听力与言语-语言病理学

行为科学

医学伦理学

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  • Efficacy and safety of malarial prophylaxis with mefloquine during pregnancy in Kisangani, Democratic Republic of Congo: A randomized clinical trial.

    abstract:AIMS:Kisangani is an area with intense malaria transmission and sulfadoxine-pyrimethamine resistance. Alternative antimalaria prophylaxis medication and protocols are needed, particularly with pregnant individuals. In this study, we compare the tolerance and effectiveness of mefloquine regimen as a split dose with a me...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14720

    authors: Labama Otuli N,Marini Djang'eing'a R,Losimba Likwela J,Bosenge Nguma JD,Maindo Alongo MA,Ahuka Ona Longombe A,Mbutu Mango B,M N Bono D,L Mokili J,Manga Okenge JP

    更新日期:2021-01-04 00:00:00

  • Pilot drug and therapeutic committee program in Sierra Leone: a descriptive mixed method study.

    abstract:INTRODUCTION:Irrational medicine use is a global crisis, but incidences are proportionately higher in low and middle-income countries like Sierra Leone. This study explores the structure, functions, and challenges of Drug and Therapeutics Committees (DTC) an intervention towards irrational medicines use recently pilote...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14716

    authors: Kabba JA,Koroma MM,James PB,Kitchen C,Xu S,Chang J,Saeed A,Malik UR,Jiang M,Fang Y

    更新日期:2021-01-04 00:00:00

  • Development of AITC-induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin.

    abstract:BACKGROUND AND PURPOSE:Develop a translational assay of Transient Receptor Potential Ankyrin 1 (TRPA1) activity for use as a preclinical and clinical biomarker. EXPERIMENTAL APPROACH:Allyl isothiocyanate (AITC), capsaicin or citric acid were applied to ears of wildtype and Trpa1-knock out (Trpa1 KO) rats, and changes ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14370

    authors: Joseph V,Yang X,Gao SS,Elstrott J,Weimer RM,Theess W,Thrasher C,Singh N,Lin J,Bauer RN

    更新日期:2021-01-01 00:00:00

  • Fixed-dose combination antibiotics: The search for evidence using the example of ampicillin-cloxacillin.

    abstract::High consumption of irrational fixed-dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin-cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulat...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14711

    authors: Sayer B,Bortone B,Sharland M,Hsia Y

    更新日期:2020-12-23 00:00:00

  • Establishing dose bands for commonly prescribed oral medications for children in the UK: Results of a Delphi study.

    abstract:OBJECTIVE:To establish weight-based dose bands for commonly used oral medicines, given in liquid forms, for children in the UK that could be used for prescribing and administering accurate and safe drug doses. METHODS:A list of commonly prescribed, oral liquid medications was established from the medication dispensing...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14698

    authors: Rashed AN,Tomlin S

    更新日期:2020-12-10 00:00:00

  • Impact of lipophilic vs hydrophilic statins on the clinical outcome and biomarkers of remodelling in heart failure patients: A prospective comparative randomized study.

    abstract:AIMS:There are insufficient direct comparative studies addressing the impact of the type of statin on their respective efficacy in heart failure (HF). The aim of the current study was to compare the effects of lipophilic (atorvastatin) vs hydrophilic (rosuvastatin) on left ventricular function, inflammatory and fibrosi...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14695

    authors: El Said NO,El Wakeel LM,Khorshid H,Darweesh EAG,Ahmed MA

    更新日期:2020-12-08 00:00:00

  • Investigating the interaction between nifedipine- and ritonavir-containing antiviral regimens: A physiologically based pharmacokinetic/pharmacodynamic analysis.

    abstract:AIMS:Hypertension is a common comorbidity of patients with COVID-19, SARS or HIV infection. Such patients are often concomitantly treated with antiviral and antihypertensive agents, including ritonavir and nifedipine. Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the com...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14684

    authors: Niu W,Li S,Jin S,Lin X,Zhang M,Cai W,Jiao Z,Xiang X

    更新日期:2020-12-02 00:00:00

  • Bioequivalence of macitentan and tadalafil given as fixed-dose combination or single-component tablets in healthy subjects.

    abstract:AIMS:To demonstrate the bioequivalence of macitentan/tadalafil fixed-dose combination (FDC) tablets with single-component tablets of macitentan and tadalafil in healthy subjects. METHODS:Studies AC-077-101 and AC-077-103 were single-centre, open-label, single-dose, 2-period, randomized, crossover Phase 1 studies condu...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14347

    authors: Grill S,Bruderer S,Sidharta PN,Antonova M,Globig S,Carlson J,Schultz A,Csonka D

