Pharmacodynamic monitoring during acute intervention in ischaemic heart disease using a new echo-Doppler device.

abstract：:Eleven patients with stable rheumatoid disease (RD) who were receiving regular corticosteroid therapy (CS) were investigated to discover the effect on plasma prednisolone levels of additional therapy with the non-steroidal anti-inflammatory (NSAI) drugs, indomethacin and naproxen. There was a highly significant (P les...

journal_title：British journal of clinical pharmacology

authors： Rae SA,Williams IA,English J,Baylis EM

更新日期：1982-09-01 00:00:00

abstract：:Three hypothalamic regulatory hormones, thyrotrophin-releasing hormone (TRH), luteinizing hormone/follicle-stimulating hormone-releasing hormone (LH/FSH-RH) and growth hormone-release inhibiting hormone (GH-RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative ...

journal_title：British journal of clinical pharmacology

authors： Ashton H,Millman JE,Telford R,Thompson JW,Davies TF,Hall R

更新日期：1976-08-01 00:00:00

abstract：:1 In a preliminary double-blind trial the effects of ephedrine and pseudoephedrine on the blood pressure and heart rate of resting healthy volunteers were compared. Ephedrine 60 or 90 mg were required to raise the diastolic blood pressure above 90 mmHg, whereas 210 or 240 mg pseudoephedrine were required to produce th...

journal_title：British journal of clinical pharmacology

authors： Drew CD,Knight GT,Hughes DT,Bush M

更新日期：1978-09-01 00:00:00

abstract：AIMS:Sulfonylureas are recommended as second-line treatment in the management of type 2 diabetes. However, they are still commonly used also as first-line treatment instead of metformin. Given the controversial cardiovascular safety of sulfonylureas, we aimed to determine if their use as first-line treatment is associa...

journal_title：British journal of clinical pharmacology

authors： Filion KB,Douros A,Azoulay L,Yin H,Yu OH,Suissa S

更新日期：2019-10-01 00:00:00

abstract：:1. Double-blind controlled comparisons of nomifensine with placebo, imipramine, desipramine, viloxazine, nortriptyline, a combination of amitriptyline and chlordiazepoxide, and diazepam have been carried out in various parts of the world. 2. Dosage ranged from 50-225 mg daily, and treatment lasted from 2-26 weeks. 3. ...

journal_title：British journal of clinical pharmacology

authors： Habermann W

更新日期：1977-01-01 00:00:00

abstract：AIMS:Paraquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self-poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive ther...

journal_title：British journal of clinical pharmacology

authors： Wunnapuk K,Mohammed F,Gawarammana I,Liu X,Verbeeck RK,Buckley NA,Roberts MS,Musuamba FT

更新日期：2014-10-01 00:00:00

abstract：:1 Haemodynamic effects of cigarette smoking before and during chronic treatment with propranolol and metoprolol were studied in 16 patients with essential hypertension. 2 Smoking of cigarettes induced an increase in blood pressure of the same degree in all experimental sessions. Heart rate increased by 16 beats/min du...

journal_title：British journal of clinical pharmacology

authors： Houben H,Thien T,Van 'T Laar A

更新日期：1981-07-01 00:00:00

abstract：:The effects of intravenous nicardipine (2.5 mg) on the left ventricular (LV) inotropic state, LV metabolism, and coronary haemodynamics were analysed in 22 patients with angina pectoris. Measurements were made at fixed heart rate (atrial pacing), under basal state, and during a cold pressor test. After nicardipine, co...

journal_title：British journal of clinical pharmacology

authors： Rousseau MF,Vincent MF,Cheron P,van den Berghe G,Charlier AA,Pouleur H

更新日期：1985-01-01 00:00:00

abstract：:Theophylline clearance was studied in normal healthy volunteers before and after chronic oral dosing. Oral theophylline clearance showed a significant decrease (P less than 0.001) from 59.3 +/- 6.48 ml/min (mean +/- s.e. mean, n = 10) to 48.0 +/- 6.4 ml/min. Steady-state intravenous clearance decreased by 26 +/- 2% fr...

journal_title：British journal of clinical pharmacology

authors： Efthimiou H,Morgan DJ,Ioannides-Demos L,Raymond K,McLean AJ

更新日期：1984-05-01 00:00:00

abstract：:The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher t...

journal_title：British journal of clinical pharmacology

authors： Muhiddin KA,Johnston A,Turner P

更新日期：1984-04-01 00:00:00

abstract：AIMS:To describe age- and gender-related prescription patterns of diuretics in community-dwelling elderly, and to compare diuretics to other cardiovascular (CV) medications. METHODS:Cross-sectional study of patient-specific prescription data derived from a panel of 10 Dutch community pharmacies. Determination of propo...

