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Effects of age, sex and the oral contraceptive on the platelet membrane fibrinogen binding site (glycoprotein IIb/IIIa).

Abstract：

:1. We have studied the effects of age, sex and the oral contraceptive pill on platelet fibrinogen 'receptor' density (Bmax) and affinity (Kd). 2. [125I]-fibrinogen binding to gel-filtered platelets was assessed after stimulation with adenosine 5-diphosphate (ADP) and thrombin in 60 normal subjects; 37 females and 23 males. 3. For both agonists there was no significant difference in Bmax or Kd between the sexes. A trend towards increasing affinity (reduced Kd) with age was noted in the female group following ADP stimulation. This was not considered to be physiologically relevant. In the group as a whole no significant relationship of Bmax and Kd with age was demonstrated. 4. A further group of eight women taking low dose oestrogen combined oral contraceptive pill were studied on days 7, 14, 21 and 28 of the treatment cycle and compared with eight women with regular ovulatory cycles. No significant variations in Bmax or Kd were detected within or between cycles in these two groups. :This study of the platelet membrane fibrinogen binding site, called glycoprotein IIb/IIIa, the final common pathway for platelet aggregation, measured receptor density (Bmax) and affinity (Kd) in men and women of all ages and in cycling women and in those using oral contraceptives. The subjects were 37 women aged 21-91, 23 men aged 20-83, women aged 21-33 using low-dose combined oral contraceptives containing 30-35 mcg estrogen and 150-500 mcg progestin, compared to 8 menstruating women aged 21-43. The assay measured Iodine-125-fibrinogen binding to gel-filtered platelets stimulated with ADP and thrombin. There were no significant differences between the sexes for Bmax or Kd. A trend towards increasing affinity (reduced Kd) with age was seen in women after ADP stimulation, which was within normal limits and judged not of clinical significance. There were also no significant differences in the comparison of cycling and pill using women on cycle days 7, 14, 21 and 28, between groups or phases. Thus glycoprotein II/IIIa, the final common mediator of platelet aggregation, is a stable entity with little variation with age, gender or altered hormonal status.

journal_name

Br J Clin Pharmacol

journal_title

British journal of clinical pharmacology

authors

Cahill M,Mistry R,Chapman C,Wood JK,Barnett DB

doi

10.1111/j.1365-2125.1992.tb03994.x

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

11-5

issue

eissn

0306-5251

issn

1365-2125

journal_volume

pub_type

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Effects of age, sex and the oral contraceptive on the platelet membrane fibrinogen binding site (glycoprotein IIb/IIIa).