Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children.

abstract：:The steady-state pharmacokinetic interaction between nefazodone and cimetidine was evaluated in a three-period crossover study consisting of three treatments of 1 week duration with a 1 week washout between treatments. The 18 healthy, male study subjects received: nefazodone hydrochloride 200 mg twice daily (every 12 ...

journal_title：British journal of clinical pharmacology

authors： Barbhaiya RH,Shukla UA,Greene DS

更新日期：1995-08-01 00:00:00

abstract：:The rise in plasma adenosine-3',5'-monophosphate occurring in response to insulin induced hypoglycaemia in normal human subjects, was abolished by non-selective beta-adrenoceptor blockade but unaffected by selective beta 1-adrenoceptor blockade. This implies that the rise is secondary to beta 2-adrenoceptor stimulatio...

journal_title：British journal of clinical pharmacology

authors： Armitstead JG,Lightman SL,Brown MJ,Causon RC,Vaughan NJ

更新日期：1983-12-01 00:00:00

abstract：:1. Effects of 3 h infusions of adrenaline (0.4 nmol kg-1 min-1) or placebo and of mental stress evoked by a colour word test (CWT) on adrenergic receptor function were investigated in healthy men. Responses of heart rate, blood pressure, plasma catecholamines, plasma cyclic AMP and plasma free fatty acids (FFA) were e...

journal_title：British journal of clinical pharmacology

authors： Larsson PT,Martinsson A,Olsson G,Hjemdahl P

更新日期：1989-12-01 00:00:00

abstract：:1. In order to assess the prevalence of concurrent use of more than one major psychotropic drug (polypsychopharmacy) in out-patients, a prescription database study was conducted in the Odense area for a period of 2 years. 2. During the index period 5.12% of the inhabitants purchased major psychotropic drugs. Of these,...

journal_title：British journal of clinical pharmacology

authors： Rosholm JU,Hallas J,Gram LF

更新日期：1994-06-01 00:00:00

abstract：AIMS:Navoximod (GDC-0919, NLG-919) is a small molecule inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), developed to treat the acquired immune tolerance associated with cancer. The primary objectives of this study were to assess navoximod's absolute bioavailability (aBA), determine the mass balance and routes of elim...

journal_title：British journal of clinical pharmacology

authors： Ma S,Suchomel J,Yanez E,Yost E,Liang X,Zhu R,Le H,Siebers N,Joas L,Morley R,Royer-Joo S,Pirzkall A,Salphati L,Ware JA,Morrissey KM

更新日期：2019-08-01 00:00:00

abstract：:Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reactio...

journal_title：British journal of clinical pharmacology

authors： Krueger H,Müller-Limmroth W

更新日期：1983-01-01 00:00:00

abstract：:1. The conversion of haloperidol (HAL) to reduced haloperidol (RHAL) and then back to HAL has been established in vivo and observed in psychiatric patients. The reduction of HAL to RHAL is known to be catalysed by a ketone reductase, while the nature of oxidation back to HAL is the subject of the present study. 2. We ...

journal_title：British journal of clinical pharmacology

authors： Tyndale RF,Kalow W,Inaba T

更新日期：1991-06-01 00:00:00

abstract：:1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of microsomes from nine human livers. Values for NADPH dependent toxicity ranged from 8.8-27% (15.8 +/- 5.9%) and were similar to those for microsomes from control mi...

journal_title：British journal of clinical pharmacology

authors： Coleman MD,Breckenridge AM,Park BK

更新日期：1989-10-01 00:00:00

abstract：AIMS:Drug-induced liver injury (DILI) is rare compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case...

journal_title：British journal of clinical pharmacology

authors： Teschke R,Danan G

更新日期：2018-07-01 00:00:00

abstract：:The plasma concentrations of the tetracyclic antidepressant maprotiline and its effect on histamine-induced bronchoconstriction were measured after single (50 mg) and multiple (50 mg twice daily) oral doses in healthy subjects. Histamine-induced bronchoconstriction was abolished after a single dose of maprotiline and ...

journal_title：British journal of clinical pharmacology

authors： Firkusny L,Gleiter CH

更新日期：1994-04-01 00:00:00

abstract：:The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher t...

