Abstract：
:1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hypertensive patients were successfully treated with intravenous labetalol. 4 There was a higher incidence of spontaneous labour in the labetalol group and a significant difference (P less than 0.05) in the Bishop score of the cervix between the two groups. 5 There were no apparent detrimental effects on the foetus antenatally, during labour or post partum. 6 Slight breathlessness in one patient treated with labetalol was the only side-effect observed but drowsiness, headache and postural hypotension were reported in patients receiving methyldopa.
journal_name
Br J Clin Pharmacoljournal_title
British journal of clinical pharmacologyauthors
Lamming GD,Symonds EBdoi
10.1111/j.1365-2125.1979.tb04784.xsubject
Has Abstractpub_date
1979-04-01 00:00:00pages
217S-22Seissn
0306-5251issn
1365-2125journal_volume
8 Suppl 2pub_type
杂志文章abstract：AIM:Sunitinib is an oral tyrosine kinase inhibitor approved for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). Because of the large interpatient pharmacokinetic variability and established exposure-response and exposure-toxicity relationships in clinical trial patients, therapeut...
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journal_title：British journal of clinical pharmacology
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pub_type： 临床试验,杂志文章
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
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journal_title：British journal of clinical pharmacology
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doi：10.1111/j.1365-2125.1990.tb05487.x
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abstract：AIMS:To determine role of CYP2D6 activity in the pharmacokinetics of propafenone (PPF) enantiomers in native Chinese subjects. METHODS:Sixteen extensive metabolizers (EMs) and one poor metabolizer (PM), whose phenotype had been previously assessed with dextromethorphan metabolic phenotyping, were enrolled. Blood sampl...
journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1365-2125.2001.01319.x
更新日期：2001-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1365-2125.2003.01712.x
更新日期：2003-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1983.tb01516.x
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doi：10.1111/j.1365-2125.1984.tb02369.x
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doi：10.1111/j.1365-2125.1990.tb03677.x
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1365-2125.2003.01930.x
更新日期：2003-11-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1990.tb03841.x
更新日期：1990-11-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1986.tb05165.x
更新日期：1986-02-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.2012.04233.x
更新日期：2012-06-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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更新日期：1985-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1986-11-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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journal_title：British journal of clinical pharmacology
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doi：10.1111/j.1365-2125.1981.tb01843.x
更新日期：1981-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.1983.tb02237.x
更新日期：1983-12-01 00:00:00
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journal_title：British journal of clinical pharmacology
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更新日期：2003-10-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/bcp.13482
更新日期：2018-04-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-03-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,评审
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更新日期：2019-10-01 00:00:00
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journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,评审
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更新日期：1992-12-01 00:00:00
abstract：AIMS:Several cases of acute non-infectious cholestatic hepatitis recently appeared in Italy following consumption of Curcuma longa-containing dietary supplements. The aim of this research was to describe the Tuscan (Italy) cases of acute hepatitis and to compare them with similar cases of hepatotoxicity published in th...
journal_title：British journal of clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/bcp.14460
更新日期：2020-07-13 00:00:00
abstract：:1. A bicycle exercise test was used to investigate functional capability and haemodynamics in 30 patients with heart failure (13 NYHA Class II, 17 Class III), before and after i.v. xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) 0.2 mg kg-1. 2. Resting heart rate fell from 78 to 74 beats min-1 (P less than 0.0...
journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：AIMS:In order to evaluate a hypothesized protective effect of the use of HMG Co-A reductase inhibitors (statins) on the development of Type 2 diabetes, we conducted a nested case-control study based on data from the UK-based General Practice Research Database (GPRD). METHODS:We identified a population of adults 30-79 ...
journal_title：British journal of clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1365-2125.2004.02142.x
更新日期：2004-09-01 00:00:00