journal_title：British journal of clinical pharmacology

authors： van Kraaij DJ,Jansen RW,de Gier JJ,Gribnau FW,Hoefnagels WH

更新日期：1998-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Rosiglitazone is able to increase serum adiponectin levels significantly in Type 2 diabetic patients. :The role of genetic factors that determine the marked interindividual variability in glucose-lowering efficacy of rosiglitazone in Chinese patients is not known. The current st...

journal_title：British journal of clinical pharmacology

authors： Sun H,Gong ZC,Yin JY,Liu HL,Liu YZ,Guo ZW,Zhou HH,Wu J,Liu ZQ

更新日期：2008-06-01 00:00:00

abstract：:The degrees of interactions between the H2-receptor antagonists, cimetidine and ranitidine, and several beta-adrenoceptor blockers were investigated in healthy volunteers following 7 days of oral monotherapy with penbutolol, propranolol, metoprolol, pindolol and atenolol, and after co-administration with each of the H...

journal_title：British journal of clinical pharmacology

authors： Mutschler E,Spahn H,Kirch W

更新日期：1984-01-01 00:00:00

abstract：:1. The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero-order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/-...

journal_title：British journal of clinical pharmacology

authors： Van Hoogdalem EJ,Wackwitz AT,De Boer AG,Cohen AF,Breimer DD

更新日期：1989-01-01 00:00:00

abstract：:1 To compare the haemodynamic effects of secondary characteristics of beta-adrenoceptor blockers with an angiotensin converting enzyme inhibitor forty patients with previously untreated mild to moderate hypertension were prescribed either atenolol 50-100 mg day-1, labetalol 200-800 mg day-1, pindolol 10-30 mg day-1 or...

journal_title：British journal of clinical pharmacology

authors： Roberts DH,Tsao Y,Grimmer SF,Winstanley PA,Orme ML,Breckenridge AM

更新日期：1987-08-01 00:00:00

abstract：:Regulating drugs does not end when market access has been granted. Monitoring drugs over the life cycle has become state of the art, inherent to evolving legislation and societal need. Here, we explore how the drug label could move along in a changing playing-field and become a sustainable label for the future. A dial...

journal_title：British journal of clinical pharmacology

authors： Gispen-de Wied CC,Weemers J,Boon W,Mol PGM,Stolk P

更新日期：2019-10-01 00:00:00

abstract：WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT:Randomized controlled trials (RCTs) are believed to be one of the best methods of clinical research because they can minimize systematic errors of various types. Temporal trends in the various aspects of RCTs have been studied in several medical fields (e.g. nephrology, hepatolo...

journal_title：British journal of clinical pharmacology

authors： Falagas ME,Pitsouni EI,Bliziotis IA

更新日期：2008-06-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) is of great importance in pharmacology because it catalyzes the metabolism (methylation) of endogenous and xenobiotic catechols. Moreover, inhibition of COMT is the drug target in the management of central nervous system (CNS) disorders such as Parkinson's disease due to its role in...

journal_title：British journal of clinical pharmacology

authors： Ma Z,Liu H,Wu B

更新日期：2014-03-01 00:00:00

abstract：AIMS:The protease inhibitor indinavir is characterized by an important interindividual pharmacokinetic variability, which results from the actions of the metabolizing enzymes cytochrome P450 (CYP) 3A and the multidrug efflux pump P-glycoprotein (P-gp), encoded by MDR1. Using a population pharmacokinetic approach, we in...

journal_title：British journal of clinical pharmacology

authors： Solas C,Simon N,Drogoul MP,Quaranta S,Frixon-Marin V,Bourgarel-Rey V,Brunet C,Gastaut JA,Durand A,Lacarelle B,Poizot-Martin I

更新日期：2007-09-01 00:00:00

abstract：AIMS:The objective of this study is to develop a generic model for tacrolimus pharmacokinetics modelling using a meta-analysis approach, that could serve as a first step towards a prediction tool to inform pharmacokinetics-based optimal dosing of tacrolimus in different populations and indications. METHODS:A systemati...

journal_title：British journal of clinical pharmacology

authors： Nanga TM,Doan TTP,Marquet P,Musuamba FT

更新日期：2019-12-01 00:00:00

abstract：AIMS:The effects of a single dose of oxymetazoline nasal spray on nasal patency have been compared with placebo using three separate measuring systems in normal subjects. METHODS:The study was a placebo-controlled, randomised double-blind crossover trial. Subjects without ear, nose or throat disease and with resting n...