journal_title：British journal of clinical pharmacology

authors： Muhiddin KA,Johnston A,Turner P

更新日期：1984-04-01 00:00:00

abstract：:The fall in blood pressure produced by captopril is not accompanied by a compensatory tachycardia. Angiotensin converting enzyme may participate in the metabolism of endogenous opioids and these substances can lower blood pressure without reflex tachycardia. It is therefore possible that the hypotensive effect of capt...

journal_title：British journal of clinical pharmacology

authors： Rubin PC,Millar JA,Sturani S,Lawrie C,Reid JL

更新日期：1984-06-01 00:00:00

abstract：AIM:The large inter-individual variability in clopidogrel response is attributed to pharmacokinetics. Although, it has been used since the late 1990s the pharmacokinetic fate of clopidogrel and its metabolites are poorly explained. The variable response to clopidogrel is believed to be multi-factorial, caused both by g...

journal_title：British journal of clinical pharmacology

authors： Ganesan S,Williams C,Maslen CL,Cherala G

更新日期：2013-06-01 00:00:00

abstract：:The frequency distributions of the 0-8 h urinary metabolic ratios of debrisoquine and mephenytoin were measured in 111 healthy, unrelated Sinhalese resident in Sri Lanka. Blood samples were taken from 77 of these subjects for CYP2D6 genotyping. Bimodality in the distribution of the log10 debrisoquine/4-hydroxydebrisoq...

journal_title：British journal of clinical pharmacology

authors： Weerasuriya K,Jayakody RL,Smith CA,Wolf CR,Tucker GT,Lennard MS

更新日期：1994-11-01 00:00:00

abstract：:Submaximal dose pentagastrin tests conducted in normal male volunteers with L-643.441, a novel histamine H2-receptor antagonist, indicate that it is a potent and long-acting inhibitor of gastric acid secretion. The effect appears dose-dependent and single doses of 50 mg are sufficient to reduce secretory potential by ...

journal_title：British journal of clinical pharmacology

authors： Henry DA,Somerville KW,Kitchingman GK,Holmes IB,Tobert JA,Langman MJ

更新日期：1985-08-01 00:00:00

abstract：:1. We have utilised a new non-imaging echo-Doppler cardiac output device, using the principle of attenuated compensated volume flow (ACVF), to assess the cardiovascular effects of atenolol and buccal nitroglycerin (NTG) in a placebo-controlled study of 30 patients with coronary disease. 2. Atenolol (4 mg i.v.) reduced...

journal_title：British journal of clinical pharmacology

authors： Silke B,Verma SP,Taylor SH

更新日期：1990-06-01 00:00:00

abstract：:1. The influence of food on the absorption of frusemide and bumetanide was compared in two separate randomized crossover studies. 2. On three separate occasions frusemide 40 mg was administered to eight healthy male volunteers intravenously, orally in the fasting state and orally after a standard breakfast. Blood and ...

journal_title：British journal of clinical pharmacology

authors： McCrindle JL,Li Kam Wa TC,Barron W,Prescott LF

更新日期：1996-12-01 00:00:00

abstract：AIMS:The aim of this analysis was to develop a population pharmacokinetic model for Emfilermin (recombinant human leukaemia inhibitory factor, r-hLIF) following subcutaneous administration to healthy postmenopausal women and to infertile patients undergoing in vitro fertilization and embryo transfer (IVF-ET). METHODS:...

journal_title：British journal of clinical pharmacology

authors： Goggin T,Nguyen QT,Munafo A

更新日期：2004-05-01 00:00:00

abstract：AIMS:Aldosterone has been found to influence cancer cell growth, cell cycle regulation and cell migration, including in prostate cancer cells. Spironolactone is an aldosterone antagonist used for managing chronic heart failure (HF) with known antiandrogenic effects. We examined the effect of spironolactone exposure amo...

journal_title：British journal of clinical pharmacology

authors： Hiebert BM,Janzen BW,Sanjanwala RM,Ong AD,Feldman RD,Kim JO

更新日期：2020-09-28 00:00:00

abstract：:1 In healthy male volunteers dazoxiben (UK 37248), an inhibitor of thromboxane synthetase, abolished the arterial and venous vasoconstriction produced in the forearm by cold stimulation. 2 Aspirin alone had no effect on this vasoconstriction but negated the effect of dazoxiben. 3 In vitro dazoxiben increased the produ...