    更新日期:2020-12-01 00:00:00

  • Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model.

    abstract::Regulatory science underpins the objective evaluation of medicinal products. It is therefore imperative that regulatory science and expertise remain at the cutting edge so that innovations of ever-increasing complexity are translated safely and swiftly into effective, high-quality therapies. We undertook a comprehensi...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14099

    authors: Hines PA,Guy RH,Brand A,Humphreys AJ,Papaluca-Amati M

    更新日期:2020-12-01 00:00:00

  • Pregabalin poisoning and rising recreational use: a retrospective observational series.

    abstract:AIMS:With rising use worldwide, pregabalin is increasingly implicated in poisoning deaths. We aimed to investigate the clinical effects and complications of pregabalin poisoning. METHODS:This is a retrospective review of patients presenting with pregabalin poisoning to two tertiary toxicology units from 1 July 2014 to...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14348

    authors: Isoardi KZ,Polkinghorne G,Harris K,Isbister GK

    更新日期:2020-12-01 00:00:00

  • Prospective validation of a model-informed precision dosing tool for vancomycin in intensive care patients.

    abstract:AIMS:Vancomycin is an important antibiotic for critically ill patients with Gram-positive bacterial infections. Critically ill patients typically have severely altered pathophysiology, which leads to inefficacy or toxicity. Model-informed precision dosing may aid in optimizing the dose, but prospectively validated tool...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14360

    authors: Ter Heine R,Keizer RJ,van Steeg K,Smolders EJ,van Luin M,Derijks HJ,de Jager CPC,Frenzel T,Brüggemann R

    更新日期:2020-12-01 00:00:00

  • The first-in-human study of CNTO 7160, an anti-interleukin-33 receptor monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis.

    abstract:AIMS:To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). METHODS:In Part 1 of this Phase I, randomized, double-blind, placebo-c...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14361

    authors: Nnane I,Frederick B,Yao Z,Raible D,Shu C,Badorrek P,van den Boer M,Branigan P,Duffy K,Baribaud F,Fink D,Yang TY,Xu Z

    更新日期:2020-12-01 00:00:00

  • Role of TDM-based dose adjustments for taxane anticancer drugs.

    abstract::The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Still, the optimal use and the value of pharmacological personalization of the taxanes is still controversial. We give an overview on the pharmacologica...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14678

    authors: Muth M,Ojara FW,Kloft C,Joerger M

    更新日期:2020-11-28 00:00:00

  • Medication-related osteonecrosis of the jaw: Analysing the range of implicated drugs from the Australian database of adverse event notifications.

    abstract:AIMS:Medication-related osteonecrosis of the jaw (MRONJ) is an uncommon but potentially debilitating condition, characterised by nonhealing jawbone, with or without mucosal exposure, in the presence of certain drugs. Those already strongly associated with MRONJ include antiresorptives denosumab and bisphosphonates; how...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14681

    authors: Teoh L,Moses G,Nguyen AP,McCullough MJ

    更新日期:2020-11-27 00:00:00

  • Towards a better use of scientific advice for developers of advanced therapies.

    abstract::Scientific advice (SA) is an important tool offered by regulators to help developers generate robust evidence on a medicine's benefits and risks. Drawing on accumulated experience and looking at the SA provided by the European Medicines Agency in 2018 to advanced therapy medicinal products originally developed by publ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14672

    authors: Tavridou A,Rogers D,Bonelli M,Schiel A,Hidalgo-Simon A

    更新日期:2020-11-25 00:00:00

  • Proof of pharmacology of Org 48775-0, a p38 MAP kinase inhibitor, in healthy volunteers.

    abstract:AIM:To investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of the highly selective oral p38alpha/beta mitogen-activated protein (MAP) kinase inhibitor Org 48,775-0 in a first-in-human study. METHODS:In the single ascending dosing (SAD) study, an oral dose of Org 48,775-0 (0.3-600 mg) was evalua...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14655

    authors: Moerland M,Kales AJ,Broekhuizen K,Nässander U,Nelissen R,de Kam ML,Peeters PAM,Burggraaf J

    更新日期:2020-11-17 00:00:00

  • Exposure-response relationships of dapagliflozin on cardiorenal risk markers and adverse events: A pooled analysis of 13 phase II/III trials.