journal_title：British journal of clinical pharmacology

authors： Bickford L,Shakib S,Taverner D

更新日期：1999-07-01 00:00:00

abstract：AIMS:Spirometry, plethysmography and impulse oscillometry (IOS) measure different aspects of lung function. These methods have not been compared for their ability to assess long- and short-acting anticholinergic agents. We therefore performed a double-blind, placebo-controlled, four-way cross-over study in 30 healthy s...

journal_title：British journal of clinical pharmacology

authors： Singh D,Tal-Singer R,Faiferman I,Lasenby S,Henderson A,Wessels D,Goosen A,Dallow N,Vessey R,Goldman M

更新日期：2006-04-01 00:00:00

abstract：:1 As part of a prospective study on the use of digoxin in a general practice, plasma digoxin concentrations were measured in all patients receiving the drug. 2 A low mean plasma digoxin concentration was observed, suggesting a cautious approach to digitalization. 3 The correlation between plasma digoxin concentration ...

journal_title：British journal of clinical pharmacology

authors： Holt DW,Williamson JD,Volans GN

更新日期：1977-06-01 00:00:00

abstract：:Simultaneous cerebrospinal fluid (CSF), total and free plasma valproic acid (VPA) concentrations were measured in 17 patients receiving two weight-adjusted VPA doses as seizure prophylaxis prior to diagnostic myelography or cisternography. Free drug concentrations were similar when measured by equilibrium dialysis (ED...

journal_title：British journal of clinical pharmacology

authors： Rapeport WG,Mendelow AD,French G,MacPherson P,Teasdale E,Agnew E,Thompson GG,Brodie MJ

更新日期：1983-10-01 00:00:00

abstract：AIMS:Drug-induced liver injury (DILI) is rare compared to the worldwide frequent acute or chronic liver diseases. Therefore, patients included in series of suspected DILI are at high risk of not having DILI, whereby alternative causes may confound the DILI diagnosis. The aim of this review is to evaluate published case...

journal_title：British journal of clinical pharmacology

authors： Teschke R,Danan G

更新日期：2018-07-01 00:00:00

abstract：AIMS:It has been shown that the cellular uptake and cytotoxicity of anthracyclines decrease with increasing cell density in vitro, an event termed 'the inocculum effect'. It is not known whether such an effect occurs in vivo. In this study the relationships between white blood cell (WBC) count, plasma and cellular conc...

journal_title：British journal of clinical pharmacology

authors： Bogason A,Quartino AL,Lafolie P,Masquelier M,Karlsson MO,Paul C,Gruber A,Vitols S

更新日期：2011-04-01 00:00:00

abstract：AIMS:To examine the feasibility of using the human iris in vivo for the assessment of the interaction between tyramine and monoamine oxidase (MAO) inhibitors. To examine the relative roles of the two forms of MAO in terminating the response to sympathomimetic amines in the iris, by comparing the effects of single oral ...

journal_title：British journal of clinical pharmacology

authors： Bitsios P,Langley RW,Tavernor S,Pyykkö K,Scheinin M,Szabadi E,Bradshaw CM

更新日期：1998-06-01 00:00:00

abstract：AIMS:This study compares physicians' recall of the claims of benefits on cardiovascular disease and diabetes made by pharmaceutical sales representatives for drugs approved on the basis of a surrogate outcome, i.e., an off-label claim, compared with those approved on the basis of a serious morbidity or mortality (clini...

journal_title：British journal of clinical pharmacology

authors： Habibi R,Lexchin J,Mintzes B,Holbrook A

更新日期：2017-11-01 00:00:00

abstract：:The pharmacokinetics of CGP 15 210 G, a new 5-HT uptake inhibitor in poor and extensive metabolisers of debrisoquine, give indirect evidence of an association between its metabolism and polymorphic hydroxylation of the debrisoquine type. ...

journal_title：British journal of clinical pharmacology

authors： Gleiter CH,Aichele G,Nilsson E,Hengen N,Antonin KH,Bieck PR

更新日期：1985-07-01 00:00:00

abstract：:The purpose of this randomized, double-blind, crossover trial was to compare the hypotensive effects of a fixed combination of captopril (C) 50 mg and hydrochlorothiazide (HCTZ) 25 mg (C 50/HCTZ 25) once daily with those of a fixed combination of C 25 mg and HCTZ 12.5 mg (C 25/HCTZ 12.5) twice daily. We studied 199 pa...

journal_title：British journal of clinical pharmacology

authors： Lacourcière Y,Poirier L,Provencher P,Guivarc'h PH

更新日期：1991-07-01 00:00:00