journal_title：British journal of clinical pharmacology

authors： Cowley AJ,Jones EW,Hanley SP

更新日期：1983-01-01 00:00:00

abstract：:There is concern in the UK about nonmedical use (NMU) of alprazolam (Xanax). We investigated the epidemiology of alprazolam NMU compared with diazepam using data from the Survey of Non-Medical Use of Prescription Drugs (NMURx) programme (collected 28 September-1 December 2017). The survey included 10 019 respondents a...

journal_title：British journal of clinical pharmacology

authors： Hockenhull J,Amioka E,Black JC,Haynes CM,Dargan PI,Dart RC,Wood DM

更新日期：2019-08-01 00:00:00

abstract：AIMS:The therapeutic action of tricyclic agents may be accompanied by unwanted effects on the cardiovascular system. The evidence for the effects on vascular and nonvascular smooth muscle comes from animal studies. Whether these studies can be extrapolated to human vessels remains to be determined. Therefore, the prese...

journal_title：British journal of clinical pharmacology

authors： Vila JM,Medina P,Segarra G,Lluch P,Pallardó F,Flor B,Lluch S

更新日期：1999-08-01 00:00:00

abstract：:People who are 60 years old and older have the highest incidence of developing new-onset epilepsy. The increase of the ageing population has resulted in a greater number of patients with new-onset epilepsy or at risk of developing the condition. Previously published review articles regarding epilepsy in older patients...

journal_title：British journal of clinical pharmacology

authors： Vu LC,Piccenna L,Kwan P,O'Brien TJ

更新日期：2018-10-01 00:00:00

abstract：:Scientific advice (SA) is an important tool offered by regulators to help developers generate robust evidence on a medicine's benefits and risks. Drawing on accumulated experience and looking at the SA provided by the European Medicines Agency in 2018 to advanced therapy medicinal products originally developed by publ...

journal_title：British journal of clinical pharmacology

authors： Tavridou A,Rogers D,Bonelli M,Schiel A,Hidalgo-Simon A

更新日期：2020-11-25 00:00:00

abstract：:1 The effect of labetalol has been assessed in an open clinical trial in 19 patients with sub-optimal control of blood pressure on other therapy, and in a placebo-controlled cross-over study. Most patients were taking a diuretic before the trial and they continued to do so during the trial. 2 In the open trial, labeta...

journal_title：British journal of clinical pharmacology

authors： Bolli P,Waal-Manning J,Wood AJ,Simpson FO

更新日期：1976-08-01 00:00:00

abstract：:1 The anticholinergic effects of atropine and two antihistamines (terfenadine and mequitazine) were investigated vs placebo in a double-blind study. 2 Salivary secretion, basal pupil diameter, pilocarpine (0.25%) induced miosis and heart rate were determined in eight healthy volunteers, seven male and one female, aged...

journal_title：British journal of clinical pharmacology

authors： Brion N,Beaumont D,Advenier C

更新日期：1988-01-01 00:00:00

abstract：:1. The antihypertensive efficacy and tolerability of a low dose combination of the angiotensin converting enzyme inhibitor ramipril (2.5 mg) and the extended release formulation of the dihydropyridine calcium channel antagonist felodipine (5 mg) were assessed in a double-blind, double dummy placebo controlled, randomi...

journal_title：British journal of clinical pharmacology

authors： Bainbridge AD,Macfadyen RJ,Stark S,Lees KR,Reid JL

更新日期：1993-10-01 00:00:00

abstract：:1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5-hydroxy...

journal_title：British journal of clinical pharmacology

authors： Leonard BE

更新日期：1978-01-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Venous thromboembolism is a frequent complication in critically ill patients that has a negative impact on patient outcomes. Critically ill patients have significantly lower plasma anti-factor-Xa activity levels compared with control patients after administration of subcutaneous...

journal_title：British journal of clinical pharmacology

authors： Gouya G,Palkovits S,Kapiotis S,Madl C,Locker G,Stella A,Wolzt M,Heinz G

更新日期：2012-11-01 00:00:00

abstract：:1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 ...

journal_title：British journal of clinical pharmacology

authors： Gazzard BG,Willison RA,Weston MJ,Thompson RP,Williams R

更新日期：1974-06-01 00:00:00