver transplant recipients. Little is known about the pharmacokinetics of ciclosporin in patients undergoing haematopoietic allogeneic stem c...

journal_title：British journal of clinical pharmacology

authors： Wilhelm AJ,de Graaf P,Veldkamp AI,Janssen JJ,Huijgens PC,Swart EL

更新日期：2012-04-01 00:00:00

abstract：:The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-blind crossover trial using an automated psychomotor test battery (APT), postural sway (PS), blood pressure (BP) and puls...

journal_title：British journal of clinical pharmacology

authors： Kinirons MT,Jackson SH,Kalra L,Trevit RT,Swift CG

更新日期：1993-10-01 00:00:00

abstract：:1. We have measured [3H]-ouabain binding to lymphocyte membranes in eight healthy volunteers before and after they had taken lithium carbonate for 14 days in doses which maintained the serum lithium concentration in the range 0.5-1.0 mmol 1-1. 2. There was a statistically significant increase in the [3H]-ouabain bindi...

journal_title：British journal of clinical pharmacology

authors： Antia IJ,Dorkins CE,Wood AJ,Aronson JK

更新日期：1992-12-01 00:00:00

abstract：:The effects on carotid artery blood flow of atenolol (a selective beta 1-adrenoceptor antagonist) and xamoterol (a beta 1-adrenoceptor partial agonist with 43% agonist activity) were measured using a Doppler technique in eight healthy volunteers. Atenolol produced a decrease in blood pressure and blood velocity flow, ...

journal_title：British journal of clinical pharmacology

authors： Fitzgerald DE,Harry JD

更新日期：1989-01-01 00:00:00

abstract：AIMS:Using human liver microsomes from donors of the CYP2D6 poor and extensive metabolizer genotypes, the role of individual cytochromes P-450 in the oxidative metabolism of dihydrocodeine was investigated. METHODS:The kinetics of formation of N- and O-demethylated metabolites, nordihydrocodeine and dihydromorphine, w...

journal_title：British journal of clinical pharmacology

authors： Kirkwood LC,Nation RL,Somogyi AA

更新日期：1997-12-01 00:00:00

abstract：:The pharmacokinetic basis for using various experimental indices, (urinary drug: metabolite and metabolite:drug + metabolite ratios, urinary metabolite recovery and AUC values), for detecting polymorphic oxidative drug metabolism was examined. Pharmacokinetic determinants in addition to partial metabolic clearance dow...

journal_title：British journal of clinical pharmacology

authors： Jackson PR,Tucker GT,Lennard MS,Woods HF

更新日期：1986-11-01 00:00:00

abstract：AIMS:To investigate the impact of cytochrome P450 2D6 (CYP2D6) on dose-adjusted serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol in a therapeutic drug monitoring (TDM) cohort of psychiatric patients. We also studied the functional impact of CYP2D6*41 on dose-adjusted serum concentration...

journal_title：British journal of clinical pharmacology

authors： Waade RB,Solhaug V,Høiseth G

更新日期：2020-10-28 00:00:00

abstract：:1. Azole antifungal agents such as ketoconazole act by inhibiting cytochrome P-450 mediated sterol synthesis in the fungal cell membrane and thus have the potential to interfere with mammalian steroidogenesis. Fluconazole is a novel orally-effective antifungal triazole which has been reported to have more specific eff...

journal_title：British journal of clinical pharmacology

authors： Devenport MH,Crook D,Wynn V,Lees LJ

更新日期：1989-06-01 00:00:00

abstract：:1. Labetalol, a new drug combining alpha-and beta-adrenoceptor blocking properties, has been compared with placebo in a double-blind crossover study of a group of patients with mild to moderate essential hypertension (blood pressure 150/100 to 189/114 mmHg). 2. Labetalol and propranolol lowered blood pressure satisfac...

journal_title：British journal of clinical pharmacology

authors： Pugsley DJ,Nassim M,Armstrong BK,Beilin L

更新日期：1979-01-01 00:00:00

abstract：:In a dog model of partial myocardial ischaemia, superimposed ST segment elevations in epicardial ECGs were inhibited by nicardipine over a cumulative i.v. dose range of 1-20 micrograms kg-1. Over the cumulative i.v. dose range of 0.5-166.5 micrograms kg-1, nicardipine had little overall effect on gross cardiac conduct...

journal_title：British journal of clinical pharmacology

authors： Alps BJ,Calder C,Wilson A

更新日期：1985-01-01 00:00:00

abstract：:1. We compare the sensitivity and specificity of chosen outcome criteria in a placebo-controlled, randomised cross-over study of the efficacy of maintenance therapy with the levodopa/carbidopa combination (Sinemet Plus) alone. Patients were characterised by having idiopathic Parkinsonism with no overt fluctuations in ...