    abstract:AIMS:Dapagliflozin is a sodium-glucose co-transporter 2 inhibitor that has been developed as oral glucose lowering drug. The original dosefinding studies focused on optimal glycaemic effects. However, dapagliflozin also affects various cardiorenal risk markers and provides cardiorenal protection. To evaluate whether th...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14318

    authors: Koomen JV,Stevens J,Heerspink HJL

    更新日期:2020-11-01 00:00:00

  • Me-too pharmaceutical products: History, definitions, examples, and relevance to drug shortages and essential medicines lists.

    abstract::We define a me-too drug as a pharmacologically active compound that is structurally related to a first-in-class compound, regarded as belonging to the same therapeutic class as the original compound, and used for the same therapeutic purposes, but which may differ in some respects, such as specificity of pharmacologic...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14327

    authors: Aronson JK,Green AR

    更新日期:2020-11-01 00:00:00

  • Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers.

    abstract:AIMS:The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. METHODS:In a randomized 3-phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingest...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14315

    authors: Misaka S,Abe O,Ono T,Ono Y,Ogata H,Miura I,Shikama Y,Fromm MF,Yabe H,Shimomura K

    更新日期:2020-11-01 00:00:00

  • Assessing the impact of cystic fibrosis on the antipyretic response of ibuprofen in children: Physiologically-based modeling as a candle in the dark.

    abstract:AIM:The goal of this study is to present the utility of quantitative modelling for extrapolation of drug safety and efficacy to underrepresented populations in controlled clinical trials. To illustrate this, the stepwise development of an integrated disease/pharmacokinetics/pharmacodynamics model of antipyretic efficac...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14326

    authors: Cicali B,Long T,Kim S,Cristofoletti R

    更新日期:2020-11-01 00:00:00

  • Impact of CYP2D6 on serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol.

    abstract:AIMS:To investigate the impact of cytochrome P450 2D6 (CYP2D6) on dose-adjusted serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol in a therapeutic drug monitoring (TDM) cohort of psychiatric patients. We also studied the functional impact of CYP2D6*41 on dose-adjusted serum concentration...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14626

    authors: Waade RB,Solhaug V,Høiseth G

    更新日期:2020-10-28 00:00:00

  • A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single-dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers.

    abstract:AIMS:This study investigated the safety, tolerability and pharmacokinetics after administration of a specific Cannabis sativa cultivar extract, standardised to cannabidiol (CBD) content as sublingual wafer or oil formulation compared to nabiximols oromucosal spray. METHODS:For the single-dose study, the design was an ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14617

    authors: Hosseini A,McLachlan AJ,Lickliter JD

    更新日期:2020-10-19 00:00:00

  • The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple-dose trial.

    abstract:AIMS:Pupillography is a noninvasive and cost-effective method to determine autonomic nerve activity. Genetic variants in cytochrome P450 (CYP), dopamine receptor (DRD2, DRD3), serotonin receptor (HTR2A, HTR2C) and ATP-binding cassette subfamily B (ABCB1) genes, among others, were previously associated with the pharmaco...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14300

    authors: Koller D,Saiz-Rodríguez M,Zubiaur P,Ochoa D,Almenara S,Román M,Romero-Palacián D,de Miguel-Cáceres A,Martín S,Navares-Gómez M,Mejía G,Wojnicz A,Abad-Santos F

    更新日期:2020-10-01 00:00:00

  • Impact of spironolactone exposure on prostate cancer incidence amongst men with heart failure: A Pharmacoepidemiological study.

    abstract:AIMS:Aldosterone has been found to influence cancer cell growth, cell cycle regulation and cell migration, including in prostate cancer cells. Spironolactone is an aldosterone antagonist used for managing chronic heart failure (HF) with known antiandrogenic effects. We examined the effect of spironolactone exposure amo...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14568

    authors: Hiebert BM,Janzen BW,Sanjanwala RM,Ong AD,Feldman RD,Kim JO

    更新日期:2020-09-28 00:00:00

  • Scientifically based combination therapies with immuno-oncology checkpoint inhibitors.

    abstract::The discovery of immune checkpoints and their role in modulating immune response have revolutionised cancer treatment in recent years. The immune checkpoints, cytotoxic T-lymphocyte-associated protein 4, programmed cell death protein 1 and its ligand, programmed cell death-ligand 1, have been extensively studied. Curr...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14338

    authors: Chew HY,Dolcetti R,Simpson F

    更新日期:2020-09-01 00:00:00

  • Direct-acting oral anticoagulants and alopecia: The valuable support of postmarketing data.

    abstract::Little is known about the administration of direct-acting oral anticoagulants (DOACs) and the occurrence of alopecia. Our aim was to analyse the reports of alopecia following DOAC administration received until 2 May 2018 from VigiBase, the World Health Organization database. A descriptive analysis of age, sex, serious...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14221

    authors: Bonaldo G,Vaccheri A,Motola D

    更新日期:2020-08-01 00:00:00

  • The effects of meclizine on motion sickness revisited.

    abstract:AIMS:Antihistamines make up the first line of treatments against motion-sickness. Still, their efficacy and specific mechanism have come into question. The aim of this study was to investigate the effect of meclizine on motion-sensitivity. METHODS:This study was carried out as a triple-blinded randomized trial involvi...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14257

    authors: Wibble T,Engström J,Verrecchia L,Pansell T

    更新日期:2020-08-01 00:00:00

  • Antiseizure drugs and risk of developing smoking-related chronic obstructive pulmonary disease or lung cancer: A population-based case-control study.

    abstract:AIMS:To determine whether enzyme-inducing antiseizure drugs (ASDs) affect the risk of developing chronic obstructive pulmonary disease (COPD) or lung cancer in smokers. METHODS:Cases of COPD and lung cancer and matched controls without these conditions were identified from a population of smokers with ≥1 prescription ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14501

    authors: Leuppi-Taegtmeyer AB,Reinau D,Yilmaz S,Rüegg S,Krähenbühl S,Jick SS,Leuppi JD,Meier CR

    更新日期:2020-08-01 00:00:00

  • A multicentre prospective study evaluating the impact of proton-pump inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations.

    abstract::Voriconazole is an antifungal metabolised by CYP2C19 enzyme, which can be inhibited by proton-pump inhibitors (PPIs). A prospective observational study was carried out to determine the influence of PPIs on voriconazole pharmacokinetic. The 78 patients included were divided into 4 groups: omeprazole (n = 32), pantopraz...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14267

    authors: Blanco Dorado S,Maroñas Amigo O,Latorre-Pellicer A,Rodríguez Jato MT,López-Vizcaíno A,Gómez Márquez A,Bardán García B,Belles Medall D,Barbeito Castiñeiras G,Pérez Del Molino Bernal ML,Campos-Toimil M,Otero Espinar F,Blanco Hortas

    更新日期:2020-08-01 00:00:00

  • A semi-mechanistic model based on glutathione depletion to describe intra-individual reduction in busulfan clearance.

    abstract:AIM:To develop a semi-mechanistic model, based on glutathione depletion and predict a previously identified intra-individual reduction in busulfan clearance to aid in more precise dosing. METHODS:Busulfan concentration data, measured as part of regular care for allogeneic hematopoietic cell transplantation (HCT) patie...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14256

    authors: Langenhorst JB,Boss J,van Kesteren C,Lalmohamed A,Kuball J,Egberts ACG,Boelens JJ,Huitema ADR,van Maarseveen EM

    更新日期:2020-08-01 00:00:00

  • Long-term trajectories of medicine use among older adults experiencing polypharmacy in Australia.

    abstract:AIMS:To explore longitudinal changes in the number and type of medicines used among older people who experience polypharmacy. METHODS:We used pharmaceutical claims for a 10% sample of Australian Pharmaceutical Benefits Scheme beneficiaries to identify people aged 70 years and older who were exposed to 5 or more medici...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14504

    authors: Falster MO,Charrier R,Pearson SA,Buckley NA,Daniels B

    更新日期:2020-07-31 00:00:00

  • Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports.

    abstract:AIMS:Several cases of acute non-infectious cholestatic hepatitis recently appeared in Italy following consumption of Curcuma longa-containing dietary supplements. The aim of this research was to describe the Tuscan (Italy) cases of acute hepatitis and to compare them with similar cases of hepatotoxicity published in th...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14460

    authors: Lombardi N,Crescioli G,Maggini V,Ippoliti I,Menniti-Ippolito F,Gallo E,Brilli V,Lanzi C,Mannaioni G,Firenzuoli F,Vannacci A

    更新日期:2020-07-13 00:00:00

  • Advances and roadblocks in the treatment of malaria.

    abstract::The deployment of artesunate for severe malaria and the artemisinin combination therapies (ACTs) for uncomplicated malaria has been a major advance in antimalarial therapeutics. These drugs have reduced treated mortality, accelerated recovery and reduced treatment failure rates and transmission from the treated infect...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14474

    authors: Hanboonkunupakarn B,White NJ

    更新日期:2020-07-12 00:00:00

  • Assuming one dose per day yields a similar estimate of medication adherence in patients with stroke: An exploratory analysis using linked registry data.