journal_title：British journal of clinical pharmacology

authors： Bowes SG,Clark PK,Charlett A,O'Neill CJ,Leeman AL,Weller C,Nicholson PW,Deshmukh AA,Dobbs SM,Dobbs RJ

更新日期：1991-03-01 00:00:00

abstract：AIMS:Drug disposition in children may vary from adults due to age-related variation in drug metabolism. Microdose studies present an innovation to study pharmacokinetics (PK) in paediatrics; however, they should be used only when the PK is dose linear. We aimed to assess dose linearity of a [14 C]midazolam microdose, b...

journal_title：British journal of clinical pharmacology

authors： van Groen BD,Vaes WH,Park BK,Krekels EHJ,van Duijn E,Kõrgvee LT,Maruszak W,Grynkiewicz G,Garner RC,Knibbe CAJ,Tibboel D,de Wildt SN,Turner MA

更新日期：2019-10-01 00:00:00

abstract：:1. The effects of the voltage dependent calcium channel blocking agent nifedipine, and of a calcium free bathing medium, on the responses of human blood vessels obtained postmortem to various agonists have been compared with those of the rat aorta. The human vessels studied were digital arteries, basilar arteries and ...

journal_title：British journal of clinical pharmacology

authors： Iwanov V,Moulds RF

更新日期：1991-01-01 00:00:00

abstract：AIM:To investigate the effect of sepsis upon the volume of distribution (Vd) of gentamicin in neonates. METHODS:A retrospective chart review was conducted of neonates admitted to Dunedin Hospital who had gentamicin concentrations performed between 1st January 2000 and 30th October 2003. Data from 277 neonates, includi...

journal_title：British journal of clinical pharmacology

authors： Lingvall M,Reith D,Broadbent R

更新日期：2005-01-01 00:00:00

abstract：AIMS:To investigate whether the drug-drug interaction between fexofenadine and ketoconazole is localized to efflux transport proteins of the small intestine, and to determine and classify the effective jejunal permeability (Peff) of fexofenadine according to the Biopharmaceutics Classification System (BCS). METHODS:Tw...

journal_title：British journal of clinical pharmacology

authors： Tannergren C,Knutson T,Knutson L,Lennernäs H

更新日期：2003-02-01 00:00:00

abstract：:After oral administration of 100 mg dapsone (DDS) to 25 healthy volunteers peak serum DDS concentrations between 1.10 and 2.33 mg l-1 were reached within 0.5 to 4 h. AUCs varied from 20.3 to 75.4 mg l-1 h, while the elimination half-lives ranged from 11.5 to 29.2 h. The apparent volumes of distribution were 0.84 to 1....

journal_title：British journal of clinical pharmacology

authors： Pieters FA,Zuidema J

更新日期：1986-10-01 00:00:00

abstract：:1 Plasma concentrations of metoprolol and a pharmacologically active metabolite, H119/66, have been measured in young and elderly volunteers after a single dose of 100 mg metoprolol tartrate and after repeated administrated over a period of 1 week. Whilst concentrations of metoprolol are similar in each group, concent...

journal_title：British journal of clinical pharmacology

authors： Quarterman CP,Kendall MJ,Jack DB

更新日期：1981-03-01 00:00:00

abstract：:1. The effects of chronic dosing with N-acetylcysteine (NAC), on nitrate-induced haemodynamic changes during the acute and chronic treatment of healthy volunteers with glyceryl trinitrate (GTN) patches (Transiderm nitro) has been investigated. 2. Seven volunteers were treated in a double-blind randomised crossover man...

journal_title：British journal of clinical pharmacology

authors： Hogan JC,Lewis MJ,Henderson AH

更新日期：1989-10-01 00:00:00

abstract：:The thermogenic beta 3-adrenoceptor agonist BRL 26830A has been shown to increase weight loss in dieting subjects but tremor was a frequent adverse effect. We have investigated the magnitude and nature of this tremor after a single oral dose in 18 subjects. Two complementary techniques were used to attach the recordin...

journal_title：British journal of clinical pharmacology

authors： Connacher AA,Lakie M,Powers N,Elton RA,Walsh EG,Jung RT

更新日期：1990-10-01 00:00:00

abstract：:The effects of intravenous nicardipine (2.5 mg) on the left ventricular (LV) inotropic state, LV metabolism, and coronary haemodynamics were analysed in 22 patients with angina pectoris. Measurements were made at fixed heart rate (atrial pacing), under basal state, and during a cold pressor test. After nicardipine, co...

journal_title：British journal of clinical pharmacology

authors： Rousseau MF,Vincent MF,Cheron P,van den Berghe G,Charlier AA,Pouleur H

更新日期：1985-01-01 00:00:00