    abstract:PURPOSE:Prescribed daily dose (PDD), the number of doses prescribed to be taken per day, is used to calculate medication adherence using pharmacy claims data. PDD can be substituted by (i) one dose per day (1DD), (ii) an estimate based on the 75th percentile of days taken by patients to refill a script (PDD75 ) or (iii...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14468

    authors: Ung D,Dalli LL,Lopez D,Sanfilippo FM,Kim J,Andrew NE,Thrift AG,Cadilhac DA,Anderson CS,Kilkenny MF

    更新日期:2020-07-08 00:00:00

  • A framework for simplification of quantitative systems pharmacology models in clinical pharmacology.

    abstract::Quantitative systems pharmacology (QSP) is a relatively new discipline within modelling and simulation that has gained wide attention over the past few years. The application of QSP models spans drug-target identification and validation, through all drug development phases as well as clinical applications. Due to thei...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1111/bcp.14451

    authors: Derbalah A,Al-Sallami H,Hasegawa C,Gulati A,Duffull SB

    更新日期:2020-07-04 00:00:00

  • Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia.

    abstract:AIMS:To characterize the pharmacokinetics (PK) of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in adults with relapsed or refractory hairy cell leukaemia, we examined data from a phase 1 study (Study 1001; n = 49) and from the pivotal clinical study (Study 1053; n = 74). METHODS:Data from both studies ...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14250

    authors: Kuruvilla D,Chia YL,Balic K,Yao NS,Kreitman RJ,Pastan I,Li X,Standifer N,Liang M,Tseng CM,Faggioni R,Roskos L

    更新日期:2020-07-01 00:00:00

  • Efficacy gap between phase II and subsequent phase III studies in oncology.

    abstract:AIMS:There is a trend for more flexibility in timing of evidence generation in relation to marketing authorization, including the option to complete phase III trials after authorization or not at all. This paper investigated the relation between phase II and III clinical trial efficacy in oncology. METHODS:All oncolog...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14237

    authors: Vreman RA,Belitser SV,Mota ATM,Hövels AM,Goettsch WG,Roes KCB,Leufkens HGM,Mantel-Teeuwisse AK

    更新日期:2020-07-01 00:00:00

  • Systemic exposure to 5-fluorouracil and its metabolite, 5,6-dihydrofluorouracil, and development of a limited sampling strategy for therapeutic drug management of 5-fluorouracil in patients with gastrointestinal malignancy.

    abstract:AIMS:5-Fluorouracil (5-FU) is widely used in combination chemotherapy, and literature suggests pharmacokinetic-guided dosing to improve clinical efficacy and reduce toxicity. This study aimed to determine the pharmacokinetic exposure of both 5-FU and its metabolite, 5,6-dihydrofluorouracil (DHFU), in patients with gast...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14444

    authors: Jacob J,Mathew SK,Chacko RT,Aruldhas BW,Singh A,Prabha R,Mathew BS

    更新日期:2020-06-27 00:00:00

  • Model informed dosing of hydroxycholoroquine in COVID-19 patients: Learnings from the recent experience, remaining uncertainties and gaps.

    abstract:AIMS:In the absence of a commonly agreed dosing protocol based on pharmacokinetic (PK) considerations, the dose and treatment duration for hydroxychloroquine (HCQ) in COVID-19 disease currently vary across national guidelines and clinical study protocols. We have used a model-based approach to explore the relative impa...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14436

    authors: Thémans P,Dauby N,Schrooyen L,Lebout F,Delforge M,Nasreddine R,Libois A,Payen MC,Konopnicki D,Wuillaume F,Lescrainier C,Verlinden V,Dogné JM,Hamdani J,Musuamba FT

    更新日期:2020-06-19 00:00:00

  • First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection.

    abstract:AIMS:SAR247799 is a selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist with potential to restore endothelial function in vascular pathologies. SAR247799, a first-in-class molecule differentiated from previous S1P1 -desensitizing molecules developed for multiple sclerosis, can activate S1P1 wi...

    journal_title:British journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1111/bcp.14422

    authors: Bergougnan L,Armani S,Golor G,Tardat A,Vitse O,Hurbin F,Scemama M,Poitiers F,Radzik D,Gaudin C,Hovsepian L,Muslin AJ,Kirkesseli S,Deutsch P,Parkar AA

    更新日期:2020-06-10 00:00:00

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